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Biomimicking Leaf-Vein Engraved Soft and Elastic Membrane Promotes Vascular Reconstruction (Adv. Healthcare Mater. 2/2023)
Jinghan Fang, Huaqian Liu, Wei Qiao, Tianpeng Xu, Yuhe Yang, Huizhi Xie, Chun-Hei Lam, Kelvin W. K. Yeung, Xin Zhao
doi : 10.1002/adhm.202370005
Volume 12, Issue 2
Enhanced Tumor Accumulation of Multimodal Magneto-Plasmonic Nanoparticles via an Implanted Micromagnet-Assisted Delivery Strategy (Adv. Healthcare Mater. 2/2023)
Sajanlal R. Panikkanvalappil, Sharath K. Bhagavatula, Kyle Deans, Oliver Jonas, Mohammad Rashidian, Shruti Mishra
doi : 10.1002/adhm.202370007
Mussel-Inspired Tough Hydrogel with In Situ Nanohydroxyapatite Mineralization for Osteochondral Defect Repair
Donglin Gan, Zhixiong Wang, Chaoming Xie, Xiao Wang, Wensi Xing, Xiang Ge, Huipin Yuan, Kefeng Wang, Hui Tan, Xiong Lu
doi : 10.1002/adhm.202203040
ROS-Responsive Blended Nanoparticles: Cascade-Amplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process
Pengying Wu, Wei Dong, Xuyan Guo, Xiaoyang Qiao, Shifang Guo, Lei Zhang, Mingxi Wan, Yujin Zong
doi : 10.1002/adhm.202203109
Biomimicking Leaf-Vein Engraved Soft and Elastic Membrane Promotes Vascular Reconstruction
Jinghan Fang, Huaqian Liu, Wei Qiao, Tianpeng Xu, Yuhe Yang, Huizhi Xie, Chun-Hei Lam, Kelvin W. K. Yeung, Xin Zhao
doi : 10.1002/adhm.202201220
Hierarchical vasculature reconstruction is fundamental for tissue regeneration. The regeneration of functional vascular network requires a proper directional guidance, especially in case of large-size defects.
Enhanced Tumor Accumulation of Multimodal Magneto-Plasmonic Nanoparticles via an Implanted Micromagnet-Assisted Delivery Strategy
Sajanlal R. Panikkanvalappil, Sharath K. Bhagavatula, Kyle Deans, Oliver Jonas, Mohammad Rashidian, Shruti Mishra
doi : 10.1002/adhm.202201585
One of the major shortcomings of nano carriers-assisted cancer therapeutic strategies continues to be the inadequate tumor penetration and retention of systemically administered nanoformulations and its off-target toxicity.
GSH-Responsive Organosilica Hybrid Nanosystem as a Cascade Promoter for Enhanced Starvation and Chemodynamic Therapy
Huan Wu, Xianglong Li, Shi Liu, Qinghua Wang, Yuanyuan Cao, Ji-Na Hao, Yongsheng Li
doi : 10.1002/adhm.202201262
Glucose oxidase (GOD)-mediated starvation therapy (ST) that causes intratumoral glucose depletion is a promising strategy for tumor treatment. However, the ultimate efficacy is inevitably limited by tumor hypoxia, as oxygen is a key component in the consumption of glucose by GOD.
Complementary and Synergistic Design of Bi-Layered Double Hydroxides Modified Magnesium Alloy toward Multifunctional Orthopedic Implants
Dongdong Zhang, Mei Li, Ru Xu, Juning Xie, Yu Zhang, Shi Qian, Yuqin Qiao, Feng Peng, Xuanyong Liu
doi : 10.1002/adhm.202201367
Magnesium (Mg)-based alloys have been regarded as promising implants for future clinic orthopedics, however, how to endow them with good anti-corrosion and biofunctions still remains a great challenge, especially for complicated bone diseases.
Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug
Anaïs Brion, Juliane Chaud, Jérémie Léonard, Frédéric Bolze, Stefan Chassaing, Benoît Frisch, Béatrice Heurtault, Antoine Kichler, Alexandre Specht
doi : 10.1002/adhm.202201474
Photolytic reactions allow the optical control of the liberation of biological effectors by photolabile protecting groups. The development of versatile technologies enabling the use of deep-red or NIR light excitation still represents a challenging issue, in particular for light-induced drug release (e.g., light-induced prodrug activation).
Light-Programmable Nanocomposite Hydrogel for State-Switchable Wound Healing Promotion and Bacterial Infection Elimination
Zhekun Zhang, Juning Xie, Jun Xing, Changhao Li, Tak Man Wong, Hui Yu, Yuanxing Li, Fabang Yang, Yu Tian, Huan Zhang, Wei Li, Chengyun Ning, Xiaolan Wang, Peng Yu
doi : 10.1002/adhm.202201565
Developing an ideal wound dressing that not only accelerates wound healing but also eliminates potential bacterial infections remains a difficult balancing act.
Bioessential Inorganic Molecular Wire-Reinforced 3D-Printed Hydrogel Scaffold for Enhanced Bone Regeneration
Jin Woong Lee, Sudong Chae, Seungbae Oh, Dai-Hwan Kim, Si Hyun Kim, Seung Jae Kim, Jae-Young Choi, Jung Heon Lee, Si Young Song
doi : 10.1002/adhm.202201665
Materials with physicochemical properties and biological activities similar to those of the natural extracellular matrix are in high demand in tissue engineering. In particular, Mo3Se3− inorganic molecular wire (IMW) is a promising material composed of bioessential minerals and possess nanometer-scale diameters, negatively charged surfaces, physical flexibility, and nanotopography characteristics, which are essential for interactions with cell membrane proteins.
Calcium Hydride-Based Dressing to Promote Wound Healing
Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng
doi : 10.1002/adhm.202201771
Wound microenvironment with excess reactive oxygen species (ROS) can significantly inhibit wound healing. Encouraged by hydrogen molecules (H2) with effective ROS scavenging and calcium hydride (CaH2) with sufficient H2 supply, the authors for the first time employed CaH2 as a therapeutic H2 donor and starch as a diluent to construct CaH2 pulvis dressing for wound healing treatment.
Partially Oxidized Alginate as a Biodegradable Carrier for Glucose-Responsive Insulin Delivery and Islet Cell Replacement Therapy
Lisa R. Volpatti, Matthew A. Bochenek, Amanda L. Facklam, Delaney M. Burns, Corina MacIsaac, Alexander Morgart, Benjamin Walters, Robert Langer, Daniel G. Anderson
doi : 10.1002/adhm.202201822
Self-regulated insulin delivery that mimics native pancreas function has been a long-term goal for diabetes therapies. Two approaches towards this goal are glucose-responsive insulin delivery and islet cell transplantation therapy.
Swelling-Dependent Shape-Based Transformation of a Human Mesenchymal Stromal Cells-Laden 4D Bioprinted Construct for Cartilage Tissue Engineering
Pedro J. DÃÂaz-Payno, Maria Kalogeropoulou, Iain Muntz, Esther Kingma, Nicole Kops, Matteo D'Este, Gijsje H. Koenderink, Lidy E. Fratila-Apachitei, Gerjo J. V. M. van Osch, Amir A. Zadpoor
doi : 10.1002/adhm.202201891
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs.
Supramolecular Polypeptide Self-Assembly Mediated In Situ Elicitation of Robust Innate and Adaptive Immune Responses Boosts Immunogenic Photothermal Therapy toward “Cold� Tumor
Kai Shi, Xiu Liu, Yuli Liu, Chang Liu, Yaxin Wang, Yunmeng Liu
doi : 10.1002/adhm.202202017
As a promising cancer treatment modality that has emerged, photothermal therapy can harness antitumor immunity by triggering immunogenic cell death (ICD) in addition to direct cell ablation.
Porphyrin Centered Paclitaxel Tetrameric Prodrug Nanoassemblies as Tumor-Selective Theranostics for Synergized Breast Cancer Therapy
Xiaodong Ma, Pengfei Wang, Qiwei Wu, Junnian Zhou, Dongqing Wang, Deependra Yadav, Hongbo Zhang, Yuezhou Zhang
doi : 10.1002/adhm.202202024
Although having undergone decades of development, nanoparticulate drug delivery vehicles for efficient cancer therapy remain a challenge, confined by low drug loading, instability, and poor cancer tissue selectivity.
An In Vitro Engineered Osteochondral Model as Tool to Study Osteoarthritis Environment
Annachiara Scalzone, Giorgia Cerqueni, Xiao-Nong Wang, Ana Ferreira-Duarte, Kenny Dalgarno, Monica Mattioli-Belmonte, Piergiorgio Gentile
doi : 10.1002/adhm.202202030
Osteoarthritis (OA) is a joint degenerative pathology characterized by mechanical and inflammatory damages affecting synovium, articular cartilage (AC), and subchondral bone (SB).
A Bioinspired Orthopedic Biomaterial with Tunable Mechanical Properties Based on Sintered Titanium Fibers
Matthias Rüger, Andreas Martin Seitz, Katja Nuss, Brigitte von Rechenberg, Daniel Seitz, Cris Kostmann, Peter Quadbeck, Olaf Andersen, Caitlyn Collins
doi : 10.1002/adhm.202202106
Inadequate mechanical compliance of orthopedic implants can result in excessive strain of the bone interface, and ultimately, aseptic loosening. It is hypothesized that a fiber-based biometal with adjustable anisotropic mechanical properties can reduce interface strain, facilitate continuous remodeling, and improve implant survival under complex loads. The biometal is based on strategically layered sintered titanium fibers. Six different topologies are manufactured.
Inhibition of Pro-Survival Autophagy Induced by Rare-Earth Nanocomposites for Promoting Photothermal Therapy of Visualized Tumors
Shanshan Peng, Lizhen Wang, Lin Liu, Liang Song, Junpeng Shi, Hanrun Zheng, Jixuan Xu, Rui Rong, Yun Zhang
doi : 10.1002/adhm.202202117
Manipulation of autophagic processes has emerged as a promising strategy for synergizing nanoagent-mediated photothermal therapy (PTT).
Banoxantrone Coordinated Metal−Organic Framework for Photoacoustic Imaging-Guided High Intensity Focused Ultrasound Therapy
Tingyu Sun, Jingnan Li, Chao Zeng, Chengyan Luo, Xirui Luo, Huanan Li
doi : 10.1002/adhm.202202348
Photoacoustic (PA) imaging with high spatial resolution has great potential as desired monitoring means in the high-intensity focused ultrasound (HIFU) surgery of tumor.
