New England Journal of Medicine




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سفارش

Is It Burnout or Depression? Expanding Efforts to Improve Physician Well-Being

Srijan Sen, M.D., Ph.D.

doi : 10.1056/NEJMp2209540

Vol. 387 No. 18

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Pharmaceutical Marketing Revisited — United States v. Biogen Idec

Troyen Brennan, M.D., M.P.H.

doi : 10.1056/NEJMp2210637

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Climate, Pollution, and Children’s Health

Kari Nadeau, M.D., Ph.D., Frederica Perera, Dr.P.H., Ph.D., Renee N. Salas, M.D., M.P.H., and Caren G. Solomon, M.D., M.P.H.

doi : 10.1056/NEJMp2213408

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Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Guy M. Goodwin, F.Med.Sci., Scott T. Aaronson, M.D., Oscar Alvarez, M.R.C.Psych., Peter C. Arden, M.P.H., Annie Baker, R.G.N., James C. Bennett, M.Sc., Catherine Bird, M.Sc., Renske E. Blom, M.D., Christine Brennan, M.Sc., Donna Brusch, C.C.R.C., Lisa Burke, M.Sc., Kete Campbell-Coker, R.G.N.,

doi : 10.1056/NEJMoa2206443

In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant depression to receive a single dose of a proprietary, synthetic formulation of psilocybin at a dose of 25 mg, 10 mg, or 1 mg (control), along with psychological support.

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Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin’s Lymphoma

Sharon M. Castellino, M.D., Qinglin Pei, Ph.D., Susan K. Parsons, M.D., David Hodgson, M.D., Kathleen McCarten, M.D., Terzah Horton, M.D., Ph.D., Steve Cho, M.D., Yue Wu, M.S., Angela Punnett, M.D., Hema Dave, M.D., Tara O. Henderson, M.D., Bradford S. Hoppe, M.D.,

doi : 10.1056/NEJMoa2206660

In adults with advanced-stage Hodgkin’s lymphoma, the CD30-directed antibody–drug conjugate brentuximab vedotin combined with multiagent chemotherapy has been shown to have greater efficacy, but also more toxic effects, than chemotherapy alone. The efficacy of this targeted therapy approach in children and adolescents with Hodgkin’s lymphoma is unclear.

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Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years

Frank H. Bloomfield, Ph.D., Yannan Jiang, Ph.D., Jane E. Harding, D.Phil., Caroline A. Crowther, M.D., and Barbara E. Cormack, Ph.D. for the ProVIDe Trial Group*

doi : 10.1056/NEJMoa2204886

Whether higher parenteral amino acid intake improves outcomes in infants with extremely low birth weight is unclear.

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Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age

Evan J. Anderson, M.D., C. Buddy Creech, M.D., M.P.H., Vladimir Berthaud, M.D., M.P.H., Arin Piramzadian, D.O., Kimball A. Johnson, M.D., Marcus Zervos, M.D., Fredric Garner, M.D., Carl Griffin, M.D., Khozema Palanpurwala, M.D., Mark Turner, M.D., Jeffrey Gerber, M.D., Ph.D., Richard L. Bennett, M.D.,

doi : 10.1056/NEJMoa2209367

The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown.

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Noninvasive Respiratory Support for Adults with Acute Respiratory Failure

Laveena Munshi, M.D., Jordi Mancebo, M.D., and Laurent J. Brochard, M.D.

doi : 10.1056/NEJMra2204556

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The Zollinger–Ellison Syndrome

Quentin Binet, M.D., and Ivan Borbath, M.D., Ph.D.

doi : 10.1056/NEJMicm2203797

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Scaphoid Shift Test in Scapholunate Ligament Injury

Tun H. Lui, F.H.K.A.M. (Ortho. Surg.), and Amanda M.Y. Slocum, F.H.K.A.M. (Ortho. Surg.)

doi : 10.1056/NEJMicm2202238

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A Shear Decline

Marla Lipsyc-Sharf, M.D., Nathan T. Connell, M.D., M.P.H., John W. Ostrominski, M.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2115778

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Psilocybin in Treatment-Resistant Depression

Bertha K. Madras, Ph.D.

doi : 10.1056/NEJMe2210975

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Are We Too Reliant on Radiation Therapy for Children with Hodgkin’s Lymphoma?

Mark Roschewski, M.D., and Catherine M. Bollard, M.B., Ch.B., M.D.

doi : 10.1056/NEJMe2211587

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Parenteral Protein in Extremely Preterm Infants — More Is Not Better

Camilia R. Martin, M.D.

doi : 10.1056/NEJMe2212522

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Audio Interview: Caring for Hospitalized Patients with Covid-19

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., C. Corey Hardin, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2214245

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Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas

doi : 10.1056/NEJMc2210175

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Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2

doi : 10.1056/NEJMc2211055

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Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes

doi : 10.1056/NEJMc2212585

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Teclistamab in Relapsed or Refractory Multiple Myeloma

doi : 10.1056/NEJMc2211969

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Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

doi : 10.1056/NEJMx220009

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