Fibroblast A20 and its suppressor DREAM regulate fibrosis in SSc

Sarah Onuora 

doi : 10.1038/s41584-022-00886-1

Volume 19 Issue 1, January 2023

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Pre-RA autoantibodies recognize arthritogenic gut bacterium

Robert Phillips 

doi : 10.1038/s41584-022-00884-3

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Targeting the DNA damage response attenuates SLE-associated B cell characteristics

Robert Phillips 

doi : 10.1038/s41584-022-00882-5

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Reversal of inflammatory priming prevents arthritic flares

Jessica McHugh 

doi : 10.1038/s41584-022-00881-6

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Targeting IAPs ameliorates MPO-AAV

Sarah Onuora 

doi : 10.1038/s41584-022-00885-2

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Mapping the immune landscape of MDA5+ dermatomyositis

Jessica McHugh 

doi : 10.1038/s41584-022-00879-0

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Cutaneous bacteria promote autoimmunity in mice

Robert Phillips 

doi : 10.1038/s41584-022-00878-1

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Understanding synovial cell diversity in post-traumatic OA

Jason S. Rockel & Mohit Kapoor 

doi : 10.1038/s41584-022-00876-3

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Hydroxychloroquine dose: balancing toxicity and SLE flare risk

Tiphaine Lenfant & Nathalie Costedoat-Chalumeau 

doi : 10.1038/s41584-022-00868-3

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Can molecular dynamics facilitate the design of protein–protein-interaction inhibitors?

Masashi Honma & Hiroshi Suzuki 

doi : 10.1038/s41584-022-00877-2

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Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

Ilaria Bernabei, Alexander So, Nathalie Busso & Sonia Nasi 

doi : 10.1038/s41584-022-00875-4

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be observed both at the cartilage surface and in its deeper layers.

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Glycobiology of rheumatic diseases

Theresa Kissel, René E. M. Toes, Thomas W. J. Huizinga & Manfred Wuhrer 

doi : 10.1038/s41584-022-00867-4

Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor interactions and signal transduction. In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes and disease progression.

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Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia

Ana Margarida Pinto, Rinie Geenen, Tor D. Wager, Mark A. Lumley, Winfried Häuser, Eva Kosek, Jacob N. Ablin, Kirstine Amris, Jaime Branco, Dan Buskila, João Castelhano, Miguel Castelo-Branco, Leslie J. Crofford, Mary-Ann Fitzcharles, Marina López-Solà, Mariana Luís, Tiago Reis Marques, Philip J. Mease, Filipe Palavra, Jamie L. Rhudy, Lucina Q. Uddin, Paula Castilho, Johannes W. G. Jacobs & José A. P. da Silva 

doi : 10.1038/s41584-022-00873-6

Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other symptoms, and has a substantial socioeconomic impact.

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