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Acute kidney injury in the tropics
Prit Kusirisin, Geraldo Bezerra da Silva Junior, Visith Sitprija, Nattachai Srisawat
doi : 10.1111/nep.14118
The tropics are a region consisting of more than 125 countries, accounting for 40% of the world's population. The region's population is expected to increase up to 60% in the coming decades.
Cigarette smoking and adverse health outcomes in patients treated with maintenance dialysis
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
doi : 10.1111/nep.14122
The association of smoking with new-onset cardiovascular disease, chronic lung disease, malignancy and mortality in dialysis is well-known. The smoking prevalence and its association with clinical outcome was assessed.
Alpha 2-Heremans-Schmid glycoprotein gene polymorphism (rs4918) is associated with coronary artery calcification in incident peritoneal dialysis patients
Shuqi Dai, Yun Chen, Da Shang, Xiaolin Ge, Huanqing Yan, Chuanming Hao, Tongying Zhu
doi : 10.1111/nep.14126
Coronary artery calcification (CAC) is a common and severe complication in peritoneal dialysis (PD) patients, and it progresses in a majority of patients. Fetuin-A, encoded by the alpha 2-Heremans-Schmid glycoprotein (AHSG) gene, is a serum calcification inhibitor. The study aimed to examine the role of AHSG gene polymorphism rs4918 in CAC and CAC progression of PD patients.
Comparing survival in patients with chronic kidney disease across three countries – Results from the study of heart and renal protection-extended review
Benjamin Talbot, Alan Cass, Robert Walker, Lai Hooi, Meg Jardine, Min Jun, Kris Rogers, Louisa Sukkar, Brendan Smyth, Martin Gallagher
doi : 10.1111/nep.14127
This study examined whether survival and causes of death differed between participants enrolled from Australia (AUS), Malaysia (MYL), and New Zealand (NZ) in extended follow-up of the Study of Heart and Renal Protection (SHARP), a randomized controlled trial (RCT) of participants with moderate to severe chronic kidney disease comparing placebo to combination therapy with Simvastatin and Ezetimibe.
α1- and β2-Microglobulin reduction ratios and survival in patients on predilution online haemodiafiltration
Sonoo Mizuiri, Yoshiko Nishizawa, Kazuomi Yamashita, Toshiki Doi, Aiko Okubo, Kenichi Morii, Koji Usui, Michiko Arita, Takayuki Naito, Kenichiro Shigemoto, Takao Masaki
doi : 10.1111/nep.14125
β2-Microglobulin (β2-MG) and α1-microglobulin (α1-MG) have molecular weights of 11,800 and 33,000 Da, respectively. We studied the α1-MG and β2-MG reduction ratios (RRs) and survival in patients on predilution online haemodiafiltration (Pre-OL-HDF).
Pre-transplant serum Beta Trace Protein indicates risk for post-transplant major cardiac adverse events
Sebastian Schwab, Daniel Pörner, Carola-Ellen Kleine, Roxana Werberich, Louisa Werberich, Stephan Reinhard, Dominik Bös, Christian P. Strassburg, Sibylle von Vietinghoff, Philipp Lutz, Rainer P. Woitas
doi : 10.1111/nep.14131
Beta Trace Protein (BTP) is a biomarker for residual kidney function which has been linked to cardiovascular and all-cause mortality in haemodialysis patients. Following renal transplantation, recipients remain at increased risk for cardiovascular events compared with the general population. We aimed to determine the relationship of pre-transplant BTP to major adverse cardiac events (MACE) in patients following kidney transplantation.
Metformin prevents hypoxia-induced podocyte injury by regulating the ZEB2/TG2 axis
Lakshmi P. Kolligundla, Rajesh Kavvuri, Ashish K. Singh, Dhanunjay Mukhi, Anil K. Pasupulati
doi : 10.1111/nep.14121
Podocytes, a vital component of the glomerular filtration barrier, are vulnerable to various noxious stimuli, including Hypoxic. HIF1α that transduces hypoxic adaptations induces Transglutaminase 2 (TG2), which catalyses cross-linking of extracellular matrix proteins. In this study, we investigated the mechanism of regulation of TG2 by HIF1α.
The association of frailty with chronic kidney disease in older adults using the ASPirin in reducing events in the elderly cohort
Rowan G. Walker, Rory Wolfe, Elisa Bongetti, Kevan R. Polkinghorne, Robyn L. Woods, Joanne Ryan, Sara Espinoza, Anne Murray, Michael E. Ernst, John J. Mcneil, ASPREE Investigator Group
doi : 10.1111/nep.14123
