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Thirty-five Years of Heart Transplantation in Medellin: Colombia's First Center for Cardiac Transplantation.
Vinck, Eric E. MD 1; Rendon, Juan C. MD 1; Escobar, Jose J. MD 1; Gomez, Alejandro Quintero MD 1; Perez, Luz E. MD 2; Canas, Eliana M. RN 2; Echeverri, Diego A. MD 3; Fernandez, Ricardo L. MD 3; Quintero, Alvaro M. MD 3; Hernandez, Alberto Villegas MD 1
Research Highlights.
Lewik, Guido MD 1; Beckett, Joseph BSc 1; Issa, Fadi DPhil, FRCS 1
Has the Time Come for Widespread MHC Class I MICA Genotyping in Solid Organ Transplantation?.
Schinstock, Carrie A. MD 1; Valenzuela, Nicole M. PhD 2
Meeting Report: Third International Congress of the International Society of Uterus Transplantation, Tubingen.
Brannstrom, Mats MD, PhD 1; Tullius, Stefan G. MD, PhD 2; Fronek, Jiri MD, PhD 3; Brucker, Sara Y. MD, PhD 4
doi : 10.1097/TP.0000000000004188
AB Uterus transplantation (UTx) is currently the only available treatment for absolute uterine factor infertility. The International Society of Uterus Transplantation (ISUTx) was formally founded in 2017 and joined the Transplantation Society as a formal section in 2021.
Research Involving the Newly Deceased Following Death by Neurologic Criteria: Ethical Justification and Guidelines.
Parent, Brendan JD 1
Aspects of the CPRRD Affecting Xenotransplantation Research in Human Heart-beating Brain-dead Decedents.
Wall, Anji MD, PhD 1
From the Wright Brothers to the A380: Developing Transplantation Takes Teams of Teams.
Chapman, Jeremy R. AC, FRACP 1
"Creating Blue Skies Overhead for All" Introduction of the 2022 Recipient of the Medawar Prize of the Transplantation Society: Professor Jeremy Chapman.
Wong, Germaine 1,2,3; Pleass, Henry 1; O'Connell, Philip 1; Nankivell, Brian 1; Allen, Richard 1; Craig, Jonathan C. 4; the Westmead Transplant and Research Unit
Introduction of Dr Mannikam Suthanthiran as Recipient of the Medawar Prize for 2022.
Gill, John S. MD, MS, FRCPC, FAST 1
The Medawar Prize Acceptance Speech 2022.
Suthanthiran, Manikkam MD 1
Right Versus Left: Progress but No Conclusion in Selecting Donors for Live Donor Liver Transplantation.
Emond, Jean C. MD 1
Machine Perfusion as "Comfort Zone": What Are Key Challenges of Liver Viability Assessment Today?.
Schlegel, Andrea MD, MBA, FEBS 1,2
Improving Access to Renal Transplantation for Highly Sensitized Patients.
Mason, Phil PhD, MD 1; Robb, Matthew L. PhD 2
Interventions Against Posttransplantation Diabetes: A Scientific Rationale for Treatment Hierarchy Based on Literature Review.
Sharif, Adnan MD 1,2
doi : 10.1097/TP.0000000000004198
AB Posttransplant diabetes (PTD) is a common medical complication after solid organ transplantation. Because of adverse outcomes associated with its development and detrimental impact on long-term survival, strategies to prevent or manage PTD are critically important but remain underresearched.
Updated Views on Neutrophil Responses in Ischemia-Reperfusion Injury.
Shepherd, Hailey M. MD 1; Gauthier, Jason M. MD 1; Terada, Yuriko MD 1; Li, Wenjun MD 1; Krupnick, Alexander S. MD 2; Gelman, Andrew E. MD 1,3; Kreisel, Daniel MD, PhD 1,3
doi : 10.1097/TP.0000000000004221
AB Ischemia-reperfusion injury is an inevitable event during organ transplantation and represents a primary risk factor for the development of early graft dysfunction in lung, heart, liver, and kidney transplant recipients.
The Value of Single-cell Technologies in Solid Organ Transplantation Studies.
Peereboom, Emma T.M. MSc 1; Matern, Benedict M. PhD 1; Spierings, Eric PhD 1; Geneugelijk, Kirsten PhD 1
doi : 10.1097/TP.0000000000004237
AB Single-cell technologies open up new opportunities to explore the behavior of cells at the individual level. For solid organ transplantation, single-cell technologies can provide in-depth insights into the underlying mechanisms of the immunological processes involved in alloimmune responses after transplantation by investigating the role of individual cells in tolerance and rejection.
Novel Complement C5 Small-interfering RNA Lipid Nanoparticle Prolongs Graft Survival in a Hypersensitized Rat Kidney Transplant Model.
Ishigooka, Hidetoshi MD 1; Katsumata, Haruki MD, PhD 1,2; Saiga, Kan PhD 1,3; Tokita, Daisuke MD, PhD 1,4; Motoi, Sotaro MS 5; Matsui, Chiyuki MS 5; Suzuki, Yuta PhD 6; Tomimatsu, Ayaka MS 5; Nakatani, Tomoya 5; Kuboi, Yoshikazu MS 5; Yamakawa, Takafumi MD 1,2; Ikeda, Takashi MD 1; Ishii, Rumi MD, PhD 1; Imai, Toshio PhD 5; Takagi, Toshio MD, PhD 1; Tanabe, Kazunari MD, PhD 1
doi : 10.1097/TP.0000000000004207
Prophylaxis of antibody-mediated rejection (AMR) caused by donor-specific antibodies remains challenging. Given the critical roles of complement activity in antibody-mediated graft injury, we developed a lipid nanoparticle (LNP) formulation of small-interfering RNA against complement C5 (C5 siRNA-LNP) and investigated whether C5 siRNA-LNP could downregulate the complement activity and act as an effective treatment for AMR.
Long-term Transplant Function After Thrombolytic Treatment Ex Vivo of Donated Kidneys Retrieved 4 to 5 H After Circulatory Death.
Olausson, Michael MD, PhD 1,2; Antony, Deepti MSc 2; Johansson, Martin MD, PhD 3; Travnikova, Galina MS 2; Nayakawde, Nikhil B. MSc, PhD 2; Banerjee, Debashish MVSc, PhD 2; Mackay Softeland, John MD, PhD 1,2; Ognissanti, Damiano MSc 4; Andresen Bergstrom, Moa MSc, PhD 3,5; Hammarsten, Ola MD, PhD 3,5; Premaratne, Goditha U. MD, PhD 2
doi : 10.1097/TP.0000000000004235
Using a novel thrombolytic technique, we present long-term transplant function, measured by creatinine and iohexol clearance, after utilizing kidneys from porcine donors with uncontrolled donation after circulatory deaths, with 4.5-5 h of warm ischemia.
Extracellular Vesicles Released During Normothermic Machine Perfusion Are Associated With Human Donor Kidney Characteristics.
Woud, Wouter W. MSc 1; Arykbaeva, Asel S. BSc 2,3; Alwayn, Ian P.J. PhD, MD 2,3; Baan, Carla C. PhD 1; Minnee, Robert C. PhD, MD 4; Hoogduijn, Martin J. PhD 1; Boer, Karin PhD 1
doi : 10.1097/TP.0000000000004215
Extracellular vesicles (EVs) are tissue-specific particles released by cells containing valuable diagnostic information in the form of various biomolecules. The characterization of EVs released by kidney grafts during normothermic machine perfusion (NMP) may present a promising avenue to assess graft status before transplantation. Methods
Right Lobe Versus Left Lobe Living Donor Liver Transplantation: A Systematic Review and Meta-analysis of Donor and Recipient Outcomes.
Acuna, Sergio A. MD, PhD 1; Zhang, Wei MD 2; Yoon, Peter D. MBBS 3; Ivanics, Tommy MD 3; Zhu, Mary P. MD 4; Claasen, Marco MD 3; Zuckerman, Jesse MDCM, MSc 1; Ghanekar, Anand MD, PhD 1,3; Cattral, Mark S. MD 1,3; Sapisochin, Gonzalo MD, PhD 1,3
doi : 10.1097/TP.0000000000004213
Living donor liver transplantation (LDLT) is an established treatment for advanced liver disease. Whether right lobe (RL) or left lobe (LL) LDLT provides the best outcomes for donors and recipients remains contentious.
Donor Simvastatin Treatment Is Safe and Might Improve Outcomes After Liver Transplantation: A Randomized Clinical Trial.
Pagano, Duilio MD, PhD 1; Bosch, Jaime MD, PhD 2; Tuzzolino, Fabio MS 3; Oliva, Elisabetta MS 4; Ekser, Burcin MD, PhD 5; Zito, Giovanni MS, PhD 3; Cintorino, Davide MD, PhD 1; di Francesco, Fabrizio MD, PhD 1; Li Petri, Sergio MD 1; Ricotta, Calogero MD, PhD 1; Bonsignore, Pasquale MD, PhD 1; Calamia, Sergio MD 1; Magro, Bianca MD 1; Trifiro, Gianluca MD, PhD 6; Alduino, Rossella MS 3; Barbara, Marco MS 3; Conaldi, Pier Giulio MD, PhD 3; Gallo, Alessia MS, PhD 3; Venuti, Francesca MS 3; Luca, Angelo MD 7; Gruttadauria, Salvatore MD, PhD 1,8
doi : 10.1097/TP.0000000000004220
The current curative approaches for ischemia/reperfusion injury on liver transplantation are still under debate for their safety and efficacy in patients with end-stage liver disease.
Predicting Early Allograft Function After Normothermic Machine Perfusion.
Watson, Christopher J.E. MD 1,2,3,4; Gaurav, Rohit MS 4; Fear, Corrina 4; Swift, Lisa 4; Selves, Linda RGN 1,4; Ceresa, Carlo D.L. DPhil 5; Upponi, Sara S. MPhil 6; Brais, Rebecca BA, MB 7; Allison, Michael PhD 4,8; Macdonald-Wallis, Corrie PhD 9; Taylor, Rhiannon MSc 9; Butler, Andrew J. MChir 1,2,3,4
doi : 10.1097/TP.0000000000004263
Normothermic ex situ liver perfusion is increasingly used to assess donor livers, but there remains a paucity of evidence regarding criteria upon which to base a viability assessment or criteria predicting early allograft function.
Excess Mortality Among Solid Organ Transplant Recipients in the United States During the COVID-19 Pandemic.
Clarke, Jacob A. MD 1; Wiemken, Timothy L. PhD 2; Korenblat, Kevin M. MD 3
doi : 10.1097/TP.0000000000004341
The COVID-19 pandemic is the first sustained respiratory disease pandemic to arise since the start of solid organ transplantation (SOT). Prior studies have demonstrated that SOT recipients are at greater risk for severe complications of infection and are less likely to respond to vaccination.
High Prevalence of Long-COVID Among Kidney Transplant Recipients: A Longitudinal Cohort Study.
Amorim, Carlos Eduardo Neves MD, PhD 1; Gomes, Vinicius Lafico Teixeira 2; Cristelli, Marina Pontello MD, PhD 2; Viana, Laila Almeida MD 2; de Luca Correa, Hugo MD 3; Lima, Gierisson Brenno Borges MSc 1; de Sousa Silva, Flaviana Santos MSc 1; de Castro Lima, Gabriel Santos MSc 1; Rosa, Thiago dos Santos PhD 3; Nakamura, Monica Rika MSc 2; Quintino, Priscilla Monteiro MSc 2; Tedesco-Silva, Helio MD, PhD 2; Medina-Pestana, Jose MD, PhD 2
doi : 10.1097/TP.0000000000004359
Kidney transplant recipients are at a higher risk to develop more severe clinical forms of coronavirus disease 2019 (COVID-19), perhaps increasing the risk of presenting its long-term clinical complications, labeled as Long-COVID.
Impact of the Kidney Transplantation Moratorium in France Because of the COVID-19 Pandemic: A Cohort-based Study.
Bonnemains, Vincent MSc 1; Le Borgne, Florent PhD 1,2; Savoye, Emile MSc 3; Legeai, Camille MD 3; Pastural, Myriam MD 3; Bayat-Makoei, Sahar PhD 4; Lenain, Remi MD 1,5; Ragot, Stephanie PhD 6; Leffondre, Karen PhD 7; Couchoud, Cecile MD, PhD 3,8; Foucher, Yohann PhD 1,6
doi : 10.1097/TP.0000000000004369
The COVID-19 pandemic has resulted in worldwide kidney transplantation (KT) moratoriums. The impacts of these moratoriums on the life expectancy of KT candidates remain unclear.
Incidence, Risk Factors, and Outcomes of COVID-19 Infection in a Large Cohort of Solid Organ Transplant Recipients.
Sahota, Amandeep MD, MS 1; Tien, Andy MD, MS 1; Yao, Janis MS 2; Dong, Elizabeth MD 1; Herald, John MD 3; Javaherifar, Sarah MD, MPH 4; Neyer, Jonathan MD 3; Hwang, Jennifer MD 5; Lee, Roland MD 6; Fong, Tse-Ling MD 7,8
doi : 10.1097/TP.0000000000004371
Solid organ transplant recipients (SOTr) are at increased risk for severe disease from coronavirus disease 2019 (COVID-19) compared with non-SOTr. Methods. We performed a retrospective cohort study between March 1, 2020, and March, 30, 2021, in an integrated healthcare system with 4.3 million members aged >=18 y including 5126 SOTr.
Combining Donor-derived Cell-free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology as Confirmation.
Halloran, Philip F. MD, PhD 1; Reeve, Jeff PhD 1; Madill-Thomsen, Katelynn S. PhD 1; Kaur, Navchetan PhD 2; Ahmed, Ebad PhD 2; Cantos, Carlos MSc 2; Al Haj Baddar, Nour PhD 2; Demko, Zachary PhD 2; Liang, Nathan BA 2; Swenerton, Ryan K. PhD 2; Zimmermann, Bernhard G. PhD 2; Van Hummelen, Paul PhD 2; Prewett, Adam MBA 2; Rabinowitz, Matthew PhD 2; Tabriziani, Hossein MD 2; Gauthier, Phil MD 2; Billings, Paul MD, PhD 2; the Trifecta Investigators*; Fryc, Justyna; Naumnik, Beata; Bromberg, Jonathan; Weir, Matt; Costa, Nadiesda; Brennan, Daniel; Kant, Sam; Viswanathan, Vignesh; Samaniego-Picota, Milagros; Francis, Iman; Patel, Anita; Debska-Slizien, Alicja; Konopa, Joanna; Chamienia, Andrzej; Wiecek, Andrzej; Piecha, Grzegorz; Veceric-Haler, Zeljka; Arnol, Miha; Kojc, Nika; Glyda, Maciej; Smykal-Jankowiak, Katarzyna; Viklicky, Ondrej; Hruba, Petra; Bloudickova, Silvie Rajnochova; Slatinska, Janka; Miglinas, Marius; Myslak, Marek; Mazurkiewicz, Joanna; Gryczman, Marta; Domanski, Leszek; Kamel, Mahmoud; Perkowska-Ptasinska, Agnieszka; Deborska-Materkowska, Dominika; Ciszek, Michal; Durlik, Magdalena; Paczek, Leszek; Grenda, Ryszard; Banasik, Miroslaw; Knotek, Mladen; Vucur, Ksenija; Jurekovic, Zeljka; Muller, Thomas; Schachtner, Thomas; Malone, Andrew; Alhamad, Tarek; Jittirat, Arksarapuk; Poggio, Emilio; Fatica, Richard; Zaky, Ziad; Chow, Kevin; Hughes, Peter; Anand, Sanjiv; Gupta, Gaurav; Kamal, Layla; Kumar, Dhiren; Moinuddin, Irfan; Bobba, Sindhura
doi : 10.1097/TP.0000000000004212
Donor-derived cell-free DNA (dd-cfDNA) fraction and quantity have both been shown to be associated with allograft rejection. The present study compared the relative predictive power of each of these variables to the combination of the two, and developed an algorithm incorporating both variables to detect active rejection in renal allograft biopsies.
The New 2021 CKD-EPI Equation Without Race in a European Cohort of Renal Transplanted Patients.
Delanaye, Pierre MD, PhD 1,2; Masson, Ingrid MD 3; Maillard, Nicolas MD, PhD 3; Pottel, Hans PhD 4; Mariat, Christophe MD, PhD 3
doi : 10.1097/TP.0000000000004234
Whether the new chronic kidney disease-epidemiology (CKD-EPI) equation without the race variable remains accurate enough for glomerular filtration rate (GFR) estimation in non-US kidney transplant recipients (KTRs) is unclear. We sought to compare the predictive performance between this equation and the classical CKD-EPI equation in a French cohort of KTRs.
Impact of Sensitization on Waiting Time Prior to Kidney Transplantation in Germany.
Zecher, Daniel MD 1; Zeman, Florian MS 2; Drasch, Thomas MD 1; Tieken, Ineke MD 3; Heidt, Sebastiaan PhD 4,5; Haasnoot, Geert W. BSc 5; Vogelaar, Serge MD 3; Rahmel, Axel MD 6; Banas, Bernhard MD 1
doi : 10.1097/TP.0000000000004238
Assignment of unacceptable HLA mismatches (UAMs) prevents transplantation of incompatible grafts but potentially prolongs waiting time. Whether this is true in the Eurotransplant Kidney Allocation System (ETKAS) and the Eurotransplant Senior Program in Germany is highly debated and relevant for UAM policies.
Relevance of Anti-HLA Antibody Strength Underestimation in Single Antigen Bead Assay for Shared Eplets.
Claisse, Guillaume MD 1; Devriese, Magali PharmD 2!,3; Lion, Julien PhD 3; Maillard, Nicolas PhD 1; Caillat-Zucman, Sophie MD, PhD 2; Mooney, Nuala PhD 3; Taupin, Jean Luc PhD 2,3
doi : 10.1097/TP.0000000000004247
HLAs contain combinations of multiple eplets, sometimes shared between numerous HLA alleles. Some authors suggested that single antigen bead (SAB) assays may underestimate the signal of anti-HLA antibodies (Ab) when several beads share the targeted eplet.
"Digital Tomosynthesis" As a Technique for the Evaluation of Endobronchial Stents in Lung Transplant Recipients.
Banifadel, Momen MD, MPH 1; Vonau, Martin MD 1; Young, Benjamin MD 1; Panchabhai, Tanmay MD 1; Gilkeson, Robert C. MD 2; Schilz, Robert DO 1; Matta, Maroun MD, MSc 1
doi : 10.1097/TP.0000000000004248
AB Lung transplant patients often suffer from posttransplant airway pathologies that require placement of endobronchial stents. In addition to surveillance bronchoscopy, patients often undergo radiographic stent evaluations. Chest x-rays are extremely limited in their ability to diagnose stent complications, so many patients require chest computed tomography (CT) scans for stent evaluation.
Successful Kidney Transplantation for Children Within 3 Weeks of COVID-19 Infection.
Donald, Julia S. MD 1; Yeoh, Daniel MBBS 2,3; McCarthy, Hugh J. PhD 4; Larkins, Nicholas G. PhD 1,5
Transplanting Kidneys From Donors With SARS-CoV-2 RNA Positivity in Brazil: Early Success Under a Detailed Surveillance Approach.
Viana, Laila Almeida MD 1; Cristelli, Marina Pontello MD, PhD 1; Mendes Leite, Vitor MD 1; Nakamura, Monica Rika MSc 1; Custodio, Luciana de Fatima Porini MD 1; Carneiro, Vanessa Ayres MSc 1; Amorim, Laysla Verhalen Pouzo 1; Martins, Suelen Bianca Stopa MD 1; Tedesco-Silva, Helio MD, PhD 1; Medina-Pestana, Jose MD, PhD 1
The Predictors for Severe SARS-CoV-2 Omicron (B.1.1.529) and Pre-Omicron Variants Infection Among Kidney Transplant Recipients.
Banjongjit, Athiphat MD 1; Lertussavavivat, Tanat MD 1; Paitoonpong, Leilani MD 2,3; Putcharoen, Opass MD 2,3; Vanichanan, Jakapat MD 3; Wattanatorn, Salin RN 1; Tungsanga, Kriang MD 1; Eiam-Ong, Somchai MD 1; Avihingsanon, Yingyos MD 1,4,5; Tungsanga, Somkanya MD 1; Townamchai, Natavudh MD 1,4,5
SARS-CoV-2 mRNA Vaccination Is Not Associated With the Risk of Allosensitization in Patients Awaiting Kidney Transplantation.
Zahradka, Ivan MD 1; Petr, Vojtech MD 1; Modos, Istvan PhD 2; Kabrtova, Katerina MSc 3; Slavcev, Antonij MD, PhD 3; Viklicky, Ondrej MD, PhD 1
COVID-19 Infected Kidney Transplant Patients Outpatient Management-A Single-center Experience With a Hospital-at-home Program.
Liew, Ian Tatt MRCP 1,2; Tan, Woei Jen Michelle FCFP 3; Ho, Quan Yao MRCP 1,2; Thangaraju, Sobhana MRCP 1,2; Yong, Jin Hua BSc 2; Ng, Eleanor BSc 2; He, Xia BSc 2; Kwan, Natelie BN 2; Kee, Terence FRCP 1
A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology: Erratum.
Clinical Effectiveness of SARS-CoV-2 Vaccination in Renal Transplant Recipients. Antibody Levels Impact in Pneumonia and Death: Erratum.
Establishing the Controlled Delivery of VEGF Using a Hydrogel Loaded Soft Robotic Drug Delivery System With the Aim to Prevascularise Implant Site for Islet Transplantation: Erratum.
