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Associate Editorial Board
doi : 10.1016/S0007-0912(22)00605-5
Volume 129, Issue 6, December 2022, Page ii
Maternal mortality, safe abortion, and the anaesthetist
Cynthia A. Wong 1,* , Helen F. Galley 2 and Kate Leslie
doi : 10.1016/j.bja.2022.08.020
Volume 129, Issue 6, December 2022, Pages 833-835
Unrecognised oesophageal intubation: time for action
Paul A. Baker 1,2,* , Ellen P. O’Sullivan 3 and Michael F. Aziz
doi : 10.1016/j.bja.2022.08.027
Volume 129, Issue 6, December 2022, Pages 836-840
Changes in healthcare utilisation after surgical treatment: mitigating risk through multidisciplinary and collaborative care
Guy Haller
doi : 10.1016/j.bja.2022.09.015
Volume 129, Issue 6, December 2022, Pages 840-842
Mechanical complications after central venous catheterisation in the ultrasound-guided era: a prospective multicentre cohort study
Maria Adrian 1,2, *, Ola Borgquist 1,2 , Tina Kr€oger 3 , Erik Linne 1,4 , Peter Bentzer 1,4 , Martin Spa ̊ ngfors1,5 , Jonas A ̊ keson 1,6 , Anders Holmstr€om1,6 , Rikard Linner 1,2 and Thomas Kander
doi : 10.1016/j.bja.2022.08.036
Volume 129, Issue 6, December 2022, Pages 843-850
Limited data are available on the incidence of mechanical complications after ultrasound-guided central venous catheterisation. We aimed to determine the incidence of mechanical complications in hospitals where real-time ultrasound guidance is clinical practice for central venous access and to identify variables associated with mechanical complications.
Evaluation of the quality of COVID-19 guidance documents in anaesthesia using the Appraisal of Guidelines for Research and Evaluation II instrument
Sinead M. O’Shaughnessy 1, *, Arnaldo Dimagli 2 , Bessie Kachulis 1 , Mohamed Rahouma 2 , Michelle Demetres 3 , Nicolas Govea 1 and Lisa Q. Rong
doi : 10.1016/j.bja.2022.09.008
Volume 129, Issue 6, December 2022, Pages 851-860
Guidance documents are a valuable resource to clinicians to guide evidenced-based decision making. The quality of guidelines in anaesthesia and across other specialties has been demonstrated to be poor.
The drug titration paradox: more drug does not correlate with more effect in individual clinical data
Thomas W. Schnider 1, *, Charles F. Minto 2 , Martin Luginbu ̈ hl 3 and Talmage D. Egan
doi : 10.1016/j.bja.2022.05.036
Volume 129, Issue 6, December 2022, Pages 861-867
A fundamental concept in pharmacology is that increasing dose increases drug effect. This is the basis of anaesthetic titration: the dose is increased when increased drug effect is desired and decreased when reduced drug effect is desired.
Remifentanil pharmacodynamics during conscious sedation using algometry: a more clinically relevant pharmacodynamical model
Ana Abad-Torrent 1,2, * ,y, Pablo Martı �nez-Vazquez 3,y, Jacques Somma 4 , Yung-Wei Hsu 5 and Elisenda Izquierdo
doi : 10.1016/j.bja.2022.08.026
Volume 129, Issue 6, December 2022, Pages 868-878
The Minto remifentanil pharmacokinetic/pharmacodynamic (PK/PD) model is used in target-controlled infusion (TCI) devices.
Functional analysis of RYR1 variants in patients with confirmed susceptibility to malignant hyperthermia
Ruth White 1 , Anja H. Schiemann 1 , Sophie M. Burling 1 , Andrew Bjorksten 2 , Terasa Bulger 3 , Robyn Gillies 2 , Philip M. Hopkins 4 , Erik-Jan Kamsteeg 5 , Roslyn G. Machon 3 , Sean Massey 1,6 , Dorota Miller 4 , Margaret Perry 7 , Marc M. J. Snoeck 8 , Jeremy Stephens 1 , Neil Street 7 , Luuk R. van den Bersselaar 8 and Kathryn M. Stowell
doi : 10.1016/j.bja.2022.08.029
Volume 129, Issue 6, December 2022, Pages 879-888
A major bottleneck to the introduction of noninvasive presymptomatic diagnostic tests for the pharmacogenetic disorder malignant hyperthermia is the lack of functional data for associated variants.
Change in healthcare utilisation after surgical treatment: observational study of routinely collected patient data from primary and secondary care
Alexander J. Fowler 1,2, *, Bhavi Trivedi 2 , Kambiz Boomla 3 , Rupert Pearse 1 and John Prowle
doi : 10.1016/j.bja.2022.07.012
Volume 129, Issue 6, December 2022, Pages 889-897
Most patients fully recover after surgery. However, high-risk patients may experience an increased burden of medical disease.
Patent foramen ovale and perioperative stroke in noncardiac surgery: a systematic review and meta-analysis
Gael Rais 1 , Paola Vassallo 2 , Raoul Schorer 1 , Bernardo Bollen Pinto 1 and Alessandro Putzu
doi : 10.1016/j.bja.2022.06.036
Volume 129, Issue 6, December 2022, Pages 898-908
Patent foramen ovale (PFO) is associated with perioperative stroke in noncardiac surgery. The magnitude of this association was assessed in a systematic review and meta-analysis.
Perioperative considerations in patients with chemotherapy-induced cognitive impairment: a narrative review
Ekin Guran 1,2 , Jian Hu 3 , Jeffrey S. Wefel4,5 , Caroline Chung 4,5 and Juan P. Cata
doi : 10.1016/j.bja.2022.08.037
Volume 129, Issue 6, December 2022, Pages 909-922
Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice
Jun Hu 1,y, Yu Zhang 1,y, Chunxia Huang 1 , Xiaomei Feng 2 , Shufang He 1 , Ye Zhang 1, * and Mervyn Maze
doi : 10.1016/j.bja.2022.08.019
Volume 129, Issue 6, December 2022, Pages 923-936
Interleukin-6 (IL-6), a pleiotropic cytokine with both degenerative and regenerative properties, is necessary and sufficient to provoke perioperative neurocognitive disorders after aseptic trauma in mice.
Tranexamic acid dose–response relationship for antifibrinolysis in postpartum haemorrhage during Caesarean delivery: TRACES, a double-blind, placebo-controlled, multicentre, dose-ranging biomarker study
Anne-Sophie Ducloy-Bouthors 1,2, *, Sixtine Gilliot 2 , Maeva Kyheng 3,4 , David Faraoni 5 , Alexandre Turbelin 1 , Hawa Keita-Meyer 6 , Agnes Rigouzzo 7 , Gabriela Moyanotidou 8 , Benjamin Constant 9 , Francoise Broisin 10 , Agnes L. Gouez 11 , Remi Favier 12 , Edith Peynaud13 , Louise Ghesquiere 14 , Gilles Lebuffe2,15 , Alain Duhamel 3,4 , Delphine Allorge 16 , Sophie Susen 17 , Benjamin Hennart 16 , Emmanuelle Jeanpierre 17 , Pascal Odou 2 , and the TRACES working group
doi : 10.1016/j.bja.2022.08.033
Volume 129, Issue 6, December 2022, Pages 937-945
The optimal dose of tranexamic acid to inhibit hyperfibrinolysis in postpartum haemorrhage is unclear. Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Cesarean Delivery (TRACES) was a double-blind, placebo-controlled, randomised, multicentre dose-ranging study to determine the dose–effect relationship for two regimens of intravenous tranexamic acid vs placebo.
Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis
Chengluan Xuan 1 , Wen Yan 2 , Dan Wang1 , Cong Li 1 , Haichun Ma 1 , Ariel Mueller 3 , Vanessa Chin 3 , Timothy T. Houle 3 and Jingping Wang
doi : 10.1016/j.bja.2022.08.038
Volume 129, Issue 6, December 2022, Pages 946-958
Preemptive analgesia may improve postoperative pain management, but the optimal regimen is unclear. This study aimed to compare the effects and adverse events of preemptive analgesia on postoperative pain and opioid consumption.
The nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in young rats
Yang Ren 1,2,3,4,y,z, Yinhui Zhou 1,2,3,4,y, Zerong You 1,3 , Hao Deng 1,3,5 , William R. Kem6 , Jianren Mao 1,3 , Wei Zhang 4 and J. A. Jeevendra Martyn
doi : 10.1016/j.bja.2022.07.055
Volume 129, Issue 6, December 2022, Pages 959-969
Repetitive opioid use does not always alleviate basal pain, procedural pain, or both after burn injury. Mitigation of burn injury-site pain can be achieved by GTS-21 stimulation of α7-acetylcholine nicotinic receptors (α7AChRs) and reduced microglia activation in rat.
Local infiltration of HYR-PB21, a sustained-release formulation of bupivacaine, provides analgesia and reduces opioid requirement after haemorrhoidectomy: a randomised controlled trial
Jinjie Cui 1 , Qing Xu 2 , Zhengya Yu3 , Jinwen Sun 4 , Yi Zheng 1 , Wei Huang 5 , Yunxian Yu6 , Shu Gao 2 , Zhenjun Wang1, * and Shanchun Zhang
doi : 10.1016/j.bja.2022.08.035
Volume 129, Issue 6, December 2022, Pages 970-976
HYR-PB21 is a new sustained-release formulation of bupivacaine indicated for controlling postoperative pain. The objectives of this study were to investigate the analgesic efficacy and safety profile of HYR-PB21 in patients after haemorrhoidectomy.
Pre-hospital tracheal intubation in severe traumatic brain injury: a systematic review and meta-analysis
Jordan Anderson 1,2, *, Annalize Ebeid 1,3 and Catrin Stallwood-Hall
doi : 10.1016/j.bja.2022.07.033
Volume 129, Issue 6, December 2022, Pages 977-984
Severe traumatic brain injury (TBI) continues to be a leading cause of death, particularly in young adults. Severe TBI contributes to significant socioeconomic burden secondary to the long-term disability, impacting the individual and their family, and wider society.
Associations between state policies, race, ethnicity and rurality, and maternal mortality and morbidity following the United States Supreme Court Dobbs v. Jackson Women's Health Organization ruling
Ashley M. Williams 1 , Rahul Chaturvedi2 , Isabella Pollalis 3 , Jose Ibarra-Cobarru3 , Jaime A. Aaronson2 and Robert S. White
doi : 10.1016/j.bja.2022.08.016
Volume 129, Issue 6, December 2022, Pages e145-e147
Development and validation of a prediction model for catheter-related bladder discomfort: a prospective observational study
Shuang Liang1 , Zhaohua Pang 1 , Nannan Zhou 1 , Zhuoyi Liu1 , Qulian Guo1 , Jiapeng Huang2 and Wangyuan Zou
doi : 10.1016/j.bja.2022.08.018
Volume 129, Issue 6, December 2022, Pages e147-e149
The pitfalls of labelling opioids as weak or strong. Comment on Br J Anaesth 2022; 129: 137–42
Jane Quinlan1,* and Pamela E. Macintyre
doi : 10.1016/j.bja.2022.08.023
Volume 129, Issue 6, December 2022, Pages e150-e153
Association between systematic use of bio-occlusive dressing and general anaesthesia-associated corneal injury
Riley N. Sanders1,y, Abdelrahman M. Elhusseiny 1,y, Muhammad Z. Chauhan 1 , Stewart Scruggs 2 , Alvin Stewart2 , Sarah Tingle2 and Ahmed B. Sallam 1,*
doi : 10.1016/j.bja.2022.08.028
Volume 129, Issue 6, December 2022, Pages e153-e155
Development and validation of a multivariable prediction model for early prediction of chronic postsurgical pain in adults: a prospective cohort study. Comment on Br J Anaesth 2022; 129: 407–15
Yi Shun Wang and Dong Xu Chen
doi : 10.1016/j.bja.2022.09.002
Volume 129, Issue 6, December 2022, Page e155
Ropivacaine concentrations after single-shot erector spinae plane block in children: a pilot pharmacokinetic modelling study
Karla E. Wyatt1,2 , Chyong-jy J. Liu1,2 , Brady Moffett3 , Adam M. Vogel4 , Eduardo Medellin1 , Margaret Owens-Stuberfield 1 , Andrew Lee1 and Rahul G. Baijal
doi : 10.1016/j.bja.2022.08.030
Volume 129, Issue 6, December 2022, Pages e156-e158
Efficacy and safety of proximal popliteal sciatic nerve block compared with distal sciatic bifurcation or selective tibial and peroneal nerve block: a systematic review and meta-analysis of randomised controlled trials
Leigh White1,2,* , Matthew Bright3 , Gina Velli 4 , Meghan Boon 1 and Christopher Thang
doi : 10.1016/j.bja.2022.08.025
Volume 129, Issue 6, December 2022, Pages e158-e162
SARS-CoV-2 viral load in heat and humidity exchange filters during invasive mechanical ventilation of patients with COVID-19
Giorgio Enzo Fulceri1,* , Fabio Morecchiato2 , Alberto Antonelli2,3 , Manuela Bonizzoli1 , Michele Cecchi 4 , Gian Maria Rossolini2,3 and Adriano Peris
doi : 10.1016/j.bja.2022.08.031
Volume 129, Issue 6, December 2022, Pages e163-e164
Environmental and economic impact of using increased fresh gas flow to reduce carbon dioxide absorbent consumption during clinical anaesthesia practice
George Zhong1,2,3,* , Philip Choi 2 and Alpha M. S. Tung
doi : 10.1016/j.bja.2022.09.003
Volume 129, Issue 6, December 2022, Pages e165-e166
Carbon footprint of inhalational and total intravenous anaesthesia for paediatric anaesthesia: a modelling study. Comment on Br J Anaesth 2022; 129: 231–43
Alexander Stilwell * , Usman Ali and Helen Hume-Smith
doi : 10.1016/j.bja.2022.09.001
Volume 129, Issue 6, December 2022, Pages e166-e167
Systems engineering-based framework of process risks in perioperative medication delivery
Sarah M. Coppola1 , David M. Neyens2 , Kenneth Catchpole4 , Ayse P. Gurses3 , Patience Osei 3 , Joshua M. Biro2 , Myrtede Alfred3 , Maya Rucks 2 , Catherine D. Tobin 4 , Candace Jaruzal 4 , James H. Abernathy III 3,* for the Operating Room System based Medication Administration error Reduction Team (OR SMART) Research Group
doi : 10.1016/j.bja.2022.09.004
Volume 129, Issue 6, December 2022, Pages e168-e170
Delayed emergence after remimazolam induction in end-stage liver disease. Comment on Br J Anaesth 2021; 127: 415–23
Amit Singal 1 , Rotem Naftalovich 1,2,* , Asad R. Syed1 , Faraz A. Chaudhry1 , Patrick J. Discepola1 and Daniel T. Rodriguez-Correa 1
doi : 10.1016/j.bja.2022.09.006
Volume 129, Issue 6, December 2022, Pages e171-e172
Use of a human induced pluripotent stem cell-derived dorsal root ganglion neurone model to study analgesics in vitro: proof of principle using lidocaine
Pascal S. H. Smulders1 , Werner ten Hoope1,2 , Carmen Bernardino Morcillo1 , Jeroen Hermanides1 , Markus W. Hollmann1,* and Nina C. Weber
doi : 10.1016/j.bja.2022.09.009
Volume 129, Issue 6, December 2022, Pages e172-e175
