دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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ALK Immunoexpression is Specific for Inflammatory Myofibroblastic Tumor Among Vulvovaginal Mesenchymal Neoplasms.
Christopher J. Bowman, M.D., Ph.D., Fabiola Medeiros, M.D., Oluwole Fadare, M.D., Ankur R. Sangoi, M.D., Andrew E. Horvai, M.D., Ph.D., W. Patrick Devine, M.D., Ph.D. , W. Glenn McCluggage, F.R.C.Path., and Joseph T. Rabban, M.D., M.P.H.
doi : 10.1097/PGP.0000000000000858
AB Gynecologic tract origin of inflammatory myofibroblastic tumor (IMT), a receptor tyrosine kinase fusion driven tumor with malignant potential, is uncommon and mostly involves the uterine corpus where misclassification as a smooth muscle tumor may occur due to overlapping morphologic features.
The Expression of HPV E6/E7 mRNA In Situ Hybridization in HPV Typing-negative Cervical Cancer.
Xu, Yating M.M.; Sun, Yonghong M.M.; Chang, Hui M.M.; Cai, Jingjing M.B.; Cao, Chengcheng M.M.; Zhang, Baogang M.D.; Zhang, Youzhong M.D.; Liu, Yuzhen M.D.
doi : 10.1097/PGP.0000000000000870
AB High-risk human papillomavirus (HPV) persistent infection is the major tumorigenesis factor for cervical cancer (CC). However, the incidence of HPV-negative CC is 5% to 30% with different HPV detection methods.
Epstein-Barr Virus-positive Mucocutanous Ulcer of the Uterine Cervix: Report of a Rare and Evolving Entity.
Razack, Rubina M.D., M.B.Ch.B., M.Med., F.C.Path.; Cariem, Rabia M.B.Ch.B.; Irusen, Semira M.B.Ch.B., F.C.Path., M.Med.; Mohosho, Mokoena M.B.Ch.B., M.Med.; de Jager, Louis M.B.Ch.B., M.Med., F.C.Path.
doi : 10.1097/PGP.0000000000000861
AB Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described lymphoproliferative lesion characterized by the proliferation of EBV-positive atypical B cells in a variable inflammatory background associated with mucosal or cutaneous ulcers.
Clinicopathologic Evaluation and Molecular Profiling of Recurrent Stage IA Endometrial Endometrioid Carcinoma: A Case-control Study.
Sharma, Aarti E. M.D.; Moran, Angelica M.D., Ph.D.; Somasegar, Sahana M.D.; Steinhardt, George Ph.D.; Chapel, David B. M.D.; Lastra, Ricardo R. M.D.; Lee, Nita K. M.D.; Ritterhouse, Lauren L. M.D., Ph.D.; Bennett, Jennifer A. M.D.
doi : 10.1097/PGP.0000000000000856
AB Most low-grade, early-stage endometrial endometrioid carcinomas (EEC) have an excellent prognosis; however, recurrences occur in a small subset with several studies reporting an increase in CTNNB1 exon 3 mutations in this population. Herein we evaluated 10 recurrent low-grade (FIGO 1 or 2), early-stage (FIGO IA) EECs matched to 10 nonrecurrent EECs to further characterize their clinicopathologic features and molecular phenotype.
PRAME Expression in Endometrioid and Serous Endometrial Carcinoma: A Potential Immunotherapeutic Target and Possible Diagnostic Pitfall.
Coppock, Joseph D. M.D., Ph.D.; Gradecki, Sarah E. M.D.; Mills, Anne M. M.D.
doi : 10.1097/PGP.0000000000000864
AB Preferentially expressed antigen in melanoma (PRAME) is a cancer testes antigen initially employed as a diagnostic marker for melanoma. Although negative in most normal tissues, its expression has been reported in benign endometrial glands.
Clinicopathologic Evaluation of CTNNB1 Mutations in High-Intermediate Risk Endometrial Endometrioid Carcinoma.
Haag, Jennifer G. M.D.; Wolsky, Rebecca J. M.D.; Moroney, Marisa R. M.D.; Sheren, Jamie Ph.D.; Sheeder, Jeanelle Ph.D.; Bitler, Benjamin G. Ph.D.; Corr, Bradley R. M.D.
doi : 10.1097/PGP.0000000000000865
AB CTNNB1 mutations convey increased risk of recurrence in low-risk endometrial endometrioid carcinoma (EEC). Results from previous high-intermediate risk (HIR) cohorts are mixed.
Uterine Tumor Resembling Ovarian Sex Cord Tumor With Aggressive Histologic Features Harboring a GREB1-NCOA2 Fusion: Case Report With a Brief Review.
Yin, Xiaona M.D.; Wang, Min M.D.; He, Huiying M.D., Ph.D.; Ru, Guoqing M.D.; Zhao, Ming M.D., Ph.D.
doi : 10.1097/PGP.0000000000000849
AB Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare mesenchymal neoplasm, of uncertain lineage, that shows predominantly sex cord-like differentiation with a broad range of histologic appearances and polyphenotypic immunohistochemical features.
High-grade Endometrial Carcinoma With a Hepatoid Carcinoma-like Component.
Nishida, Kenji M.D., Ph.D.; Toji, Tomohiro M.D., Ph.D.; Taniguchi, Kohei M.D., Ph.D.; Shibata, Rei M.D.; Ono, Sawako D.D.S., Ph.D.; Tanaka, Takehiro M.D., Ph.D.; Yoshino, Tadashi M.D., Ph.D.; Yanai, Hiroyuki M.D., Ph.D.
doi : 10.1097/PGP.0000000000000852
AB Endometrial carcinoma with hepatoid differentiation is rare and <20 reported cases have been reported as endometrial hepatoid carcinoma (EHC). We present a case of EHC associated with serous carcinoma in a 76-yr-old Japanese woman.
Pilomatrix-like High-grade Endometrioid Carcinoma is a Morphologically and Immunophenotypically Distinct Entity and May Show Mismatch Repair Deficiency.
Arciuolo, Damiano M.D.; Travaglino, Antonio M.D.; Santoro, Angela M.D.; Roberti, Paola T.E.C.H.N.; Raffone, Antonio M.D.; Inzani, Frediano M.D.; Zannoni, Gian Franco M.D.
Microscopic Sertoliform Sex Cord Proliferations: A Rare Incidental Finding Associated With Endometriosis and Ovarian Epithelial Neoplasia.
Talia, Karen L. F.R.C.P.A.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000873
AB Microscopic sex cord proliferations are a rare incidental finding seen in association with ovarian and uterine stromal or epithelial neoplasms and more uncommonly non-neoplastic conditions such as endometriosis and adenomyosis.
Ovarian Malignant Mixed Germ Cell Tumor Composed Mainly of a Polyembryoma Pattern With Vasculogenic Mesenchymal Tumor Components.
Kouchi, Yusuke M.D.; Komatsu, Shugo M.D., Ph.D.; Harada, Sakurako M.D.; Shinomiya, Yoshiki M.S.; Ikeda, Jun-ichiro M.D., Ph.D.; Kishimoto, Takashi M.D., Ph.D.
doi : 10.1097/PGP.0000000000000867
AB Ovarian germ cell tumors composed of numerous well-formed embryonal bodies have been described as exhibiting a "polyembryoma pattern." In addition, some germ cell tumors are occasionally concomitant with neoplastic vascular proliferation.
BAP1 Tumor Predisposition Syndrome Presenting as a Recurrent Ovarian Sex Cord-Stromal Tumor.
Albright, Benjamin B. M.D., M.S.; Wignall, Elizabeth M.S., C.G.C.; Bentley, Rex C. M.D.; Havrilesky, Laura J. M.D., M.H.Sc.; Previs, Rebecca A. M.D.; Strickland, Kyle C. M.D., Ph.D.
doi : 10.1097/PGP.0000000000000855
AB The BRCA1-associated protein 1 (BAP1) gene encodes a tumor suppressor that functions as a ubiquitin hydrolase involved in DNA damage repair. BAP1 germline mutations are associated with increased risk of multiple solid malignancies, including mesothelioma, uveal melanoma, renal cell carcinoma, and high-grade rhabdoid meningiomas.
Serous Tubal Intraepithelial Carcinoma in a Risk-reducing Salpingo-oophorectomy Specimen From a RAD51D Mutation Carrier: A Case Report.
Gregory-Davis, Kalin J. B.A.; Walker, Allison M.D.; Colello, Laura S. M.S., C.G.C.; McKinnon, Wendy M.S., C.G.C.; Everett, Elise M.D., M.Sc.; Chang, Martin C. M.D., Ph.D.
doi : 10.1097/PGP.0000000000000857
AB The RAD51D gene codes a protein-paralog of the RAD51 DNA recombinase, which catalyzes DNA strand exchange during homologous recombination. Similar to BRCA1/BRCA2, mutations in RAD51D both predispose to ovarian carcinoma and impart sensitivity to poly (ADP-ribose) polymerase inhibitors in preclinical studies.
Unusual Ovarian Tumors With Endometrioid Proliferations Co-Expressing Estrogen Receptor and CDX-2 Arising in Cystadenofibromatous Background: Report of 3 Cases.
McMullen-Tabry, Emily R. M.D.; Sciallis, Andrew P. M.D.; Udager, Aaron M. M.D., Ph.D.; Skala, Stephanie L. M.D.
doi : 10.1097/PGP.0000000000000862
AB This report describes 3 cases of ovarian tumors with unusual glandular proliferations co-expressing estrogen receptor and CDX-2 by immunohistochemistry set in cystadenofibromatous background.
Two Cases of Mesonephric-like Carcinoma Arising From Endometriosis: Case Report and Review of the Literature.
Chang, Connie Shinru B.S.; Carney, Michael E. M.D.; Killeen, Jeffrey L. M.D.
doi : 10.1097/PGP.0000000000000863
AB Endometriosis is a common condition in reproductive age women that is defined as the presence of endometrial tissue (epithelial and/or stromal) outside the uterine corpus. While not a premalignant lesion, it is a condition with a potential for malignancy, especially in the ovaries.
