David A. Ansell, M.D., M.P.H., Kaitlyn Fruin, M.D., Redia Holman, Ayesha Jaco, M.A.M., Bich Ha Pham, J.D., and David Zuckerman, M.P.P.
doi : 10.1056/NEJMp2213465
Soleil Shah, M.Sc., Hayden Rooke-Ley, B.A., and Erin C. Fuse Brown, J.D., M.P.H.
doi : 10.1056/NEJMp2212841
Louis J. Aronne, M.D., Sarah Bramblette, Julie R. Ingelfinger, M.D., Ania M. Jastreboff, M.D., Ph.D., Sriram Machineni, M.D., Ph.D., Nikki Massie, and Clifford J. Rosen, Ph.D.
doi : 10.1056/NEJMp2215794
Atrial fibrillation is a chronic, progressive disorder, and persistent forms of atrial fibrillation are associated with increased risks of thromboembolism and heart failure. Catheter ablation as initial therapy may modify the pathogenic mechanism of atrial fibrillation and alter progression to persistent atrial fibrillation.
doi : 10.1056/NEJMoa2212540
The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients.
doi : 10.1056/NEJMoa2204233
David Pellerin, M.D., Matt C. Danzi, Ph.D., Carlo Wilke, M.D., Mathilde Renaud, M.D., Ph.D., Sarah Fazal, Ph.D., Marie-Josée Dicaire, B.Sc., Carolin K. Scriba, B.Sc., Catherine Ashton, M.B., B.S., Christopher Yanick, B.S., Danique Beijer, Ph.D., Adriana Rebelo, Ph.D., Clarissa Rocca, M.Sc.,
doi : 10.1056/NEJMoa2207406
We sequenced the genomes of six persons with autosomal dominant LOCA who were members of three French Canadian families and identified a candidate pathogenic repeat expansion.
David W. Bates, M.D., David M. Levine, M.D., M.P.H., Hojjat Salmasian, M.D., Ph.D., M.P.H., Ania Syrowatka, Ph.D., David M. Shahian, M.D., Stuart Lipsitz, Sc.D., Jonathan P. Zebrowski, M.D., M.H.Q.S., Laura C. Myers, M.D., M.P.H., Merranda S. Logan, M.D., M.P.H., Christopher G. Roy, M.D., M.P.H., Christine Iannaccone, M.P.H., Michelle L. Frits, B.A.,
doi : 10.1056/NEJMsa2206117
Adverse events during hospitalization are a major cause of patient harm, as documented in the 1991 Harvard Medical Practice Study. Patient safety has changed substantially in the decades since that study was conducted, and a more current assessment of harm during hospitalization is warranted.
Cynthia A. Stuenkel, M.D., and Anne Gompel, M.D., Ph.D.
doi : 10.1056/NEJMcp2116488
Ren-Hao Chan, M.D., and Wei-Hung Lin, M.D., Ph.D.
doi : 10.1056/NEJMicm2205643
Chad W. Vokoun, M.D., Mark C. Murphy, M.D., Kerry L. Reynolds, M.D., and Melanie S. Haines, M.D.
doi : 10.1056/NEJMcpc2211366
Roopinder K. Sandhu, M.D., M.P.H., and Christine M. Albert, M.D., M.P.H.
doi : 10.1056/NEJMe2214425
Phyllis August, M.D., M.P.H.
doi : 10.1056/NEJMe2215286
Donald M. Berwick, M.D., M.P.P.
doi : 10.1056/NEJMe2213567
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2300211
doi : 10.1056/NEJMc2214293
doi : 10.1056/NEJMc2208055
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