دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Expanding the Database of Signal-Anchor-Release Domain Endolysins Through Metagenomics
Marco Túlio Pardini Gontijo, Mateus Pereira Teles, Pedro Marcus Pereira Vidigal & Marcelo BrocchiÂ
doi : 10.1007/s12602-022-09948-y
Endolysins are bacteriophage-derived lytic enzymes with antimicrobial activity. The action of endolysins against Gram-negative bacteria remains a challenge due to the physical protection of the outer membrane.
Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14
Radja Teiar, Adrián Pérez-Ramos, Hassan Zgheib, Benoit Cudennec, Yanath Belguesmia & Djamel DriderÂ
doi : 10.1007/s12602-022-09954-0
In this study, we investigate the interactions between the leaderless class IIb bacteriocin, enterocin DD14 (EntDD14), or the methicillin or the combination of these antibacterials, and two methicillin-resistant Staphylococcus aureus strains (MRSA-S1 and USA 300) which are respectively a clinical strain and a reference strain.
Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures
Chelsea Woods, Lindsey Woolley, Gavin Partridge, Mengqi Chen, Evan F. Haney, Robert E. W. Hancock, Nicky Buller & Andrew CurrieÂ
doi : 10.1007/s12602-022-09928-2
Rotifers are used as the first feed for marine fish larvae and are grown in large cultures that have high loads of organic matter and heterotrophic bacteria; these bacteria are passed on to the developing fish larvae and can potentially lead to bacterial infections.
Skin Microbiome—The Next Frontier for Probiotic Intervention
Isabella J. McLoughlin, Eva M. Wright, John R. Tagg, Rohit Jain & John D. F. HaleÂ
doi : 10.1007/s12602-021-09824-1
The skin is the largest organ in the human body, and it orchestrates many functions that are fundamentally important for our survival. Although the skin might appear to present a relatively inhospitable or even hostile environment, a multitude of commensals and also some potentially pathogenic microorganisms have successfully adapted to survive and/or thrive within the diverse ecological niches created by the skin’s topographical architecture.
Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities
Rohit SharmaÂ
doi : 10.1007/s12602-021-09903-3
The significance of diversity, composition, and functional attributes of the gut microbiota in shaping human health is well recognized. Studies have shown that gut microbiota is closely linked to human aging, and changes in the gut microbiome can predict human survival and longevity. In addition, a causal relationship between gut microbiota dysbiosis and chronic age-related disorders is also becoming apparent.
Haloalkaline Lipase from Bacillus flexus PU2 Efficiently Inhibits Biofilm Formation of Aquatic Pathogen Vibrio parahaemolyticus
Esakkiraj Palanichamy, Ayyanna Repally, Natwar Jha & Arul VenkatesanÂ
doi : 10.1007/s12602-022-09908-6
A gene encoding lipase enzyme from Bacillus flexus PU2 was cloned and expressed in E. coli BL21 (DE3) pLysS and purified protein having the molecular weight of 34Â kDa. This lipase was found to be alkaline (pH 9) and slightly thermophilic. This lipase was observed to retain its activity in the presence of methanol, ethanol, DMSO, and acetone.
In Vitro-In Vivo Correlation for the Antibacterial Effect of Lactiplantibacillus plantarum as a Topical Healer for Infected Burn Wound
Fatemeh Moraffah, Melika Kiani, Mohammad Abdollahi, Sepideh Yoosefi, Alireza Vatanara & Nasrin SamadiÂ
doi : 10.1007/s12602-022-09934-4
Difficulties in delivering antimicrobial agents to wound areas and emersion of multiple drug resistant organisms (MDROs) have converted managing burn infections into a complicated task in medicine.
Modulation of Virulence Gene Expression in Salmonella enterica subsp. enterica typhimurium by Synthetic Milk-Derived Peptides
Eman Ali & Gisèle LaPointeÂ
doi : 10.1007/s12602-022-09936-2
The hydrolysis of milk proteins produces valuable bioactive peptides, some of which show antivirulence activity. In this study, five synthetic milk-derived peptides (β-LG f(9–18), β-CN f(5–15), β-CN f(17–27), β-CN f(94–106), and β-CN f(129–137)) were shown to decrease the expression of virulence genes in Salmonella enterica subsp.
Altered Salivary Microbiota Following Bifidobacterium animalis Subsp. Lactis BL-11 Supplementation Are Associated with Anthropometric Growth and Social Behavior Severity in Individuals with Prader-Willi Syndrome
Kevin Liu & Xue-Jun KongÂ
doi : 10.1007/s12602-022-09938-0
To evaluate the influence of oral probiotic Bifidobacterium animalis subsp. lactis (BL-11) supplementation on salivary microbiota composition and the association with growth parameters, and behavioral symptoms in individuals with Prader-Willi syndrome (PWS).
Combinatorial Therapeutic Strategy of Biogenics Derived from Lactobacillus fermentum PUM and Zingerone Against Pseudomonas aeruginosa PAO1-Induced Surgical Site Infection: an Experimental Study
Swati Chandla, Kusum Harjai & Geeta ShuklaÂ
doi : 10.1007/s12602-022-09944-2
Pseudomonas aeruginosa, a WHO-prioritized multidrug-resistant Gram-negative bacteria, is one of the frequently implicated pathogen in surgical site infection (SSI) due to its virulence phenotypes and biofilm-forming ability.
Evaluation of the Potential Probiotic Yeast Characteristics with Anti-MRSA Abilities
Yong Shen, Xue Bai, Yan Zhang, Qian Gao, Xiujuan Bu, Ying Xu & Na GuoÂ
doi : 10.1007/s12602-022-09942-4
Methicillin-resistant Staphylococcus aureus (MRSA) is a disreputable pathogenic bacterium that has been proven to colonize the intestinal tract. The goal of this study is to find anti-MRSA probiotic yeast from food and evaluate its probiotic characteristics and safety.
Protecting Effect of Bacillus coagulans T242 on HT-29 Cells Against AAPH-Induced Oxidative Damage
Xiaoxi Gao, Yuhong Zhang, Guangqing Mu, Yunpeng Xu, Xinmiao Wang, Yanfeng Tuo & Fang QianÂ
doi : 10.1007/s12602-022-09917-5
The aim of the present study was to investigate the in vitro antioxidant potential of Bacillus coagulans T242. B. coagulans T242 showed better antioxidant activities, including the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging ability, lipid peroxidation inhibiting ability and reducing ability, than those exerted by Lactobacillus rhamnosus GG (LGG). B. coagulans T242 positively regulated the expression of the nuclear factor erythroid 2-relatedfactor 2/Kelch-like ECH-associated protein-1 (Nrf2/Keap1) pathway-related proteins (Nrf2, Keap1, heine oxygenase-1 (HO-1)); increased antioxidant enzymes (glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD)); reduced the content of malondialdehyde (MDA) level; decreased the expression of inflammatory-related cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α); and thus increased the survival rate in 2,2′-azobis (2-methylpropionamidine) dihydrochloride (AAPH)-damaged HT-29 cells. This study proved that B. coagulans T242 exerted antioxidative effects by quenching oxygen free radicals and activating the Nrf2 signaling pathway in HT-29 cells.
A κ-OR Agonist Protects the Endothelial Function Impaired by Hyperuricemia Through Regulating the Akt/eNOS Signal Pathway
Qin Zheng, Qi Wu, Hong Yang, Qiuhong Chen, Xiaohui Li & Jingyi GuoÂ
doi : 10.1007/s12602-022-09945-1
To investigate the effects of κ-OR agonist on hyperuricemia rats and injured endothelial function, as well as the underlying mechanism. A hyperuricemia model was established on rats. The endothelial protective effects of U50,488H were evaluated and compared to the controlled groups.
In Vitro Inactivation of Respiratory Viruses and Rotavirus by the Oral Probiotic Strain Weissella cibaria CMS1
Mi-Sun Kang & Geun-Yeong ParkÂ
doi : 10.1007/s12602-022-09947-z
Weissella cibaria CMS1 (oraCMS1) has been commercially used in Korea as an oral care probiotic for several years. Human respiratory syncytial virus (RSV) and the influenza A virus (H1N1) are representative viruses that cause infantile lower respiratory tract infections. Rotavirus A (RVA) is the most common cause of diarrhea in infants and young children.
Levilactobacillus brevis KU15151 Inhibits Staphylococcus aureus Lipoteichoic Acid–Induced Inflammation in RAW 264.7 Macrophages
Won-Ju Kim, Hyung-Seok Yu, Na-Kyoung Lee & Hyun-Dong PaikÂ
doi : 10.1007/s12602-022-09949-x
Inflammation is a host defense response to harmful agents, such as pathogenic invasion, and is necessary for health. Excessive inflammation may result in the development of inflammatory disorders. Levilactobacillus brevis KU15151 has been reported to exhibit probiotic characteristics and antioxidant activities, but the effect of this strain on inflammatory responses has not been determined.
