Circulation

Harmony R. Reynolds, Akiko Maehara, Raymond Y. Kwong, Tara Sedlak, Jacqueline Saw, Nathaniel R. Smilowitz, Ehtisham Mahmud, Janet Wei, Kevin Marzo, Mitsuaki Matsumura, Ayako Seno, Anais Hausvater, Caitlin Giesler, Nisha Jhalani, Catalin Toma, Bryan Har, Dwithiya Thomas, Laxmi S. Mehta, Jeffrey Trost, Puja K. Mehta, Bina Ahmed, Kevin R. Bainey, Yuhe Xia, Binita Shah, Michael Attubato, Sripal Bangalore, Louai Razzouk, Ziad A. Ali, Noel Bairey Merz, Ki Park, Ellen Hada, Hua Zhong, Judith S. Hochman

doi : 10.1161/CIRCULATIONAHA.120.052008

Circulation. 2021;143:624–640

Myocardial infarction with nonobstructive coronary arteries (MINOCA) occurs in 6% to 15% of myocardial infarctions (MIs) and disproportionately affects women. Scientific statements recommend multimodality imaging in MINOCA to define the underlying cause. We performed coronary optical coherence tomography (OCT) and cardiac magnetic resonance (CMR) imaging to assess mechanisms of MINOCA.

خرید پکیج و مشاهده آنلاین مقاله

Gender-Based Differences in Outcomes Among Resuscitated Patients With Out-of-Hospital Cardiac Arrest

Purav Mody, Ambarish Pandey, Arthur S. Slutsky, Matthew W. Segar, Alex Kiss, Paul Dorian, Janet Parsons, Damon C. Scales, Valeria E. Rac, Sheldon Cheskes, Arlene S. Bierman, Beth L. Abramson, Sara Gray, Rob A. Fowler, Katie N. Dainty, Ahamed H. Idris, Laurie Morrison

doi : 10.1161/CIRCULATIONAHA.120.050427

Circulation. 2021;143:641–649

Studies examining gender-based differences in outcomes of patients experiencing out-of-hospital cardiac arrest have demonstrated that, despite a higher likelihood of return of spontaneous circulation, women do not have higher survival.

خرید پکیج و مشاهده آنلاین مقاله

Trends in Recurrent Coronary Heart Disease After Myocardial Infarction Among US Women and Men Between 2008 and 2017

Sanne A.E. Peters, Lisandro D. Colantonio, Yuling Dai, Hong Zhao, Vera Bittner, Michael E. Farkouh, Paul Dluzniewski, Bharat Poudel, Paul Muntner, Mark Woodward

doi : 10.1161/CIRCULATIONAHA.120.047065

Circulation. 2021;143:650–660

Rates for recurrent coronary heart disease (CHD) events have declined in the United States. However, few studies have assessed whether this decline has been similar among women and men.

خرید پکیج و مشاهده آنلاین مقاله

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy

Andrea M. Russo, Emily P. Zeitler, Anna Giczewska, Adam P. Silverstein, Hussein R. Al-Khalidi, Yong-Mei Cha, Kristi H. Monahan, Tristram D. Bahnson, Daniel B. Mark, Douglas L. Packer, Jeanne E. Poole, and For the CABANA Investigators

doi : 10.1161/CIRCULATIONAHA.120.051558

Circulation. 2021;143:661–672

Among patients with atrial fibrillation (AF), women are less likely to receive catheter ablation and may have more complications and less durable results. Most information about sex-specific differences after ablation comes from observational data. We prespecified an examination of outcomes by sex in the 2204-patient CABANA trial (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation).

خرید پکیج و مشاهده آنلاین مقاله

Comparison of the Efficacy and Safety Outcomes of Edoxaban in 8040 Women Versus 13 065 Men With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial

Thomas A. Zelniker, Maddalena Ardissino, Felicita Andreotti, Michelle L. O’Donoghue, Ophelia Yin, Jeong-Gun Park, Sabina A. Murphy, Christian T. Ruff, Hans J. Lanz, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano, Piera Angelica Merlini

doi : 10.1161/CIRCULATIONAHA.120.052216

Circulation. 2021;143:673–684

Female sex is an independent risk factor for stroke and systemic embolic events in patients with atrial fibrillation. This study aimed to examine the efficacy and safety profile of edoxaban in women versus men.

خرید پکیج و مشاهده آنلاین مقاله

Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials

Emily S. Lau, Eugene Braunwald, David A. Morrow, Robert P. Giugliano, Elliott M. Antman, C. Michael Gibson, Benjamin M. Scirica, Erin A. Bohula, Stephen D. Wiviott, Deepak L. Bhatt, Marc P. Bonaca, Christopher P. Cannon, KyungAh Im, Jianping Guo, Marc S. Sabatine, Michelle L. O’Donoghue

doi : 10.1161/CIRCULATIONAHA.120.052339

Circulation. 2021;143:685–695

Women are underrepresented across cardiovascular clinical trials. Whether women are more likely than men to prematurely discontinue study drug or withdraw consent once enrolled in a clinical trial is unknown.

خرید پکیج و مشاهده آنلاین مقاله

Adherence to Study Drugs

Sofia Sederholm Lawesson, Eva Swahn, Joakim Alfredsson

doi : 10.1161/CIRCULATIONAHA.121.053493

Circulation. 2021;143:696–698

خرید پکیج و مشاهده آنلاین مقاله

Cardiac Remodeling During Pregnancy With Metabolic Syndrome

Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser

doi : 10.1161/CIRCULATIONAHA.120.051264

Circulation. 2021;143:699–712

The heart undergoes physiological hypertrophy during pregnancy in healthy individuals. Metabolic syndrome (MetS) is now prevalent in women of child-bearing age and might add risks of adverse cardiovascular events during pregnancy. The present study asks if cardiac remodeling during pregnancy in obese individuals with MetS is abnormal and whether this predisposes them to a higher risk for cardiovascular disorders.

خرید پکیج و مشاهده آنلاین مقاله

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Robin J.G. Hartman, Katie Owsiany, Lijiang Ma, Simon Koplev, Ke Hao, Lotte Slenders, Mete Civelek, Michal Mokry, Jason C. Kovacic, Gerard Pasterkamp, Gary Owens, Johan L.M. Bj?rkegren, Hester M. den Ruijter

doi : 10.1161/CIRCULATIONAHA.120.051231

Circulation. 2021;143:713–726

Although sex differences in coronary artery disease are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology of such differences remains largely unknown. In coronary artery disease, recent integrative systems biological studies have inferred gene regulatory networks (GRNs). Within these GRNs, key driver genes have shown great promise but have thus far been unidentified in women.

خرید پکیج و مشاهده آنلاین مقاله

Maternal Stroke

Islam Y. Elgendy, Syed Bukhari, Amr F. Barakat, Carl J. Pepine, Kathryn J. Lindley, Eliza C. Miller, and On behalf of the American College of Cardiology Cardiovascular Disease in Women Committee

doi : 10.1161/CIRCULATIONAHA.120.051460

Circulation. 2021;143:727–738

Maternal mortality rates have been steadily increasing in the United States, and cardiovascular mortality is the leading cause of death among pregnant and postpartum women. Maternal stroke accounts for a significant burden of cardiovascular mortality. Data suggest that rates of maternal stroke have been increasing in recent years. Advancing maternal age at the time of birth and the increasing prevalence of traditional cardiovascular risk factors, and other risk factors, as well, such as hypertensive disorders of pregnancy, migraine, and infections, may contribute to increased rates of maternal stroke. In this article, we provide an overview of the epidemiology of maternal stroke, explore mechanisms that may explain increasing rates of stroke among pregnant women, and identify key knowledge gaps for future investigation in this area.

خرید پکیج و مشاهده آنلاین مقاله

Sex-Related Differences in Cardiac Channelopathies

Babken Asatryan, Lauren Yee, Yael Ben-Haim, Stephan Dobner, Helge Servatius, Laurent Roten, Hildegard Tanner, Lia Crotti, Jonathan R. Skinner, Carol Ann Remme, Philippe Chevalier, Argelia Medeiros-Domingo, Elijah R. Behr, Tobias Reichlin, Katja E. Odening, Andrew D. Krahn

doi : 10.1161/CIRCULATIONAHA.120.048250

Circulation. 2021;143:739–752

Sex-related differences in prevalence, clinical presentation, and outcome of cardiac channelopathies are increasingly recognized, despite their autosomal transmission and hence equal genetic predisposition among sexes. In congenital long-QT syndrome, adult women carry a greater risk for Torsades de pointes and sudden cardiac death than do men. In contrast, Brugada syndrome is observed predominantly in adult men, with a considerably higher risk of arrhythmic sudden cardiac death in adult men than in women. In both conditions, the risk for arrhythmias varies with age. Sex-associated differences appear less evident in other cardiac channelopathies, likely a reflection of their rare(r) occurrence and our limited knowledge. In several cardiac channelopathies, sex-specific predictors of outcome have been identified. Together with genetic and environmental factors, sex hormones contribute to the sex-related disparities in cardiac channelopathies through modulation of the expression and function of cardiac ion channels. Despite these insights, essential knowledge gaps exist in the mechanistic understanding of these differences, warranting further investigation. Precise application of the available knowledge may improve the individualized care of patients with cardiac channelopathies. Promoting the reporting of sex-related phenotype and outcome parameters in clinical and experimental studies and advancing research on cardiac channelopathy animal models should translate into improved patient outcomes. This review provides a critical digest of the current evidence for sex-related differences in cardiac channelopathies and emphasizes their clinical implications and remaining gaps requiring further research.

خرید پکیج و مشاهده آنلاین مقاله

Rising Prepregnancy Hypertension, Preeclampsia Disparities Raise Alarm

Bridget M. Kuehn

doi : 10.1161/CIRCULATIONAHA.120.053190

Circulation. 2021;143:753–754

خرید پکیج و مشاهده آنلاین مقاله

Temporal Trends in the Proportion of Women Physician Speakers at Major Cardiovascular Conferences

Celina M. Yong, Sowmya Balasubramanian, Pamela S. Douglas, Prachi Agarwal, Ulrika Birgersdotter-Green, Santosh Gummidipundi, Wayne Batchelor, Claire S. Duvernoy, Robert A. Harrington, Roxana Mehran

doi : 10.1161/CIRCULATIONAHA.120.052663

Circulation. 2021;143:755–757

خرید پکیج و مشاهده آنلاین مقاله

Sudden Cardiac Arrest in Young Women

Orianne Weizman, Ardalan Sharifzadehgan, Wulfran Bougouin, Kumar Narayanan, Noémie Tence, Florence Dumas, Victor Waldmann, Lionel Lamhaut, Daniel Jost, Karim Wahbi, Olivier Varenne, Rodrigue Garcia, Nicole Karam, Alain Cariou, Xavier Jouven, Eloi Marijon,

doi : 10.1161/CIRCULATIONAHA.120.052219

Circulation. 2021;143:758–760

خرید پکیج و مشاهده آنلاین مقاله

Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes

Hongwei Ji, Teemu J. Niiranen, Florian Rader, Mir Henglin, Andy Kim, Joseph E. Ebinger, Brian Claggett, C. Noel Bairey Merz, Susan Cheng

doi : 10.1161/CIRCULATIONAHA.120.049360

Circulation. 2021;143:761–763

خرید پکیج و مشاهده آنلاین مقاله

Regional Heterogeneity in the Coronary Vascular Response in Women With Chest Pain and Nonobstructive Coronary Artery Disease

Malik Elharram, Elizabeth Hillier, Selwynne Hawkins, Yoko Mikami, Bobak Heydari, Naeem Merchant, James A. White, Todd Anderson, Matthias G. Friedrich, Louise Pilote

doi : 10.1161/CIRCULATIONAHA.120.052520

Circulation. 2021;143:764–766

خرید پکیج و مشاهده آنلاین مقاله

Ten-Year Differences in Women’s Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association

Mary Cushman, Christina M. Shay, Virginia J. Howard, Monik C. Jiménez, Jennifer Lewey, Jean C. McSweeney, L. Kristin Newby, Ram Poudel, Harmony R. Reynolds, Kathryn M. Rexrode, Mario Sims, Lori J. Mosca, and On behalf of the American Heart Association

doi : 10.1161/CIR.0000000000000907

Circulation. 2021;143:e239–e248

High awareness that cardiovascular disease is the leading cause of death (LCOD) among women is critical to prevention. This study evaluated longitudinal trends in this awareness among women.

خرید پکیج و مشاهده آنلاین مقاله

Correction to: Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association

doi : 10.1161/CIR.0000000000000956

Circulation. 2021;143:e249

خرید پکیج و مشاهده آنلاین مقاله