دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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http://medilib.ir
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قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity
Lea-Maxie Haag, Britta Siegmund
LOXL2 in pancreatic tumourigenesis: the complexity of tumour–stromal crosstalk exemplified
Seth B Coffelt, Jennifer P Morton
Health-code-based triage versus universal COVID-19 PCR testing before endoscopy in a low incidence area: a real-world experience
Zhihui Duan, Dengxiang Liu, Shengyun Zhou, Hui Li, Xiaofang Sun, Chunqian Zhao, Qiong Duan, Liwei Li, Xiaochong Zhang, Lingxuan Jin
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities
Shamaine Wei Ting Ho, Taotao Sheng, Manjie Xing, Wen Fong Ooi, Chang Xu, Raghav Sundar, Kie Kyon Huang, Zhimei Li, Vikrant Kumar, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Zul Fazreen Bin Adam Isa, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Dustin Shigaki, Haoran Ma, Angie Lay Keng Tan, Xuewen Ong, Ming Hui Lee, Su Ting Tay, Yu Amanda Guo, Weitai Huang, Shang Li, Michael A. Beer, Roger Sik Yin Foo, Ming Teh, Anders Jacobsen Skanderup, Bin Tean Teh, Patrick Tan
doi : 10.1136/gutjnl-2021-326483
Objective Gastric cancer (GC) comprises multiple molecular subtypes. Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype with few treatment options. Combining multiple studies, we derived and applied a consensus Mes-GC classifier to define the Mes-GC enhancer landscape revealing disease vulnerabilities.
Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models
Yin Tong, Priscilla S W Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S Y Chan, April S Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H N Yan
doi : 10.1136/gutjnl-2022-327121
Objective Cell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells.
Phase II trial of weekly erlotinib dosing to reduce duodenal polyp burden associated with familial adenomatous polyposis
N Jewel Samadder, Nathan Foster, Ryan P McMurray, Carol A Burke, Elena Stoffel, Priyanka Kanth, Rohit Das, Marcia Cruz-Correa, E Vilar, Gautam Mankaney, Navtej Buttar, Selvi Thirumurthi, Danielle K Turgeon, Michael Sossenheimer, Michelle Westover, Ellen Richmond, Asad Umar, Gary Della'Zanna, Luz M Rodriguez, Eva Szabo, David Zahrieh, Paul J Limburg
doi : 10.1136/gutjnl-2021-326532
Importance Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal adenomas and cancer. Combination sulindac and erlotinib was previously shown to reduce duodenal polyp burden but was associated with a relatively high adverse event (AE) rate. Objective: To evaluate if a once weekly dosing schedule for erlotinib intervention improves the AE profile, while still providing efficacy with respect to reduced polyp burden, in participants with FAP. Design, setting and participants: Single-arm trial, enrolling 46 participants with FAP, conducted from October 2017 to September 2019 in eight academic cancer centres.
Efficacy of biological therapies and small molecules in induction and maintenance of remission in luminal Crohn’s disease: systematic review and network meta-analysis
Brigida Barberio, David J Gracie, Christopher J Black, Alexander C Ford
doi : 10.1136/gutjnl-2022-328052
Objective There are numerous biological therapies and small molecules licensed for luminal Crohn’s disease (CD), but these are often studied in placebo-controlled trials, meaning relative efficacy is uncertain. We examined this in a network meta-analysis.
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Luz del Carmen MartÃnez-Sánchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Günther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J M Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F Neurath, RocÃo López-Posadas
doi : 10.1136/gutjnl-2021-325520
Objective Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the role of live cell extrusion in epithelial barrier alterations in IBD.
Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic
Nicholas A Kennedy, Malik Janjua, Neil Chanchlani, Simeng Lin, Claire Bewshea, Rachel Nice, Timothy J McDonald, Cressida Auckland, Lorna W Harries, Merlin Davies, Stephen Michell, Klaartje B Kok, Christopher A Lamb, Philip J Smith, Ailsa L Hart, Richard CG Pollok, Charlie W Lees, Rosemary J Boyton, Daniel M Altmann, Shaji Sebastian, Nicholas Powell, James R Goodhand, Tariq Ahmad
doi : 10.1136/gutjnl-2022-327570
Objective Antitumour necrosis factor (TNF) drugs impair serological responses following SARS-CoV-2 vaccination. We sought to assess if a third dose of a messenger RNA (mRNA)-based vaccine substantially boosted anti-SARS-CoV-2 antibody responses and protective immunity in infliximab-treated patients with IBD.
Targeted intervention to achieve waste reduction in gastrointestinal endoscopy
João A Cunha Neves, Joana Roseira, PatrÃcia Queirós, Helena Tavares Sousa, Gianluca Pellino, Miguel F Cunha
doi : 10.1136/gutjnl-2022-327005
Objective Endoscopy is healthcare’s third largest generator of medical waste in hospitals. This prospective study aimed to measure a single unit’s waste carbon footprint and perform a pioneer intervention towards a more sustainable endoscopy practice. The relation of regulated medical waste (RMW; material fully contaminated with blood or body fluids or containing infectious agents) versus landfill waste (non-recyclable material not fully contaminated) may play a critical role.
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
Kassem Makki, Harald Brolin, Natalia Petersen, Marcus Henricsson, Dan Ploug Christensen, Muhammad Tanweer Khan, Annika Wahlström, Per-Olof Bergh, Valentina Tremaroli, Kristina Schoonjans, Hanns-Ulrich Marschall, Fredrik Bäckhed
doi : 10.1136/gutjnl-2021-326541
Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble dietary fibre oligofructose improves host metabolism by modulating bacterial transformation of secondary bile acids in mice fed western-style diet.
Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
Kevin M Sullivan, Xiuyun Jiang, Prajna Guha, Christopher Lausted, Jason A Carter, Cynthia Hsu, Kevin P Labadie, Karan Kohli, Heidi L Kenerson, Sara K Daniel, Xiaowei Yan, Changting Meng, Arezou Abbasi, Marina Chan, Y David Seo, James O Park, Ian Nicholas Crispe, Raymond S Yeung, Teresa S Kim, Taranjit S Gujral, Qiang Tian, Steven C Katz, Venu G Pillarisetty
doi : 10.1136/gutjnl-2021-325808
Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell and chimeric antigen receptor T (CAR-T) cell antitumour function in CRLM slice cultures.
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
Eileen Morgan, Melina Arnold, A Gini, V Lorenzoni, C J Cabasag, Mathieu Laversanne, Jerome Vignat, Jacques Ferlay, Neil Murphy, Freddie Bray
doi : 10.1136/gutjnl-2022-327736
Objective Colorectal cancer (CRC) is the third most common cancer worldwide. The geographical and temporal burden of this cancer provides insights into risk factor prevalence and progress in cancer control strategies. We examine the current and future burden of CRC in 185 countries in 2020 and 2040.
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
Marta Alonso-Nocelo, Laura Ruiz-Cañas, Patricia Sancho, Kıvanç Görgülü, Sonia Alcalá, Coral Pedrero, Mireia Vallespinos, Juan Carlos López-Gil, Marina Ochando, Elena GarcÃa-GarcÃa, Sara Maria David Trabulo, Paola Martinelli, Patricia Sánchez-Tomero, Carmen Sánchez-Palomo, Patricia Gonzalez-SantamarÃa, Lourdes Yuste, Sonja Maria Wörmann, Derya KabacaoÄŸlu, Julie Earl, Alberto Martin, Fernando Salvador, Sandra Valle, Laura Martin-Hijano, Alfredo Carrato, Mert Erkan, Laura GarcÃa-Bermejo, Patrick C Hermann, Hana Algül, Gema Moreno-Bueno, Christopher Heeschen, Francisco Portillo, Amparo Cano, Bruno Sainz
doi : 10.1136/gutjnl-2021-325564
Objective The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci, Rossano Lattanzio, Gianluca Sala, Paola Cappello, Francesco Novelli, Elisa Giovannetti, Caterina Vicentini, Silvia Andreani, Pietro Delfino, Vincenzo Corbo, Aldo Scarpa, Paolo Ettore Porporato, Andrea Morandi, Emilio Hirsch, Miriam Martini
doi : 10.1136/gutjnl-2021-325117
Objective Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited therapeutic options. However, metabolic adaptation to the harsh PDAC environment can expose liabilities useful for therapy. Targeting the key metabolic regulator mechanistic target of rapamycin complex 1 (mTORC1) and its downstream pathway shows efficacy only in subsets of patients but gene modifiers maximising response remain to be identified.
Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals
Alessandro Mantovani, Graziana Petracca, Alessandro Csermely, Giorgia Beatrice, Stefano Bonapace, Andrea Rossi, Herbert Tilg, Christopher D Byrne, Giovanni Targher
doi : 10.1136/gutjnl-2022-327672
Objective Recent studies reported an association between non-alcoholic fatty liver disease (NAFLD) and increased risk of new-onset heart failure (HF). However, the magnitude of the risk and whether this risk changes with severity of liver disease remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between NAFLD and risk of new-onset HF.
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study
Stephan Buch, Hamish Innes, Philipp Ludwig Lutz, Hans Dieter Nischalke, Jens U Marquardt, Janett Fischer, Karl Heinz Weiss, Jonas Rosendahl, Astrid Marot, Marcin Krawczyk, Markus Casper, Frank Lammert, Florian Eyer, Arndt Vogel, Silke Marhenke, Johann von Felden, Rohini Sharma, Stephen Rahul Atkinson, Andrew McQuillin, Jacob Nattermann, Clemens Schafmayer, Andre Franke, Christian Strassburg, Marcella Rietschel, Heidi Altmann, Stefan Sulk, Veera Raghavan Thangapandi, Mario Brosch, Carolin Lackner, Rudolf E Stauber, Ali Canbay, Alexander Link, Thomas Reiberger, Mattias Mandorfer, Georg Semmler, Bernhard Scheiner, Christian Datz, Stefano Romeo, Stefano Ginanni Corradini, William Lucien Irving, Joanne R Morling, Indra Neil Guha, Eleanor Barnes, M Azim Ansari, Jocelyn Quistrebert, Luca Valenti, Sascha A Müller, Marsha Yvonne Morgan, Jean-François Dufour, Jonel Trebicka, Thomas Berg, Pierre Deltenre, Sebastian Mueller, Jochen Hampe, Felix Stickel
doi : 10.1136/gutjnl-2022-327196
Objective Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis.
Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
Giulia Angelini, Simona Panunzi, Lidia Castagneto-Gissey, Francesca Pellicanò, Andrea De Gaetano, Maurizio Pompili, Laura Riccardi, Matteo Garcovich, Marco Raffaelli, Luigi Ciccoritti, Ornella Verrastro, Maria Francesca Russo, Fabio Maria Vecchio, Giovanni Casella, James Casella-Mariolo, Luigi Papa, Pier Luigi Marini, Francesco Rubino, Carel W le Roux, Stefan Bornstein, Geltrude Mingrone
doi : 10.1136/gutjnl-2022-327498
Objective Clinical diagnosis and approval of new medications for non-alcoholic steatohepatitis (NASH) require invasive liver biopsies. The aim of our study was to identify non-invasive biomarkers of NASH and/or liver fibrosis.
Y90-radioembolisation in hepatocellular carcinoma induces immune responses calling for early treatment with multiple checkpoint blockers
Licia Rivoltini, Sherrie Bhoori, Chiara Camisaschi, Laura Bergamaschi, Luca Lalli, Paola Frati, Davide Citterio, Chiara Castelli, Vincenzo Mazzaferro
Could war and the supply chain crisis affect the sustainability of gastrointestinal endoscopy and single-use endoscopes?
Andrea Sorge, Gian Eugenio Tontini, Lucia Scaramella, Nicoletta Nandi, Flaminia Cavallaro, Maurizio Vecchi, Luca Elli
Reply to Sachan and Mandavdhare
Sana Fatima Memon, Nitin Jagtap, D Nageshwar Reddy
Modelling chronic pancreatitis as a complex genetic disease in mice
Zsanett Jancsó, Alexandra Demcsák, Miklós Sahin-Tóth
Withdrawal of the British Society of Gastroenterology IBD risk grid for COVID-19 severity
Charlie W Lees, Tariq Ahmad, Christopher Andrew Lamb, Nick Powell, Shahida Din, Rachel Cooney, Nicholas A Kennedy, Rachel Ainley, Ruth Wakeman, Christian Philipp Selinger
White small bowel in a patient with chronic diarrhoea
Charles Houdeville, Suzanne Chartier, Matthieu Delaye, Bettina Fabiani, Nicolas Stocker, Xavier Dray
