Nicole T. Christian, M.D., and Virginia F. Borges, M.D.
doi : 10.1056/NEJMp2209249
Eric Perakslis, Ph.D.
doi : 10.1056/NEJMp2205144
Dov Fox, J.D., D.Phil., L.L.M.
doi : 10.1056/NEJMp2206007
Anna H. Grummon, Ph.D., M.S.P.H., and Marissa G. Hall, Ph.D., M.S.P.H.
doi : 10.1056/NEJMp2206494
Shannon M. MacDonald, M.D., and Julia Berv, P.A.-C.
doi : 10.1056/NEJMp2206471
Bon-Kwon Koo, M.D., Xinyang Hu, M.D., Jeehoon Kang, M.D., Jinlong Zhang, M.D., Jun Jiang, M.D., Joo-Yong Hahn, M.D., Chang-Wook Nam, M.D., Joon-Hyung Doh, M.D., Bong-Ki Lee, M.D., Weon Kim, M.D., Jinyu Huang, M.D., Fan Jiang, M.D.,
doi : 10.1056/NEJMoa2201546
In patients with coronary artery disease who are being evaluated for percutaneous coronary intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) for decision making regarding revascularization and stent implantation. However, the differences in clinical outcomes when only one method is used for both purposes are unclear.
Ronen Arbel, Ph.D., Yael Wolff Sagy, Ph.D., Moshe Hoshen, Ph.D., Erez Battat, M.B.A., Gil Lavie, M.D., Ruslan Sergienko, M.A., Michael Friger, Ph.D., Jacob G. Waxman, M.D., Noa Dagan, M.D., Ran Balicer, M.D., Yatir Ben-Shlomo, B.Sc., Alon Peretz, M.D.,
doi : 10.1056/NEJMoa2204919
The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effectiveness of nirmatrelvir in preventing severe coronavirus disease 2019 (Covid-19) outcomes from the B.1.1.529 (omicron) variant are limited.
Kunjal Patel, D.Sc., Yanling Huo, M.S., Jennifer Jao, M.D., Kathleen M. Powis, M.D., Paige L. Williams, Ph.D., Deborah Kacanek, Sc.D., Lynn M. Yee, M.D., Ellen G. Chadwick, M.D., Stephanie Shiau, Ph.D., Denise L. Jacobson, Ph.D., Sean S. Brummel, Ph.D., Leila Sultan-Beyer, M.D.,
doi : 10.1056/NEJMoa2200600
Francesca Conradie, M.B., B.Ch., Tatevik R. Bagdasaryan, M.D., Sergey Borisov, M.D., Pauline Howell, M.D., Lali Mikiashvili, M.D., Nosipho Ngubane, M.D., Anastasia Samoilova, M.D., Sergey Skornykova, M.D., Elena Tudor, M.D., Ebrahim Variava, M.D., Petr Yablonskiy, Ph.D., Daniel Everitt, M.D.,
doi : 10.1056/NEJMoa2119430
The bedaquiline–pretomanid–linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg of linezolid daily has been high. The appropriate dose of linezolid and duration of treatment with this agent to minimize toxic effects while maintaining efficacy against highly drug-resistant tuberculosis are unclear.
Joseph Y. Yoon, M.D., and Joshua P. Klein, M.D., Ph.D.
doi : 10.1056/NEJMicm2119871
Sulakshan Rasiah, B.M., B.S., and Max Whitchurch, M.B., B.S.
doi : 10.1056/NEJMicm2200611
Clement D. Lee, M.D., Evan Shirey, M.D., Brittany Guttadauria, M.D., and Chén C. Kenyon, M.D., M.S.H.P.
doi : 10.1056/NEJMcps2205676
Guy Thwaites, F.R.C.P., and Nhung V. Nguyen, M.D., Ph.D.
doi : 10.1056/NEJMe2208554
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Soumya Swaminathan, M.B., B.S., M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2211564
Eugenia South, M.D., Atheendar Venkataramani, M.D., Ph.D., and George Dalembert, M.D.
doi : 10.1056/NEJMms2209521
doi : 10.1056/NEJMc2119461
doi : 10.1056/NEJMc2209527
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