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Interstitial Lung Disease, Intestinal Pseudo-obstruction, Biliary Tract Dilatation in a Patient with Sjogren’s Syndrome
Xiaojun Mai, Jiajia Wu, Shuping Cai, Xiuji Huang, Hui Li & Canmao Xie
doi : 10.1007/s10620-022-07702-6
Volume 68, issue 1, January 2023
Addiction Prescription: A Bridge Between Addiction Medicine and Digestive Diseases
Patrick A. Twohig, Nathalie Khoury, Kenneth A. Zoucha & Marco A. Olivera
Runaway Insufflation: Does Anesthesia or Spasm Hinder Insufflation During Colonoscopy?
Kenneth W. HungÂ
Surveillance of Non-advanced Adenomas: Small May Be Big
Xiang Liu & Joseph C. Anderson
Hepatocellular Carcinoma in Hemochromatosis: Where or When?
Paul C. Adams
Individualization of HCC and Portal Hypertension Surveillance in Patients with Compensated Advanced Chronic Liver Disease and SVR
Mattias Mandorfer
DDS Perspective: The Joy of Discovery and the Art of Mentoring
Juanita L. MerchantÂ
Professional Networking at Gastroenterology Scientific Meetings: A Trainee’s Practical Guide
Joseph Sleiman, Nikki Duong, Elizabeth S. Aby, Daniela Guerrero Vinsard, Rashmi Advani & Mohammad Bilal
Management of Short Bowel Syndrome (SBS) and Intestinal Failure
Mark Radetic, Amir Kamel, Mark Lahey, Michelle Brown & Anil Sharma
doi : 10.1007/s10620-022-07760-w
Short bowel syndrome (SBS) is a chronic disease whose natural history requires a changing array of management strategies over time.
Functional Implications and Clinical Potential of MicroRNAs in Irritable Bowel Syndrome: A Concise Review
Luis Alberto Bravo-Vázquez, Ixchel Medina-RÃos, Luis David Márquez-Gallardo, Josué Reyes-Muñoz, Francisco I. Serrano-Cano, Surajit Pathak, Antara Banerjee, Anindya Bandyopadhyay, Asim K. Duttaroy & Sujay Paul
doi : 10.1007/s10620-022-07516-6
MicroRNAs (miRNAs) are tiny (20–24 nucleotides long), non-coding, highly conserved RNA molecules that play a crucial role within the post-transcriptional regulation of gene expression via sequence-specific mechanisms.
A Dancer with Fractures: What Lies Beneath?
Samima Habbsa, Andrew Canakis, Lauren George, Afton Thomas, Yinin Hu, Raymond K. Cross & Hilary B. Whitlatch
Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence
Erica J. Brenner, Millie D. Long, Michael D. Kappelman, Xian Zhang, Robert S. Sandler & Edward L. Barnes
doi : 10.1007/s10620-022-07517-5
Medication adherence impacts disease control in inflammatory bowel disease (IBD). Existing adherence measures such as the Morisky Medication Adherence Scale 8© are often costly, non-medication-specific, and time-consuming.
Ustekinumab Is Associated with Real-World Long-Term Effectiveness and Improved Health-Related Quality of Life in Crohn's Disease
Anders Forss, Mark Clements, Pär Myrelid, Hans Strid, Charlotte Söderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, The PROSE SWIBREG study group, Ola Olén, Jonas Halfvarson & Jonas F. Ludvigsson
doi : 10.1007/s10620-022-07501-z
Prospectively and systematically collected long-term real-world clinical data on ustekinumab (anti-interleukin-12/23) are still scarce.
Overlooked Symptoms in Autoimmune Hepatitis Negatively Impact Many Facets of Life
Emma Jones, Margaret Watkins, Erin Anderson, Kayla Gelow, Kelsey Green, Claire Draucker & Craig Lammert
doi : 10.1007/s10620-022-07484-x
Significant reduction in quality of life among patients with autoimmune hepatitis (AIH) patients has been observed in several studies. While acute symptoms associated with AIH have been well described, little is known about the overall impact of living with AIH on patients’ quality of life.
Patient Priorities in Autoimmune Hepatitis: The Need for Better Treatments, More Education and Challenging Stigma
Charlotte Lloyd, Jessica Leighton, Lin Lee Wong, Anna Goulding, Ann Brownlee, Penney Gray, Emma Culver, Neil Halliday, Doug Thorburn, Michael A. Heneghan, David E. J. Jones, Catherine Exley & Jessica K. Dyson
doi : 10.1007/s10620-022-07525-5
Data show that patients with autoimmune hepatitis have significantly reduced quality-of-life and that corticosteroids carry marked side effects.
Electroacupuncture Enhances Gastric Accommodation via the Autonomic and Cytokine Mechanisms in Functional Dyspepsia
Xiaoli Chen, Xin Chen, Binrui Chen, Lijun Du, Yu Wang, Zhihui Huang, Ning Dai, Jiande D. Z. Chen & Qian Cao
doi : 10.1007/s10620-022-07495-8
Due to complex pathophysiology of functional dyspepsia, medications to treat functional dyspepsia are not effective for all patients. Transcutaneous electrical acustimulation (TEA) is an potentially effective therapy for functional dyspepsia without proofs of definite mechanisms.
Significant Differences in Gut Microbiota Between Irritable Bowel Syndrome with Diarrhea and Healthy Controls in Southwest China
Chengjiao Yao, Yilin Li, Lihong Luo, Fengjiao Xie, Qin Xiong, Tinglin Li, Chunrong Yang & Pei-min Feng
doi : 10.1007/s10620-022-07500-0
Irritable bowel syndrome (IBS) is a heterogeneous disease, which is closely related to environmental factors and gut microbiota.
Knockdown of Circ_0003506 Impedes Radioresistance, Cell Growth, Migration and Invasion in Gastric Cancer
Kaikai Zhou, Jianwen Zhang, Shunxin Song, Kaihong Xie & Xiaonan Hu
doi : 10.1007/s10620-022-07534-4
Radioresistance is a major obstacle for clinical treatment of gastric cancer (GC). has_circ_0003506 (circ_0003506) was reported as an oncogenic factor in GC, but its effect on radioresistant GC is unclear.
Gabexate Mesylate-Poloxamer 407 Conjugate Alleviates Sodium Taurocholate-Induced Severe Acute Pancreatitis in an Optimized Rat Model
Qing Song, Hanjing Gao, Wen Wu, Yu Gao, Jihua Yang, Ziyu Jiao & Yukun Luo
doi : 10.1007/s10620-022-07497-6
We have previously shown that gabexate mesylate-poloxamer 407 conjugate (GMTI) alleviates traumatic pancreatitis in rats. In this study, we evaluated the therapeutic effect of GMTI on sodium taurocholate-induced severe acute pancreatitis (SAP) in an optimized rat model.
The Effects of Umbilical Cord Mesenchymal Stem Cells on Traumatic Pancreatitis in Rats
Han Li, Zhao Zhirong, Zhou Shibo, Zhou Lichen, Shi Ming, Ji Hua, Tang Zheng & Dai Ruiwu
doi : 10.1007/s10620-022-07493-w
This study explored the therapeutic and protective effects of umbilical cord mesenchymal stem cells (ucMSCs) on traumatic pancreatitis (TP) to provide a theoretical basis for TP treatment with MCSs by establishing a TP rat model.
Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet
Meng Zhao, Lingyun Ma, Takashi Honda, Asuka Kato, Taichi Ohshiro, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Yoji Ishizu, Masanao Nakamura, Hiroki Kawashima, Noriko M. Tsuji, Masatoshi Ishigami & Mitsuhiro Fujishiro
doi : 10.1007/s10620-022-07489-6
Postmenopausal estrogen decline increases the risk of developing nonalcoholic steatohepatitis (NASH), and it might accelerate progression to cirrhosis and hepatocellular carcinoma.
Retained Food During Esophagogastroduodenoscopy Is a Risk Factor for Gastric-to-Pulmonary Aspiration
Aoife M. Feighery, Nicholas R. Oblizajek, Matthew N. P. Vogt, Danse Bi, John League III, Navtej S. Buttar & David O. Prichard
doi : 10.1007/s10620-022-07536-2
Residual food (RF) during esophagogastroduodenoscopy (EGD) is thought, but not proven, to be a risk factor for gastric-to-pulmonary aspiration.
Factors That Influence the Speed and Completion of Double Balloon Enteroscopy in Patients with Arteriovenous Malformations
Hollie Saunders, Hassan Ghoz, Pedro Cortes, Wail Alsafi, Obaie Mzaik, Victor Ciofoaia, Paul Kroner, Andrea Rodriguez, Alex Kesler, Andrea Koralewski, Matthew Crawford, Frank Lukens, Mark Stark, Bhaumik Brahmbhatt & Fernando Stancampiano
doi : 10.1007/s10620-022-07528-2
Double balloon enteroscopy remains a resource and time-intensive procedure that is not available in many endoscopy units.
Clinical Predictors of a Positive Ct Angiogram Study Used for the Evaluation of Acute Gastrointestinal Hemorrhage
Zachary Spiritos, Anthony Horton, Alice Parish, Donna Niedzwiecki, Geargin Wilson, Charles Y. Kim & Daniel Wild
doi : 10.1007/s10620-022-07514-8
Acute gastrointestinal (GI) bleeding is one of the leading causes of emergency department visits and hospital admissions. CT angiography (CTA) has had an expanding role in the evaluation of acute GI bleeding because it is rapidly performed, widely available, reasonably sensitive and provides precise localization when positive.
RHEMITT Score Predicts Rebleed After Capsule Endoscopy: First Validation at a U.S. Tertiary Care Center
Tina Boortalary, Ryan Erwin, Michael Dong, Brianna Shinn, Anthony Infantolino & Christina Tofani
doi : 10.1007/s10620-022-07527-3
Patients with obscure gastrointestinal bleeding undergo small bowel capsule endoscopy (SBCE), but often return for recurrent bleeding or anemia. The RHEMITT score evaluates patients based on 7 variables (heart failure, chronic kidney disease, Saurin P1/P2 lesions, major bleeding, incomplete SBCE, smoking status, and endoscopic treatment) and seeks to predict the risk of rebleeding.
Effect of Walking Exercise and Intestinal Cleansing Interval on Bowel Preparation Quality, a Single-Blind, Randomized Controlled Trial
Xin Gao, Qiugui Bian, Wenqin Ding, Haisheng Qian, Wenjie Li, Guoxin Zhang & Xuan Li
doi : 10.1007/s10620-022-07526-4
High-quality intestinal preparation could promote intestinal cleanliness and lead to more accurate diagnosis, which patients will benefit from. This study aimed to explore the effectiveness of walking exercise and intestinal cleansing interval in bowel preparation before colonoscopy.
Factors Associated with Difficulty Maintaining Insufflation of the Colon During Endoscopy
Mohammad F. Madhoun, Nimrah Bader, Ijlal Ali, Bryce Yohannan, Alyssa Grossen, Mahum Nadeem, Thomas J. Corredine & Richard Harty
doi : 10.1007/s10620-022-07592-8
Insufflation of the colon allows for adequate visualization of the mucosal tissue and advancement of the endoscope during colonoscopy. Most colonoscopies are performed with sedation to mitigate discomfort and enhance the colonoscopy experience for both the patient and the endoscopist.
E-cigarette Use and Disease Outcomes in Inflammatory Bowel Diseases: A Case-Control Study
Gabriel T. Sheehan, Shaina W. Twardus, Andrew Cagan & Ashwin N. Ananthakrishnan
doi : 10.1007/s10620-022-07539-z
Traditional cigarette use adversely impacts disease outcomes in Crohn’s disease (CD). There has been a worldwide increase in the use of e-cigarettes over the past decade. The impact of use of nicotine containing e-cigarettes on disease outcomes in CD or ulcerative colitis (UC) has not been well defined.
Characteristics of Patients with Crohn’s Disease With or Without Perianal Fistulae in the CorEvitas Inflammatory Bowel Disease Registry
Yanni Fan, SÃlvia Delgado-Aros, Wendell C. Valdecantos, Jud C. Janak, Page C. Moore, Margaux M. Crabtree & Ryan W. Stidham
doi : 10.1007/s10620-022-07491-y
There are limited real-world data characterizing perianal fistulae in patients with Crohn’s disease (CD).
Comparative Long-Term Drug Survival of Vedolizumab, Adalimumab, and Infliximab in Biologic-Naïve Patients with Ulcerative Colitis
Rahul S. Dalal, Emma L. McClure, Jenna Marcus & Jessica R. Allegretti
doi : 10.1007/s10620-022-07472-1
The comparative long-term survival of first-line biologics for UC and reasons for drug discontinuation are poorly understood. We sought to compare the long-term drug survival related to non-response (NR) and adverse effects (AEs) for vedolizumab, adalimumab, and infliximab among biologic-naïve patients with UC.
Neutrophil-to-Lymphocyte Ratio: An Easy Marker for the Diagnosis and Monitoring of Inflammatory Bowel Disease in Children
Pınar Şimşek-Onat, Hayriye Hizarcioglu-Gulsen, Yasin Maruf Ergen, Ersin Gumus, Hasan Özen, Hülya Demir, Seza Özen & İnci Nur Saltık-Temizel
doi : 10.1007/s10620-022-07547-z
The neutrophil-to-lymphocyte ratio (NLR) is a simple and inexpensive inflammation biomarker that reflects systemic inflammation based on complete blood count values.
Adoption of Optimal Small (6–9 mm) Colorectal Polyp Resection Technique Over Time
Larissa Muething, Bill Quach, Derek E. Smith, Dexiang Gao, Joshua A. Smith, Robert T. Simril III, Amanda Tompkins, Jeannine Espinoza, Michelle L. Cowan, Hazem Hammad, Sachin Wani & Swati G. Patel
doi : 10.1007/s10620-022-07554-0
Cold snare polypectomy (CSP) is the preferred resection technique for small (6–9 mm) polyps due to lower rate of incomplete resection compared to cold forceps polypectomy (CFP) and improved safety profile over hot snare polypectomy (HSP).
Feasibility and Safety of Endoscopic Ischemic Polypectomy and Clinical Outcomes in Patients with Peutz–Jeghers Syndrome (with Video)
Kenji J. L. Limpias Kamiya, Naoki Hosoe, Kaoru Takabayashi, Anna Okuzawa, Hinako Sakurai, Yukie Hayashi, Ryoichi Miyanaga, Tomohisa Sujino, Haruhiko Ogata & Takanori Kanai
doi : 10.1007/s10620-022-07477-w
Peutz–Jeghers syndrome (PJS) is a rare autosomal dominant hereditary disease with a clinical features related to gastrointestinal (GI) hamartomatous polyposis, frequently observed in the small bowel.
Risk of Metachronous Advanced Colorectal Neoplasia After Removal of Diminutive Versus Small Nonadvanced Adenomas: A Multicenter Study
Chi-Liang Cheng, Shuo-Wei Chen, I-Chia Su, Chi-Huang Wu, Yen-Lin Kuo, Tsuo-Hsuan Chien, Yuh-Ying Liu, Kuang-Chen Huang, Cheng-Han Xie, Mu-Hsien Lee, Jui-Hsiang Tang, Yi-Ning Tsui, Bai-Ping Lee & Nai-Jen Liu
doi : 10.1007/s10620-022-07608-3
Current postpolypectomy guidelines treat 1–9 mm nonadvanced adenomas (NAAs) as carrying the same level of risk for metachronous advanced colorectal neoplasia (ACRN).
Feasibility of Cholangioscopy Using Multibending Ultra-Slim Endoscope Through a Lumen-Apposing Metal Stent for Choledochoduodenostomy
Hae Won Yoo, Jong Ho Moon, Yun Nah Lee, Il Sang Shin, Jae Kook Yang, Tae Hoon Lee, Sang-Woo Cha, Young Deok Cho & Sang-Heum Park
doi : 10.1007/s10620-022-07531-7
Endoscopic ultrasound (EUS) guided choledochoduodenostomy using a lumen-apposing metal stent (LAMS) allows access to the biliary system with a sufficiently large diameter stent. However, an appropriate endoscope for this purpose is required.
Usefulness of Liquid-Based Cytology in Diagnosing Biliary Tract Cancer Compared to Conventional Smear and Forceps Biopsy
Min Woo Lee, Woo Hyun Paik, Sang Hyub Lee, Jung Won Chun, Gunn Huh, Nam Young Park, Joo Seong Kim, In Rae Cho, Ji Kon Ryu, Yong Tae Kim, Haeryoung Kim & Kyoungbun Lee
doi : 10.1007/s10620-022-07535-3
Liquid�based cytology (LBC) has been shown to improve the diagnostic efficacy of brush cytology for thyroid, cervical and pancreatic cancer. To evaluate the diagnostic performance of LBC for biliary tract cancer, we compared it with conventional smears and forceps biopsies.
Antibiotic Prophylaxis for Upper Gastrointestinal Bleed in Liver Cirrhosis; Less May Be More
Yousaf B Hadi, Raja S. Khan, Dhairya A. Lakhani, Ali Y. Khan, Rida U. Jannat, Adnan Aman Khan, Syeda Fatima Naqvi, George Obeng, Justin T. Kupec & Ashwani K. Singal
doi : 10.1007/s10620-022-07481-0
Administration of antibiotics in patients with cirrhosis and upper gastrointestinal bleeding has been shown to improve outcomes. Little is known regarding optimum duration of prophylactic antibiotics.
Liver Disease and Poor Adherence Limit Hepatitis C Cure: A Real-World Australian Treatment Cohort
Paul J. Clark, Patricia C. Valery, Simone I. Strasser, Martin Weltman, Alexander J. Thompson, Miriam Levy, Barbara Leggett, Amany Zekry, Julian Rong, Peter Angus, Jacob George, Steven Bollipo, Bruce McGarity, William Sievert, Gerry Macquillan, Edmund Tse, Amanda Nicoll, Amanda Wade, Geoff Chu, Damian Harding, Wendy Cheng, Geoff Farrell & Stuart K. Roberts
doi : 10.1007/s10620-022-07483-y
In 2016, direct-acting antiviral (DAA) treatment for hepatitis C (HCV) became available through Australia’s universal health care system, with the aim of HCV elimination. We report real-world effectiveness of DAA HCV treatment in Australia from a clinically well-informed cohort, enriched for cirrhosis and prior HCV treatment.
Role of Hepatitis C Infection in Acute Liver Injury/Acute Liver Failure in North America
Ashwin Rao, Jody A. Rule, Giuliana Cerro-Chiang, Richard T. Stravitz, Brendan M. McGuire, Goo Lee, Robert J. Fontana & William M. Lee
doi : 10.1007/s10620-022-07524-6
While hepatitis A and B are well-known causes of acute liver failure (ALF), few well-documented cases of hepatitis C virus (HCV) infection (absent preexisting liver disease or other liver insults) have been described that result in ALF.
Risk of Hepatocellular Carcinoma in Patients with Various HFE Genotypes
Yamini Natarajan, Parth Patel, Jinna Chu, Xian Yu, Ruben Hernaez, Hashem El-Serag & Fasiha Kanwal
doi : 10.1007/s10620-022-07602-9
Hereditary hemochromatosis (HH) is associated with increased risk of hepatocellular carcinoma (HCC). However, HCC risk factors within this population and across various HFE genotypes remain unclear.
Comparing Predictability of Non-invasive Tools for Hepatocellular Carcinoma in Treated Chronic Hepatitis C Patients
Yen-Chun Liu, Ya-Ting Cheng, Yi-Cheng Chen, Yi-Chung Hsieh, Wen-Juei Jeng, Chun-Yen Lin, Rong-Nan Chien, Dar-In Tai & I.-Shyan Sheen
doi : 10.1007/s10620-022-07621-6
Non-invasive tools including liver stiffness measurement (LSM) or FIB-4, assessed before or after direct acting antivirals (DAA), have been suggested to predict hepatocellular carcinoma (HCC).
Retraction Note to: A Novel Method for the Prevention and Treatment of Small‑for‑Size Syndrome in Liver Transplantation
Yanhu Feng, Zhijian Han, Baohong Gu, Xuemei Li, Bofang Wang, Facai Guo, Raaj Kumar Praseedom, Furong Wang, Huijuan Cheng, Alexandra Lucas, Yumin Li & Hao Chen
Retraction Note to: BBOX1‑AS1 Accelerates Gastric Cancer Proliferation by Sponging miR‑3940‑3p to Upregulate BIRC5 Expression
Yan Yang, Qiong Yu, Bing Li, Renzhen Guan, ChangYong Huang & XiuCheng Yang
