Arthur R. Derse, M.D., J.D.
doi : 10.1056/NEJMp2201630
Vol. 387 No. 8
Honora Englander, M.D., and Corey S. Davis, J.D., M.S.P.H.
doi : 10.1056/NEJMp2204687
C. Joseph Ross Daval, J.D., Aaron S. Kesselheim, M.D., J.D., M.P.H., and Ameet Sarpatwari, Ph.D., J.D.
doi : 10.1056/NEJMp2206492
John P. Thornhill, M.D., Ph.D., Sapha Barkati, M.D., Sharon Walmsley, M.D., Juergen Rockstroh, M.D., Andrea Antinori, M.D., Luke B. Harrison, M.D., Ph.D., Romain Palich, M.D., Ph.D., Achyuta Nori, M.D., Iain Reeves, M.D., Maximillian S. Habibi, M.D., Ph.D., Vanessa Apea, M.D., M.P.H., Christoph Boesecke, M.D.,
doi : 10.1056/NEJMoa2207323
Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined.
Chirag D. Jhaveri, M.D., Adam R. Glassman, M.S., Frederick L. Ferris, III, M.D., Danni Liu, M.S.P.H., Maureen G. Maguire, Ph.D., John B. Allen, M.D., Carl W. Baker, M.D., David Browning, M.D., Ph.D., Matthew A. Cunningham, M.D., Scott M. Friedman, M.D., Lee M. Jampol, M.D., Dennis M. Marcus, M.D.,
doi : 10.1056/NEJMoa2204225
In eyes with diabetic macular edema, the relative efficacy of administering aflibercept monotherapy as compared with bevacizumab first with a switch to aflibercept if the eye condition does not improve sufficiently (a form of step therapy) is unclear.
Lawrence Steinman, M.D., Edward Fox, M.D., Ph.D., Hans-Peter Hartung, M.D., Enrique Alvarez, M.D., Ph.D., Peiqing Qian, M.D., Sibyl Wray, M.D., Derrick Robertson, M.D., DeRen Huang, M.D., Ph.D., Krzysztof Selmaj, M.D., Ph.D., Daniel Wynn, M.D., Gary Cutter, Ph.D., Koby Mok, Ph.D.,
doi : 10.1056/NEJMoa2201904
Josef S. Smolen, M.D., Eugen Feist, M.D., Saeed Fatenejad, M.D., Sergey A. Grishin, M.D., Ph.D., Elena V. Korneva, M.D., Ph.D., Evgeniy L. Nasonov, M.D., Mikhail Y. Samsonov, M.D., Ph.D., and Roy M. Fleischmann, M.D. for the CREDO2 Group*
doi : 10.1056/NEJMoa2201302
The cytokine interleukin-6 is involved in the pathogenesis of rheumatoid arthritis. Olokizumab, a humanized monoclonal antibody targeting the interleukin-6 cytokine directly, is being tested for the treatment of rheumatoid arthritis.
Rachel C. Sisodia, M.D., and Marcela G. del Carmen, M.D., M.P.H.
doi : 10.1056/NEJMra2108956
Takeshi Zoshima, M.D., Ph.D., and Mitsuhiro Kawano, M.D., Ph.D.
doi : 10.1056/NEJMicm2117718
Sujatha Manjunathan, M.D., and Lokesh Saini, M.D., D.M.
doi : 10.1056/NEJMicm2120226
Krishna P. Reddy, M.D., Melissa C. Price, M.D., Jeffrey A. Barnes, M.D., Ph.D., Nancy A. Rigotti, M.D., and Rory K. Crotty, M.D.
doi : 10.1056/NEJMcpc2201247
H. Clifford Lane, M.D., and Anthony S. Fauci, M.D.
doi : 10.1056/NEJMe2210535
David C. Musch, Ph.D., M.P.H., and Emily Y. Chew, M.D.
doi : 10.1056/NEJMe2208454
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2211254
Ryan C. Hunt, M.D., and Chava Kimchi-Sarfaty, Ph.D.
doi : 10.1056/NEJMcibr2207405
doi : 10.1056/NEJMc2209529
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