New England Journal of Medicine




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سفارش

What Dobbs Means for Patients with Breast Cancer

Nicole T. Christian, M.D., and Virginia F. Borges, M.D.

doi : 10.1056/NEJMp2209249

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Responding to the Escalating Cybersecurity Threat to Health Care

Eric Perakslis, Ph.D.

doi : 10.1056/NEJMp2205144

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“Fertility Fraud� Legislation — A Turning Point for Informed Consent?

Dov Fox, J.D., D.Phil., L.L.M.

doi : 10.1056/NEJMp2206007

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Updated Health Warnings for Alcohol — Informing Consumers and Reducing Harm

Anna H. Grummon, Ph.D., M.S.P.H., and Marissa G. Hall, Ph.D., M.S.P.H.

doi : 10.1056/NEJMp2206494

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Losing Contact — Covid-19, Telemedicine, and the Patient–Provider Relationship

Shannon M. MacDonald, M.D., and Julia Berv, P.A.-C.

doi : 10.1056/NEJMp2206471

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Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI

Bon-Kwon Koo, M.D., Xinyang Hu, M.D., Jeehoon Kang, M.D., Jinlong Zhang, M.D., Jun Jiang, M.D., Joo-Yong Hahn, M.D., Chang-Wook Nam, M.D., Joon-Hyung Doh, M.D., Bong-Ki Lee, M.D., Weon Kim, M.D., Jinyu Huang, M.D., Fan Jiang, M.D.,

doi : 10.1056/NEJMoa2201546

In patients with coronary artery disease who are being evaluated for percutaneous coronary intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) for decision making regarding revascularization and stent implantation. However, the differences in clinical outcomes when only one method is used for both purposes are unclear.

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Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge

Ronen Arbel, Ph.D., Yael Wolff Sagy, Ph.D., Moshe Hoshen, Ph.D., Erez Battat, M.B.A., Gil Lavie, M.D., Ruslan Sergienko, M.A., Michael Friger, Ph.D., Jacob G. Waxman, M.D., Noa Dagan, M.D., Ran Balicer, M.D., Yatir Ben-Shlomo, B.Sc., Alon Peretz, M.D.,

doi : 10.1056/NEJMoa2204919

The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effectiveness of nirmatrelvir in preventing severe coronavirus disease 2019 (Covid-19) outcomes from the B.1.1.529 (omicron) variant are limited.

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Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States

Kunjal Patel, D.Sc., Yanling Huo, M.S., Jennifer Jao, M.D., Kathleen M. Powis, M.D., Paige L. Williams, Ph.D., Deborah Kacanek, Sc.D., Lynn M. Yee, M.D., Ellen G. Chadwick, M.D., Stephanie Shiau, Ph.D., Denise L. Jacobson, Ph.D., Sean S. Brummel, Ph.D., Leila Sultan-Beyer, M.D.,

doi : 10.1056/NEJMoa2200600

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Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis

Francesca Conradie, M.B., B.Ch., Tatevik R. Bagdasaryan, M.D., Sergey Borisov, M.D., Pauline Howell, M.D., Lali Mikiashvili, M.D., Nosipho Ngubane, M.D., Anastasia Samoilova, M.D., Sergey Skornykova, M.D., Elena Tudor, M.D., Ebrahim Variava, M.D., Petr Yablonskiy, Ph.D., Daniel Everitt, M.D.,

doi : 10.1056/NEJMoa2119430

The bedaquiline–pretomanid–linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg of linezolid daily has been high. The appropriate dose of linezolid and duration of treatment with this agent to minimize toxic effects while maintaining efficacy against highly drug-resistant tuberculosis are unclear.

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Subacute Combined Degeneration from Nitrous Oxide Use

Joseph Y. Yoon, M.D., and Joshua P. Klein, M.D., Ph.D.

doi : 10.1056/NEJMicm2119871

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Severe Subcutaneous Emphysema

Sulakshan Rasiah, B.M., B.S., and Max Whitchurch, M.B., B.S.

doi : 10.1056/NEJMicm2200611

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Telescoping the Diagnostic Process

Clement D. Lee, M.D., Evan Shirey, M.D., Brittany Guttadauria, M.D., and Chén C. Kenyon, M.D., M.S.H.P.

doi : 10.1056/NEJMcps2205676

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Choosing a Method for Guiding PCI

Jane A. Leopold, M.D.

doi : 10.1056/NEJMe2209148

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Linezolid for Drug-Resistant Tuberculosis

Guy Thwaites, F.R.C.P., and Nhung V. Nguyen, M.D., Ph.D.

doi : 10.1056/NEJMe2208554

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Audio Interview: Covid-19 and the WHO

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Soumya Swaminathan, M.B., B.S., M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2211564

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Building Black Wealth — The Role of Health Systems in Closing the Gap

Eugenia South, M.D., Atheendar Venkataramani, M.D., Ph.D., and George Dalembert, M.D.

doi : 10.1056/NEJMms2209521

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Pretomanid in the Treatment of Patients with Tuberculosis in the United States

doi : 10.1056/NEJMc2119461

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Long-Term MC4R Agonist Treatment in POMC-Deficient Patients

doi : 10.1056/NEJMc2207442

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PD-1 Blockade in Mismatch Repair–Deficient Rectal Cancer

doi : 10.1056/NEJMc2209706

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Restriction of Intravenous Fluid in ICU Patients with Septic Shock

doi : 10.1056/NEJMc2210366

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Tranexamic Acid in Patients Undergoing Noncardiac Surgery

doi : 10.1056/NEJMc2208614

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Sequential Stem Cell–Kidney Transplantation in Schimke Immuno-osseous Dysplasia

doi : 10.1056/NEJMc2209527

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Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer

doi : 10.1056/NEJMx220007

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