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The times they are a-changin’: new co-principal editors at NPP
Tony P. George & Lisa M. MonteggiaÂÂ
doi : 10.1038/s41386-022-01476-1
Volume 48 Issue 2, January 2023
Whole brain metabolic mapping�another chapter in a great book on the effects of cocaine in monkeys
Charles W. BradberryÂÂ
Five recommendations for using large-scale publicly available data to advance health among American Indian peoples: the Adolescent Brain and Cognitive Development (ABCD) StudySM as an illustrative case
Evan J. White, Mara J. Demuth, Andrea Wiglesworth, Ashleigh D. Coser, Brady A. Garrett, Terrence K. Kominsky, Valarie Jernigan, Wesley K. Thompson, Martin Paulus & Robin AupperleÂÂ
doi : 10.1038/s41386-022-01498-9
American Indian and Alaska Native (AIAN) populations have suffered a history of exploitation and abuse within the context of mental health research and related fields. This history is rooted in assimilation policies, historical trauma, and cultural loss, and is promulgated through discrimination and disregard for traditional culture and community knowledge.
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders
Jiewei Liu, Yuqi Cheng, Ming Li, Zhijun Zhang, Tao Li & Xiong-Jian LuoÂÂ
doi : 10.1038/s41386-022-01456-5
Psychiatric disorders impose tremendous economic burden on society and are leading causes of disability worldwide. However, only limited drugs are available for psychiatric disorders and the efficacy of most currently used drugs is poor for many patients.
Evidence from “big data� for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples
Luke J. Norman, Gustavo Sudre, Jolie Price, Gauri G. Shastri & Philip ShawÂÂ
doi : 10.1038/s41386-022-01408-z
We sought to identify resting-state characteristics related to attention deficit/hyperactivity disorder, both as a categorical diagnosis and as a trait feature, using large-scale samples which were processed according to a standardized pipeline.
Residual deficits in functional brain activity after chronic cocaine self-administration in rhesus monkeys
Linda J. Porrino, Hilary R. Smith, Thomas J. R. Beveridge, Mack D. Miller, Susan H. Nader & Michael A. NaderÂÂ
doi : 10.1038/s41386-021-01136-w
Previous studies in humans and in animals have shown dramatic effects of cocaine on measures of brain function that persist into abstinence.
Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade
Martin Trøstheim, Marie Eikemo, Jan Haaker, J. James Frost & Siri LeknesÂÂ
doi : 10.1038/s41386-022-01416-z
Non-human animal studies outline precise mechanisms of central mu-opioid regulation of pain, stress, affiliation and reward processing. In humans, pharmacological blockade with non-selective opioid antagonists such as naloxone and naltrexone is typically used to assess involvement of the mu-opioid system in such processing.
A novel stress-based intervention reduces cigarette use in non-treatment seeking smokers
Alexandra Barnabe, Karine Gamache, João Vitor Paes de Camargo, Erin Allen-Flanagan, Mathilde Rioux, Jens Pruessner, Marco Leyton & Karim NaderÂÂ
doi : 10.1038/s41386-022-01455-6
Tobacco use is the leading cause of preventable mortality worldwide. Since current smoking cessation aids show only modest efficacy, new interventions are needed. Given the evidence that stress is a potent trigger for smoking, the present randomized clinical trial tested whether stress could augment the effects of a memory updating (retrieval-extinction) intervention.
Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach
Delin Sun, Viraj R. Adduru, Rachel D. Phillips, Heather C. Bouchard, Aristeidis Sotiras, Andrew M. Michael, Fiona C. Baker, Susan F. Tapert, Sandra A. Brown, Duncan B. Clark, David Goldston, Kate B. Nooner, Bonnie J. Nagel, Wesley K. Thompson, Michael D. De Bellis & Rajendra A. MoreyÂÂ
doi : 10.1038/s41386-022-01457-4
Cortical thickness changes dramatically during development and is associated with adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the underlying spatially heterogeneous effects of alcohol.
Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction
Zhonghua Dai, Ying Liu, Lina Nie, Weiqi Chen, Xing Xu, Yonghui Li, Jianjun Zhang, Fang Shen, Nan Sui & Jing LiangÂÂ
doi : 10.1038/s41386-022-01477-0
Extinction training during the reconsolidation window following memory recall is an effective behavioral pattern for promoting the extinction of pathological memory.
Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism
Sara MartÃÂnez-Torres, Araceli Bergadà-MartÃÂnez, Jorge E. Ortega, Lorena Galera-López, Arnau Hervera, LucÃÂa de los Reyes-RamÃÂrez, Antonio Ortega-ÃÂ�lvaro, Floortje Remmers, Emma Muñoz-Moreno, Guadalupe Soria, José Antonio del RÃÂo, Beat Lutz, Jose ÃÂ�ngel RuÃÂz-Ortega, J. Javier Meana, Rafael Maldonado & Andrés OzaitaÂÂ
doi : 10.1038/s41386-022-01436-9
Peripheral inputs continuously shape brain function and can influence memory acquisition, but the underlying mechanisms have not been fully understood. Cannabinoid type-1 receptor (CB1R) is a well-recognized player in memory performance, and its systemic modulation significantly influences memory function.
Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus
Stephanie Murphy, Metika Collis Glynn, Tiarani N. Dixon, Harvey J. Grill, Gavan P. McNally & Zhi Yi OngÂÂ
doi : 10.1038/s41386-022-01448-5
Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake but the relevant neural phenotypes and pathways remain elusive.
Interactive relationships of Type 2 diabetes and bipolar disorder with cognition: evidence of putative premature cognitive ageing in the UK Biobank Cohort
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Michael Berk, Neville Owen, Susan L. Rossell & Tamsyn E. Van RheenenÂÂ
doi : 10.1038/s41386-022-01471-6
Type 2 diabetes (T2D) is disproportionately prevalent in bipolar disorder (BD) and is associated with cognitive deficits in psychiatrically healthy cohorts. Whether there is an interaction effect between T2D and BD on cognition remains unclear.
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
Peter M. Lambert, Richard Ni, Ann Benz, Nicholas R. Rensing, Michael Wong, Charles F. Zorumski & Steven MennerickÂÂ
doi : 10.1038/s41386-022-01450-x
Neurosteroids that positively modulate GABAA receptors are among a growing list of rapidly acting antidepressants, including ketamine and psychedelics.
Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders
Guido K. W. Frank, Megan E. Shott, Tamara Pryor, Skylar Swindle, Tyler Nguyen & Joel StoddardÂÂ
doi : 10.1038/s41386-022-01440-z
Anxious traits are elevated in eating disorders (EDs), are considered risk factors for ED development, and trait anxiety has been linked to ED psychopathology. How trait anxiety relates to ED neurobiology is not well understood.
Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer’s disease
Shu Shu, Si-Yi Xu, Lei Ye, Yi Liu, Xiang Cao, Jun-Qiu Jia, Hui-Jie Bian, Ying Liu, Xiao-Lei Zhu & Yun XuÂÂ
doi : 10.1038/s41386-022-01435-w
Alzheimer’s disease (AD) is the most common neurodegenerative disease and has an insidious onset. Exploring the characteristics and mechanism of the early symptoms of AD plays a critical role in the early diagnosis and intervention of AD.
Defining brain-based OCD patient profiles using task-based fMRI and unsupervised machine learning
Alessandro S. De Nadai, Kate D. Fitzgerald, Luke J. Norman, Stefanie R. Russman Block, Kristin A. Mannella, Joseph A. Himle & Stephan F. TaylorÂÂ
doi : 10.1038/s41386-022-01353-x
While much research has highlighted phenotypic heterogeneity in obsessive compulsive disorder (OCD), less work has focused on heterogeneity in neural activity. Conventional neuroimaging approaches rely on group averages that assume homogenous patient populations.
PET imaging of kappa opioid receptors and receptor expression quantified in neuron-derived extracellular vesicles in socially housed female and male cynomolgus macaques
Bernard N. Johnson, Ashish Kumar, Yixin Su, Sangeeta Singh, Kiran Kumar Solingapuram Sai, Susan H. Nader, Songye Li, Beth A. Reboussin, Yiyun Huang, Gagan Deep & Michael A. NaderÂÂ
doi : 10.1038/s41386-022-01444-9
Recent positron emission tomography (PET) studies of kappa opioid receptors (KOR) in humans reported significant relationships between KOR availability and social status, as well as cocaine choice.
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
James Glazer, Conor H. Murray, Robin Nusslock, Royce Lee & Harriet de WitÂÂ
doi : 10.1038/s41386-022-01479-y
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms.
In Memoriam Donald S. Robinson, MD
William Z. Potter, Angelo Sambunaris & Steven M. PaulÂÂ
