Arthritis and Rheumatology




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American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5

Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls

doi : 10.1002/art.42372

To provide guidance to rheumatology providers on the use of COVID-19 vaccines for patients with rheumatic and musculoskeletal diseases (RMDs).

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The Climate Emergency and the Health of Our Patients: The Role of the Rheumatologist

Paul F. Dellaripa, Thomas Bush, Frederick W. Miller, Candace H. Feldman

doi : 10.1002/art.42279

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Management of Orofacial Manifestations of Juvenile Idiopathic Arthritis: Interdisciplinary Consensus-Based Recommendations

Peter Stoustrup, Cory M. Resnick, Shelly Abramowicz, Thomas K. Pedersen, Ambra Michelotti, Annelise Küseler, Bernd Koos, Carlalberta Verna, Ellen B. Nordal, Eric J. Granquist, Josefine Mareile Halbig, Kasper D. Kristensen, Leonard B. Kaban, Linda Z. Arvidsson, Lynn Spiegel, Matthew L. Stoll, Melissa A. Lerman, Mia Glerup, Patrizia Defabianis, Paula Frid, Per Alstergren, Randy Q. Cron, Sarah Ringold, Sven Erik Nørholt, Timo Peltomaki, Tore A. Larheim, Troels Herlin, Zachary S. Peacock, Christian J. Kellenberger, Marinka Twilt, on behalf of the Temporomandibular Joint Juvenile Arthritis Working Group

doi : 10.1002/art.42338

Involvement of the temporomandibular joint (TMJ) is common in juvenile idiopathic arthritis (JIA). TMJ arthritis can lead to orofacial symptoms, orofacial dysfunction, and dentofacial deformity with negative impact on quality of life.

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American College of Rheumatology/EULAR Remission Criteria for Rheumatoid Arthritis: 2022 Revision

Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson

doi : 10.1002/art.42347

In 2011, the American College of Rheumatology (ACR) and EULAR endorsed provisional criteria for remission in rheumatoid arthritis (RA), both Boolean- and index-based.

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Should Low Serum Urate Be Exonerated? Untangling the Influence of Sarcopenia in Observational Studies

Kanon Jatuworapruk, Nicola Dalbeth

doi : 10.1002/art.42322

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Winner of the 2022 American College of Rheumatology Annual Image Competition

doi : 10.1002/art.42367

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Peripheral Blood DNA Methylation–Based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biologic Specimens and Data From the Osteoarthritis Initiative and Johnston County Osteoarthritis Project

Christopher M. Dunn, Cassandra Sturdy, Cassandra Velasco, Leoni Schlupp, Emmaline Prinz, Vladislav Izda, Liubov Arbeeva, Yvonne M. Golightly, Amanda E. Nelson, Matlock A. Jeffries

doi : 10.1002/art.42316

The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is a key unmet need in OA clinical research. The objective of this study was to develop baseline peripheral blood epigenetic biomarker models to predict knee OA progression.

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Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients

Magali Berland, Victoria Meslier, Samar Berreira Ibraim, Emmanuelle Le Chatelier, Nicolas Pons, Nicolas Maziers, Florence Thirion, Franck Gauthier, Florian Plaza Oñate, Jean-Pierre Furet, Ariane Leboime, Roula Said-Nahal, Florence Levenez, Nathalie Galleron, Benoît Quinquis, Philippe Langella, Stanislav Dusko Ehrlich, Maxime Breban

doi : 10.1002/art.42289

Gut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) patients and could be critically involved in the pathogenesis of this disorder.

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Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites

Ananta Paine, Paul S. Brookes, Soumyaroop Bhattacharya, Dongmei Li, Maria De La Luz Garcia-Hernandez, Francisco Tausk, Christopher Ritchlin

doi : 10.1002/art.42288

The transition from psoriasis to psoriatic arthritis (PsA) occurs in 20–30% of patients; however, the mechanisms underlying the emergence of musculoskeletal disease are not well understood.

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Phosphatidylinositol 3-Kinase δ Deficiency Protects From Antimyeloperoxidase Vasculitis

Fernanda Flórez-Barrós, Simon Freeley, El Li Tham, Michael G. Robson

doi : 10.1002/art.42298

Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is a systemic autoimmune disease in which glomerulonephritis is an important manifestation. Antibodies against myeloperoxidase (MPO) or proteinase 3 are thought to be important in pathogenesis.

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Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Takashi Kudo, Daigo Nakazawa, Kanako Watanabe-Kusunoki, Masatoshi Kanda, Satoka Shiratori-Aso, Nobuya Abe, Saori Nishio, Jun-ichiro Koga, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Miwako Yamasaki, Masahiko Watanabe, Sakiko Masuda, Utano Tomaru, Masaaki Murakami, Yasuaki Aratani, Akihiro Ishizu, Tatsuya Atsumi

doi : 10.1002/art.42314

Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is pathologically characterized by focal fibrinoid necrosis, in which ANCA-mediated neutrophil extracellular trap (NET) formation and subsequent endothelial cell necrosis occur.

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Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Maria Prendecki, Kavita Gulati, Noelle Pisacano, Damilola Pinheiro, Tejal Bhatt, Marie-Anne Mawhin, Frederic Toulza, Esteban S. Masuda, Andrew Cowburn, Katharine M. Lodge, Frederick W. K. Tam, Candice Roufosse, Charles D. Pusey, Stephen P. McAdoo

doi : 10.1002/art.42321

Syk is a cytoplasmic protein tyrosine kinase that plays a role in signaling via B cell and Fc receptors (FcR). FcR engagement and signaling via Syk is thought to be important in antineutrophil cytoplasm antibody (ANCA) IgG–mediated neutrophil activation.

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Association of 18F-Fluorodeoxyglucose–Positron Emission Tomography Activity With Angiographic Progression of Disease in Large Vessel Vasculitis

Kaitlin A. Quinn, Mark A. Ahlman, Hugh D. Alessi, Michael P. LaValley, Tuhina Neogi, Jamie Marko, Elaine Novakovich, Peter C. Grayson

doi : 10.1002/art.42290

To assess whether vascular activity seen on 18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) scan is associated with angiographic change in large vessel vasculitis (LVV).

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Alterations of the Primary Cilia Gene SPAG17 and SOX9 Locus Noncoding RNAs Identified by RNA-Sequencing Analysis in Patients With Systemic Sclerosis

Elisha D. O. Roberson, Mary Carns, Li Cao, Kathleen Aren, Isaac A. Goldberg, David J. Morales-Heil, Benjamin D. Korman, John P. Atkinson, John Varga

doi : 10.1002/art.42281

Systemic sclerosis (SSc) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-sequencing analysis on skin biopsy samples and peripheral blood mononuclear cells (PBMCs) from SSc patients and unaffected controls to better understand the pathogenesis of SSc.

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Clinical Images: Chronic, refractory childhood-onset cutaneous lupus erythematosus of the face responsive to lenalidomide

Matthew A. Sherman, Hemalatha Srinivasalu, A. Yasmine Kirkorian, Michael A. Cardis

doi : 10.1002/art.42326

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Clinical Images: Nivolumab-induced tracheobronchial chondritis in a patient with hypopharyngeal cancer

Kazu Hamada-Ode, Yoshinori Taniguchi, Marina Osaki, Rika Yoshimatsu, Noriko Nitta

doi : 10.1002/art.42317

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Gout and Excess Risk of Severe SARS–CoV-2 Infection Among Vaccinated Individuals: A General Population Study

Dongxing Xie, Hyon K. Choi, Nicola Dalbeth, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Chao Zeng, Xiaoxiao Li, Jie Wei, Guanghua Lei, Yuqing Zhang

doi : 10.1002/art.42339

Gout patients often have multiple comorbidities, making them susceptible to SARS–CoV-2 infection and poor outcomes. This study was undertaken to examine the association between gout and the risk of SARS–CoV-2 infection and severe outcomes, especially in patients who have received a SARS–CoV-2 vaccine.

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Associations Between Low Serum Urate, Body Composition, and Mortality

Joshua F. Baker, David R. Weber, Tuhina Neogi, Michael D. George, Jin Long, Lindsay N. Helget, Bryant R. England, Ted R. Mikuls

doi : 10.1002/art.42301

Controversy remains as to whether low serum urate or uric acid (UA) levels contribute to adverse outcomes. We evaluated the relation between low serum UA levels and sarcopenia and assessed whether sarcopenia confounds associations between these low levels and mortality.

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No differences in myocardial perfusion between treatment-naive, early rheumatoid arthritis patients and healthy controls

John D. Biglands, Bara Erhayiem, Graham Fent, John P. Greenwood, Raluca B. Dumitru, Jacqueline Andrews, Paul Emery, Maya H. Buch, Sven Plein

doi : 10.1002/art.42341

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Itaconate for lupus remission: the next therapeutic frontier? Comment on the article by Blanco et al

Qi Huang, Wang-Dong Xu

doi : 10.1002/art.42332

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