دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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U.S. Health Insurance Coverage and Financing
Sabrina Corlette, J.D., and Christine H. Monahan, J.D.
doi : 10.1056/NEJMp2206049
Vol. 387 No. 25
Revaluing Primary Care — Going Beyond RVU Increases
Elizabeth P. Griffiths, M.D., M.P.H.
doi : 10.1056/NEJMp2209203
Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia
Alik Farber, M.D., Matthew T. Menard, M.D., Michael S. Conte, M.D., John A. Kaufman, M.D., Richard J. Powell, M.D., Niteesh K. Choudhry, M.D., Ph.D., Taye H. Hamza, Ph.D., Susan F. Assmann, Ph.D., Mark A. Creager, M.D., Mark J. Cziraky, Pharm.D., Michael D. Dake, M.D., Michael R. Jaff, D.O.,
doi : 10.1056/NEJMoa2207899
Patients with chronic limb-threatening ischemia (CLTI) require revascularization to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an initial strategy of endovascular therapy or surgical revascularization for CLTI is superior for improving limb outcomes.
Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis
Evan S. Dellon, M.D., M.P.H., Marc E. Rothenberg, M.D., Ph.D., Margaret H. Collins, M.D., Ikuo Hirano, M.D., Mirna Chehade, M.D., M.P.H., Albert J. Bredenoord, M.D., Ph.D., Alfredo J. Lucendo, M.D., Ph.D., Jonathan M. Spergel, M.D., Ph.D., Seema Aceves, M.D., Xian Sun, Ph.D., Matthew P. Kosloski, Ph.D., Mohamed A. Kamal, Pharm.D., Ph.D.,
doi : 10.1056/NEJMoa2205982
Dupilumab, a fully human monoclonal antibody, blocks interleukin-4 and interleukin-13 signaling, which have key roles in eosinophilic esophagitis.
A 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis
Bern-Thomas Nyang’wa, M.B., B.S., Catherine Berry, B.Med., Emil Kazounis, M.Med.Sci., Ilaria Motta, Ph.D., Nargiza Parpieva, Sc.D., Zinaida Tigay, M.D., Varvara Solodovnikova, M.D., Irina Liverko, Sc.D., Ronelle Moodliar, M.B., B.S., Matthew Dodd, M.Sc., Nosipho Ngubane, M.B., B.Ch., Mohammed Rassool, M.B., B.Ch.,
doi : 10.1056/NEJMoa2117166
In patients with rifampin-resistant tuberculosis, all-oral treatment regimens that are more effective, shorter, and have a more acceptable side-effect profile than current regimens are needed.
Lentiviral Gene Therapy for Artemis-Deficient SCID
Morton J. Cowan, M.D., Jason Yu, Ph.D., Janelle Facchino, P.N.P., Carol Fraser-Browne, B.A., Ukina Sanford, M.S., Misako Kawahara, B.A., Jasmeen Dara, M.D., Janel Long-Boyle, Pharm.D., Ph.D., Jess Oh, M.S., Wendy Chan, B.S., Shivali Chag, M.S., Lori Broderick, M.D., Ph.D.,
doi : 10.1056/NEJMoa2206575
The DNA-repair enzyme Artemis is essential for rearrangement of T- and B-cell receptors. Mutations in DCLRE1C, which encodes Artemis, cause Artemis-deficient severe combined immunodeficiency (ART-SCID), which is poorly responsive to allogeneic hematopoietic-cell transplantation.
Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura
Lars M. Asmis, M.D., Andreas Serra, M.D., Alexander Krafft, M.D., Abraham Licht, M.D., Elke Leisinger, M.D., Jana Henschkowski-Serra, M.D., Michael T. Ganter, M.D., Steffen Hauptmann, M.D., Marianne Tinguely, M.D., and Johanna A. Kremer Hovinga, M.D.
doi : 10.1056/NEJMoa2211113
Serpentine Supravenous Hyperpigmentation
Nadine S. Maalouf, M.D., and Meggie Morand, M.D.
doi : 10.1056/NEJMicm2207158
Case 39-2022: A 31-Year-Old Woman with Postpartum Abdominal Pain and Fever
Sarah E. Little, M.D., M.P.H., Onofrio A. Catalano, M.D., Ph.D., Andrea G. Edlow, M.D., and Stuti G. Shroff, M.B., B.S., Ph.D.
doi : 10.1056/NEJMcpc2211363
Surgical Revascularization — Best for Limb Ischemia?
Jonathan Golledge, M.Chir., F.R.A.C.S.
doi : 10.1056/NEJMe2214046
Biologics in Eosinophilic Esophagitis — Ready for Prime Time?
Alex Straumann, M.D.
doi : 10.1056/NEJMe2213030
Audio Interview: Potential Covid Vaccine Strategies
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2216362
Recombinant ADAMTS13 in Severe Neonatal Thrombotic Thrombocytopenic Purpura
doi : 10.1056/NEJMc2210781
