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Thiazides in chronic kidney disease: “back to the future�
Rafael de la Espriella, Marta Cobo, Julio Núñez
doi : 10.1093/ckj/sfac228
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 1–4
The thiazide class diuretics are first-line agents for managing hypertension either as monotherapy or as a fixed-dose combination with other antihypertensive drugs
Intradialytic parenteral nutrition for patients on hemodialysis: when, how and to whom?
Juan J Carrero, David Severs, Didier Aguilera, Enrico Fiaccadori, Martin G Gonzalez, Christoph C Haufe, Daniel Teta, Pablo Molina, Wesley Visser
doi : 10.1093/ckj/sfac171
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 5–18
Hemodialysis is associated with high morbidity and mortality rates as well as low quality of life. Altered nutritional status and protein-energy wasting are important indicators of these risks.
From cardiorenal syndromes to cardionephrology: a reflection by nephrologists on renocardiac syndromes
Borja Quiroga, Alberto Ortiz, Juan F Navarro-González, Rafael SantamarÃa, Patricia de Sequera, Javier DÃez
doi : 10.1093/ckj/sfac113
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 19–29
Cardiorenal syndromes (CRS) are broadly defined as disorders of the heart and kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other.
Alleviating symptoms in patients undergoing long-term hemodialysis: a focus on chronic kidney disease-associated pruritus
Rajiv Agarwal, James Burton, Maurizio Gallieni, Kamyar Kalantar-Zadeh, Gert Mayer, Carol Pollock, Jacek C Szepietowski
doi : 10.1093/ckj/sfac187
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 30–40
Since the breakthrough of kidney replacement therapy, increases in life expectancy for patients with end-stage kidney disease have been limited.
Thiazide diuretics are back in CKD: the case of chlorthalidone
Roberto Minutolo, Luca De Nicola, Francesca Mallamaci, Carmine Zoccali
doi : 10.1093/ckj/sfac198
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 41–51
Sodium and volume excess is the fundamental risk factor underlying hypertension in chronic kidney disease (CKD) patients, who represent the prototypical population characterized by salt-sensitive hypertension.
SGLT-2 inhibitors in nephrotic-range proteinuria: emerging clinical evidence
Zeynepgul Kalay, Ozgun E Sahin, Sidar Copur, Senem Danacı, Alberto Ortiz, Kevin Yau, David Z I Cherney, Mehmet Kanbay
doi : 10.1093/ckj/sfac189
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 52–60
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are a class of novel oral anti-hyperglycemic agents which are increasingly used in clinical practice.
Regional variation in tolvaptan prescribing across England: national data and retrospective evaluation from an expert centre
Jiehan Chong, Tess Harris, Albert C M Ong
doi : 10.1093/ckj/sfac190
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 61–68
Tolvaptan, a vasopressin V2 receptor antagonist, was approved in 2015 by the UK National Institute for Health and Care Excellence for use in patients with autosomal dominant polycystic kidney disease (ADPKD) and rapid disease progression.
Mesenteric elasticity assessed by shear wave elastography and its relationship with peritoneal function in peritoneal dialysis patients
Xiangwen Diao, Yujun Chen, Jianxiong Lin, Ming Xu, Peiyi Cao, Yuan Peng, Haishan Wu, Qunying Guo, Fengxian Huang, Haiping Mao, Xueqing Yu, Xiaoyan Xie, Xiao Yang
doi : 10.1093/ckj/sfac192
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 69–77
We evaluated the mesenteric elasticity in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) using shear wave elastography (SWE) and investigated its relationships with peritoneal function.
Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity
I-Wen Wu, Yi-Lun Wu, Huang-Yu Yang, Cheng-Kai Hsu, Lun-Ching Chang, Yuh-Ching Twu, Ya-Ling Chang, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
doi : 10.1093/ckj/sfac196
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 78–89
Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood.
The use of plasma biomarker-derived clusters for clinicopathologic phenotyping: results from the Boston Kidney Biopsy Cohort
Insa M Schmidt, Steele Myrick, Jing Liu, Ashish Verma, Anand Srivastava, Ragnar Palsson, Ingrid F Onul, Isaac E Stillman, Claire Avillach, Prasad Patil, Sushrut S Waikar
doi : 10.1093/ckj/sfac202
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 90–99
Protein biomarkers may provide insight into kidney disease pathology but their use for the identification of phenotypically distinct kidney diseases has not been evaluated.
Renal involvement is frequent in adults with primary mitochondrial disorders: an observational study
Hugo Bakis, Aurélien Trimouille, Agathe Vermorel, Cyril Goizet, Yaniss Belaroussi, Sacha Schutz, Guilhem Solé, Christian Combe, Marie-Laure Martin-Negrier, Claire Rigothier
doi : 10.1093/ckj/sfac195
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 100–110
Mitochondrial functions are controlled by genes of both mitochondrial and nuclear DNA. Pathogenic variants affecting any of these are responsible for primary mitochondrial disorders (MIDs), which can be diagnosed during adulthood.
Twenty years of real-world data to estimate chronic kidney disease prevalence and staging in an unselected population
Carla Santos-Araújo, LuÃs Mendonça, Daniel Seabra Carvalho, Filipa Bernardo, Marisa Pardal, João Couceiro, Hugo Martinho, Cristina Gavina, Tiago Taveira-Gomes, Ricardo Jorge Dinis-Oliveira
doi : 10.1093/ckj/sfac206
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 111–124
Chronic kidney disease (CKD) represents a global public health burden, but its true prevalence is not fully characterized in the majority of countries.
Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders
Dries Deleersnijder, Wim Laurens, Johan De Meester, Evert Cleenders, Amélie Dendooven, Evelyne Lerut, An S De Vriese, Tom Dejagere, Mark Helbert, Rachel Hellemans, Priyanka Koshy, Bart Maes, Lissa Pipeleers, Amaryllis H Van Craenenbroeck, Steven Van Laecke, Johan Vande Walle, Marie M Couttenye, Gert Meeus, Ben Sprangers, the FCGG collaborative group
doi : 10.1093/ckj/sfac208
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 125–137,
The Flemish Collaborative Glomerulonephritis Group (FCGG) registry provides complete population data on kidney disease epidemiology in the region of Flanders (Belgium), as it captures all native kidney biopsies performed in its population of 6.5 million inhabitants.
Pregnancy in women on chronic dialysis in the last decade (2010–2020): a systematic review
Hayet Baouche, Jean-Philippe Jais, Samy Meriem, Mimi Kareche, Olivier Moranne, Cécile Vigneau, Cécile Couchoud
doi : 10.1093/ckj/sfac204
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 138–150
Pregnant women with end-stage renal disease on chronic dialysis are at a high risk of maternal and foetal complications. Over the years, the prognosis of their pregnancies has improved with advances in dialysis treatments and maternal and neonatal care.
A Phase 1, open-label, crossover study evaluating the effect of a single dose of sodium zirconium cyclosilicate on the pharmacokinetics of tacrolimus and cyclosporin
Mats Någård, Nurul Choudhury, Ayman Al-Shurbaji, Vera Lisovskaja, Neil Mackillop
doi : 10.1093/ckj/sfac205
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 151–158
Sodium zirconium cyclosilicate (SZC) is an oral, highly selective potassium binder approved for the treatment of hyperkalaemia in adults. SZC may change the absorption of co-administered drugs that exhibit pH-dependent bioavailability.
Microemboli induced by air bubbles may be deposited in organs as a consequence of contamination during medical care
Ulf Forsberg, Per Jonsson, Bernd Stegmayr
doi : 10.1093/ckj/sfac217
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 159–166,
Larger volumes of accidental air infused during medical care may end up as emboli while microbubbles of air are supposed to be absorbed and cause no harm.
Low BMI and high waist-to-hip ratio are associated with mortality risk among hemodialysis patients: a multicenter prospective cohort study
Yaya Yang, Haixia Zhang, Xiaolei Lan, Xianhui Qin, Yan Huang, Jieyu Wang, Pei Luo, Zhen Wen, Yumin Li, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Junzhi Chen, Zihan Lei, Yanhuan He, Zizhen Lin, Youbao Li, Min Liang
doi : 10.1093/ckj/sfac210
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 167–175
Data are limited on the relationship between waist-to-hip ratio (WHR) and mortality risk among maintenance hemodialysis (MHD) patients.
Patiromer utilization in patients with advanced chronic kidney disease under nephrology care in Germany
Roberto Pecoits-Filho, Keith McCullough, Daniel Muenz, Carol Moreno Quinn, Jeff Budden, John Golden, Antonio Ramirez de Arellano, Frank-Peter Tillmann, Johannes Duttlinger, Viviane Calice-Silva, Ziad A Massy, Brian Bieber, Bruce M Robinson, Danilo Fliser, Helmut Reichel, CKDopps Investigators*
doi : 10.1093/ckj/sfac209
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 176–183
Hyperkalemia (HK) is a frequent condition in patients with chronic kidney disease (CKD) that is associated with high morbidity and mortality. Patiromer has recently been introduced as a potassium binder.
Zonulin, as a marker of intestinal permeability, is elevated in IgA nephropathy and IgA vasculitis with nephritis
Qianqian Li, Xiaohan Yuan, Sufang Shi, Lijun Liu, Jicheng Lv, Li Zhu, Hong Zhang
doi : 10.1093/ckj/sfac214
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 184–191
Immunoglobulin A nephropathy (IgAN) and IgA vasculitis with nephritis (IgAV-N) are considered related diseases and share some similar clinicopathologic phenotypes.
Hemizygous loss of function mutations in CLCN5 causing end-stage kidney disease without Dent disease phenotype
Gary Leggatt, Christine Gast, Rodney D Gilbert, Kristin Veighey, Tahmina Rahman, Sarah Ennis
doi : 10.1093/ckj/sfac127
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 192–194
Dent disease type 1 is suspected in the presence of a complete phenotype of low molecular weight (LMW) proteinuria, hypercalciuria and at least one of the following: nephrocalcinosis, nephrolithiasis, haematuria, hypophosphatemia or chronic kidney disease (CKD).
Type VI collagen-related nephropathy
Mutsuki Mori, Kan Katayama, Kensuke Joh, Eiji Ishikawa, Kaoru Dohi
doi : 10.1093/ckj/sfac126
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 195–196
The impact of Omicron on outcomes following infection with SARS-CoV-2 in patients with kidney failure in Scotland
Samira Bell, Jacqueline Campbell, Chrissie Watters, Martin O'Neil, Alison Almond, Katharine Buck, Edward J Carr, Zoe Cousland, Mark Findlay, Nicola Joss, Wendy Metcalfe, Elaine Spalding, Shona Methven, Patrick B Mark
doi : 10.1093/ckj/sfac173
Clinical Kidney Journal, Volume 16, Issue 1, January 2023, Pages 197–200
