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What should European nephrology do with the new CKD-EPI equation?
Ron T Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria José Soler, Christoph Wanner
doi : 10.1093/ndt/gfac254
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 1–6
Transition of care of adolescent kidney transplant recipients—a call to action
Chia Wei Teoh, Christoph Licht
doi : 10.1093/ndt/gfac243
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 7–9
Mineralocorticoid receptor antagonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease
Alberto Ortiz, Charles J Ferro, Olga Balafa, Michel Burnier, Robert Ekart, Jean-Michel Halimi, Reinhold Kreutz, Patrick B Mark, Alexandre Persu, Patrick Rossignol, Luis M Ruilope, Roland E Schmieder, Jose M Valdivielso, Lucia del Vecchio, Carmine Zoccali, Francesca Mallamaci, Pantelis Sarafidis, for the European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) and the Hypertension and the Kidney Working Group of the European Society of Hypertension (ESH)
doi : 10.1093/ndt/gfab167
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 10–25
Diabetic kidney disease (DKD) develops in ∼40% of patients with diabetes and is the most common cause of chronic kidney disease (CKD) worldwide. Patients with CKD, especially those with diabetes mellitus, are at high risk of both developing kidney failure and cardiovascular (CV) death.
Tertiary lymphoid tissues: a regional hub for kidney inflammation
Yuki Sato, Masaru Tamura, Motoko Yanagita
doi : 10.1093/ndt/gfab212
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 26–33
Tertiary lymphoid tissues (TLTs) are inducible ectopic lymphoid tissues that develop at sites of chronic inflammation in nonlymphoid organs. As with lymph nodes, TLTs initiate adaptive immune responses and coordinate local tissue immunity.
HbA1c and beyond
Peter Rossing
doi : 10.1093/ndt/gfab243
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 34–40
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on Diabetes Management in Chronic Kidney Disease from 2020 comes at an opportune time when progress in diabetes technology and therapeutics offers new options to manage the large population of patients with diabetes and chronic kidney disease (CKD) at high risk of poor health outcomes.
Climate change and nephrology
Fumihiko Sasai, Carlos Roncal-Jimenez, Keegan Rogers, Yuka Sato, Jared M Brown, Jason Glaser, Gabriela Garcia, Laura Gabriela Sanchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Butler Dawson, Cecilia Sorensen, Ana Andres Hernando, Marvin Gonzalez-Quiroz, Miguel Lanaspa, Lee S Newman, Richard J Johnson
doi : 10.1093/ndt/gfab258
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 41–48
Climate change should be of special concern for the nephrologist, as the kidney has a critical role in protecting the host from dehydration, but it is also a favorite target of heat stress and dehydration.
Transitional care models in adolescent kidney transplant recipients—a systematic review
Dermot Michael Wildes, Caoimhe S Costigan, Mairead Kinlough, Joan Flynn, Niamh Dolan, Michael Riordan, Clodagh Sweeney, Maria Stack, Mary Waldron, Orla Walsh, Kathleen M Gorman, Atif Awan
doi : 10.1093/ndt/gfac175
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 49–55
Adolescence is a time of significant change for patients, guardians and clinicians. The paediatrician must ensure patients develop the necessary skills and knowledge required to transition and to function as an independent entity, with autonomy over their own care.
Armed conflicts and kidney patients: a consensus statement from the Renal Disaster Relief Task Force of the ERA
Mehmet S Sever, Raymond Vanholder, Valerie Luyckx, Kai-Uwe Eckardt, Mykola Kolesnyk, Andrzej Wiecek, Ewa Pawlowicz-Szlarska, Daniel Gallego, Rukshana Shroff, Andrej Škoberne, Ionut Nistor, Mohamed Sekkarie, Dmytro Ivanov, Edita Noruišiene, Serhan Tuglular
doi : 10.1093/ndt/gfac247
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 56–65
During conflicts, people with kidney disease, either those remaining in the affected zones or those who are displaced, may be exposed to additional threats because of medical and logistical challenges.
ANCA-associated vasculitis in children
Silvia Bernardi, Laure Seugé, Olivia Boyer
doi : 10.1093/ndt/gfac265
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 66–69
Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study
Helena Bächle, Peggy Sekula, Pascal Schlosser, Inga Steinbrenner, Yurong Cheng, Fruzsina Kotsis, Heike Meiselbach, Helena Stockmann, Sebastian Schönherr, Kai-Uwe Eckardt, Olivier Devuyst, Jürgen Scherberich, Anna Köttgen, Ulla T Schultheiss, GCKD investigators
doi : 10.1093/ndt/gfac187
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 70–79
The progression of chronic kidney disease (CKD), a global public health burden, is accompanied by a declining number of functional nephrons. Estimation of remaining nephron mass may improve assessment of CKD progression.
Protective effect of sacubitril/valsartan (Entresto) on kidney function and filtration barrier injury in a porcine model of partial nephrectomy
Juan Brignone, Mia Jensen, Boye L Jensen, Kasper Bostlund Assersen, Jens P Goetze, Lars Jødal, Trine Borup Andersen, Sigriður Olga Magnusdottir, Brian Kloster, Morten Jønler, Lars Lund
doi : 10.1093/ndt/gfac200
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 80–92
Kidney surgery often includes organ ischaemia with a risk of acute kidney injury.
Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction
Lyuben Lyubenov, Chongxu Shi, Danyang Zhao, Luying Yang, Yutian Lei, Elmina Mammadova-Bach, Letizia de Chiara, Roberto Semeraro, Samuela Landini, Paola Romagnani, Elena Vörg, Satish K Devarapu, Ricarda Welz, Stephan T Kiessig, Hans-Joachim Anders
doi : 10.1093/ndt/gfac273
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 93–105
Cholesterol crystal (CC) embolism causes acute kidney injury (AKI) and ischaemic cortical necrosis associated with high mortality. We speculated that sustaining the fibrinolytic system with Glu-plasminogen (Glu-Plg) could be a safe way to attenuate AKI and prevent ischaemic infarction upon CC embolism.
Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Björk, Natalie Ebert, Björn O Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bökenkamp, Ulla B Berg, Kajsa Åsling-Monemi, Anna Åkesson, Anders Larsson, Etienne Cavalier, R Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehlé, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P Strogoff-de-Matos, Justine B Bukabau, Ernest K Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
doi : 10.1093/ndt/gfac241
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 106–118
A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.
Removing race from the CKD-EPI equation and its impact on prognosis in a predominantly White European population
Edouard L Fu, Josef Coresh, Morgan E Grams, Catherine M Clase, Carl-Gustaf Elinder, Julie Paik, Chava L Ramspek, Lesley A Inker, Andrew S Levey, Friedo W Dekker, Juan J Carrero
doi : 10.1093/ndt/gfac197
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 119–128
While American nephrology societies recommend using the 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation without a Black race coefficient, it is unknown how this would impact disease distribution, prognosis and kidney failure risk prediction in predominantly White non-US populations.
Risk of glomerular diseases, proteinuria and hematuria following mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines
Franco Wing Tak Cheng, Carlos King Ho Wong, Simon Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Esther W Chan, Chi Ho Au, Xuxiao Ye, Sydney Chi Wai Tang, Ian Chi Kei Wong
doi : 10.1093/ndt/gfac292
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 129–137
With accruing case reports on de novo or relapsing glomerular diseases (GD) following different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, we evaluated the risk of GD following BNT162b2 and CoronaVac vaccines.
Acute kidney injury increases risk of kidney stones—a retrospective propensity score matched cohort study
Hicham I Cheikh Hassan, Karumathil Murali, Kelly Lambert, Maureen Lonergan, Brendan McAlister, Thomas Suesse, Judy Mullan
doi : 10.1093/ndt/gfac023
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 138–147
Acute kidney injury (AKI) is common. An episode of AKI may modify the risk of developing kidney stones by potential long-term effects on urine composition. We aimed to investigate the association between AKI and the risk of kidney stone presentations.
Adding creatinine to routine pregnancy tests: a decision tree for calculating the cost of identifying patients with CKD in pregnancy
Giorgina Barbara Piccoli, Antoine Chatrenet, Manuela Cataldo, Massimo Torreggiani, Rossella Attini, Bianca Masturzo, Gianfranca Cabiddu, Elisabetta Versino, Kidney and Pregnancy Study Group of the Italian Society of Nephrology
doi : 10.1093/ndt/gfac051
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 148–157
Even in its early stages, chronic kidney disease (CKD) is associated with adverse pregnancy outcomes. The current guidelines for pregnancy management suggest identifying risk factors for adverse outcomes but do not mention kidney diseases.
Long-term effectiveness of a primary care practice facilitation program for chronic kidney disease management: an extended follow-up of a cluster-randomized FROM-J study
Toshiyuki Imasawa, Chie Saito, Hirayasu Kai, Kunitoshi Iseki, Junichiro James Kazama, Yugo Shibagaki, Hitoshi Sugiyama, Daisuke Nagata, Ichiei Narita, Tomoya Nishino, Hajime Hasegawa, Hirokazu Honda, Shoichi Maruyama, Mariko Miyazaki, Masashi Mukoyama, Hideo Yasuda, Takashi Wada, Yuichi Ishikawa, Ryoya Tsunoda, Kei Nagai, Reiko Okubo, Masahide Kondo, Junichi Hoshino, Kunihiro Yamagata
doi : 10.1093/ndt/gfac041
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 158–166
Practice facilitation program by multidisciplinary care for primary care physicians (PCPs) is expected to improve chronic kidney disease (CKD) outcomes, but there is no clear evidence of its long-term effectiveness.
Clinical trajectories and impact of acute kidney disease after acute kidney injury in the intensive care unit: a 5-year single-centre cohort study
Arthur Orieux, Mathilde Prezelin-Reydit, Renaud Prevel, Christian Combe, Didier Gruson, Alexandre Boyer, Sébastien Rubin
doi : 10.1093/ndt/gfac054
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 167–176
Patients suffering from acute kidney injury(AKI) in the intensive care unit (ICU) can have various renal trajectories and outcomes. Aims were to assess the various clinical trajectories after AKI in the ICU and to determine risk factors for developing chronic kidney disease (CKD).
Factors associated with sex differences in the risk of kidney stones
Pietro Manuel Ferraro, Eric N Taylor, Gary C Curhan
doi : 10.1093/ndt/gfac037
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 177–183
Men are at higher risk of developing stones compared with women; however, recent data suggest a changing epidemiology, with women being relatively more affected than before.
Urea levels and cardiovascular disease in patients with chronic kidney disease
Solène M Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M Robinson, Bénédicte Stengel, Sophie Liabeuf, Ziad A Massy, the CKD-REIN study collaborators
doi : 10.1093/ndt/gfac045
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 184–192
Elevated serum urea levels are common in moderate-to-advanced chronic kidney disease (CKD). Several studies have shown that urea is a direct and indirect uraemic toxin, especially with regard to cardiovascular disease.
Association of single and serial measures of serum phosphorus with adverse outcomes in patients on peritoneal dialysis: results from the international PDOPPS
Marcelo Barreto Lopes, Angelo Karaboyas, Junhui Zhao, David W Johnson, Talerngsak Kanjanabuch, Martin Wilkie, Kosaku Nitta, Hideki Kawanishi, Jeffrey Perl, Ronald L Pisoni, The PDOPPS Steering Committee
doi : 10.1093/ndt/gfac249
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 193–202
While high serum phosphorus levels have been related to adverse outcomes in hemodialysis patients, further investigation is warranted in persons receiving peritoneal dialysis (PD).
Effect of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on cardiovascular outcomes in dialysis patients: a systematic review and meta-analysis
Panagiotis I Georgianos, Georgios Tziatzios, Stefanos Roumeliotis, Vasilios Vaios, Vasiliki Sgouropoulou, Dimitrios G Tsalikakis, Vassilios Liakopoulos, Rajiv Agarwal
doi : 10.1093/ndt/gfac253
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 203–211
Angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) are recommended by guidelines as first-line antihypertensive therapies in the general population or in patients with earlier stages of kidney disease.
Prediction of measured GFR after living kidney donation from pre-donation parameters
Marco van Londen, Jessica van der Weijden, Robert S Niznik, Aidan F Mullan, Stephan J L Bakker, Stefan P Berger, Ilja M Nolte, Jan-Stephan F Sanders, Gerjan Navis, Andrew D Rule, Martin H de Borst
doi : 10.1093/ndt/gfac202
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 212–221
One of the challenges in living kidney donor screening is to estimate remaining kidney function after donation. Here we developed a new model to predict post-donation measured glomerular filtration rate (mGFR) from pre-donation serum creatinine, age and sex.
Recurrence of immune complex and complement-mediated membranoproliferative glomerulonephritis in kidney transplantation
Fernando Caravaca-Fontán, Natalia Polanco, Blanca Villacorta, Anna Buxeda, Armando Coca, Ana Ã�vila, RocÃo MartÃnez-Gallardo, Cristina Galeano, RosalÃa Valero, Natalia Ramos, Natalia Allende, Leónidas Cruzado-Vega, MarÃa José Pérez-Sáez, Ã�ngel Sevillano, Esther González, Ana Hernández, Emilio Rodrigo, Mario Fernández-Ruiz, José MarÃa Aguado, Miguel Ã�ngel Pérez Valdivia, Julio Pascuall, Amado Andrés, Manuel Praga, The Spanish Group for the Study of Glomerular Diseases and the Spanish Group of Kidney Transplant
doi : 10.1093/ndt/gfac148
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 222–235
Membranoproliferative glomerulonephritis (MPGN) represents a histologic pattern of glomerular injury that may be due to several aetiologies. Few studies have comprehensively analysed the recurrence of MPGN according to the current classification system.
Adrenal insufficiency is common amongst kidney transplant recipients receiving maintenance prednisolone and can be predicted using morning cortisol
Maria Tomkins, Julie Martin-Grace, Carmel Kennedy, Olive McEnroe, Karen Heverin, Shari Srinivasan, Dilly Little, Peter Conlon, Declan De Freitas, Mark Denton, Colm Magee, Conall O'Seaghdha, Michael W O'Reilly, Chris J Thompson, Mark Sherlock
doi : 10.1093/ndt/gfac044
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 236–245
Long-term glucocorticoid therapy is a key component of immunosuppression for kidney transplant recipients (KTRs), leading to significant cumulative glucocorticoid exposure.
Biomarkers of kidney tubule injury and dysfunction and risk of incident hypertension in community-living individuals: results from the multi-ethnic study of atherosclerosis
Rakesh Malhotra, Ronit Katz, Paul L Kimmel, Ramachandran S Vasan, Jeffrey S Schelling, Jason H Greenberg, Chirag R Parikh, Joseph V Bonventre, Tala Al-Rousan, Mark J Sarnak, Orlando M Gutierrez, Michael G Shlipak, Joachim H Ix
doi : 10.1093/ndt/gfac293
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 246–248
Humoral and cellular responses after a third dose of SARS-CoV-2 mRNA vaccine in patients with glomerular disease
Maxime Teisseyre, Daisy Graça, Daniel Re, Marion Cremoni, Sylvia Benzaken, Kévin Zorzi, Céline Fernandez, Vincent L M Esnault, Jérôme Barrière, Vesna Brglez, Barbara Seitz-Polski
doi : 10.1093/ndt/gfac294
Nephrology Dialysis Transplantation, Volume 38, Issue 1, January 2023, Pages 249–251
