ACR Open Rheumatology




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سفارش

Machine Learning Applied to Patient-Reported Outcomes to Classify Physician-Derived Measures of Rheumatoid Arthritis Disease Activity

Jeffrey R. Curtis, Yujie Su, Shawn Black, Stephen Xu, Wayne Langholff, Clifton O. Bingham, Shelly Kafka, Fenglong Xie

doi : 10.1002/acr2.11499

Patient-reported outcome (PRO) data have assumed increasing importance in the care of patients with rheumatoid arthritis (RA), yet physician-derived disease activity measures, such as Clinical Disease Activity Index (CDAI), remain the most accepted metrics to assess disease activity. The possibility that newer longitudinal PRO data might be used as a proxy for the CDAI has not been evaluated.

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A Pilot Analysis of Genome-Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis

Vladislav Izda, Christopher M. Dunn, Emmaline Prinz, Leoni Schlupp, Emily Nguyen, Cassandra Sturdy, Matlock A. Jeffries

doi : 10.1002/acr2.11506

Cartilage epigenetic changes are strongly associated with human osteoarthritis (OA). However, the influence of individual environmental OA risk factors on these epigenetic patterns has not been determined; herein we characterize cartilage DNA methylation patterns associated with aging and OA in a mouse model.

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Long-Term Clinical and Radiographic Outcomes in Patients With Clinically Isolated Aortitis

Adam Mayer, Alexandra Sperry, Laarni Quimson, Rennie L. Rhee

doi : 10.1002/acr2.11504

The optimal management of patients with incidentally found clinically isolated aortitis (CIA) after aneurysm repair is unclear. This study compared long-term surgical and clinical outcomes after surgical repair of thoracic aortic aneurysm between patients with CIA and patients with noninflammatory etiologies.

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Reconciling Between Medication Orders and Medication Fills for Lupus in Pregnancy

Julia F. Simard, Emily F. Liu, Eliza Chakravarty, Amadeia Rector, Miranda Cantu, Daniel Z. Kuo, Gary M. Shaw, Maurice Druzin, Michael H. Weisman, Monique M. Hedderson

doi : 10.1002/acr2.11501

Most studies consider either medications ordered or filled, but not both. Medication underuse based on filling data cannot necessarily be ascribed to patient nonadherence. Using both data sources, we quantified primary medication adherence in a cohort of prevalent systemic lupus erythematosus (SLE) pregnancies.

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Beyond the visual analog scale: results from a multimodal pain assessment pilot study in first-degree relatives of patients with rheumatoid arthritis

Cairistin McDougall, Dana Wiens, Irene Smolik, Yvonne C. Lee, Hani S. El-Gabalawy, Liam J. O'Neil

doi : 10.1002/acr2.11497

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Clinical Images: Dacryoadenitis in eosinophilic granulomatosis with polyangiitis mimicking immunoglobulin G4–related disease

Sho Ishigaki, Mitsuhiro Akiyama

doi : 10.1002/acr2.11508

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Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More

Jiha Lee, Namrata Singh, Shelly L. Gray, Una E. Makris

doi : 10.1002/acr2.11503

The world population is aging, and the rheumatology workforce must be prepared to care for medically complex older adults. We can learn from our colleagues and experts in geriatrics about how to best manage multimorbidity, polypharmacy, geriatric syndromes, and shifting priorities of older adults in the context of delivering care for rheumatic and musculoskeletal diseases (RMDs).

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Perceived Impact of the COVID-19 Pandemic on Physical Activity Among Adult Patients With Rheumatologic Disease

Shruti Saxena-Beem, Teresa A. Dickson, Tessa R. Englund, Rebecca J. Cleveland, Emily M. McCormick, Andres E. Santana, Julie A. Walker, Kelli D. Allen, Saira Z. Sheikh

doi : 10.1002/acr2.11507

The objective of this cross-sectional study was to investigate the impact of the COVID-19 pandemic on physical activity (PA) levels of patients with rheumatic and musculoskeletal diseases (RMDs) and to examine factors associated with decreased PA.

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A Diagnostic Prediction Model to Distinguish Multisystem Inflammatory Syndrome in Children

Matthew T. Clark, Danielle A. Rankin, Lauren S. Peetluk, Alisa Gotte, Alison Herndon, William McEachern, Andrew Smith, Daniel E. Clark, Edward Hardison, Adam J. Esbenshade, Anna Patrick, Natasha B. Halasa, James A. Connelly, Sophie E. Katz

doi : 10.1002/acr2.11509

Features of multisystem inflammatory syndrome in children (MIS-C) overlap with other syndromes, making the diagnosis difficult for clinicians. We aimed to compare clinical differences between patients with and without clinical MIS-C diagnosis and develop a diagnostic prediction model to assist clinicians in identification of patients with MIS-C within the first 24 hours of hospital presentation.

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