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A Cell-Free Silk Fibroin Biomaterial Strategy Promotes In Situ Cartilage Regeneration Via Programmed Releases of Bioactive Molecules (Adv. Healthcare Mater. 1/2023)
Zhinan Mao, Xuewei Bi, Chengai Wu, Yufeng Zheng, Xiong Shu, Sujun Wu, Juan Guan, Robert O. Ritchie
doi : 10.1002/adhm.202370001
Volume 12, Issue 1
Spatiotemporal Regulation of the Bone Immune Microenvironment via Dam-Like Biphasic Bionic Periosteum for Bone Regeneration (Adv. Healthcare Mater. 1/2023)
Zonghan Xu, Liang Wu, Yu Tang, Kun Xi, Jincheng Tang, Yichang Xu, Jingzhi Xu, Jian Lu, Kaijin Guo, Yong Gu, Liang Chen
doi : 10.1002/adhm.202370002
Assembly of Clay Nanotubes on Cotton Fibers Mediated by Biopolymer for Robust and High-Performance Hemostatic Dressing (Adv. Healthcare Mater. 1/2023)
Yue Feng, Yunqing He, Xiaoying Lin, Mingyang Xie, Mingxian Liu, Yuri Lvov
doi : 10.1002/adhm.202370004
Advances in the Translation of Electrochemical Hydrogel-Based Sensors
Houda Shafique, Justin de Vries, Julia Strauss, Arash Khorrami Jahromi, Roozbeh Siavash Moakhar, Sara Mahshid
doi : 10.1002/adhm.202201501
Novel biomaterials for bio- and chemical sensing applications have gained considerable traction in the diagnostic community with rising trends of using biocompatible and lowly cytotoxic material.
Antibody–Antimicrobial Conjugates for Combating Antibiotic Resistance
Luofeng Yu, Zifang Shang, Qizhe Jin, Siew Yin Chan, Weilin Hong, Nan Li, Peng Li
doi : 10.1002/adhm.202202207
As the development of new antibiotics lags far behind the emergence of drug-resistant bacteria, alternative strategies to resolve this dilemma are urgently required. Antibody-drug conjugate is a promising therapeutic platform to delivering cytotoxic payloads precisely to target cells for efficient disease treatment.
A Cell-Free Silk Fibroin Biomaterial Strategy Promotes In Situ Cartilage Regeneration Via Programmed Releases of Bioactive Molecules
Zhinan Mao, Xuewei Bi, Chengai Wu, Yufeng Zheng, Xiong Shu, Sujun Wu, Juan Guan, Robert O. Ritchie
doi : 10.1002/adhm.202201588
In situ tissue regeneration using cell-free biofunctional scaffolds has been extensively studied as a promising alternative strategy to promote cartilage repair. In this study, a cartilage-biomimetic silk fibroin (SF)-based scaffold with controlled sequential release of two bioactive molecules is developed.
Spatiotemporal Regulation of the Bone Immune Microenvironment via Dam-Like Biphasic Bionic Periosteum for Bone Regeneration
Zonghan Xu, Liang Wu, Yu Tang, Kun Xi, Jincheng Tang, Yichang Xu, Jingzhi Xu, Jian Lu, Kaijin Guo, Yong Gu, Liang Chen
doi : 10.1002/adhm.202201661
The bone immune microenvironment (BIM) regulates bone regeneration and affects the prognosis of fractures. However, there is currently no effective strategy that can precisely modulate macrophage polarization to improve BIM for bone regeneration.
Assembly of Clay Nanotubes on Cotton Fibers Mediated by Biopolymer for Robust and High-Performance Hemostatic Dressing
Yue Feng, Yunqing He, Xiaoying Lin, Mingyang Xie, Mingxian Liu, Yuri Lvov
doi : 10.1002/adhm.202202265
Uncontrollable bleeding from military conflicts, accidents, and surgical procedures is a major life-threatening factor. Rapid, safe, and convenient hemostasis is critical to the survival of bleeding patients in prehospital care.
Zwitterionic Polymer/Polydopamine Coating of Electrode Arrays Reduces Fibrosis and Residual Hearing Loss after Cochlear Implantation
Anning Chen, Dongxiu Chen, Kai Lv, Guowei Li, Jing Pan, Dong Ma, Jie Tang, Hongzheng Zhang
doi : 10.1002/adhm.202200807
Since the first surgery 50 years ago, cochlear implantation (CI) is the major treatment for patients with severe sensorineural hearing loss. However, unexpected foreign body reactions (FBRs) after surgery are reported in 90% of CI recipients, resulting in the formation of fibrosis in the cochlea and progressive residual hearing loss.
3D Printed Hybrid Aerogel Gauzes Enable Highly Efficient Hemostasis
Xiaoxu Yang, Nan Shi, Jian Liu, Qingqing Cheng, Guangyong Li, Jing Lyu, Fengguo Ma, Xuetong Zhang
doi : 10.1002/adhm.202201591
Hemostatic materials have played a significant role in mitigating traumatic injury by controlling bleeding, however, the fabrication of the desirable material's structure to enhance the accumulation of blood cells and platelets for highly efficient hemostasis is still a great challenge.
An ECM-Mimicking, Injectable, Viscoelastic Hydrogel for Treatment of Brain Lesions
Yan Hu, Yuanbo Jia, Siwei Wang, Yufei Ma, Guoyou Huang, Tan Ding, Dayun Feng, Guy M. Genin, Zhao Wei, Feng Xu
doi : 10.1002/adhm.202201594
Brain lesions can arise from traumatic brain injury, infection, and craniotomy. Although injectable hydrogels show promise for promoting healing of lesions and health of surrounding tissue, enabling cellular ingrowth and restoring neural tissue continue to be challenging.
ZIF@VO2 as an Intelligent Nano-Reactor for On-Demand Angiogenesis and Disinfection
Tiejun Yuan, Hui Wang, Minhong Tan, Yang Xu, Qiyao Xiao, Chen Wu, Lihua Peng
doi : 10.1002/adhm.202201608
Absent angiogenesis and bacterial infection are two major challenges that simultaneously delay the repair of injured tissues and organs. However, most current therapeutic systems deliver therapeutic cues in a separate and inaccurate manner which stimulates angiogenesis or inhibits infection leading to limited repair and side effects.
Bioinspired and Inflammation-Modulatory Glycopeptide Hydrogels for Radiation-Induced Chronic Skin Injury Repair
Zujian Feng, Yumin Zhang, Chunfang Yang, Xiang Liu, Yini Huangfu, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Jinjian Liu, Jianfeng Liu, Deling Kong, Weiwei Wang
doi : 10.1002/adhm.202201671
Clinical wound management of radiation-induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused by an imbalance in macrophage homeostasis.
Vacancy-Modulated of CuS for Highly Antibacterial Efficiency via Photothermal/Photodynamic Synergetic Therapy
Zhihao Zhang, Jinghong Wen, Jie Zhang, Donggang Guo, Quanxi Zhang
doi : 10.1002/adhm.202201746
Cu-based nanomaterials have been developed to alleviate the problem of antibiotic resistance due to their superior properties and good biocompatibility.
Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition
Jae Hee Lee, Yuri Ahn, Han Eol Lee, You Na Jang, A. Yeon Park, Shinho Kim, Young Hoon Jung, Sang Hyun Sung, Jung Ho Shin, Seung Hyung Lee, Sang Hyun Park, Ki Soo Kim, Min Seok Jang, Beom Joon Kim, Sang Ho Oh, Keon Jae Lee
doi : 10.1002/adhm.202201796
Wearable light-emitting diode (LED)-based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation.
Collagen Niches Affect Direct Transcriptional Conversion toward Human Nucleus Pulposus Cells via Actomyosin Contractility
Kesi Shi, Chengzhen Liang, Xianpeng Huang, Shaoke Wang, Jiangjie Chen, Feng Cheng, Chenggui Wang, Liwei Ying, Zhaoqi Pan, Yuang Zhang, Jiawei Shu, Biao Yang, Jingkai Wang, Kaishun Xia, Xiaopeng Zhou, Hao Li, Fangcai Li, Yiqing Tao, Qixin Chen
doi : 10.1002/adhm.202201824
Cellular niches play fundamental roles in regulating cellular behaviors. However, the effect of niches on direct converted cells remains unexplored.
A Conductive Bioengineered Cardiac Patch for Myocardial Infarction Treatment by Improving Tissue Electrical Integrity
Qi Yin, Ping Zhu, Wei Liu, Zhongbao Gao, Luming Zhao, Chunlan Wang, Siwei Li, Miaomiao Zhu, Qi Zhang, Xiao Zhang, Changyong Wang, Jin Zhou
doi : 10.1002/adhm.202201856
Conductive scaffolds are of great value for constructing functional myocardial tissues and promoting tissue reconstruction in the treatment of myocardial infarction (MI).
Squid Suckerin-Spider Silk Fusion Protein Hydrogel for Delivery of Mesenchymal Stem Cell Secretome to Chronic Wounds
Kenrick Koh, Jun Kit Wang, James Xiao Yuan Chen, Shu Hui Hiew, Hong Sheng Cheng, Bartosz Gabryelczyk, Marcus Ivan Gerard Vos, Yun Sheng Yip, Liyan Chen, Radoslaw M. Sobota, Damian Kang Keat Chua, Nguan Soon Tan, Chor Yong Tay, Ali Miserez
doi : 10.1002/adhm.202201900
Chronic wounds are non-healing wounds characterized by a prolonged inflammation phase. Excessive inflammation leads to elevated protease levels and consequently to a decrease in growth factors at wound sites.
Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D
Sauradeep Sinha, Manish Ayushman, Xinming Tong, Fan Yang
doi : 10.1002/adhm.202202147
Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor in adults. Hydrogels have been employed as 3D in vitro culture models to elucidate how matrix cues such as stiffness and degradation drive GBM progression and drug responses.
A Conductive Hydrogel Microneedle-Based Assay Integrating PEDOT:PSS and Ag-Pt Nanoparticles for Real-Time, Enzyme-Less, and Electrochemical Sensing of Glucose
Peyman GhavamiNejad, Amin GhavamiNejad, Hanjia Zheng, Karan Dhingra, Melisa Samarikhalaj, Mahla Poudineh
doi : 10.1002/adhm.202202362
Continuous glucose meters (CGMs) have tremendously boosted diabetes care by emancipating millions of diabetic patients’ need for repeated self-testing by pricking their fingers every few hours.
