Dermatologic Therapy




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سفارش

Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication

Maddalena Napolitano, Gabriella Fabbrocini, Fabrizio Martora, Lucia Genco, Matteo Noto, Cataldo Patruno

doi : 10.1111/dth.15901

Atopic dermatitis (AD) is a chronic inflammatory, itching skin with a significant psychosocial impact on patients and relatives. In adults and adolescents besides flexural eczema, head and neck eczema, and hand eczema, which are the most frequent clinical phenotypes (84.9% and 84.2%, respectively), there are also other possible presentation such as, portrait-like dermatitis (20.1%), diffuse eczema (6.5%), eczema nummulare-like (5.8%), prurigo nodularis-like (2.1%) and erythrodermia (0.7%).

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Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Bruna Bravo, Priscila Correia, José Euzébio Gonçalves Junior, Beatriz Sant'Anna, Delphine Kerob

doi : 10.1111/dth.15903

Skin aging goes beyond a chronological process and also results from extrinsic factors referred to as the exposome. Hyaluronic acid (HA) is an important component of the extracellular matrix, with loss starting at 25 years old. While many studies of HA concern topical use, few literature reviews only address the use of topical HA in dermatology.

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Comparison of the efficacy and safety of lasers, topical timolol, and combination therapy for the treatment of infantile hemangioma: A meta-analysis of 10 studies

Huaxu Huang, Xuanfeng Chen, Beichen Cai, Jiaqi Yu, Biao Wang

doi : 10.1111/dth.15907

Topical timolol and lasers are widely used for the treatment of infantile hemangioma (IH), and they can replace propranolol as the first-line treatment of IH. We aimed to investigate the efficacy and safety of topical timolol alone or lasers plus topical timolol versus lasers alone for the treatment of IH using a meta-analysis.

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Real-world evidence of biological agents in dermatology: A review of its applications, advantages, and limitations

Jiaqing Shen, Yi Liu

doi : 10.1111/dth.15909

Randomized controlled trials (RCTs) are regarded as the gold standard of evidence-based medicine. However, the disadvantages of RCTs have been well-documented for a lengthy period of time.

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Off-label uses of ustekinumab

Lihua Ye, Zhenfei Wu, Changrong Li, Xiaoxia Zhao, Mengjie Wan, Li Wang

doi : 10.1111/dth.15910

Ustekinumab (brand name Stelara®) is a human interleukin-12 and -23 antagonist and has been indicated for the treatments of moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease and ulcerative colitis.

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Cyclosporine-induced gingival overgrowth�Review

Joanna Chojnacka-Purpurowicz, Ewa Wygonowska, Waldemar Placek, Agnieszka Owczarczyk-Saczonek

doi : 10.1111/dth.15912

Drug-induced gingival overgrowth (DIGO) is an undesirable effect resulting from the therapy of one of the three groups of drugs: phenytoin, calcium channel blockers, and cyclosporine A (CsA). It is caused by a fibrous overgrowth leading to gingivitis, periodontitis, and even tooth loss.

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Efficacy of topical steroids in preventing radiation dermatitis: A systematic review and meta-analysis

Xinyi Shao, Tingqiao Chen, Hao Li, Yangmei Chen, Yujie Zhang, Jiayi Chen, Yuxin Li, Lin Liu, Yihuan Pu, Jin Chen

doi : 10.1111/dth.15918

To evaluate the relative efficacy of topical steroids in preventing radiation dermatitis (RD). Multiple databases including Medline, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Biological Medicine (SinoMed), and Wanfang Database were searched for randomized controlled trials (RCTs) of RD prevention in patients with cancer from inception to November 26, 2021, followed by an update on June 1, 2021.

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Atypical presentation of Sweet syndrome with nodular erythema and oral ulcerations provoked by Ad26.COV2.S SARS-CoV-2 vaccination and review of literature

Agata Bechtold, Agnieszka Owczarczyk-Saczonek

doi : 10.1111/dth.15923

The aim of this article is to present the case of acute febrile neutrophilic dermatosis (Sweet syndrome�SS) after Ad26.COV2.S vaccination against SARS-CoV-2. To the best of our knowledge, this is the second case of SS provoked by this specific vaccine.

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Dupilumab: Advances in the off-label usage of IL4/IL13 antagonist in dermatoses

Fengming Jia, Qing Zhao, Peidian Shi, Hong Liu, Furen Zhang

doi : 10.1111/dth.15924

Type 2 immune response refers to a complicated series of immune responses characterized by Th2 polarization and Th2 cytokines secretion.

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Comparison between chronic spontaneous urticaria and chronic induced urticaria on the efficacy of omalizumab treatment: A systematic review and meta-analysis

Zhu-Han He, Shuo-Cheng Qiu, Zhi-Wei Huang, Guo-Qiang Zhang, Qing-Qing An, Feng Qu, Na Wang

doi : 10.1111/dth.15928

This meta-analysis aimed to assess the efficacy of omalizumab in the treatment of refractory-to-antihistamines chronic induced urticaria (CIndU) in comparison with that of refractory-to-antihistamines chronic spontaneous urticaria (CSU). We retrieved interventional studies and observational studies on omalizumab efficacy to CIndU patients and efficacy comparison between CSU and CIndU both refractory to H1-antihistamines in electronic databases (accessed till May 2022).

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Treatment of atopic dermatitis using topical antifungal drugs: A meta-analysis

Dan He, Yujie Han, Hongmei Wu, Min Liu, Mao Li, Mao Lu

doi : 10.1111/dth.15930

Several studies have focused on treating atopic dermatitis (AD) using topical antifungal drugs. However, their findings are inconsistent. This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the safety and efficacy of topical antifungal drugs for the treatment of AD.

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Tapinarof for the treatment of psoriasis

Sofia Nogueira, Maria Alexandra Rodrigues, Ron Vender, Tiago Torres

doi : 10.1111/dth.15931

Although topical drugs are the mainstay of treatment for patients with mild-to-moderate psoriasis, the developments observed in this field in the last two decades have been limited. The most commonly used drugs are still vitamin D analogues and corticosteroids, both with several limitations.

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Update of pathophysiology and treatment options of seborrheic keratosis

Surajit Gorai, Shahzaib Ahmad, Syeda Sadia Masood Raza, Hadin Darain Khan, Muhammad Asad Raza, Farshid Etaee, Clay J. Cockerell, Zoe Apalla, Mohamad Goldust

doi : 10.1111/dth.15934

Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition.

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Fatal low-dose methotrexate toxicity: A case report and literature review

Samantha Ouellette, Rohan Shah, Shazli Razi, Gina Ashforth, Cindy Wassef

doi : 10.1111/dth.15945

Methotrexate (MTX) is a chemotherapeutic agent that acts primarily by inhibiting the folic acid cycle. In addition to its application for treating malignancies, MTX is also used to treat chronic inflammatory diseases including psoriasis. Adverse effects have been reported even at low doses (up to 25 mg/week), and there is risk of toxicity in the form of myelosuppression, hepatotoxicity, or pulmonary fibrosis. 

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Benvitimod for the treatment of psoriasis: A systematic review and meta-analysis of randomized controlled trials

Muhammad Ehsan, Aqeeb Ur Rehman, Farwa Athar, Biah Mustafa, Haseeba Javed, Huzaifa Ahmad Cheema, Muhammad Ayyan, Abia Shahid, Uzair Jafar, Mohamad Goldust

doi : 10.1111/dth.15957

Benvitimod is a topical drug that has recently been approved for mild to moderate psoriasis and atopic dermatitis. The drug has just completed phase 3 trials for psoriasis, which calls for a systematic update of current evidence on the efficacy and safety of this drug. We searched MEDLINE (PubMed), EMBASE, Science Direct, International Clinical Trials Registry Platform (ICTRP), Cochrane Central Register of Controlled Trials, and Google Scholar for all available randomized controlled trials concerning the topic.

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Is cysteamine use effective in the treatment of melasma? A systematic review and meta-analysis

Agenor Gomes dos Santos-Neto, Ã�sis Carolline Valério da Silva, Carlisson Ramos Melo, Adilson Allef Moraes Santana, Ricardo Luiz Cavalcanti de Albuquerque-Junior

doi : 10.1111/dth.15961

Melasma is a recurrent hypermelanosis disorder characterized by the appearance of brownish and symmetrical spots on the skin. It affects the quality of life and is resistant to available treatment approaches.

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Melanoma surgery�An update

Uwe Wollina

doi : 10.1111/dth.15966

Cutaneous melanoma is the major cause of mortality from all skin cancers. The treatment has been revolutionized in recent years by introduction of immunotherapy and targeted therapy for melanoma patients Stages III and IV. Therefore, the role of surgery in melanoma treatment needs to be redefined.

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Real-world experience and long-term evaluation of tofacitinib in refractory alopecia areata: A prospective, open-label, single-center study in Asian Arab population

Husein Husein-ElAhmed, Nada Abdulla, Amina Al-Obaidli, Majid Ali-Alam, Martin Steinhoff

doi : 10.1111/dth.15871

Tofacitinib is a pan-janus kinase inhibitor (JAK) which has been tested off-label in alopecia areata (AA) with promising results. However, evidence of tofacitinib in real-life setting is still poor. We evaluated long-term efficacy and safety of tofacitinib for refractory AA. This is a prospective, open-label, observational, single-center cohort study conducted between January 2018 and December 2020.

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Real world experience of brodalumab treatment in patients with moderate-to-severe plaque psoriasis in the Greek population: Results from an interim analysis of the BrIDGE study

Dimitrios Rigopoulos, Charalampos Angelakopoulos, Zoi Apalla, Sophia Georgiou, Florentina Delli, Alexandros Drosos, Efterpi Zafiriou, John Katsantonis, Elisavet Lazaridou, Pantelis Panagakis, Evangelia Papadavid, Markos Papakonstantis, Angeliki-Viktoria Roussaki-Schulze, Elena Sotiriou, Georgios Anastasiadis, Eleftheria Tampouratzi, Vasiliki Chasapi, Konstantinos Sfaelos, Dimitrios Ioannides, The BrIDGE Study Group

doi : 10.1111/dth.15886

Brodalumab's clinical efficacy and favorable safety profile have been demonstrated during controlled clinical trials, but real-world data remain scarce. BrIDGE, an ongoing 104 week, observational, prospective, multicenter study conducted in Greece, enrolled moderate-to-severe plaque psoriasis patients, with body surface area (BSA) > 10 or psoriasis area severity index score (PASI) > 10 and dermatology life quality index (DLQI) > 10, based on European consensus, initiating brodalumab treatment as per routine clinical practice.

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Ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma in the treatment of atrophic acne scars: A systematic review and meta-analysis

Yara E. Aljefri, Abdullah A. Ghaddaf, Rana A. Alahmadi, Taif A. Alkhamisi, Tala A. Alkhunani, Sahal J. Samarkandy, Awadh M. Alamri

doi : 10.1111/dth.15888

Atrophic acne scars are the most common cutaneous seqaule of acne vulgaris, representing 80%–90% of all acne scars. Ablative fractional carbon dioxide (FCO2) laser is the gold standard treatment for atrophic scars. Additionally, platelet-rich plasma (PRP) is suggested to accelerate the healing process and collagen synthesis.

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Comparison of sulfur ointment and permethrin treatments in scabies

Goksen Ertugrul, Habibullah Aktas

doi : 10.1111/dth.15897

Scabies is a contagious, parasitic skin disease that adversely affects the quality of life and, can cause systemic complications if it is not properly treated. Sulfur ointment and permethrin cream are among the most used topical agents in the treatment of scabies.

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Applicability of glucocorticoid toxicity index in pemphigus: Comparison between two groups of rituximab-treated and rituximab-naïve patients

Elham Mazaherpour, Nika Kianfar, Shayan Dasdar, Mojtaba Sedaghat, Hassan Seyrafi, Kamran Balighi, Fatemeh Saberi, Ali Nili, Zeinab Farimani, Pedram Molhem Azar, Hamidreza Mahmoodi, Dedee F. Murrell, Maryam Daneshpazhooh

doi : 10.1111/dth.15902

Rituximab (RTX) combined with short-term glucocorticoids (GC) is an effective therapeutic option for pemphigus. The newly developed Glucocorticoid Toxicity Index (GTI) tool provides the possibility to measure GC toxicities over time. To compare 1-year GTI between two groups of RTX-treated and RTX-naïve patients with pemphigus. The responsiveness of the GTI was also investigated.

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Gradually increasing the dosing interval of Secukinumab for moderate to severe plaque psoriasis: A single-center, uncontrolled, prospective study in 36 weeks

Xi-Bei Chen, Yu-Xin Zheng, Li-Ran Ye, Xue-Yan Chen, Xiao-Yong Man

doi : 10.1111/dth.15911

Secukinumab is a recombinant, fully human monoclonal anti-IL-17A antibody approved to treat moderate-to-severe psoriasis and psoriatic arthritis. Its effectiveness and safety have been confirmed, but a gradual increase in the secukinumab dosing interval has not been investigated.

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Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant alopecia areata

Mai Mohamed Omar, Zakaria Mahran Obaid, Osama Magdy Elshahat Sayedahmed

doi : 10.1111/dth.15913

Alopecia areata (AA) is a disease that affects the psychological well-being of the affected individuals. Laser-assisted drug delivery and microneedling (MN) are promising methods for the treatment of different dermatological diseases. The aim of the study was to compare the efficacy of topical application of triamcinolone acetonide after fractional carbon dioxide laser versus MN in the treatment of resistant AA from a clinical and dermoscopic perspective.

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The impact of face masks on acne-prone skin in Polish young adults during COVID-19 pandemic

StanisÅ‚aw Anczyk, Maciej StÄ™pieÅ„, MichaÅ‚ RaczyÅ„ski, Adam Anczyk, Maja Woźniakowska, Bartosz MizioÅ‚ek, Karina Polak, Beata Bergler-Czop

doi : 10.1111/dth.15922

COVID-19 pandemic raised many problems for patients with acne-prone skin: a limited access to health care services, the necessity of developing telemedical consultations also in dermatology, and the usage of face masks.

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Which is more effective in atrophic acne scars treatment microneedling alone or platelet rich plasma alone or combined both therapeutic modalities?

Sahar A. Ismail, Nanis A. H. Khella, Doaa A. E. Abou-Taleb

doi : 10.1111/dth.15925

Acne scarring usually causes cosmetic and psychological problems. Our aim of the study was to compare the efficacy of microneedling alone, intradermal injection of platelet rich plasma (PRP) alone and combined microneedling with PRP in the treatment of atrophic post-acne scars.

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Secukinumab is effective and safe in the long-term treatment of plaque psoriasis in a daily practice setting: Multicenter study in 384 Spanish patients

Pablo Chicharro, Mar Llamas-Velasco, Susana Armesto, Enrique Herrera Acosta, David Vidal, Eva Vilarrasa, Raquel Rivera-Diaz, Pablo De-la-Cueva, Antonio Martorell-Calatayud, Ferran Ballescà, Isabel Belinchon, Gregorio Carretero, Lourdes Rodriguez, Alberto Romero-Maté, Josep Pujol-Montcusí, Laura Salgado, Antonio Sahuquillo-Torralba, Pablo Coto-Segura, Ofelia Baniandrés Rodríguez, Rosa Feltes, José Riera-Monroig, Esteban Dauden

doi : 10.1111/dth.15929

The aim of the study was to assess the long-term effectiveness and safety of secukinumab in Spanish patients with moderate-to-severe psoriasis in a daily practice setting.

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Dupilumab dose spacing after initial successful treatment or adverse events in adult patients with atopic dermatitis: A retrospective analysis

Cataldo Patruno, Luca Potestio, Gabriella Fabbrocini, Maddalena Napolitano

doi : 10.1111/dth.15933

Strategies on long-term management of patients affected by atopic dermatitis (AD) undergoing treatment with dupilumab achieving good clinical response (GCR) or experiencing dupilumab-related adverse events (AEs) are scant.

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Intralesional combined furosemide and digoxin in cutaneous warts treatment: A randomized controlled clinical trial

Amira Reda Lofty, Asmaa Mohamed Elbakry, Ghada Abdel Badea Omar, Mervat Hamdino

doi : 10.1111/dth.15935

Although being a benign lesion, Warts can affect the quality of life by causing discomfort, disfigurement, and social embarrassment besides the tendency to spread. Cutaneous wart treatment faces many challenges as the development of an antiviral drug that can eradicate the human papilloma virus (HPV) is difficult.

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Comparison of efficacy, safety and satisfaction of latanoprost versus minoxidil, betamethasone and in combination in patients with alopecia areata: A blinded multiple group randomized controlled trial

Mohammadreza Ghassemi, Nafise Yazdanian, Elham Behrangi, Mohammadamin Jafari, Azadeh Goodarzi

doi : 10.1111/dth.15943

Alopecia areata (AA), a polygenic and chronic autoimmune disease and there is no definitive cure. We aimed to evaluate latanoprost effects in patients with AA. In this controlled randomized double-blind clinical trial, we enrolled patients with AA randomly assigned to six groups of 18; Group 1 received latanoprost eye drops; group 2 minoxidil 5% solution; group 3 latanoprost eye drops and minoxidil 5% solution; group 4 betamethasone and minoxidil 5% solution; group 5 betamethasone solution and latanoprost eye drops; group 6 (the control group) betamethasone solution.

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Influence of serum vitamin D level in the response of actinic keratosis to ingenol mebutate

Ricardo Moreno-Alonso de Celada, Tamara Gracia-Cazaña, Laura Najera-Botello, Paulina Cerro-Muñoz, Angeles Juarranz, Salvador Gonzalez, Yolanda Gilaberte

doi : 10.1111/dth.15949

Vitamin D (VD) serum levels, and keratinocytic basal expression of vitamin D receptor (VDR) before treatment of actinic keratoses (AK) have been previously reported as possible biomarkers of the response of AK to treatments.

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Baricitinib 2 mg for the treatment of atopic dermatitis in North America: Long-term efficacy and patient-reported outcomes

Eric Simpson, April Armstrong, Mark Boguniewicz, Zelma C. Chiesa Fuxench, Meghan Feely, Evangeline Pierce, Luna Sun, Yun-Fei Chen, Robinette Angle, Jonathan I. Silverberg

doi : 10.1111/dth.15954

To address the need for long-term efficacy and patient-reported outcomes (PROs) data for patients with atopic dermatitis (AD) treated with baricitinib 2 mg, a study was conducted to evaluate the efficacy of baricitinib 2 mg in adult patients with moderate-to-severe AD.

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Ixekizumab for the treatment of the patients with moderate to severe plaque psoriasis: Clinical data from a real-world experience

Melis Gönülal, Ä°lknur Kıvanç Altunay, Sinan DoÄŸan, Meltem Türkmen, Didem Didar Balcı, Serap Öztürkcan

doi : 10.1111/dth.15955

Real-life data about any particular treatment is very helpful for clinicians, particularly when managing a chronic disease such as psoriasis. In our study, we aimed to reflect our clinical experience during 48 weeks with an IL-17 antagonist ixekizumab. This study was designed as a retrospective multi-center study.

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Real-world experience of secukinumab in moderate to severe psoriasis patients in Thailand: Characteristics, effectiveness, and safety

Pravit Asawanonda, Bensachee Pattamadilok, Leena Chularojanamontri, Mati Chuamanochan, Charoen Choonhakarn, Panlop Chakkavittumrong, Naruemon Sangob, Natta Rajatanavin

doi : 10.1111/dth.15958

Secukinumab demonstrated high efficacy and favorable safety profile in patients with moderate-to-severe plaque psoriasis (PsO) in clinical trials. However, understanding of patient characteristics and clinical outcomes in real world in Thailand is still limited.

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High versus low dose oral isotretinoin in the treatment of cutaneous and genital warts

Ahmad Nofal, Mohamed M. Fawzy, Fatma Eldeeb, Hager Nofal, Esraa E. El-Hawary

doi : 10.1111/dth.15964

Although oral isotretinoin has been considered as a potential therapeutic option for the treatment of different types of warts, the optimum dosage regimen is not yet well-established.

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Investigating the efficacy and safety of calcipotriol/betamethasone dipropionate foam and laser microporation for psoriatic nail disease�A hybrid trial using a smartphone application, optical coherence tomography, and patient-reported outcome measures

Vinzent Kevin Ortner, Victor Desmond Mandel, Kresten Skak, John Robert Zibert, Mélanie Bourlioux, Christoffer Valdemar Nissen, Christine Sofie Krohn Fuchs, Peter Alshede Philipsen, Merete Haedersdal

doi : 10.1111/dth.15965

There is a lack of efficacious topical treatments for patients suffering from psoriatic nail disease (PND). We investigated the efficacy of Calcipotriol-Betamethasone Dipropionate (Cal/BD) foam with and without ablative fractional laser (AFL) in patients with PND. A total of 144 nails from 11 patients were treated in a 24-week long, open-label, randomized, intra-patient controlled proof-of-concept hybrid trial.

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Efficacy and safety of date palm leaf-based ointment for treatment of cutaneous warts: A pilot clinical trial

Azin Ayatollahi, Nima Aramipour, Arash Sadri, Alireza Firooz, Reza M. Robati, Mahsa Fattahi, Masoud Ayazi, Mohammad Saber

doi : 10.1111/dth.15968

Despite the considerably high prevalence of cutaneous warts, no optimally effective and safe treatment is available.

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Simvastatin and non-segmental vitiligo: A new potential treatment option?

Engi Seif E. Shaker, Sherihan H. Allam, Maaly M. Mabrouk, Nashwa M. Elgharbawy, Shady Fikry Abdel Salaam

doi : 10.1111/dth.15969

There is a paucity of data about the impact of systemic statins on vitiliginous lesions in non-segmental vitiligo (NSV) patients. To the best of our knowledge, no other studies have considered the correlation between lipid disturbances in vitiligo and vitiligo disease activity (VIDA) score.

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Comparison of 1064 nm Q-switched Nd:YAG laser and Jessner peeling in melasma treatment

Ilgen Ertam Sagduyu, Onur Marakli, Gokturk Oraloglu, Ecem Bulut Okut, Idil Unal

doi : 10.1111/dth.15970

Melasma is an acquired hyperpigmentation disease characterized by hyperpigmented patches in sun-exposed areas that significantly impairs life quality. Topical treatments such as hydroquinone, retinoic acid, azelaic acid, chemical peels and laser treatments are among the main treatment options.

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Evaluation of the efficacy and relapse rates of treatment protocols for moderate acne using isotretinoin based on the global acne grading system: Randomized, controlled, comparative study

Bushra Kassem, Mohammad Ismail, Fouz Hassan

doi : 10.1111/dth.15974

Protocols for treating acne with isotretinoin have varied widely because some factors associated with relapse and treatment duration have not yet been fully determined.

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Sequential treatments of Hailey-Hailey disease with photodynamic therapy, botulinum toxin type A and dapsone: A case report

Fabio Lobefaro, Giulio Gualdi, Gabriella Andreassi, Paolo Amerio

doi : 10.1111/dth.15841

Hailey–Hailey disease is a rare autosomal dominant chronic recalcitrant blistering genodermatosis involving the intertriginous areas.

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Pigmented purpuric dermatosis persistent over 20 years treated with an ozone nanobubble water oral rinse: A case study

Yasuhiro Horiuchi

doi : 10.1111/dth.15854

Pigmented purpuric dermatosis is a rare, unique purpuric skin disorder, most commonly located on the lower extremities and characterized by petechiae with tiny red rashes and brown pigmented patches

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Paradoxical psoriasiform reactions during treatment with adalimumab for hidradenitis suppurativa: Real-life experience and therapeutic response to other biological drugs

Lorenza Burzi, Federica Repetto, Simone Ribero, Luca Mastorino, Pietro Quaglino, Paolo Dapavo

doi : 10.1111/dth.15866

Adalimumab is the only biological drug approved to date for the treatment of moderate and/or severe hidradenitis suppurativa.

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Silicone barrier cream in treatment of atopic dermatitis: A literature review

Angelina Labib, Ashley Vander Does, Jack Korbutov, Gil Yosipovitch

doi : 10.1111/dth.15884

Atopic dermatitis (AD) is a complex skin disorder that requires multidisciplinary treatment modalities to best improve the results of the condition. Although silicone formulations have been used for the treatments of wounds, ulcers, and burns, we aim to highlight the use of a silicon solution for the treatment of eczema.

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Lichen planus pigmentosus post COVID-19-vaccination: A case report with literature review

Kouki Chaima, Hammami Fatma, Kammoun Nadine, Kammoun Chahir, Bahloul Emna, Sellami Khadija, Amouri Mariem, Boudaya Sonia, Masmoudi Abderrahman, Boudawara Tahya, Turki Hamida

doi : 10.1111/dth.15891

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Psoriasis exacerbation after COVID-19 vaccines: A brief report of the reported cases

Amr Ehab El-Qushayri, Beatrice Nardone

doi : 10.1111/dth.15900

Despite the significant reduction of both morbidity and mortality after the introduction of many vaccines against COVID-19, recent reports indicated a worsening skin conditions in particular patients with psoriasis.

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Combination technique of polidocanol sclerotherapy and radiofrequency ablation in venous malformations of lip

Niti Khunger, Niharika Dhattarwal

doi : 10.1111/dth.15904

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Efficacy of diammonium glycyrrhizinate in the treatment of rosacea with papules and pustules: A randomized, double-blind, placebo-controlled study

Yuming Xie, Junke Huang, Juan Liu, Qing Zhang

doi : 10.1111/dth.15905

Rosacea is a kind of chronic inflammatory skin disease that usually occurs in the middle of the face.

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Topical cyclosporine hydrogel preparation: A new therapeutic option in the treatment of nail psoriasis

Giuseppe Gallo, Luca Mastorino, Diego Barilà, Francesco Cattel, Michele Panzone, Pietro Quaglino, Simone Ribero, Paolo Dapavo

doi : 10.1111/dth.15917

Nail psoriasis is a chronic nail disorder that commonly affects psoriatic patients causing severe distress despite the limited body surface area. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies, and among different systemic agents responses are unpredictable.

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Treatment of facial pigmented disorders with a 785-nm picosecond Ti:sapphire laser in Asians: A report of three cases

Jun Ki Hong, Young Gue Koh, Kapsok Li, Seong Jun Seo, Suk Bae Seo, Kui Young Park

doi : 10.1111/dth.15919

Since the advent of the theory of selective photothermolysis, the importance of targeting the chromophore and minimizing the surrounding damage has been extensively discussed. Picosecond-domain laser (ps-laser) treatment with a wide range of wavelengths is an emerging option for various pigmented lesions; however, no definitive treatment choice has been confirmed.

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Efficacy of oral tofacitinib in refractory chronic spontaneous urticaria and urticarial vasculitis

Parvin Mansouri, Nikoo Mozafari, Reza Chalangari, Katalin Martits-Chalangari

doi : 10.1111/dth.15932

The treatment of chronic urticaria (CU) is difficult, currently, antihistamines (AH) are the mainstay of treatment, however, up to 40% of patients do not respond to even high (four-fold) daily doses of AH.

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Successful treatment with ustekinumab in CARD14-associated papulosquamous eruption in a Brazilian child

Ana Elisa Kiszewski, Hiram Larangeira De Almeida Jr

doi : 10.1111/dth.15939

CARD14-associated papulosquamous eruption (CAPE) was proposed in 2018 to describe the clinical features of psoriasis and pityriasis rubra pilaris with CARD 14 mutations. We report a 5-month-old female infant who developed CAPE-associated erythroderma. Although she did not respond to conventional therapies, she responded well to ustekinumab treatment at the age of 4 years.

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Bullous lichen sclerosus–generalized morphea overlap syndrome improved by tofacitinib

Licong Liu, Yi Zhan, Yaqian Shi, Zhuotong Zeng, Jiangfan Yu, Puyu Zou, Xiangning Qiu, Ying Zhou, Guiying Zhang, Yan Ding, Rong Xiao

doi : 10.1111/dth.15942

We here report a case of a middle-aged man with an unusual case of bullous lichen sclerosus complicated with generalized morphea. He showed initial recurrent flaccid bullae, followed by ivory-white sclerotic plaques and extensive skin sclerosis, with additional walking disorder caused by knee-joint contracture, and ulcers on the lower extremities and back.

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Omalizumab as a corticosteroid-sparing agent in the treatment of bullous pemphigoid

Camilla Vassallo, Anita Somenzi, Mara De Amici, Stefania Barruscotti, Valeria Brazzelli

doi : 10.1111/dth.15946

Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease, characterized by the development of autoantibodies against hemidesmosomal components BP180 and BP230.

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Intravenous immunoglobulin therapy in children with severe atopic dermatitis

Zhen Zhang, Jiawen Chen, Yijun Yang, Ruoqu Wei, Peiyi Sun, Wenqing Zhang, Wange Zhou, Yifeng Guo, Zhirong Yao

doi : 10.1111/dth.15947

Children with severe atopic dermatitis (AD) can benefit from intravenous immunoglobulin (IVIG) therapy. This study aimed to identify the efficacy and safety of IVIG therapy in children with severe AD.

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Variation of body regional responses to Ustekinumab and Secukinumab in psoriasis patients: A real-world retrospective study and literature review

Pai-Shan Cheng, Ping-Chen Hou, Chao-Chun Yang, Chia-Bao Chu

doi : 10.1111/dth.15950

Psoriasis in different body regions displays varying therapeutic responses to biologics, whereas currently relevant studies remain scarce.

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Long lasting response to anti-tumor necrosis factor α agents in psoriasis: A real life experience

Maria Letizia Musumeci, Andrea Calogero Trecarichi, Giuliana Caruso, Alice Aleo, Helga Platania, Giuseppe Micali

doi : 10.1111/dth.15956

Psoriasis is a chronic, immune-mediated inflammatory disease for which no definitive cure exists and patients difficult to treat with moderate to severe psoriasis often require life-long therapy.

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Injection lipolysis with phosphatidylcholine and sodium deoxycholate�Is it really worth the risk?

Aleksandra FrÄ…tczak, Karina Polak, MichaÅ‚ Szczepanek, Martyna Waliczek, Beata Bergler-Czop

doi : 10.1111/dth.15805

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Efficacy and safety of baricitinib in patients with refractory alopecia areata

Yuqian Wang, Taoming Liu, Sheng Li, Shunli Tang, Peiyi Lin, Yuwei Ding, Qingmiao Sun, Dingxian Zhu, Jianjun Qiao, Hong Fang

doi : 10.1111/dth.15845

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Primary anetoderma in an African child, a probably neglected disease in this population

Luisa Martos-Cabrera, Ingrid Hiltun, Jorge Aróstegui-Aguilar, Carlos Zarco-Olivo, Covadonga Torre, Fernando Pinedo-Moraleda, Cristina Galván-Casas

doi : 10.1111/dth.15873

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Generalized pustular psoriasis recurring during pregnancy and lactation successfully treated with ixekizumab

Danyi Huang, Ting Liu, Jianjian Li, Yankun Lu, Han Ma

doi : 10.1111/dth.15878

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Successful treatment of pediatric lichen planus with topical Crisaborole

Hongzheng Lu, Rui He, Siyan Yang, Lin Ma, Bin Zhang

doi : 10.1111/dth.15893

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Transfer factor for the treatment of necrobiotic xanthogranuloma

Zhuangli Tang, Jiali Ruan, Suiqing Cai

doi : 10.1111/dth.15894

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Systemic meglumine antimoniate-induced severe dilated cardiomyopathy

Nesrine Ben Salah, Amina Aounallah, Linda Manaa, Maha Lahouel, Haifa Mkhinini, Colandane Belajouza, Mohamed Denguezli

doi : 10.1111/dth.15896

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Pityriasis rubra pilaris (type I) following administration of the BNT162b2 mRNA COVID-19 vaccine: Successful treatment with ustekinumab and acitretin

Shirley Braga Lima Gamonal, Nathália Couri Vieira Marques, Heitor Motta Bini Pereira, Aloisio Carlos Couri Gamonal

doi : 10.1111/dth.15899

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Concomitant nondermatologic adverse events in patients who develop immunotherapy-induced subacute cutaneous lupus erythematosus

Rasika Reddy, Andrew Park, Travis Vandergriff, Benjamin F. Chong

doi : 10.1111/dth.15906

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Complete remission of prurigo pigmentosa after oral doxycycline

Julia Föhr, Martin Gschnell, Tomas Cunha, Michael Hertl, Dario Didona

doi : 10.1111/dth.15908

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Photodynamic therapy in uncommon forms of lichen planus

Miriam Fernández-Parrado, Jorge Arostegui-Aguilar, Héctor Perandones-González, Ingrid Hiltun, Teresa de Dot-Gómara, Mónica Larra-García, Juan Ignacio Yanguas-Bayona

doi : 10.1111/dth.15914

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Sweet syndrome after the first dose of SARS-CoV-2 vaccine (Pfizer-BioNTech)

Min Jae Kim MD, Jee Woo Kim MD, Jung-Im Na MD, PhD

doi : 10.1111/dth.15915

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Reactive perforating collagenosis treated with dupilumab: A case report and literature review

Lan Guo, Yue-Ping Zeng, Hong-Zhong Jin

doi : 10.1111/dth.15916

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Rapid response of recalcitrant linear IgA bullous dermatosis to omalizumab: A case report and literature review

Xin Tong, Long Geng, Xing-Hua Gao, Hong-Hui Xu

doi : 10.1111/dth.15920

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Cisplatin-induced psoriasiform eruption

Sara Oulad Ali, Jihane Belcadi, Ihssane El Ouarith, Kaoutar Znati, Salma El Baz, Mariame Meziane, Karima Senouci

doi : 10.1111/dth.15921

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Treatment of acquired reactive perforating collagenosis with dupilumab in a patient with end-stage renal disease

Yu Jin Lee, June Hyunkyung Lee, Jae Eun Choi, Tae Young Han

doi : 10.1111/dth.15926

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COVID-19 vaccine-related eruption of papules and plaques�A case report

Aylin Kafelova, Valeria Mateeva, Jana Kazandjieva, Lyubka Miteva, Lyubomir Dourmishev

doi : 10.1111/dth.15927

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Local hyperthermia as a good treatment option for hands and feet warts in children: Case series report

Tingting Wang, Weifang Zhou, Xiaoyong Man, Wei Li

doi : 10.1111/dth.15936

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New onset of palmoplantar keratosis triggered by COVID-19 vaccination

Chisato Itabashi, Kentaro Ohuchi, Yuna Roh, Yoshihide Asano, Taku Fujimura

doi : 10.1111/dth.15937

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Step by step surgery for hidradenitis suppurativa

Adriana Di Guida, Patrizia Forgione, Luigi Fornaro, Dario Marasca, Gabriella Fabbrocini, Claudio Marasca

doi : 10.1111/dth.15938

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Alopecia areata induced by Adalimumab in a patient with Crohn's disease

Gianluca Esposito, Serena Spennato, Luigi Guerriero, Federica Ruggiero, Angela Patrì, Gabriella Fabbrocini, Francesca Nastro

doi : 10.1111/dth.15940

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Tildrakizumab for the treatment of moderate to severe psoriasis: Results from a single center preliminary real-life study

Angelo Ruggiero, Luca Potestio, Sara Cacciapuoti, Lucia Gallo, Teresa Battista, Elisa Camela, Gabriella Fabbrocini, Matteo Megna

doi : 10.1111/dth.15941

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Leucocytoclastic vasculitis-like reaction induced by tocilizumab in a patient with rheumatoid arthritis

Yu-Qing Hu, Xue Chen, Jian-Zhong Zhang

doi : 10.1111/dth.15944

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Intravenous immunoglobulin for pembrolizumab-induced bullous pemphigoid-like eruption: A case report

Daichi Hoshina, Moeko Hotta

doi : 10.1111/dth.15948

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Sharpen your sight: Trombiculosis under the dermatoscope with LC-OCT new insights

Simone Cappilli, Enrico Bocchino, Luigi Cornacchia, Ketty Peris, Alessandro Di Stefani

doi : 10.1111/dth.15951

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Sub-erythrodermic psoriasis successfully treated with bimekizumab: A case report

Mario Valenti, Luigi Gargiulo, Luciano Ibba, Giulia Pavia, Alessandra Narcisi, Antonio Costanzo

doi : 10.1111/dth.15952

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A case of atopic dermatitis-associated dupilumab-resistant alopecia totalis successfully treated with baricitinib

Takashi Seo, Kentaro Izumi, Takuya Kawamura, Masumi Tsujiwaki, Hideyuki Ujiie

doi : 10.1111/dth.15953

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Proton pump inhibitor-induced subacute cutaneous lupus erythematosus

Abigail Durbin, Jeffrey P. Callen, Courtney R. Schadt

doi : 10.1111/dth.15959

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Juvenile dermatomyositis-associated calcinosis successfully treated with combined immunosuppressive, bisphosphonate, oral baricitinib and physical therapy

Manuel Agud-Dios, Jorge Arroyo-Andres, Carmen Rubio-Muñiz, Carlos Zarco-Olivo, Alba Calleja-Algarra, Jaime de Inocencio, Sara Isabel Palencia Perez

doi : 10.1111/dth.15960

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Bullous pilomatricoma arising at a COVID-19 vaccination site

Bingfeng Zheng, Shaoyuan Wang, Chunshan Li

doi : 10.1111/dth.15962

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A case of erythema nodosum concomitant with ulcerative colitis relieved by tofacitinib

Kanae Nakamura, Emi Sato, Shinichi Imafuku

doi : 10.1111/dth.15963

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Cutaneous lupus erythematosus variants responsive to Janus kinase inhibition

Lokapriya Ananthan, Megan Williams, Huw Morgan, Girish K. Patel

doi : 10.1111/dth.15967

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Comprehensive treatment of basal cell carcinoma in nevoid basal cell carcinoma syndrome with 5-fluorouracil and salicylic acid

Yangyiyi Yu, Guiying Zhang, Siqi Fu

doi : 10.1111/dth.15972

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A case report of vitiligo following toripalimab therapy for a patient with metastatic melanoma

Yihao Li, Min Zhang, Hongbin Zhou, Kelei Zhao, Xiaohan Yuan, Yanting Liu, Ping Lu

doi : 10.1111/dth.15973

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Generalized vitiligo in a psoriatic patient treated with ixekizumab

Pirunthan Pathmarajah, Zara Benjamin-Laing, Maryam Abdurrahman, Antoaneta Grunova, Catriona Sinclair

doi : 10.1111/dth.15872

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Generalized versus localized vitiligo after ixekizumab: May previous treatment affect the clinical presentation?

Fabrizio Martora, Teresa Battista, Luigi Fornaro, Gabriella Fabbrocini, Matteo Megna, Vincenzo Picone, Claudio Marasca

doi : 10.1111/dth.15874

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Reply to “A case of symmetrical drug-related intertriginous and flexural exanthema-like eruption associated with Pfizer COVID-19 vaccination� by Manaa et al.

Elisa Camela, Massimiliano Scalvenzi, Matteo Megna, Luca Potestio, Gianluca Guerrasio, Luigi Fornaro, Gabriella Fabbrocini, Claudia Costa

doi : 10.1111/dth.15881

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Reactivation of pustular psoriasis following mRNA vaccination versus COVID-19 infection: An overlap?

Rodrigo Oliveira Almeida, Thaísa Hanemann, Fernanda Lagares Xavier Peres, Gabriela Fortes Escobar, Renan Rangel Bonamigo

doi : 10.1111/dth.15892

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More than a genital psoriasis

Riccardo Balestri, Giulia Rech, Carlo Rene Girardelli, Michela Magnano

doi : 10.1111/dth.15971

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Correction to “Adjuvant PD-1 inhibitor versus high-dose interferon α-2b for Chinese patients with cutaneous and acral melanoma: A retrospective cohort analysis�

doi : 10.1111/dth.15975

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