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Infant and child formula shortages: now is the time to prevent recurrences
Steven A Abrams, Christopher P Duggan
doi : 10.1093/ajcn/nqac149
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 289–292
An acute shortage of infant formulas in the United States occurred in early 2022, exacerbating a longer-standing, less severe shortage that has occurred over the last several years.
Healthy eating for healthy aging: What and when to eat as an older adult
Sylvia H Ley, Amanda M Romrell
doi : 10.1093/ajcn/nqac121
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 293–294
The quest to advance assessment of dietary intake: metabolomic meat markers
Maya K Vadiveloo, Matthew J Landry, Christopher D Gardner
doi : 10.1093/ajcn/nqac143
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 295–296
The need for nuance with dietary data
Jessica Fanzo
doi : 10.1093/ajcn/nqac120
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 297–298
Scanning the evidence: process and lessons learned from an evidence scan of riboflavin to inform decisions on updating the riboflavin dietary reference intakes
Martha S Field, Regan L Bailey, Patsy M Brannon, Jesse F Gregory, III, Alice H Lichtenstein, Ian J Saldanha, Barbara O Schneeman
doi : 10.1093/ajcn/nqac102
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 299–302
Higher vitamin B6 status is associated with improved survival among patients with stage I–III colorectal cancer
Andreana N Holowatyj, Jennifer Ose, Biljana Gigic, Tengda Lin, Arve Ulvik, Anne J M R Geijsen, Stefanie Brezina, Rama Kiblawi, Eline H van Roekel, Andreas Baierl, Jürgen Böhm, Martijn J L Bours, Hermann Brenner, Stéphanie O Breukink, Jenny Chang-Claude, Johannes H W de Wilt, William M Grady, Thomas Grünberger, Tanja Gumpenberger, Esther Herpel, Michael Hoffmeister, Eric T P Keulen, Dieuwertje E Kok, Janna L Koole, Katharina Kosma, Ewout A Kouwenhoven, Gry Kvalheim, Christopher I Li, Peter Schirmacher, Petra Schrotz-King, Marie C Singer, Fränzel J B van Duijnhoven, Henk K van Halteren, Kathy Vickers, F Jeroen Vogelaar, Christy A Warby, Evertine Wesselink, Per M Ueland, Alexis B Ulrich, Martin Schneider, Nina Habermann, Ellen Kampman, Matty P Weijenberg, Andrea Gsur, Cornelia M Ulrich
doi : 10.1093/ajcn/nqac090
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 303–313
Folate-mediated 1-carbon metabolism requires several nutrients, including vitamin B6. Circulating biomarker concentrations indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.
Dairy foods, calcium intakes, and risk of incident prostate cancer in Adventist Health Study–2
Michael J Orlich, Andrew D Mashchak, Karen Jaceldo-Siegl, Jason T Utt, Synnove F Knutsen, Lars E Sveen, Gary E Fraser
doi : 10.1093/ajcn/nqac093
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 314–324
Prostate cancer is the most common noncutaneous cancer in American males. Causal links between dairy, or dietary calcium, and this cancer are considered suggestive but limited.
Prospective study of breakfast frequency and timing and the risk of incident type 2 diabetes in community-dwelling older adults: the Cardiovascular Health Study
Allie S Carew, Rania A Mekary, Susan Kirkland, Olga Theou, Ferhan Siddiqi, Robin Urquhart, Michelle George, Chris Blanchard, Mary L Biggs, Luc Djoussé, Kenneth J Mukamal, Leah E Cahill
doi : 10.1093/ajcn/nqac087
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 325–334
No evidence-based recommendations regarding optimal breakfast frequency and timing and type 2 diabetes mellitus (T2DM) exist for older adults because of limited studies.
The effects of SCFAs on glycemic control in humans: a systematic review and meta-analysis
Anna Cherta-Murillo, Jennifer E Pugh, Sumayya Alaraj-Alshehhi, Dana Hajjar, Edward S Chambers, Gary S Frost
doi : 10.1093/ajcn/nqac085
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 335–361
Noncommunicable disease development is related to impairments in glycemic and insulinemic responses, which can be modulated by fiber intake. Fiber's beneficial effects upon metabolic health can be partially attributed to the production of SCFAs via microbial fermentation of fiber in the gastrointestinal tract.
Associations between dietary patterns and cardiovascular disease risk in Canadian adults: a comparison of partial least squares, reduced rank regression, and the simplified dietary pattern technique
Svilena V Lazarova, Mahsa Jessri
doi : 10.1093/ajcn/nqac117
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 362–377
Hybrid methodologies have gained continuing interest as unique data reduction techniques for establishing a direct link between dietary exposures and clinical outcomes.
Dietary quality and risk of heart failure in men
Xiao Gu, Dong D Wang, Teresa T Fung, Dariush Mozaffarian, Luc Djoussé, Bernard Rosner, Frank M Sacks, Walter C Willett
doi : 10.1093/ajcn/nqac119
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 378–385
Due to the increasing disease burden, strategies to predict and prevent heart failure (HF) are urgently needed.
The association of genetic susceptibility to smoking with cardiovascular disease mortality and the benefits of adhering to a DASH diet: The Singapore Chinese Health Study
Tingting Geng, Xuling Chang, Ling Wang, Gang Liu, Jianjun Liu, Chiea Chuen Khor, Nithya Neelakantan, Jian-Min Yuan, Woon-Puay Koh, An Pan, Rajkumar Dorajoo, Chew-Kiat Heng
doi : 10.1093/ajcn/nqac128
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 386–393
Understanding the genetic predisposition to cardiovascular disease (CVD) may help to improve clinical intervention strategies. Lifestyle factors, such as diet, may differ among ethnic groups and may, in turn, modify individuals’ risks to diseases.
Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study
Elin M Hård af Segerstad, Xiang Liu, Ulla Uusitalo, Daniel Agardh, Carin Andrén Aronsson, for the TEDDY Study Group
doi : 10.1093/ajcn/nqac086
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 394–403
High gluten intake is associated with increased risk of celiac disease (CD) in children at genetic risk.
Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation
Eva C Diaz, David K Williams, Matthew Cotter, Clark R Sims, Robert R Wolfe, Aline Andres, Elisabet Børsheim
doi : 10.1093/ajcn/nqac097
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 404–414
Offspring of obese rodents develop a metabolic phenotype that favors fat deposition. Data regarding the impact of maternal obesity programing of offspring fuel usage in humans is scarce.
Affordability influences nutritional quality of seafood consumption among income and race/ethnicity groups in the United States
David C Love, Andrew L Thorne-Lyman, Zach Conrad, Jessica A Gephart, Frank Asche, Dakoury Godo-Solo, Acree McDowell, Elizabeth M Nussbaumer, Martin W Bloem
doi : 10.1093/ajcn/nqac099
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 415–425
The 2020 US Dietary Guidelines for Americans recommend that the US population consume more seafood. Most analyses of seafood consumption ignore heterogeneity in consumption patterns by species, nutritional content, production methods, and price, which have implications for applying recommendations.
Estimates of child mortality reductions attributed to vitamin A supplementation in sub-Saharan Africa: scale up, scale back, or refocus?
Kaleab Baye, Arnaud Laillou, Yohannes Seyoum, Charity Zvandaziva, Kudakwashe Chimanya, Mara Nyawo
doi : 10.1093/ajcn/nqac082
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 426–434
Vitamin A supplementation (VAS) has been implemented in over 82 countries globally, primarily because of its beneficial effect in preventing child mortality. Secular reductions in child mortality and the implementation of alternative programs to promote vitamin A intake have led to questions on the need for national VAS programs.
Metagenomic profile of the fecal microbiome of preterm infants consuming mother's own milk with bovine milk–based fortifier or infant formula: a cross-sectional study
Miriam Aguilar-Lopez, Christine Wetzel, Alissa MacDonald, Thao T B Ho, Sharon M Donovan
doi : 10.1093/ajcn/nqac081
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 435–445
Preterm (PT) infants harbor a different gut microbiome than full-term infants. Multiple factors affect gut microbial colonization of PT infants, including low gestational age, high rates of Cesarean section, exposure to antibiotics, and diet. Human milk, whether it's mother's own milk (MOM) or donor human milk, is the preferred feeding mode for PT infants but needs to be fortified to achieve adequate nutrient content.
Effectiveness of an integrated agriculture, nutrition-specific, and nutrition-sensitive program on child growth in Western Kenya: a cluster-randomized controlled trial
Rita Wegmüller, Kelvin Musau, Lucie Vergari, Emily Custer, Hellen Anyango, William E S Donkor, Marion Kiprotich, Kim Siegal, Nicolai Petry, James P Wirth, Sonia Lewycka, Bradley A Woodruff, Fabian Rohner
doi : 10.1093/ajcn/nqac098
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 446–459
Stunting rates remain unacceptably high in many regions, including sub-Saharan Africa. Agricultural programs have led to increased yields and household incomes but showed limited success in improving nutritional status.
Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort
R Colin Carter, Marjanne Senekal, Christopher P Duggan, Neil C Dodge, Ernesta M Meintjes, Christopher D Molteno, Joseph L Jacobson, Sandra W Jacobson
doi : 10.1093/ajcn/nqac101
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 460–469
Animal models have demonstrated that maternal nutrition can alter fetal vulnerability to prenatal alcohol exposure (PAE). Few human studies have examined the role of nutrition in fetal alcohol spectrum disorders (FASD).
Early pregnancy vitamin D status is associated with blood pressure in children: an Odense Child Cohort study
Josefine N Pedersen, Christine Dalgård, Sören Möller, Louise B Andersen, Anna Birukov, Marianne Skovsager Andersen, Henrik T Christesen
doi : 10.1093/ajcn/nqac118
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 470–481
Blood pressure in childhood tracks into later life. Vitamin D status in adults is associated with blood pressure, but the impact of vitamin D status in pregnancy and childhood on blood pressure still needs investigation.
Association between postterm pregnancy and adverse growth outcomes in preschool-age children
Jun Tang, Wanglong Gou, Yuanqing Fu, Kelei Li, Xiaofei Guo, Tao Huang, Huijuan Liu, Duo Li, Ju-Sheng Zheng
doi : 10.1093/ajcn/nqac127
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 482–490
Postterm pregnancy has been associated with higher risk of perinatal mortality and morbidity, but its long-term health effects on offspring are poorly understood.
Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial
Rachida Rafiq, Floor E Aleva, Jasmijn A Schrumpf, Johannes M Daniels, Pierre M Bet, Wim G Boersma, Paul Bresser, Michiel Spanbroek, Paul Lips, Tim J van den Broek, Bart J F Keijser, André J A M van der Ven, Pieter S Hiemstra, Martin den Heijer, Renate T de Jongh, PRECOVID-study group
doi : 10.1093/ajcn/nqac083
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 491–499
Vitamin D deficiency is frequently found in patients with chronic obstructive pulmonary disease (COPD). Vitamin D has antimicrobial, anti-inflammatory, and immunomodulatory effects. Therefore, supplementation may prevent COPD exacerbations, particularly in deficient patients.
Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children
Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti
doi : 10.1093/ajcn/nqac091
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 500–510
Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the 10-formyltetrahydrofolate dehydrogenase enzyme in serine-to-glycine conversion.
Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention
Chunxiao Li, Fumiaki Imamura, Roland Wedekind, Isobel D Stewart, Maik Pietzner, Eleanor Wheeler, Nita G Forouhi, Claudia Langenberg, Augustin Scalbert, Nicholas J Wareham
doi : 10.1093/ajcn/nqac094
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 511–522
Self-reported meat consumption is associated with disease risk but objective assessment of different dimensions of this heterogeneous dietary exposure in observational and interventional studies remains challenging.
The impacts of measurement errors on a dietary pattern analyses:a simulation study based on dietary data from the China Multi-Ethnic Cohort (CMEC) study
Yifan Hu, Dan Tang, Fan Yang, Suyao Dai, Xiong Xiao, Xing Zhao
doi : 10.1093/ajcn/nqac092
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 523–530
Measurement error is a significant challenge in nutritional epidemiology research. Compared with traditional, isolated-nutrient research, dietary-pattern studies provide a more comprehensive approach to chronic disease prevention and have become popular in recent years. However, few studies have examined the impacts of measurement errors on dietary pattern analyses.
Vitamin D and brain health: an observational and Mendelian randomization study
Shreeya S Navale, Anwar Mulugeta, Ang Zhou, David J Llewellyn, Elina Hyppönen
doi : 10.1093/ajcn/nqac107
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 531–540
To investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke.
Bioavailability of phosphorus and kidney function in the Jackson Heart Study
Chi N Duong, Oladimeji J Akinlawon, Joseph Gung, Sabrina E Noel, Sherman Bigornia, Kaylea Flanagan, Shirin Pourafshar, Pao-Hwa Lin, Clemontina A Davenport, Jane Pendergast, Julia J Scialla, Katherine L Tucker
doi : 10.1093/ajcn/nqac116
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 541–550
High phosphorus (P) exposure may have negative effects on kidney function. Nutrient databases provide total P, but bioavailability varies by source.
Estimating national and subnational nutrient intake distributions of global diets
Simone Passarelli, Christopher M Free, Lindsay H Allen, Carolina Batis, Ty Beal, Anja Pia Biltoft-Jensen, Sabri Bromage, Ling Cao, Analà Castellanos-Gutiérrez, Tue Christensen, Sandra P Crispim, Arnold Dekkers, Karin De Ridder, Selma Kronsteiner-Gicevic, Christopher Lee, Yanping Li, Mourad Moursi, Isabelle Moyersoen, Josef Schmidhuber, Alon Shepon, Daniel F Viana, Christopher D Golden
doi : 10.1093/ajcn/nqac108
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 551–560
Access to high-quality dietary intake data is central to many nutrition, epidemiology, economic, environmental, and policy applications. When data on individual nutrient intakes are available, they have not been consistently disaggregated by sex and age groups, and their parameters and full distributions are often not publicly available.
Association of cow's milk intake in early childhood with adiposity and cardiometabolic risk in early adolescence
Caitriona McGovern, Sheryl L Rifas-Shiman, Karen M Switkowski, Jennifer A Woo Baidal, Jenifer R Lightdale, Marie-France Hivert, Emily Oken, Izzuddin M Aris
doi : 10.1093/ajcn/nqac103
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 561–571,
Prior studies have provided conflicting evidence regarding associations of pediatric milk consumption with subsequent adiposity.
The effect of a Mediterranean diet on the symptoms of depression in young males (the “AMMEND: A Mediterranean Diet in MEN with Depression� study): a randomized controlled trial
Jessica Bayes, Janet Schloss, David Sibbritt
doi : 10.1093/ajcn/nqac106
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 572–580
Depression is a common mental health condition that affects 1 in 8 males each year, especially young adults. Young adulthood offers an opportunity for early dietary interventions, with research suggesting that a Mediterranean diet (MD) could be beneficial in treating depression.
Time to revisit the passive overconsumption hypothesis? Humans show sensitivity to calories in energy-rich meals
Annika N Flynn, Kevin D Hall, Amber B Courville, Peter J Rogers, Jeffrey M Brunstrom
doi : 10.1093/ajcn/nqac112
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 581–588
A possible driver of obesity is insensitivity (passive overconsumption) to food energy density (ED, kcal/g); however, it is unclear whether this insensitivity applies to all meals.
Gastrointestinal dysfunction during enteral nutrition delivery in intensive care unit (ICU) patients: Risk factors, natural history, and clinical implications. A post-hoc analysis of The Augmented versus Routine approach to Giving Energy Trial (TARGET)
Tejaswini Arunachala Murthy, Lee-anne S Chapple, Kylie Lange, Chinmay S Marathe, Michael Horowitz, Sandra L Peake, Marianne J Chapman
doi : 10.1093/ajcn/nqac113
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 589–598
Slow gastric emptying occurs frequently during critical illness and is roughly quantified at bedside by large gastric residual volumes (GRVs). A previously published trial (The Augmented versus Routine approach to Giving Energy Trial; TARGET) reported larger GRVs with energy-dense (1.5 kcal/mL) compared with standard (1.0 kcal/mL) enteral nutrition (EN), warranting further exploration.
Folate intake and incident chronic kidney disease: a 30-year follow-up study from young adulthood to midlife
Mengyi Liu, Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Panpan He, Yuanyuan Zhang, Jing Nie, Min Liang, Fan Fan Hou, Xianhui Qin
doi : 10.1093/ajcn/nqac109
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 599–607
The relation of long-term dietary folate intake with incident chronic kidney disease (CKD) remains uncertain.
Re: Adjustment for energy intake in nutritional research: a causal inference perspective
Walter C Willett, Meir Stampfer, Deirdre K Tobias
doi : 10.1093/ajcn/nqac114
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 608–609
Reply to WC Willett et al.
Georgia D Tomova, Kellyn F Arnold, Mark S Gilthorpe, Peter W G Tennant
doi : 10.1093/ajcn/nqac115
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 609–610
Clarification on our critique of the energy balance hypothesis of obesity
Vicente Torres-Carot, Andrés Suárez-González, Cecilia Lobato-Foulques
doi : 10.1093/ajcn/nqac160
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 610–611
Leaving energy balance behind
Mark I Friedman
doi : 10.1093/ajcn/nqac161
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 611–612
The energy balance model compared with the carbohydrate-insulin model
Gary Taubes
doi : 10.1093/ajcn/nqac162
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 612–614
Reply to G Taubes, MI Friedman, and V Torres-Carot et al
Kevin D Hall, I Sadaf Farooqi, Jeffery M Friedman, Samuel Klein, Ruth J F Loos, David J Mangelsdorf, Stephen O'Rahilly, Eric Ravussin, Leanne M Redman, Donna H Ryan, John R Speakman, Deirdre K Tobias
doi : 10.1093/ajcn/nqac163
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 614–616
Nondietary covariates of colorectal cancer risk in population cohorts
Ilker Tasci, M Ilkin Naharci
doi : 10.1093/ajcn/nqac132
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 616–617
Residual confounding by antioxidants and multicollinearity in the polyphenol–colorectal cancer association
Yujia Lu, Yu Chen Zhao, Yuchen Liu, Mingyang Song
doi : 10.1093/ajcn/nqac133
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Pages 617–618
Reply to Tasci et al. and Lu et al
Landon T Fike, Heather Munro, Danxia Yu, Qi Dai, Martha J Shrubsole
doi : 10.1093/ajcn/nqac135
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Page 618
ASN highlights the need for multiple methods within nutrition research to advance the field
Paul M Coates
doi : 10.1093/ajcn/nqac100
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Page 619
Calendar of Events
doi : 10.1093/ajcn/nqac196
The American Journal of Clinical Nutrition, Volume 116, Issue 2, August 2022, Page 620
