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The anxiogenic effects of adolescent psychological stress in male and female mice
Paula Torres Mu ̃noz , Tamara Brook Franklin
doi : 10.1016/j.bbr.2022.113963
Volume 432, 26 August 2022, 113963
Adolescence is a period of transition during which there is extensive development of the brain and the hypothalamic-pituitary-adrenal axis.
Repeated administration of rapastinel produces exceptionally prolonged rescue of memory deficits in phencyclidine-treated mice
Lakshmi Rajagopal a, Mei Huang a, Wenqi He a,1, Chelsea Ryan a, Ahmad Elzokaky a, Pradeep Banerjee b, Herbert Y. Meltzer
doi : 10.1016/j.bbr.2022.113964
Volume 432, 26 August 2022, 113964
Rapastinel, a positive N-methyl-D-aspartate receptor (NMDAR) modulator with rapid-acting antidepressant properties, rescues memory deficits in rodents.
Mice expressing P301S mutant human tau have deficits in interval timing
Travis Larson a,b,1, Vaibhav Khandelwal b,1, Matthew A. Weber b, Mariah R. Leidinger c, David K. Meyerholz c, Nandakumar S. Narayanan b,*, Qiang Zhang
doi : 10.1016/j.bbr.2022.113967
Volume 432, 26 August 2022, 113967
Interval timing is a key executive process that involves estimating the duration of an interval over several seconds or minutes. Patients with Alzheimer’s disease (AD) have deficits in interval timing.
Repeated testing modulates chronic unpredictable mild stress effects in male rats
Kari Bosch a,*, Giulia Sbrini b, Irene Burattini b, Desir �ee Nieuwenhuis a, Francesca Calabrese b, Dirk Schubert a, Marloes J.A.G. Henckens a, Judith R. Homberg
doi : 10.1016/j.bbr.2022.113960
Volume 432, 26 August 2022, 113960
Depression is a highly prevalent, debilitating mental disorder. Chronic unpredictable mild stress (CUMS) is the most widely applied model to study this affliction in rodents.
Effects of RhoA on depression-like behavior in prenatally stressed offspring rats
Jiahao Zhou a, Yao Ma a, Jinfeng Chen a, Dan Yao b, Caixia Feng a, Yankai Dong a, Yating Ren a, Hengyu Ma a, Zhifei Wang a, Ge Li a, Hui Li b,*, Zhongliang Zhu
doi : 10.1016/j.bbr.2022.113973
Volume 432, 26 August 2022, 113973
Depression is a common mental disease that can lead to suicide when severe. Exposure to prenatal stress (PS) can lead to depression-like behavior in offspring, but the mechanism is unclear.
Nanocurcumin substantially alleviates noise stress-induced anxiety-like behavior:Â The roles of tight junctions and NMDA receptors in the hippocampus
Azam Alinaghipour a,b, Mahmoud Salami c, Fatemeh Nabavizadeh
doi : 10.1016/j.bbr.2022.113975
Volume 432, 26 August 2022, 113975
Environmental noise stress affects non-auditory brain regions such as the hippocampus; an area of the brain implicated in cognition and emotion. Recent experimental data indicate that dysfunction of the blood-brain barrier (BBB) and overexpression of NMDA receptors may cause anxiety.
Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat
Sofia Zelleroth *, Erik Nylander , Ellinor Kjellgren , Alfhild Gr ̈onbladh , Mathias Hallberg
doi : 10.1016/j.bbr.2022.113971
Volume 432, 26 August 2022, 113971
Anabolic androgenic steroids (AAS) are frequently used to improve physical appearance and strength. AAS are known to affect muscle growth, but many AAS-users also experience psychiatric and behavioral changes after long-term use. The AAS-induced effects on the brain seem to depend on the type of steroid used, but the rationale behind the observed effect is still not clear.
Divergent neural and endocrine responses in wild-caught and laboratory-bred Rattus norvegicus
Joanna Jacob a,1, Sally Watanabe a,1, Jonathan Richardson a, Nick Gonzales a, Emily Ploppert a, Garet Lahvis b, Aaron Shiels c, Sadie Wenger a, Kelly Saverino a, Janhavi Bhalerao a, Brendan Crockett a, Erin Burns a, Olivia Harding a, Krista Fischer-Stenger a, Kelly Lambert
doi : 10.1016/j.bbr.2022.113978
Volume 432, 26 August 2022, 113978
Although rodents have represented the most intensely studied animals in neurobiological investigations for more than a century, few studies have systematically compared neural and endocrine differences between wild rodents in their natural habitats and laboratory strains raised in traditional laboratory environments.
Inhibition of the ventral midline thalamus does not alter encoding, short-term holding or retrieval of spatial information in rats performing a water-escape working memory task
Laurine Boch a,b,1, Thomas Morvan a,b,1, Thibaut Neige a,b,1, Nino Kobakhidze a,b, Elodie Panzer a,b, Brigitte Cosquer a,b, Anne Pereira de Vasconcelos a,b, Aline Stephan a,b, Jean- Christophe Cassel
doi : 10.1016/j.bbr.2022.113979
Volume 432, 26 August 2022, 113979
Working memory (WM) is a function operating in three successive phases: encoding (sample trial), holding (delay), and retrieval (test trial) of information. Studies point to a possible implication of the thalamic reuniens nucleus (Re) in spatial WM (SWM).
Effects of wheel-running on anxiety and depression-relevant behaviours in the MCAO mouse model of stroke: moderation of brain-derived neurotrophic factor and serotonin receptor gene expression
Vanessa H. Brait a, Katherine A. Jackman a, Terence Y. Pang
doi : 10.1016/j.bbr.2022.113983
Volume 432, 26 August 2022, 113983
Stroke continues to be a major cause of mortality globally. Post-stroke treatment is complicated by the heterogenous nature of pathology and the emergence of secondary psychological symptoms are an additional challenge to the recovery process.
Do older adults mistake the accelerator for the brake pedal?: Older adults employ greater prefrontal cortical activity during a bipedal/bimanual response-position selection task
Nobuyuki Kawai a,b,*,1, Ryuzaburo Nakata
doi : 10.1016/j.bbr.2022.113976
Volume 432, 26 August 2022, 113976
Successful aging depends upon maintaining executive functions, which enable flexible response coordination. Although flexible responses are required for both hands and feet, as in driving, few studies have examined executive functions and brain activity in older adults, in terms of foot responses.
Effects of chronic mild stress on GABAergic system in the paraventricular nucleus of hypothalamus associated with cardiac autonomic activity
Janpen Bangsumruaj a, Anusak Kijtawornrat b, Sarinee Kalandakanond-Thongsong
doi : 10.1016/j.bbr.2022.113985
Volume 432, 26 August 2022, 113985
Stress is associated with cardiovascular diseases. One possible mechanism is the reduction in gamma-aminobutyric acid (GABA)ergic transmission at the paraventricular nucleus (PVN), which contributes to the disinhibition of sympathoexcitatory circuits and activates sympathetic outflow.
A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice
Tong Zhang 1, Naoya Nishitani 1, Kazuhei Niitani , Ryoma Nishida , Yusaku Futami , Satoshi Deyama , Katsuyuki Kaneda
doi : 10.1016/j.bbr.2022.113981
Volume 432, 26 August 2022, 113981
Spatiotemporal patterns of neuronal activity underlying the motivational effect of rotating running wheels (RWs) in rodents remain largely undetermined. Here, we investigated changes of neuronal activity among brain regions associated with motivation across different intensities of motivation for RWs in mice.
Pentylenetetrazole-induced seizures cause impairment of memory acquisition and consolidation in zebrafish (Danio rerio)
Kanandra Taisa Bertoncello a, Rodrigo Zanandrea b, Carla Denise Bonan
doi : 10.1016/j.bbr.2022.113974
Volume 432, 26 August 2022, 113974
Epilepsy is characterized by the occurrence of seizures, and the high prevalence of epilepsy-associated comorbidities affects the quality of patients’ life. We investigated the effects of pentylenetetrazole (PTZ) exposure in zebrafish cognitive performance on inhibitory avoidance test.
Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice
Meng-Meng Li a,1, Xi Wang b,1, Xiao-Dong Chen c,1, Hai-Long Yang d, Huai-Sha Xu d, Ping Zhou e, Rong Gao b, Ning Zhang e, Jun Wang b, Lei Jiang f,*, Na Liu
doi : 10.1016/j.bbr.2022.113987
Volume 432, 26 August 2022, 113987
NLRP3 inflammasome pathway-mediated inflammatory response is closely associated with depression.
Serotonin and consciousness – A reappraisal
Christian P. Müller
doi : 10.1016/j.bbr.2022.113970
Volume 432, 26 August 2022, 113970
The serotonergic system of the brain is a major modulator of behaviour. Here we describe a re-appraisal of its function for consciousness based on anatomical, functional and pharmacological data. For a better understanding, the current model of consciousness is expanded.
What is neurorepresentationalism? From neural activity and predictive processing to multi-level representations and consciousness
Cyriel M.A. Pennartz
doi : 10.1016/j.bbr.2022.113969
Volume 432, 26 August 2022, 113969
This review provides an update on Neurorepresentationalism, a theoretical framework that defines conscious experience as multimodal, situational survey and explains its neural basis from brain systems constructing best-guess representations of sensations originating in our environment and body (Pennartz, 2015).
Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson’s disease
Thomas Musacchio a, Jing Yin a, Fabian Kremer a, James B. Koprich b,c, Jonathan M. Brotchie b,c, Jens Volkmann a, Chi Wang Ip
doi : 10.1016/j.bbr.2022.113968
Volume 432, 26 August 2022, 113968
Degeneration of the nigrostriatal tract is a neuropathological hallmark of Parkinson’s disease (PD). A differential intraneuronal vulnerability of dopaminergic neurons within the substantia nigra (SN) has been suggested, starting as an axonopathy followed by neuronal cell loss that is accompanied with motor deficits.
