دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Is it time to rethink the current patient-reported outcome measures?
Findlay MacAskill, Arun Sahai, Majed Shabbir, Guy’s Post Pelvic Surgery Research Group & Tet YapÂÂ
doi : 10.1038/s41585-022-00661-7
Volume 20 Issue 1, January 2023
Understanding and managing the cardiovascular risks of androgen deprivation therapy for prostate cancer
Kerem Atalar & Prabhakar RajanÂÂ
PSMA-PET to detect prostate cancer recurrence after radiotherapy
Omar Alghazo & Michael O’CallaghanÂÂ
FOXA2–KIT-driven lineage plasticity in NEPC
Maria Chiara MasoneÂÂ
Single-cell and spatial sequencing of kidney cancer
Maria Chiara MasoneÂÂ
Quality checkpoints in the MRI-directed prostate cancer diagnostic pathway
Tristan Barrett, Maarten de Rooij, Francesco Giganti, Clare Allen, Jelle O. Barentsz & Anwar R. PadhaniÂÂ
doi : 10.1038/s41585-022-00648-4
Multiparametric MRI of the prostate is now recommended as the initial diagnostic test for men presenting with suspected prostate cancer, with a negative MRI enabling safe avoidance of biopsy and a positive result enabling MRI-directed sampling of lesions.
Using PSMA imaging for prognostication in localized and advanced prostate cancer
Matthew J. Roberts, Tobias Maurer, Marlon Perera, Matthias Eiber, Thomas A. Hope, Piet Ost, Shankar Siva, Michael S. Hofman, Declan G. Murphy, Louise Emmett & Wolfgang P. FendlerÂÂ
doi : 10.1038/s41585-022-00670-6
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern prostate cancer management has evolved rapidly over the past few years, helping to establish new treatment pathways and provide further insights into prostate cancer biology.
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Sze Kiat Tan, Helen Y. Hougen, Jaime R. Merchan, Mark L. Gonzalgo & Scott M. WelfordÂÂ
doi : 10.1038/s41585-022-00654-6
Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma (ccRCC) but the underlying mechanisms and importance of this biological behaviour have remained enigmatic. De novo fatty acid (FA) synthesis, uptake and suppression of FA oxidation have all been shown to contribute to lipid storage, which is a necessary tumour adaptation rather than a bystander effect.
