Vivek H. Murthy, M.D., M.B.A.
doi : 10.1056/NEJMp2207252
Vol. 387 No. 7
Adam Sherwat, M.D., John T. Brooks, M.D., Debra Birnkrant, M.D., and Peter Kim, M.D.
doi : 10.1056/NEJMp2210125
Juan P. Herrera-Escobar, M.D., M.P.H., and Jeffrey C. Schneider, M.D.
doi : 10.1056/NEJMp2205162
Scott E. Hadland, M.D., M.P.H.
doi : 10.1056/NEJMp2205560
Caroline A. Crowther, M.D., Deborah Samuel, B.Ed., Lesley M.E. McCowan, M.D., Richard Edlin, Ph.D., Thach Tran, Ph.D., and Christopher J. McKinlay, Ph.D. for the GEMS Trial Group*
doi : 10.1056/NEJMoa2204091
Carolyn T. Bramante, M.D., M.P.H., Jared D. Huling, Ph.D., Christopher J. Tignanelli, M.D., John B. Buse, M.D., Ph.D., David M. Liebovitz, M.D., Jacinda M. Nicklas, M.D., M.P.H., Kenneth Cohen, M.D., Michael A. Puskarich, M.D., Hrishikesh K. Belani, M.D., M.P.H., Jennifer L. Proper, B.S., Lianne K. Siegel, Ph.D., Nichole R. Klatt, Ph.D.,
doi : 10.1056/NEJMoa2201662
Chayarani Kelgeri, M.D., Michael Couper, M.B., Ch.B., Girish L. Gupte, M.D., Alexandra Brant, M.Sc., Mitul Patel, M.D., Lauren Johansen, M.B., B.S., Joseph Valamparampil, M.D., Evelyn Ong, F.R.C.S., Hermien Hartog, Ph.D., M.T.P.R. Perera, M.D., Darius Mirza, M.S., F.R.C.S., Indra van Mourik, M.D.,
doi : 10.1056/NEJMoa2206704
Since January 2022, there has been an increase in reports of cases of acute hepatitis of unknown cause in children. Although cases have been reported across multiple continents, most have been reported in the United Kingdom. Investigations are ongoing to identify the causative agent or agents.
L. Helena Gutierrez Sanchez, M.D., Henry Shiau, M.D., Julia M. Baker, Ph.D., Stephanie Saaybi, M.D., Markus Buchfellner, M.D., William Britt, M.D., Veronica Sanchez, Ph.D., Jennifer L. Potter, M.P.H., L. Amanda Ingram, M.P.H., David Kelly, M.D., Xiaoyan Lu, M.S., Stephanie Ayers-Millsap, M.P.H., Wesley G. Willeford, M.D., Negar Rassaei, M.D., Julu Bhatnagar, Ph.D., Hannah Bullock, Ph.D., Sarah Reagan-Steiner, M.D., Ali Martin, B.S., Michael E. Rogers, D.O., M.P.H., Anna M. Banc-Husu, M.D., Sanjiv Harpavat, M.D., Ph.D., Daniel H. Leung, M.D., Elizabeth A. Moulton, M.D., Ph.D., Daryl M. Lamson, B.S., Kirsten St. George, Ph.D., Aron J. Hall, D.V.M., Umesh Parashar, M.D., Adam MacNeil, Ph.D., Jacqueline E. Tate, Ph.D., and Hannah L. Kirking, M.D.
doi : 10.1056/NEJMoa2206294
Human adenoviruses typically cause self-limited respiratory, gastrointestinal, and conjunctival infections in healthy children. In late 2021 and early 2022, several previously healthy children were identified with acute hepatitis and human adenovirus viremia.
Dean M. Wingerchuk, M.D., and Claudia F. Lucchinetti, M.D.
doi : 10.1056/NEJMra1904655
Mauricio Kahn, M.D., and Molly Fleece, M.D.
doi : 10.1056/NEJMicm2118312
Christina M. Marra, M.D., Saurabh Rohatgi, M.D., Allyson K. Bloom, M.D., Kristopher T. Kahle, M.D., Ph.D., and Amelia K. Haj, M.D., Ph.D.
doi : 10.1056/NEJMcpc2201241
Salim S. Abdool Karim, M.B., Ch.B., Ph.D., and Nikita Devnarain, Ph.D.
doi : 10.1056/NEJMe2209017
Saul J. Karpen, M.D., Ph.D.
doi : 10.1056/NEJMe2208409
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Demetre C. Daskalakis, M.D., M.P.H., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2210967
doi : 10.1056/NEJMc2201810
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