Ying-Hua Zhang a,b,*, Ting Wang a,b, Yan-Fang Li a,b, Ya-Nan Deng a,b, Feng-Ge Shen
doi : 10.1016/j.bbr.2022.114131
Volume 437, 2 February 2023, 114131
The Notch signaling pathway is mainly involved in the regulation of neural stem cell proliferation, survival and differentiation during the development of the central nervous system.
Laura N. Pulido a,1, Jose A. Pochapski a,b,1, Adam Sugi a,b, Julie Y. Esaki a, Joao L. Stresser a, William N. Sanchez a,b,e, Gabriel Baltazar a,b, David Levcik c, Romulo Fuentes d, Claudio Da Cunha
doi : 10.1016/j.bbr.2022.114065
Volume 437, 2 February 2023, 114065
Methylphenidate is a stimulant used to treat attention deficit and hyperactivity disorder (ADHD). In the last decade, illicit use of methylphenidate has increased among healthy young adults, who consume the drug under the assumption that it will improve cognitive performance.
Lingyun Zhi a,b,c,1, Fuping Zhang a,c,1, Huanhuan Liu a,c, Xinhui Jiang a,c, Yunfei Zhang b,c, Qianling Yang a,c, Xinyue Zhang a,c, Mengke Liu b,c, Zhaohui Zhang b,*, Jinggui Song
doi : 10.1016/j.bbr.2022.114104
Volume 437, 2 February 2023, 114104
Post-stroke depression (PSD) is a common neuropsychiatric complication of stroke, which seriously affects the quality of life and prognosis of patients. Nevertheless, the pathogenesis of PSD remains unclear.
Kelsey R. Sewell a,*, Stephanie R. Rainey-Smith a,b,c,d, Victor L. Villemagne b,e,f,g, Jeremiah Peiffer a, Hamid R. Sohrabi a,b,c,h, Kevin Taddei b,c, David Ames i,j,k, Vincent Dor �e g, Paul Maruff i,l, Simon M. Laws e,m,n, Colin L. Masters i, Christopher C. Rowe g,i, Ralph N. Martins b,c,h, Kirk I. Erickson o, Belinda M. Brown
doi : 10.1016/j.bbr.2022.114108
Volume 437, 2 February 2023, 114108
Lifestyle factors such as physical activity and optimal sleep are associated with better cognition and lower levels of Alzheimer’s disease (AD) biomarkers, including brain beta-amyloid (Aβ) burden.
Samantha M. Smith a,c, Elena L. Garcia a, Caroline G. Davidson a, John J. Thompson a, Sarah D. Lovett a, Nedi Ferekides a, Quinten Federico a, Argyle V. Bumanglag a, Abbi R. Hernandez d, Jose F. Abisambra a,e, Sara N. Burke
doi : 10.1016/j.bbr.2022.114106
Volume 437, 2 February 2023, 114106
Approximately 60–70 million people suffer from traumatic brain injury (TBI) each year. Animal models continue to be paramount in understanding mechanisms of cellular dysfunction and testing new treatments for TBI.
Sadegh Moradi Vastegani a, Seyed Esmaeil Khoshnam a, Esrafil Mansouri b, Somayeh Hajipour a, Samireh Ghafouri a,c, Nima Bakhtiari d, Alireza Sarkaki a,c,*, Yaghoob Farbood
doi : 10.1016/j.bbr.2022.114100
Volume 437, 2 February 2023, 114100
Non-motor symptoms (NMS) have high prevalence in patients with Parkinson’s disease (PD). These symptoms are mainly the result of increased oxidative stress and neuronal damage.
Saskia Th �er`ese Schirmer a, Fienne-Elisa Beckmann a, Hanna Gruber a, Konstantin Schlaaff a, Denise Scheermann c, Stephanie Seidenbecher a, Coraline Danielle Metzger a, Claus Tempelmann c, Thomas Frodl
doi : 10.1016/j.bbr.2022.114098
Volume 437, 2 February 2023, 114098
Childhood trauma (CT) increases vulnerability for the development of major depressive disorder (MDD). Alterations in resting-state functional connectivity (RSFC) have frequently been reported for MDD.
Bryan D. Alvarez , Cheyenne A. Morales , Brandon L. Oliver , Cassandra Cavazos , Leslie R. Amodeo *, Dionisio A. Amodeo
doi : 10.1016/j.bbr.2022.114111
Volume 437, 2 February 2023, 114111
Autism spectrum disorder (ASD) presents with two core symptoms, impairments in social communication and the presence of restricted, repetitive behaviors (RRBs). RRBs are commonly linked to a lack of behavioral flexibility, having a significant negative impact on daily functioning for ASD individuals and their caregivers.
Xiaoju Wang 1, Peng Xia 1, Jiulong Song , Ting Yang , Changjun Yu , Kai Cheng , Anliang Chen , Xueping Li
doi : 10.1016/j.bbr.2022.114117
Volume 437, 2 February 2023, 114117
To elucidate whether cranial electrotherapy stimulation (CES) improves depression-like behavior of post-stroke depression (PSD) via regulation of glutathione peroxidase 4 (GPX4)-mediated brain-derived neurotrophic factor (BDNF) expression.
Gabriela Bielecka-Papierz a,*, Anna Serefko b,*, Aleksandra Szopa b, Sylwia Talarek c, Andrzej Wr �obel d, Bernadeta Szewczyk e, Maria Radziwo �n-Zaleska f, Małgorzata Kołtun-Jasion g, Ewa Poleszak
doi : 10.1016/j.bbr.2022.114103
Volume 437, 2 February 2023, 114103
Mephedrone, a popular psychostimulating substance widely used illegally in recreational purposes, exerts in rodents that regularly and intermittently were exposed to it a sensitized response to the drug. Behavioral sensitization is one of experimental models of drug dependency/abuse liability.
S.V. Solntseva 1, V.P. Nikitin 2, S.A. Kozyrev 3, P.V. Nikitin
doi : 10.1016/j.bbr.2022.114118
Volume 437, 2 February 2023, 114118
The study of the amnesia mechanisms is of both theoretical and practical importance. The mechanisms of anterograde amnesia are the least studied, due to the lack of an experimental model that allows studying this amnesia type molecular and cellular mechanisms.
Kyosuke Shiga a,*, Shota Miyaguchi b, Yasuto Inukai b, Naofumi Otsuru b, Hideaki Onishi
doi : 10.1016/j.bbr.2022.114110
Volume 437, 2 February 2023, 114110
Various situations in our everyday life call for response inhibition, mechanisms deputed to outright stop an ongoing course of action. This function reportedly involves the activity of the right intraparietal sulcus (rIPS).
Jared W. Young a,b,*,1, Johnny A. Kenton a,1, Morgane Milienne-Petiot a, Debbie Deben a,c, Cristian Achim a, Mark A. Geyer a,b, William Perry a, Igor E. Grant a,b,c,d, Arpi Minassian a,d, TMARC
doi : 10.1016/j.bbr.2022.114109
Volume 437, 2 February 2023, 114109
Human immunodeficiency virus (HIV) continues to infect millions worldwide, negatively impacting neurobehavioral function. Further understanding of the combined effects of HIV and methamphetamine use is crucial, as methamphetamine use is prevalent in people with HIV.
Batoul Mirbolouk a,1, Kambiz Rohampour a,b,1, Mohammad Rostampour a,b, Adele Jafari a, Behrooz Khakpour-Taleghani
doi : 10.1016/j.bbr.2022.114123
Volume 437, 2 February 2023, 114123
Depression is a devastating mood disorder affecting more than 300 million people worldwide. Almost 30Â % of patients still suffer from treatment resistant depression.
Yafei Kang a, Youming Zhang b, Kexin Huang c,*, Zhenhong Wang
doi : 10.1016/j.bbr.2022.114124
Volume 437, 2 February 2023, 114124
The D3 dopamine receptor (DRD3) plays a major role in cognitive function and is a candidate gene for schizophrenia.
Angela Saadat a,*, Ashley Blackwell b,c, Cortney Kaszowski a, Haree Pallera a, Daley Owens a, Frank Lattanzio d, Tushar Shah
doi : 10.1016/j.bbr.2022.114119
Volume 437, 2 February 2023, 114119
Neonatal hypoxic ischemic encephalopathy (HIE) is a neurological disease caused by restricted oxygen and blood flow to the brain at or around the time of birth.
Marie Martel *, Scott Glover
doi : 10.1016/j.bbr.2022.114125
Volume 437, 2 February 2023, 114125
The Motor-Cognitive model suggests a functional dissociation between motor imagery and overt action, in contrast to the Functional Equivalence view of common processes between the two behaviours.
Marie-Line Fournier , Ang �elique Faugere , Olga Barba-Vila , Catherine Le Moine
doi : 10.1016/j.bbr.2022.114122
Volume 437, 2 February 2023, 114122
Gender differences have been observed in the vulnerability to drug abuse and in the different stages of the addictive process. In opiate dependence, differences between sexes have been shown in humans and laboratory animals in various phases of opiate addiction, especially in withdrawal-associated negative affective states.
Yuyang Wang a,b,c,1, Yuwei Zhou d,1, Xinyu Zhang e, Kai Wang c,d, Xingui Chen c,d,*, Hongwei Cheng
doi : 10.1016/j.bbr.2022.114133
Volume 437, 2 February 2023, 114133
The incomplete understanding of mild traumatic brain injury (MTBI)-related cognitive impairment in the acute stage and the low cognitive needs of patients in the later stage might be the main reasons for the neglect of clinical symptoms in patients with MTBI.
Zhihao Zhu a, Hongwei Wang b, Hui Bi b, Jidong Lv a, Xiaotong Zhang c, Suhong Wang d,*, Ling Zou
doi : 10.1016/j.bbr.2022.114121
Volume 437, 2 February 2023, 114121
Patients with attention-deficit/hyperactivity disorder (ADHD) have shown abnormal functional connectivity and network disruptions at the whole-brain static level.
Carlos M. Contreras a,*,1, Ana G. Guti Ì�errez-GarcÃa
doi : 10.1016/j.bbr.2022.114146
Volume 437, 2 February 2023, 114146
Some diabetes patients develop depression, the main treatment for which is antidepressants. Pharmacological interactions between insulin and antidepressants (e.g., fluoxetine) are controversial in the literature.
D.E. Kirsch a,b,c,*, V. Le a, R. Kosted a, K. Fromme b,d, E.T.C. Lippard
doi : 10.1016/j.bbr.2022.114148
Volume 437, 2 February 2023, 114148
Using balanced placebo designs, seminal alcohol administration research has shown individuals’ beliefs about whether they have consumed alcohol, irrespective of the actual presence of alcohol, can determine level of alcohol consumption and impact social behavior.
Hsin-Yung Chen a,b, Chia-Yen Yang c, Tsung-Hsun Hsieh d,e,f, Chih-Wei Peng g, Li-Ling Chuang d,h, Ying-Ling Chang i,j, Huang-Ju Chi b, Hsin-Min Lee k,*, Sophie Hsin-Yi Liang
doi : 10.1016/j.bbr.2022.114145
Volume 437, 2 February 2023, 114145
Behavioral flexibility (or set-shifting), which is regulated by the prefrontal cortex (PFC), is often impaired in patients with attention-deficit/hyperactivity disorder (ADHD), which is characterized by poor inhibitory control and reinforcement learning.
Mohammad Amin Sadeghi a,b, Sara Hemmati c,d, Hasan Yousefi-Manesh c,d, Saba Fekrvand c,d, Laleh Foroutani c,d, Ehsan Nassireslami a,b, Mojtaba Yousefi Zoshk e,f, Yasaman Hosseini g, Ahmad Reza Dehpour c,d, Mohsen Chamanara
doi : 10.1016/j.bbr.2022.114128
Volume 437, 2 February 2023, 114128
While SSRIs are the current first-line pharmacotherapies against post-traumatic stress disorder (PTSD), they suffer from delayed onset of efficacy and low remission rates.
Huaxing Ou a,b, Jiaxin Tang a,b, Guanlong Guo a,b, Mengwen Shi a,b, Chengmei Yang a,b, Weihai Chen
doi : 10.1016/j.bbr.2022.114127
Volume 437, 2 February 2023, 114127
The 5-hydroxytryptamine 2A (5-HT2A) receptor plays an important role in schizophrenia. The 5-HT2A receptor is also involved in the regulation of prepulse inhibition (PPI) in rodents.
Jessica Rosa a,c,*, Jociane de Carvalho Myskiw a,b,d, Natalia Gindri Fiorenza a,e, Cristiane Regina Guerino Furini a,b,f, Gerson Guilherme Sapiras a,g, Ivan Izquierdo
doi : 10.1016/j.bbr.2022.114129
Volume 437, 2 February 2023, 114129
Evidence has demonstrated the hippocampal cholinergic system and the mammalian target of rapamycin (mTOR) participation during the memory formation of aversive events.
Kevin T. Murphy a, Justin Camenzuli a, Sarah J. Myers b, Shawn N. Whitehead b, Nagalingam Rajakumar b, C.W. James Melling
doi : 10.1016/j.bbr.2022.114130
Volume 437, 2 February 2023, 114130
This study examined the impact of Type 1 Diabetes Mellitus (T1DM) on executive function using a series of operant conditioning-based tasks in rats. Sprague Dawley rats were randomized to either non-diabetic (n = 12; 6 male) or diabetic (n = 14; 6 male) groups.
Minwoo Lee a, Adriana Lori b, Nicole A. Langford b,f, James K. Rilling
doi : 10.1016/j.bbr.2022.114144
Volume 437, 2 February 2023, 114144
Accurate perception of genuine vs. posed smiles is crucial for successful social navigation in humans. While people vary in their ability to assess the authenticity of smiles, little is known about the specific biological mechanisms underlying this variation.
Kelsey E. Schultz a,b,e,*, Bryan Mantell c, Elliot T. Berkman c,d, Nicole C. Swann
doi : 10.1016/j.bbr.2022.114120
Volume 437, 2 February 2023, 114120
Models of addiction have identified deficits in inhibitory control, or the ability to inhibit inappropriate or unwanted behaviors, as one factor in the development and maintenance of addictive behaviors.
Luis Romero-Morales a, Brenda GarcÃa-Saucedo a, MartÃn MartÃnez-Torres a, Mario C Ì�ardenas b, Ren Ì�e C Ì�ardenas-V Ì�azquez c, Juana Luis
doi : 10.1016/j.bbr.2022.114153
Volume 437, 2 February 2023, 114153
According to approach-avoidance model, virgin female laboratory rats display maternal behaviour when the tendency to approach and interact with the pup is stronger than avoiding it.
Ruiqi Pang a,b, Sumei Yan b, Yunfeng Tu c, Shaowen Qian b, Haipeng Yu a,b, Xianli Hu b, Huizhong Wen b, Wei Yuan d, Xing Wang c, Yi Zhou
doi : 10.1016/j.bbr.2022.114149
Volume 437, 2 February 2023, 114149
Hearing abnormalities are important symptoms of autism spectrum disorders (ASDs), a neurological and developmental disorder. However, the characteristics of hearing abnormalities associated with ASD during development have not been fully investigated.
Jesús Adri Ì�an-Ventura a,b,1, Jaime Fabregat-Nab Ì�as a,1, VÃctor Costumero a, C Ì�esar Ì�Avila
doi : 10.1016/j.bbr.2022.114152
Volume 437, 2 February 2023, 114152
Reinforcement sensitivity theory (RST) of personality establishes the punishment sensitivity trait as a source of variation in defensive avoidance/approach behaviors. These individual differences reflect dissimilar sensitivity and reactivity of the fight-flight-freeze and behavioral inhibition systems (FFFS/BIS).
Marjan Nikbakhtzadeh , Ghorbangol Ashabi , Mansoor Keshavarz , Esmail Riahi
doi : 10.1016/j.bbr.2022.114159
Volume 437, 2 February 2023, 114159
It has been shown that high-frequency deep brain stimulation (DBS) of the lateral hypothalamus (LH) prevents morphine-induced conditioned place preference (CPP) in rats.
Thays Martins Vital da Silva a,b, Angelica Miki Stein b,c,d,*, Fl �avia Gomes de Melo Coelho b, Andre Veloso Rueda e, Rosana Camarini e, Ruth Ferreira Galdur �oz
doi : 10.1016/j.bbr.2022.114126
Volume 437, 2 February 2023, 114126
Vascular endothelial growth factor (VEGF) and platelets seem to reflect the Alzheimer’s disease (AD) associated either with vascular impairment or disease. This study aimed to compare the circulating levels of VEGF and platelets between AD patients and healthy older adults.
Nicole L. Zabik a,b,c, Craig Peters a, Allesandra Iadipaolo a, Hilary A. Marusak b,c,d, Christine A. Rabinak
doi : 10.1016/j.bbr.2022.114154
Volume 437, 2 February 2023, 114154
Pavlovian conditioning paradigms model the learned fear associations inherent in posttraumatic stress disorder, including the renewal of inappropriate fear responses following extinction learning.
Jing Wu a, Binhong Yan b, Mengyi Bao a, Jue Shen c, Peilei Zheng b, Dian Wu a, Jiangping Wang a, Zhongxia Li d, Kewen Jiang
doi : 10.1016/j.bbr.2022.114160
Volume 437, 2 February 2023, 114160
Anxiety is a common emotional disorder in children. To understand its underlying mechanisms, chronic unpredictable stress (CUS) has been established as a stress model in zebrafish.
O.O. Akintoye a,*, A.J. Ajibare a, M.A. Folawiyo a, H.O. Jimoh-Abdulghaffaar b, A. Asuku d, G.A. Owolabi a, K.T. Babalola
doi : 10.1016/j.bbr.2022.114163
Volume 437, 2 February 2023, 114163
Sodium benzoate (SB) is a commonly-used food preservative, with a controversial report to its neurological benefit and toxicity. Zinc (Zn) is a trace element that plays a crucial role in memory, inflammation and oxidative stress.
Courtney K. Broadfoot a,b,*, Charles Lenell d, Cynthia A. Kelm-Nelson b, Michelle R. Ciucci
doi : 10.1016/j.bbr.2022.114157
Volume 437, 2 February 2023, 114157
Vocal communication, cognition, and affective state are key features of sustained health and wellness, and because vocalizations are often socially-motivated, social experience likely plays a role in these behaviors.
Carles Tapias-Espinosa a,*, Ana S �anchez-Gonz �alez a, Toni Ca ̃nete a, Daniel Sampedro-Viana a, Maria del Mar Castillo-Ruiz b, Ignasi Oliveras a, Adolf Tobe ̃na a, Susana Aznar c,d,**, Alberto Fern �andez-Teruel
doi : 10.1016/j.bbr.2022.114113
Volume 437, 2 February 2023, 114113
Prepulse inhibition (PPI) allows assessing schizophrenia-like sensorimotor gating deficits in rodents. Previous studies indicate that PPI is modulated by the medial prefrontal cortex (mPFC), which is in agreement with our findings showing that PPI differences in the Roman rats are associated with divergences in mPFC activity.
Lauren E. Bleakley a,1, Ryan J. Keenan a,1,2, Rachel D. Graven a, Jeremy A. Metha a,b,c, Sherie Ma d, Heather Daykin a,b, Linda Cornthwaite-Duncan a,b, Daniel Hoyer a,b,e, Christopher A. Reid a,f,*, Laura H. Jacobson
doi : 10.1016/j.bbr.2022.114105
Volume 437, 2 February 2023, 114105
Sleep is a complex biological state characterized by large populations of neurons firing in a rhythmic or synchronized manner. HCN channels play a critical role in generating and sustaining synchronized neuronal firing and are involved in the actions of anaesthetics.
Elizabeth DiLiberto a,c,d, Shwetha Phatarpekar a,b, Kelly Theodorakis a,c,d, Kathryn K. Chadman
doi : 10.1016/j.bbr.2022.114132
Volume 437, 2 February 2023, 114132
Autism spectrum disorder (ASD) is characterized by deficits in social communication and repetitive behaviors/restricted interests. One mouse model of ASD is the BTBR T+ Itprtf/J (BTBR) mice which display low levels of social behavior in several tests.
Hassina Belblidia a,b, Thomas Freret a, Marianne Leger a, Pascale Schumann-Bard
doi : 10.1016/j.bbr.2022.114151
Volume 437, 2 February 2023, 114151
Temporal order memory refers to the ability to remember the order of occurrence of items across time.
Arjan Blokland a,c,*, Thibaut Sesia
doi : 10.1016/j.bbr.2022.114161
Volume 437, 2 February 2023, 114161
The object recognition and object location task (ORT and OLT, respectively) have been applied in preclinical research to evaluate the effects of treatments on memory.
Rima Atria Japarin a, Nurul Hasnida Yusoff a, Zurina Hassan a, Christian P. Müller b, Norsyifa Harun
doi : 10.1016/j.bbr.2022.114155
Volume 437, 2 February 2023, 114155
Barry Setlowa,c,d,*, Jennifer L. Bizon
doi : 10.1016/j.bbr.2022.114147
Volume 437, 2 February 2023, 114147
Shane N. Glackina,*, Serge Ahmed
doi : 10.1016/j.bbr.2022.114134
Volume 437, 2 February 2023, 114134
Ekrem Derea,b,*, Armin Zlomuzica
doi : 10.1016/j.bbr.2022.114166
Volume 437, 2 February 2023, 114166
Renzo C. Lanfranco a,b,*, Hugh Rabagliati a, David Carmel
doi : 10.1016/j.bbr.2022.114116
Volume 437, 2 February 2023, 114116
Human faces convey essential information for understanding others’ mental states and intentions.
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