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Identification and confirmation of 14-3-3 ? as a novel target of ginsenosides in brain tissues
FeiyanChenab1LinChend1WeifengLiangbZhengguangZhangbJiaoLibWanZhengbZhuZhueJiapengZhubYunanZhaoc
doi : 10.1016/j.jgr.2020.12.007
Volume 45, Issue 4, July 2021, Pages 465-472
Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Ginsenosides are the major effective compounds of Ginseng, but their protein targets in the brain have not been determined.
Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide
Kenneth Kin LeungKwanabHuangYunabTina Ting XiaDongabKarl Wah KeungTsimab
doi : 10.1016/j.jgr.2020.09.005
Volume 45, Issue 4, July 2021, Pages 473-481
Mitochondrial dysfunction is one of the significant reasons for Alzheimer's disease (AD). Ginsenosides, natural molecules extracted from Panax ginseng, have been demonstrated to exert essential neuroprotective functions, which can ascribe to its anti-oxidative effect, enhancing central metabolism and improving mitochondrial function. However, a comprehensive analysis of cellular mitochondrial bioenergetics after ginsenoside treatment under A?-oxidative stress is missing.
Korean Red Ginseng affects ovalbumin-induced asthma by modulating IL-12, IL-4, and IL-6 levels and the NF-?B/COX-2 and PGE2 pathways
Soon-YoungLeea1Min-HeeKimb1Seung-HyunKimcTaehoAhncSung-WonKimdYi-SeongKwakdIk-HyunChoeSeung-YeolNahfSeung-SikChogKyung MokParkaDae-HunParkaChun-SikBaec
doi : 10.1016/j.jgr.2020.10.001
Volume 45, Issue 4, July 2021, Pages 482-489
Asthma is an incurable hyper-responsive disease of the pulmonary system that is caused by various allergens, including indoor and outdoor stimulators. According to the Global Asthma Network, 339 million people suffered from asthma in 2018, with particularly severe forms in children. Numerous treatments for asthma are available; however, they are frequently associated with adverse effects such as growth retardation, neurological disorders (e.g., catatonia, poor concentration, and insomnia), and physiological disorders (e.g., immunosuppression, hypertension, hyperglycemia, and osteoporosis).
Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and ?IIb?3 activation
Jung-HaeShina1Hyuk-WooKwonb1MuhammadIrfancdMan HeeRheecDong-HaLeeef
doi : 10.1016/j.jgr.2020.11.001
Volume 45, Issue 4, July 2021, Pages 490-497
Synthetic ginsenoside compounds G-Rp (1,3, and 4) and natural ginsenosides in Panax ginseng 20(S)-Rg3, Rg6, F4 and Ro have inhibitory actions on human platelets. However, the inhibitory mechanism of ginsenoside Rk1 (G-Rk1) is still unclear thus, we initiated investigation of the anti-platelet mechanism by G-Rk1 from Panax ginseng.
Red ginseng oil promotes hair growth and protects skin against UVC radiation
Van-LongTruongacYoung-SamKeumbWoo-SikJeongac
doi : 10.1016/j.jgr.2020.12.008
Volume 45, Issue 4, July 2021, Pages 498-509
A wide range of environmental factors, such as diseases, nutritional deficiencies, ageing, hormonal imbalances, stress, and ultraviolet (UV) radiation, may affect the structure and function of the skin that covers the entire surface of the human body. In this study, we investigated roles of red ginseng oil (RGO) in enhancing skin functions, including hair growth and skin protection, using mouse models.
Inhibitory activity of gintonin on inflammation in human IL-1?-stimulated fibroblast-like synoviocytes and collagen-induced arthritis in mice
MijinKimaBongjunSuraTheaVillaaSeung YeolNahbSeikwanOha
doi : 10.1016/j.jgr.2020.12.001
Volume 45, Issue 4, July 2021, Pages 510-518
Gintonin is a newly derived glycolipoprotein from the roots of ginseng. The purpose of this study is to investigate the anti-arthritic efficacy of Gintonin on various proteases and inflammatory mediators that have an important role in arthritis.
Enhancement of seed germination and microbial disinfection on ginseng by cold plasma treatment
YounmiLeeabYoung YoonLeeaYoung SooKimaKotnalaBalarajubYoung SunMokcSuk JaeYoodYonghoJeona
doi : 10.1016/j.jgr.2020.12.002
Volume 45, Issue 4, July 2021, Pages 519-526
This study aimed to investigate the effect of cold plasma treatment on the improvement of seed germination and surface sterilization of ginseng seeds.
Phenological growth stages of Korean ginseng (Panax ginseng) according to the extended BBCH scale
Yun-SooKimChol-SooParkDong-YunLeeJoon-SooLeeSeung-HwanLeeJun-GyoInTae-KyunHong
doi : 10.1016/j.jgr.2020.12.006
Volume 45, Issue 4, July 2021, Pages 527-534
Phenological studies are a prerequisite for accomplishing higher productivity and better crop quality in cultivated plants. However, there are no phenological studies on Panax ginseng that improve its production yield. This study aims to redefine the phenological growth stages of P. ginseng based on the existing Biologische Bundesanstalt, Bundessortenamt und Chemische Industrie (BBCH) scale and proposes a disease control reference.
Corona-Cov-2 (COVID-19) and ginseng: Comparison of possible use in COVID-19 and influenza
Won SikLeeDong-KwonRhee
doi : 10.1016/j.jgr.2020.12.005
Volume 45, Issue 4, July 2021, Pages 535-537
In the 1918 influenza pandemic, more than 95% of mortalities were ascribed to bacterial pneumonia. After the primary influenza infection, the innate immune system is attenuated, and the susceptibility to bacteria is increased. Subsequent bacterial pneumonia exacerbates morbidity and increases the mortality rate. Similarly, COVID-19 infection attenuates innate immunity and results in pneumonia. In addition, the current pneumococcal conjugate vaccine may have limited defense against secondary pneumococcal infection after influenza infection. Therefore, until a fully protective vaccine is available, a method of increasing immunity may be helpful. Ginseng has been shown to increase the defense against influenza in clinical trials and animal experiments, as well as the defense against pneumococcal pneumonia in animal experiments. Based on these findings, ginseng is suspected to be helpful for providing immunity against COVID-19.
