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Inspirational chemistry of bioabsorbable long-acting injectables
Thomas Tice
doi : 10.1007/s13346-022-01199-2
Volume 13, issue 2, February 2023
Long-acting injectables (LAIs) have made a tremendous impact on clinical medicine. As evidence, dozens of approved LAI products are on the market.
Clinical translation of gold nanoparticles
Rui Zhang, Fabian Kiessling, Twan Lammers & Roger M. Pallares
doi : 10.1007/s13346-022-01232-4
Gold nanoparticles display unique physicochemical features, which can be useful for therapeutic purposes.
Light-related activities of metal-based nanoparticles and their implications on dermatological treatment
Qiuyue Wang, Naiying Chen, Mingming Li, Sicheng Yao, Xinxing Sun, Xun Feng & Yang Chen
doi : 10.1007/s13346-022-01216-4
Metal-based nanoparticles (MNPs) represent an emerging class of materials that have attracted enormous attention in many fields.
Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives
Rahul Kumar, Amit K. Thakur, Nilanjana Banerjee, Ashutosh Kumar, Gajendra Kumar Gaurav & Raj Kumar Arya
doi : 10.1007/s13346-022-01219-1
The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability.
Bone regeneration in osteoporosis: opportunities and challenges
Dhrumi Patel & Sarika Wairkar
doi : 10.1007/s13346-022-01222-6
Osteoporosis is a bone disorder characterised by low bone mineral density, reduced bone strength, increased bone fragility, and impaired mineralisation of bones causing an increased risk of bone fracture.
An expanding horizon of complex injectable products: development and regulatory considerations
Kanan Panchal, Sumeet Katke, Sanat Kumar Dash, Ankit Gaur, Aishwarya Shinde, Nithun Saha, Neelesh Kumar Mehra & Akash Chaurasiya
doi : 10.1007/s13346-022-01223-5
There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications.
The exosome: a review of current therapeutic roles and capabilities in human reproduction
Marko Dimik, Pevindu Abeysinghe, Jayden Logan & Murray Mitchell
doi : 10.1007/s13346-022-01225-3
Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the human body and therefore are not prone to immunogenicity effects which would otherwise destroy unelicited foreign bodies.
Local administration of large surface area microparticle docetaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects: preclinical and clinical studies
Holly Maulhardt, Shelagh Verco, Michael Baltezor, Alyson Marin & Gere diZerega
doi : 10.1007/s13346-022-01226-2
This report describes local administration of large surface area microparticle docetaxel (LSAM-DTX: ~ 3.5- to 7.5-µm-sized particles with high relative surface area) in preclinical oncology models and in a clinical trial in urothelial carcinoma.
Long-acting injectable PLGA/PLA depots for leuprolide acetate: successful translation from bench to clinic
Samer R. Abulateefeh
doi : 10.1007/s13346-022-01228-0
The excellent properties of polyesters combined with their ease of synthesis and modification enabled their wide use in the pharmaceutical industry.
Exploration of novel drug delivery systems in topical management of osteoarthritis
Pratiksha Patil, Shweta Nene, Saurabh Shah, Shashi Bala Singh & Saurabh Srivastava
doi : 10.1007/s13346-022-01229-z
Osteoarthritis is one of the foremost disabling disorders in the world. There is no definitive treatment to prevent the progression of osteoarthritis.
Ocular barriers as a double-edged sword: preventing and facilitating drug delivery to the retina
Lixiang Wang & Hui Zhang
doi : 10.1007/s13346-022-01231-5
In recent decades, the growing of the aging population in the world brings increasingly heavy burden of vision-threatening retinal diseases.
The possibility of angiogenesis inhibition in cutaneous melanoma by bevacizumab-loaded lipid-chitosan nanoparticles
Fereshteh Abdi, Elham Arkan, Mojtaba Eidizadeh, Elahe Valipour, Tahereh Naseriyeh, Younes Hossainy Gamizgy & Kamran Mansouri Fereshteh Abdi, Elham Arkan, Mojtaba Eidizadeh, Elahe Valipour, Tahereh Naseriyeh, Younes Hossainy Gamizgy & Kamran Mansouri
doi : 10.1007/s13346-022-01215-5
Cutaneous malignant melanoma is fastest-growing cancer in white populations with a large majority of dermal cancer death.
Formulation of tizanidine hydrochloride–loaded provesicular system for improved oral delivery and therapeutic activity employing a 23 full factorial design
Amira Mohamed Mohsen, Hadeer Ahmed El-Hashemy, Abeer Salama & Asmaa Badawy Darwish
doi : 10.1007/s13346-022-01217-3
Tizanidine hydrochloride (TZN) is one of the most effective centrally acting skeletal muscle relaxants.
A proof of concept to define the parameters affecting poly-l-lactide-co-poly-ε-caprolactone shape memory electrospun nanofibers for biomedical applications
Silvia Pisani, Ida Genta, Tiziana Modena, Rossella Dorati, Giovanna Bruni, Marco Benazzo & Bice Conti
doi : 10.1007/s13346-022-01218-2
This study is a proof of concept performed to evaluate process parameters affecting shape memory effect of copolymer poly-l-lactide-co-poly-ε-caprolactone (PLA:PCL) 70:30 ratio based nanofibrous scaffolds.
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model
Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Poonam Gera, Sandhya Yadav, Godanjali Chekuri, Pradip Chaudhari, Shilpee Dutt & Rinti Banerjee
doi : 10.1007/s13346-022-01220-8
Nanotechnology-based drug delivery platforms have shown great potential in overcoming the limitations of conventional therapy for glioblastoma (GBM).
Downregulation of pro-inflammatory markers IL-6 and TNF-α in rheumatoid arthritis using nano-lipidic carriers of a quinone-based phenolic: an in vitro and in vivo study
Ravi Raj Pal, Vasundhara Rajpal, Neelu Singh, Sukhveer Singh, Nidhi Mishra, Priya Singh, Priyanka Maurya, Alka & Shubhini A. Saraf
doi : 10.1007/s13346-022-01221-7
Rheumatoid arthritis (RA) is a joint ailment with multi-factorial immune-mediated degenerative pathogenesis, including genetic and environmental defects.
Thermosensitive and mucoadhesive hydrogel containing curcumin-loaded lipid-core nanocapsules coated with chitosan for the treatment of oral squamous cell carcinoma
Ana Ortega, Ayana Brêtas da Silva, Leidyana Moraes da Costa, Kelly Cristine Zatta, Giovana Ravizzoni Onzi, Francisco Noé da Fonseca, Silvia Stanisçuaski Guterres & Karina Paese
doi : 10.1007/s13346-022-01227-1
Buccal drug administration may be chosen as a medication route to treat various diseases for local or systemic effects.
Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation
Saurabh Shrivastava & Chanchal Deep Kaur
doi : 10.1007/s13346-022-01230-6
Andrographolide, the primary bioactive constituent of Andrographis paniculata, is a promising natural substance with numerous pharmacotherapy uses. Andrographolide, the primary bioactive constituent of Andrographis paniculata, is a promising natural substance with numerous pharmacotherapy uses.
Modeling and simulation of smart magnetic self-assembled nanomicelle trajectories in an internal thoracic artery flow for breast cancer therapy
Saad Sulttan & Sohrab Rohani
doi : 10.1007/s13346-022-01234-2
Magnetic drug targeting (MDT) is one of the most modern techniques in cancer therapy for its ability to reduce the side effects of chemotherapy experienced by systemic drug administration
Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis
Huseyin Ozkan, Martina Di Francesco, Helen Willcockson, José Valdés-Fernández, Valentina Di Francesco, Froilán Granero-Moltó, Felipe Prósper, Paolo Decuzzi & Lara Longobardi
doi : 10.1007/s13346-022-01235-1
Posttraumatic osteoarthritis (PTOA) is mostly treated via corticosteroid administration, and total joint arthroplasty continues to be the sole effective intervention in severe conditions.
Correction to: Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets
Saeed Shojaee, Ali Nokhodchi & Mohammed Maniruzzaman
