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Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification
Matthew Dapas, Andrea Dunaif
doi : 10.1210/endrev/bnac001
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 927–965
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria.
The Weight of Place: Built Environment Correlates of Obesity and Diabetes
Nicholas A Howell, Gillian L Booth
doi : 10.1210/endrev/bnac005
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 966–983
In recent decades, the prevalence of obesity and diabetes has risen substantially in North America and worldwide. To address these dual epidemics, researchers and policymakers alike have been searching for effective means to promote healthy lifestyles at a population level.
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Dominik Saul, Sundeep Khosla
doi : 10.1210/endrev/bnac008
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 984–1002
More than 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing.
Clinical Biology of the Pituitary Adenoma
Shlomo Melmed, Ursula B Kaiser, M Beatriz Lopes, Jerome Bertherat, Luis V Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A H Wass, Ken K Y Ho
doi : 10.1210/endrev/bnac010
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 1003–1037
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and impact on health. To understand the clinical biology of these common yet often innocuous neoplasms, we review pituitary physiology and adenoma epidemiology, pathophysiology, behavior, and clinical consequences.
Peptidergic G Protein–Coupled Receptor Regulation of Adrenal Function: Bench to Bedside and Back
Livia Lenzini, Brasilina Caroccia, Teresa Maria Seccia, Gian Paolo Rossi
doi : 10.1210/endrev/bnac011
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 1038–1050
An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the clinical syndromes of primary aldosteronism (PA), Cushing, and pheochromocytoma.
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies
Antonio Marcondes Lerario, Dipika R Mohan, Gary D Hammer
doi : 10.1210/endrev/bnac012
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 1051–1073
The adrenal glands are paired endocrine organs that produce steroid hormones and catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal cancer of the peripheral domain of the gland, the adrenal cortex.
Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease
Kendra L Clark, Jitu W George, Emilia Przygrodzka, Michele R Plewes, Guohua Hua, Cheng Wang, John S Davis
doi : 10.1210/endrev/bnac013
Endocrine Reviews, Volume 43, Issue 6, December 2022, Pages 1074–1096
Emerging studies indicate that the Hippo pathway, a highly conserved pathway that regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology.
