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Chronotherapy based on modified-release hydrocortisone to restore the physiological cortisol diurnal rhythm
Martin J. Whitaker, Hiep Huatan & Richard J. Ross
doi : 10.1007/s13346-022-01183-w
Volume 13, issue 1, January 2023
In this inspirational note, we describe the development of an endocrine chronotherapy to restore the physiological rhythm of the essential adrenal stress hormone, cortisol. The challenges included demonstrating the circadian rhythm of the drug target, creating a drug formulation that replicated that rhythm and then proving benefit in clinical trials.
Development and characterization of gastro-floating sustained-release capsule with improved bioavailability of levodopa
Hao Yuan, Zhengyu Zhang & Liandong Hu
doi : 10.1007/s13346-022-01188-5
In this study, a new gastro-floating sustained-release capsule (GFC) with levodopa (LD) and benserazide hydrochloride (BH) was successfully developed.
Nanoformulations of flavonoids for diabetes and microvascular diabetic complications
Kopal Agarawal, Yogesh Anant Kulkarni & Sarika Wairkar
doi : 10.1007/s13346-022-01174-x
Diabetes is a chronic metabolic disease characterized by an excess of glucose in the blood. If the constant sugar level is not managed correctly in diabetic patients, it may lead to microvascular complications such as diabetic retinopathy, neuropathy, and nephropathy.
Impact of gastric and bowel surgery on gastrointestinal drug delivery
Susan Hua & Ephraem C. Lye
doi : 10.1007/s13346-022-01179-6
General surgical procedures on the gastrointestinal tract are commonly performed worldwide. Surgical resections of the stomach, small intestine, or large intestine can have a significant impact on the anatomy and physiological environment of the gastrointestinal tract.
Advanced triboelectric nanogenerator-driven drug delivery systems for targeted therapies
Muhammad Ikram & M. A. Parvez Mahmud
doi : 10.1007/s13346-022-01184-9
In the current decade, remarkable efforts have been made to develop a self-regulated, on-demand and controlled release drug delivery system driven by triboelectric nanogenerators (TENGs).
Management of bone diseases: looking at scaffold-based strategies for drug delivery
Myriam Bordone & Ana Bettencourt
doi : 10.1007/s13346-022-01191-w
The bone tissue can regenerate itself completely and continuously; however, large-scale bone defects may overpower this self-regenerative process.
Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation
K. Laxmi Swetha, Kavya Sree Maravajjala, Shyh-Dar Li, Manu Smriti Singh & Aniruddha Roy
doi : 10.1007/s13346-022-01194-7
Most of the current antitumor therapeutics were developed targeting the cancer cells only. Unfortunately, in the majority of tumors, this single-dimensional therapy is found to be ineffective.
Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system
Sharath Kumar Hari, Ankita Gauba, Neeraj Shrivastava, Ravi Mani Tripathi, Sudhir Kumar Jain & Akhilesh Kumar Pandey
doi : 10.1007/s13346-022-01197-4
Since the beginning of pharmaceutical research, drug delivery methods have been an integral part of it.
Advances in 4D printing: from stimulation to simulation
Prashant Pingale, Shilpa Dawre, Vividha Dhapte-Pawar, Namdev Dhas & Amarjitsing Rajput
doi : 10.1007/s13346-022-01200-y
The advancement of four-dimensional (4D) printing has been fueled by the rise in demand for additive manufacturing and the expansion in shape-memory materials. The printing of smart substances that respond to external stimuli is known as 4D printing.
Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis
Vahid Alimardani, Zahra Rahiminezhad, Mahvash DehghanKhold, Ghazal Farahavar, Mahboobeh Jafari, Mehdi Abedi, Leila Moradi, Uranous Niroumand, Mohammad Ashfaq, Samira Sadat Abolmaali & Gholamhossein Yousefi
doi : 10.1007/s13346-022-01211-9
The global prevalence of cancer is increasing, necessitating new additions to traditional treatments and diagnoses to address shortcomings such as ineffectiveness, complications, and high cost.
Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation
Marwah Suliman Maashi, Shatha G. Felemban, Hibah Ali Almasmoum & Mostafa Jarahian
doi : 10.1007/s13346-022-01176-9
The current study developed a biopolymer-based wound dressing by electrospinning of Nicaraven-loaded collagen solution. Firstly, collagen was dissolved in acetic acid, and then Nicaraven was added to the polymeric solution at three different concentrations of 2 w/w%, 4 w/w%, and 6 w/w%.
In vitro degradation and erosion behavior of commercial PLGAs used for controlled drug delivery
Jennifer Walker, Jason Albert, Desheng Liang, Jing Sun, Richard Schutzman, Raj Kumar, Cameron White, Moritz Beck-Broichsitter & Steven P. Schwendeman
doi : 10.1007/s13346-022-01177-8
Copolymers of lactic (or lactide) and glycolic (or glycolide) acids (PLGAs) are among the most commonly used materials in biomedical applications, such as parenteral controlled drug delivery, due to their biocompatibility, predictable degradation rate, and ease of processing.
Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model
Heba M. A. Khalil, Islam A. Khalil, Asmaa K. Al-Mokaddem, Marwa Hassan, Riham A. El-Shiekh, Hesham A. Eliwa, Azza M. Tawfek & Walaa H. El-Maadawy
doi : 10.1007/s13346-022-01181-y
Ashwagandha (ASH), a vital herb in Ayurvedic medicine, demonstrated potent preclinical hepato- and neuroprotective effects. However, its efficacy is limited due to low oral bioavailability.
Advanced harmonization techniques result in accurate establishment of in vitro–in vivo correlations for oxybenzone from four complex dermal formulations with reapplication
Paige N. Zambrana, Dana C. Hammell & Audra L. Stinchcomb
doi : 10.1007/s13346-022-01186-7
Due to high variability during clinical pharmacokinetic (PK) evaluation, the prediction of in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products has historically proven difficult.
Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies
Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A. A. Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi & Murtaza M. Tambuwala
doi : 10.1007/s13346-022-01193-8
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa.
The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel
James Flynn, Mario Culebras, Maurice N. Collins & Sarah P. Hudson
doi : 10.1007/s13346-022-01201-x
In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profile of an encapsulated bacteriocin, nisin A, are explored.
Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment
Akeemat Tijani, Prashant Dogra, Maria J. Peláez, Zhihui Wang, Vittorio Cristini & Ashana Puri
doi : 10.1007/s13346-022-01202-w
Naloxone, an FDA-approved opioid inhibitor, used to reverse opioid overdose complications has up till date faced challenges associated with its delivery.
In silico–assisted development of supersaturable preconcentrated isotropic mixture of atazanavir for augmenting biopharmaceutical performance in the presence of H2-receptor antagonist
Sheshank Sethi & Vikas Rana
doi : 10.1007/s13346-022-01210-w
The therapeutic potential of atazanavir (BCS Class II drug), a highly selective inhibitor of human immunodeficiency virus (HIV-1), has been largely limited due to its low intrinsic solubility at elevated pH resulting in low oral bioavailability.
Development, characterisation, and in vitro anti-tumor effect of self-microemulsifying drug delivery system containing polyphyllin I
Xin Wang, Rui Zhang, Shu Wang, Minju Gu, Yuan Li, Xiuping Zhuang, Chao Chen, Peimin Yang, Gongling Guo & Ping Sun
doi : 10.1007/s13346-022-01212-8
Polyphyllin I (PPI), an effective active ingredient in Paris polyphylla, has a diverse set of pharmacological properties.
