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The EMPEROR's New Clothes: Aren't We Just Treating Grades of Heart Failure With Reduced Ejection Fraction?.
Weir, Robin A.P. MD
doi : 10.1161/CIRCULATIONAHA.122.060570
Volume 146(20) pgs. 1489-1560,e282-e298 November 15, 2022
Artificial Intelligence for Contrast-Free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning-Based Virtual Native Enhancement.
Zhang, Qiang PhD ,,*; Burrage, Matthew K. MD ,,,*; Shanmuganathan, Mayooran MD; Gonzales, Ricardo A. BEng; Lukaschuk, Elena MSc; Thomas, Katharine E. MBBS; Mills, Rebecca BSc; Leal Pelado, Joana BSc; Nikolaidou, Chrysovalantou MD; Popescu, Iulia A. DPhil; Lee, Yung P. MBBS; Zhang, Xinheng PhD; Dharmakumar, Rohan PhD; Myerson, Saul G. MD; Rider, Oliver DPhil; Oxford Acute Myocardial Infarction (OxAMI) Study; Channon, Keith M. MD; Neubauer, Stefan MD; Piechnik, Stefan K. PhD ,,+; Ferreira, Vanessa M. MD, DPhil ,,+
doi : 10.1161/CIRCULATIONAHA.122.060137
Myocardial scars are assessed noninvasively using cardiovascular magnetic resonance late gadolinium enhancement (LGE) as an imaging gold standard. A contrast-free approach would provide many advantages, including a faster and cheaper scan without contrast-associated problems.
Artificial Intelligence to Extract Endogenous Tissue Characteristics: Has the Future Free From Gadolinium Contrast Arrived?.
Kwong, Raymond Y. MD, MPH; Jerosch-Herold, Michael PhD
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Gaziano, Liam PhD ,,,*; Sun, Luanluan PhD ,,*; Arnold, Matthew PhD *; Bell, Steven PhD; Cho, Kelly MD, MPH; Kaptoge, Stephen K. PhD; Song, Rebecca J. MPH; Burgess, Stephen PhD; Posner, Daniel C. PhD; Mosconi, Katja PhD; Robinson-Cohen, Cassianne PhD; Mason, Amy M. PhD; Bolton, Thomas R. PhD; Tao, Ran PhD; Allara, Elias MD, PhD; Schubert, Petra MPH; Chen, Lingyan PhD; Staley, James R. PhD; Staplin, Natalie PhD; Altay, Servet MD; Amiano, Pilar PharmD, MSc; Arndt, Volker PhD; Arnlov, Johan PhD; Barr, Elizabeth L.M. PhD; Bjorkelund, Cecilia MD; Boer, Jolanda M.A. PhD; Brenner, Hermann MD; Casiglia, Edoardo MD; Chiodini, Paolo PhD; Cooper, Jackie A. MSc; Coresh, Josef MD, PhD; Cushman, Mary MD; Dankner, Rachel MD; Davidson, Karina W. PhD; de Jongh, Renate T. MD, PhD; Donfrancesco, Chiara PhD; Engstrom, Gunnar MD; Freisling, Heinz PhD; de la Camara, Agustin Gomez PhD; Gudnason, Vilmundur MD; Hankey, Graeme J. MD; Hansson, Per-Olof MD, PhD; Heath, Alicia K. PhD; Hoorn, Ewout J. MD, PhD; Imano, Hironori MD; Jassal, Simerjot K. MD; Kaaks, Rudolf PhD; Katzke, Verena PhD; Kauhanen, Jussi MD; Kiechl, Stefan MD; Koenig, Wolfgang MD; Kronmal, Richard A. PhD; Kyro, Cecilie PhD; Lawlor, Deborah A. PhD; Ljungberg, Borje MD; MacDonald, Conor PhD; Masala, Giovanna MD; Meisinger, Christa MD; Melander, Olle MD; Moreno Iribas, Conchi PhD; Ninomiya, Toshiharu PhD; Nitsch, Dorothea MD, PhD; Nordestgaard, Borge G. MD, PhD; Onland-Moret, Charlotte PhD; Palmieri, Luigi PhD; Petrova, Dafina PhD; Garcia, Jose Ramon Quiros PhD; Rosengren, Annika MD; Sacerdote, Carlotta MD; Sakurai, Masaru MD; Santiuste, Carmen MD; Schulze, Matthias B. PhD; Sieri, Sabina PhD; Sundstrom, Johan MD; Tikhonoff, Valerie MD, PhD; Tjonneland, Anne MD; Tong, Tammy PhD; Tumino, Rosario MD; Tzoulaki, Ioanna PhD; van der Schouw, Yvonne T. PhD; Monique Verschuren, W.M. PhD; Volzke, Henry MD; Wallace, Robert B. MD; Wannamethee, S. Goya PhD; Weiderpass, Elisabete PhD; Willeit, Peter MD, PhD; Woodward, Mark PhD; Yamagishi, Kazumasa MD; Zamora-Ros, Raul PhD; Akwo, Elvis A. MD PhD; Pyarajan, Saiju PhD; Gagnon, David R. MD, MPH, PhD; Tsao, Philip S. PhD; Muralidhar, Sumitra PhD; Edwards, Todd L. PhD; Damrauer, Scott M. MD; Joseph, Jacob MD, PhD; Pennells, Lisa PhD; Wilson, Peter W.F. MD; Harrison, Seamus MD, PhD; Gaziano, Thomas A. MD, PhD; Inouye, Michael PhD; Baigent, Colin MD, PhD; Casas, Juan P. MD, PhD; Langenberg, Claudia PhD; Wareham, Nick MD; Riboli, Elio MD; Gaziano, J.Michael MD, MPH ,,+; Danesh, John MD, PhD ,,,,,,+; Hung, Adriana M. MD, MPH ,+; Butterworth, Adam S. PhD ,,,,,+; Wood, Angela M. PhD ,,,,,,+; Di Angelantonio, Emanuele MD, PhD ,,,,,,+; on behalf of the Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program; Koettgen, Anna; Shaw, Jonathan; Atkins, Robert; Zimmet, Paul; Whincup, Peter; Willeit, Peter; Willeit, Johann; Leitner, Christoph; Casiglia, Edoardo; Tikhonoff, Valerie; Tybjaerg-Hansen, Anne; Schnohr, Peter; Afzal, Shoaib; Pablos, David Lora; Arriscado, Cristina Martin; Ferreiro, Carmen Romero; Wallace, Robert B.; Stocker, Hannah; Schottker, Ben; Holleczek, Bernd; Chetrit, Angela; Welin, Lennart; Svardsudd, Kurt; Welin, Lennart; Svardsudd, Kurt; Lissner, Lauren; Hange, Dominique; Mehlig, Kirsten; Nagel, Dorothea; Norman, Paul E.; Almeida, Osvaldo; Flicker, Leon; Hata, Jun; Honda, Takanori; Furuta, Yoshihiko; Iso, Hiroyasu; Kitamura, Akihiko; Muraki, Isao; Salonen, Jukka T.; Tuomainen, Tomi-Pekka; van Zutphen, E. M.; van Schoor, N. M.; Donfrancesco, Chiara; Lo Noce, Cinzia; Palmieri, Luigi; Cushman, Mary; Kronmal, Richard; Koenig, Wolfgang; Meisinger, Christa; Lappas, Georg; Nilsson, Peter M.; Melander, Olle; Hedblad, Bo; Nitsch, Dorothea; Cooper, Jackie A.; Shaffer, Jonathan; Schwartz, Joseph; Shimbo, Daichi; Sato, Shinichi; Iso, Hiroyasu; Hayama-Terada, Mina; Jassal, Simerjot; Aspelund, Thor; Thorsson, Bolli; Sigurdsson, Gunnar; Chaker, Layal; Ikram, Kamran M.; Kavousi, Maryam; Tunstall-Pedoe, Hugh; Woodward, Mark; Volzke, Henry; Can, Gunay; Yuksel, Husniye; Ozkan, Ugur; Nakagawa, Hideaki; Morikawa, Yuko; Ishizaki, Masao; Arnlov, Johan; Arndt, Volker; Feskens, Edith; Geleijnse, Johanna M; Kromhout, Daan
doi : 10.1161/CIRCULATIONAHA.122.060700
End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.
TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.
Tang, Yawen PhD ,*; Aryal, Sajesan BS ,,*; Geng, Xiaoxiao BS; Zhou, Xinyue BS; Fast, Vladimir G. PhD; Zhang, Jianyi MD, PhD; Lu, Rui PhD ,,+; Zhou, Yang PhD ,+
doi : 10.1161/CIRCULATIONAHA.122.059713
Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as a promising strategy to remuscularize injured myocardium. However, it is insufficient to generate functional induced cardiomyocytes from human fibroblasts using conventional reprogramming cocktails, and the underlying molecular mechanisms are not well studied.
FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.
Jin, Leigang PhD ,,,*; Geng, Leiluo PhD ,,*; Ying, Lei PhD; Shu, Lingling PhD; Ye, Kevin MPhil; Yang, Ranyao PhD; Liu, Yan PhD; Wang, Yao PhD; Cai, Yin PhD; Jiang, Xue PhD; Wang, Qin MPhil; Yan, Xingqun PhD; Liao, Boya PhD; Liu, Jie MPhil; Duan, Fuyu PhD; Sweeney, Gary PhD; Woo, Connie Wai Hong PhD; Wang, Yu PhD; Xia, Zhengyuan MD, PhD; Lian, Qizhou MD, PhD; Xu, Aimin MD, PhD
doi : 10.1161/CIRCULATIONAHA.122.059631
Exercise is an effective nonpharmacological strategy to alleviate diabetic cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor 21), a peptide hormone with pleiotropic benefits on cardiometabolic homeostasis, has been identified as an exercise responsive factor.
Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction.
Zhang, Sui MD, PhD ,*; Liu, Shijie PhD ,*; Leach, John P. PhD ,*; Li, Ke MD; Perin, Emerson C. MD, PhD; Martin, James F. MD, PhD
Letter by Sherratt Regarding Article, "Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1[beta], Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy".
Sherratt, Samuel C.R.
Letter by Lakshmanan et al Regarding Article "Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1[beta], Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy".
Lakshmanan, Suvasini MD; Budoff, Matthew J. MD; Nelson, John R. MD
Advancing Peripheral Artery Disease Quality of Care and Outcomes Through Patient-Reported Health Status Assessment: A Scientific Statement From the American Heart Association.
Smolderen, Kim G. PhD, Vice Chair; Alabi, Olamide MD; Collins, Tracie C. MD, MPH, MHCDS; Dennis, Bernard BA; Goodney, Philip P. MD; Mena-Hurtado, Carlos MD; Spertus, John A. MD, MPH; Decker, Carole PhD, RN, Chair; on behalf of the American Heart Association Council on Peripheral Vascular Disease and Council on Lifestyle and Cardiometabolic Health
doi : 10.1161/CIR.0000000000001105
AB Peripheral artery disease (PAD) is chronic in nature, and individualized chronic disease management is a central focus of care. To accommodate this reality, tools to measure the impact and quality of the PAD care delivered are necessary.
Correction to: Status of Cardiovascular Health in US Adults and Children Using the American Heart Association's New "Life's Essential 8" Metrics: Prevalence Estimates From the National Health and Nutrition Examination Survey (NHANES), 2013 Through 2018.
