Stacie B. Dusetzina, Ph.D., and Haiden A. Huskamp, Ph.D.
doi : 10.1056/NEJMp2211223
Lola A. Fashoyin-Aje, M.D., M.P.H., Gautam U. Mehta, M.D., Julia A. Beaver, M.D., and Richard Pazdur, M.D.
doi : 10.1056/NEJMp2208954
Elliott M. Antman, M.D., Jane A. Leopold, M.D., William H. Sauer, M.D., and Paul C. Zei, M.D., Ph.D.
doi : 10.1056/NEJMp2212939
David Rosmarin, M.D., Thierry Passeron, M.D., Ph.D., Amit G. Pandya, M.D., Pearl Grimes, M.D., John E. Harris, M.D., Ph.D., Seemal R. Desai, M.D., Mark Lebwohl, M.D., Mireille Ruer-Mulard, M.D., Julien Seneschal, M.D., Ph.D., Albert Wolkerstorfer, M.D., Ph.D., Deanna Kornacki, Ph.D., Kang Sun, Ph.D.,
doi : 10.1056/NEJMoa2118828
Vitiligo is a chronic autoimmune disease that causes skin depigmentation. A cream formulation of ruxolitinib (an inhibitor of Janus kinase 1 and 2) resulted in repigmentation in a phase 2 trial involving adults with vitiligo.
Jesper Kjaergaard, M.D., D.M.Sc., Jacob E. Møller, M.D., D.M.Sc., Henrik Schmidt, M.D., D.M.Sc., Johannes Grand, M.D., Ph.D., Simon Mølstrøm, M.D., Britt Borregaard, R.N., Ph.D., Søren Venø, M.D., Laura Sarkisian, M.D., Ph.D., Dmitry Mamaev, M.D., Lisette O. Jensen, M.D., D.M.Sc., Benjamin Nyholm, M.D., Dan E. Høfsten, M.D., Ph.D.,
doi : 10.1056/NEJMoa2208687
Evidence to support the choice of blood-pressure targets for the treatment of comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is limited.
Henrik Schmidt, M.D., D.M.Sc., Jesper Kjaergaard, M.D., D.M.Sc., Christian Hassager, M.D., D.M.Sc., Simon Mølstrøm, M.D., Johannes Grand, M.D., Ph.D., Britt Borregaard, Ph.D., Laust E. Roelsgaard Obling, M.D., Søren Venø, M.D., Laura Sarkisian, M.D., Ph.D., Dmitry Mamaev, M.D., Lisette O. Jensen, M.D., D.M.Sc., Benjamin Nyholm, M.D.,
doi : 10.1056/NEJMoa2208686
The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown.
Lalantha Leelarathna, Ph.D., Mark L. Evans, M.D., Sankalpa Neupane, Ph.D., Gerry Rayman, M.D., Sarah Lumley, M.R.C.G.P., Iain Cranston, F.R.C.P., Parth Narendran, Ph.D., Katharine Barnard-Kelly, Ph.D., Christopher J. Sutton, Ph.D., Rachel A. Elliott, Ph.D., Vicky P. Taxiarchi, Ph.D., Georgios Gkountouras, Ph.D.,
doi : 10.1056/NEJMoa2205650
In persons with type 1 diabetes and high glycated hemoglobin levels, the benefits of intermittently scanned continuous glucose monitoring with optional alarms for high and low blood glucose levels are uncertain.
Jihye Park, M.D., and Hyung-Youl Park, M.D., Ph.D.
doi : 10.1056/NEJMicm2202181
Akshay S. Desai, M.D., M.P.H., David M. Dudzinski, M.D., Matthew T. Stib, M.D., Steven T. Chen, M.D., M.P.H., Christopher Newton-Cheh, M.D., M.P.H., Kimberly G. Blumenthal, M.D., and James R. Stone, M.D., Ph.D.
doi : 10.1056/NEJMcpc2201245
Niklas Nielsen, M.D., Ph.D., and Markus B. Skrifvars, M.D., Ph.D.
doi : 10.1056/NEJMe2211024
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2213773
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