Journal of the Neurological Sciences




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سفارش

Comparative efficacy and safety of tenecteplase and alteplase in acute ischemic stroke: A pairwise and network meta-analysis of randomized controlled trials

Aqeeb Ur Rehman a, Aleenah Mohsin a, Huzaifa Ahmad Cheema a,*, Afra Zahid a, Muhammad Ebaad Ur Rehman b, Muhammad Zain Ameer a, Muhammad Ayyan a, Muhammad Ehsan a, Abia Shahid a,*, Muhammad Aemaz Ur Rehman c, Jaffer Shah d, Ayaz Khawaja

doi : 10.1016/j.jns.2022.120537

Volume 445, 15 February 2023, 120537

Studies on tenecteplase have been yielding mixed results for several important outcomes at different doses, thus hampering objective guideline recommendations in acute ischemic stroke management. This meta-analysis stratifies doses in order to refine our interpretation of outcomes and quantify the benefits and harms of tenecteplase at different doses.

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Lumbar spinal ganglion cyst: A systematic review with case illustration

Shivam Rana a,1, Anjali Pradhan a,g, Joshua Casaos a, Khashayar Mozaffari a, Farinaz Ghodrati a,g, Brianna Sugimoto h, Isaac Yang a,b,c,d,e,f,g,*, Daniel T. Nagasawa

doi : 10.1016/j.jns.2022.120539

Volume 445, 15 February 2023, 120539

Ganglion cysts are benign soft tissue lesions found in joints, most commonly wrists. The incidence for juxtafacet cysts, the condition under which spinal ganglion cysts are categorized, is between 0.06% and 5.8%.

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Cerebral amyloid-β deposition in patients with heart disease or carotid occlusive disease: A systematic review and meta-analysis

Naomi Louisa Paula Starmans a,*, Anna Elisabeth Leeuwis b, Geert Jan Biessels a, Laurens Jaap Kappelle a, Wiesje Maria van der Flier b,c, Nelleke Tolboom

doi : 10.1016/j.jns.2023.120551

Volume 445, 15 February 2023, 120551

Cardiovascular disease is an important contributor to cognitive impairment. This likely involves prototypical vascular disease mechanisms like ischemia, but cardiovascular disease might also impact the brain by accelerating cerebral amyloid-β accumulation. We aimed to determine whether there is an association between heart disease or carotid occlusive disease (COD) and cerebral amyloid-β burden.

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MDS-UDPRS-III in the diagnosis of idiopathic Normal Pressure Hydrocephalus and identification of candidates for Ventriculo-Peritoneal Shunting surgery. Results from a retrospective large cohort of patients

Enrico Belgrado a,1, Yan Tereshko b,*,1, Francesco Tuniz c, Christian Lettieri a, Daniele Bagatto d, Sara Fabbro c, Daniele Piccolo c, Gian Luigi Gigli b, Miran Skrap c, Mariarosaria Valente

doi : 10.1016/j.jns.2022.120536

Volume 445, 15 February 2023, 120536

To evaluate the entity of extrapyramidal signs, characterize them and evaluate the dynamics of change by the mean of MDS-UPDRS-III in iNPH patients after the TT to determine if this tool may help the diagnosis of iNPH and the identification of candidates for Ventriculo-Peritoneal Shunting.

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Visual suppression of vestibulo-ocular reflex in patients treated with carotid artery revascularization: A potential biomarker for cerebral perfusion

Shigeta Miyake a,1, Koji Takahashi b,1, Yasunobu Nakai a, Yu Amano c, Ryoo Yamamoto c, Kazumitsu Amari a, Hiroya Hara b, Ken Johkura

doi : 10.1016/j.jns.2022.120534

Volume 445, 15 February 2023, 120534

Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for ischemic stroke prevention in patients with carotid artery stenosis. However, the beneficial effects of CEA/CAS for cerebral hypoperfusion due to carotid artery stenosis have yet to be fully established.

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Trends in concussion mechanism of injury during the COVID-19 pandemic

Olivia Schaffer a, Frank Xie a, Debby Cheng a, Scott N. Grossman a,c, Steven L. Galetta a,c, Laura J. Balcer

doi : 10.1016/j.jns.2022.120538

Volume 445, 15 February 2023, 120538

The primary objective was to determine the effect of the COVID-19 pandemic on volume, demographics, and mechanisms of injury (MOI) for patients seen at an urban multidisciplinary concussion center. During the first phase of the pandemic in the United States, stay-at-home orders led to decreased group activities and required cancellation of outpatient appointments or initiation of telemedicine visits.

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Glutamic acid decarboxylase antibody-associated neurological syndromes: Clinical and antibody characteristics and therapy response

Marie Madlener a,*, Christine Strippel b, Franziska S. Thaler c, Kathrin Doppler d, Klaus P. Wandinger e, Jan Lewerenz f, Marius Ringelstein g,h, Rosa Roessling i, Til Menge h, Jonathan Wickel j, Christoph Kellingshaus k, Sigrid Mues l, Andrea Kraft m, Andreas Linsa n, Simone C. Tauber o, Florian Then Berg p, Stefan T. Gerner q, Asterios Paliantonis r, Alexander Finke s, Josef Priller t, Ingo Schirotzek u,v, Marie Süße w, Kurt W. Sühs x, Christian Urbanek y, Makbule Senel f, Claudia Sommer d, Tania Kuempfel c, Harald Pruess i, Gereon R. Fink a,z, Frank Leypoldt aa, Nico Melzer b,g, Michael P. Malter a, German Network for Research on Autoimmune Encephalitis (GENERATE)1

doi : 10.1016/j.jns.2022.120540

Volume 445, 15 February 2023, 120540

Antibodies against glutamic acid decarboxylase (GAD-abs) at high serum levels are associated with diverse autoimmune neurological syndromes (AINS), including cerebellar ataxia, epilepsy, limbic encephalitis and stiff-person syndrome. The impact of low serum GAD-ab levels in patients with suspected AINS remains controversial.

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Novel ways to modulate the vestibular system: Magnetic vestibular stimulation, deep brain stimulation and transcranial magnetic stimulation / transcranial direct current stimulation

A.A. Tarnutzer a,b,*, B.K. Ward c, A.G. Shaikh

doi : 10.1016/j.jns.2023.120544

Volume 445, 15 February 2023, 120544

Advances in neurotechnologies are revolutionizing our understanding of complex neural circuits and enabling new treatments for disorders of the human brain. In the vestibular system, electromagnetic stimuli can now modulate vestibular reflexes and sensations of self-motion by artificially stimulating the labyrinth, cerebellum, cerebral cortex, and their connections.

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Self-reported factors contributing to delay in ALS diagnosis among primary care providers in a large Ohio-based US healthcare network

John A. Morren a,*, Carol Rheaume b, Erik P. Pioro

doi : 10.1016/j.jns.2022.120532

Volume 445, 15 February 2023, 120532

This study's primary objective is to identify self-reported factors that contribute to diagnostic delay in ALS among Primary Care Providers (PCPs).

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The combination of heart rate variability and ABCD2 score portends adverse outcomes after minor stroke or transient ischemic attack

Yu Tian a,b,c,d,e, Yuesong Pan a,b,c,d,e, Mengxing Wang a,b,c,d,e, Xia Meng a,b,c,d,e, Xingquan Zhao a,b,c,d,e, Liping Liu a,b,c,d,e, Yongjun Wang a,b,c,d,e, Yilong Wang

doi : 10.1016/j.jns.2022.120522

Volume 445, 15 February 2023, 120522

The residual recurrent risk of stroke, which cannot be entirely explained by the traditional ABCD2 score, still existed. Heart rate variability (HRV), a method for reflecting the function of automatic nervous system (ANS), was a novel predictor of secondary stroke events.

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Neurological soft signs are associated with reduced medial-lateral postural control in adolescent athletes

Elena M. Bonke a,b,c, Amanda Clauwaert d, Stefan M. Hillmann e, Uta Tacke f, Caroline Seer d,g, Eukyung Yhang h, Yorghos Tripodis h,i, Stian B. Sandmo j,k, Tim L.T. Wiegand a,c, David Kaufmann a,l, Elisabeth Kaufmann a,m, Sutton B. Richmond d,n, Malo Gaubert a,o,p, Johanna Seitz-Holland c, Alexander Leemans q, Stephan P. Swinnen d, Roald Bahr j, Ofer Pasternak c,r, Florian Heinen e, Inga K. Koerte a,b,c,s, Michaela V. Bonfert e,*,1, Jolien Gooijers

doi : 10.1016/j.jns.2022.120516

Volume 445, 15 February 2023, 120516

Neurological soft signs (NSS) are minor deviations from the norm in motor performance that are commonly assessed using neurological examinations. NSS may be of clinical relevance for evaluating the developmental status of adolescents. Here we investigate whether quantitative force plate measures may add relevant information to observer-based neurological examinations.

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Association between multimorbidity with cognitive dysfunction in a Peruvian population

J. Carrasco-Zavala a, J.A. Díaz-RG a, A. Bernabe-Ortiz b,c, M. Lazo-Porras

doi : 10.1016/j.jns.2023.120543

Volume 445, 15 February 2023, 120543

Previous studies have shown that multimorbidity is a risk factor for cognitive dysfunction (CD).Type 2 diabetes mellitus (T2DM) and hypertension (HT) are very common risk factors.The association between multimorbidity due to both diseases and CD has been understudied in low and middle-income countries, in which the strength of the association might be stronger.

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Safety outcomes of early initiation of antithrombotic agents within 24 h after intravenous alteplase at 0.6 mg/kg

Tetsuya Chiba a, Takeshi Yoshimoto b,*, Shinichi Wada c, Masayuki Shiozawa a, Sohei Yoshimura a, Shunsuke Kimura a, Manabu Inoue a,d, Kazunori Toyoda a, Masafumi Ihara b, Masatoshi Koga

doi : 10.1016/j.jns.2023.120546

Volume 445, 15 February 2023, 120546

We examined outcome of acute ischemic stroke (AIS) with administration of antithrombotics within 24 h after intravenous low-dose alteplase.

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Can vigilance predict the status of safe functional gait and risk of falls in patients with peripheral vestibular disorders? A cross-sectional study

Christos Nikitas a,*, Evangelia Kontogianni b, Sofia Papadopoulou a, Michalis Tsoukatos a, Dimitris Kikidis

doi : 10.1016/j.jns.2023.120547

Volume 445, 15 February 2023, 120547

Peripheral vestibular disorders except from reflexes dysfunction correspond also to cognitive decline. The objectives of this cross-sectional study were to a) identify correlations among variables of functional gait, cognitive function, and perceived dizziness and b) explore variables that could be used as prognostic factors of functional gait in people with peripheral vestibular deficits.

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M1/precuneus ratio as a surrogate marker of upper motor neuron sign in ALS

Wataru Sako a,b,*, Shotaro Haji b, Takashi Abe c, Yusuke Osaki b, Yuki Matsumoto c, Masafumi Harada c, Yuishin Izumi

doi : 10.1016/j.jns.2023.120548

Volume 445, 15 February 2023, 120548

To investigate whether primary motor cortex (M1) volume measured with an automated approach in MRI reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic lateral sclerosis (ALS).

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Limb positioning and magnitude of postural tremor ratings: A study of 100 essential tremor cases

Allison Powell, Diane S. Berry, Meagen Salinas, Elan D. Louis

doi : 10.1016/j.jns.2023.120550

Volume 445, 15 February 2023, 120550

Essential tremor (ET) is a highly prevalent movement disorder. As the diagnosis is purely clinical, it is important for clinicians to develop a reliable taxonomy of signs and symptoms of ET. Here, we investigate two common clinical maneuvers for determining the presence and severity of postural tremor in ET cases: the evaluation of tremor observed when arms are held in the outstretched and wing posture positions.

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A real-world analysis of factors associated with high healthcare resource utilization and costs in patients with myasthenia gravis receiving second-line treatment

Angela Ting a,*, Tyler Story a, Coralie Lecomte b, Adina Estrin b, Sahar Syed b, Edward Lee

doi : 10.1016/j.jns.2022.120531

Volume 445, 15 February 2023, 120531

Despite current treatments, patients with myasthenia gravis (MG) experience unpredictable and inadequately controlled symptoms, lending to variability in the clinical and economic burden of disease.

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Response to letter to Editor

Akira Tsujino*, Atsushi Nagaoka, Shunsuke Yoshimura

doi : 10.1016/j.jns.2023.120541

Volume 445, 15 February 2023, 120541

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Comment on: Nagaoka, A. et al., Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients. J Neurol Sci, 2022. 443: p. 120494

Sarah Hoffmanna,*, Werner Stenzelb, Andreas Meisel

doi : 10.1016/j.jns.2023.120542

Volume 445, 15 February 2023, 120542

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Tissue hyperoxia is not a risk factor for cerebral vasospasm following subarachnoid hemorrhage

Michele Salvagno*, Fabio Silvio Taccone, Elisa Gouvea Bogossian

doi : 10.1016/j.jns.2022.120535

Volume 445, 15 February 2023, 120535

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Impact of concomitant use of opicapone during levodopa–carbidopa intestinal gel treatment

Noriyuki Miyaue*, Yuko H. Ito, Chikako Ochi, Yuki Yamanishi, Satoshi Tada, Rina Ando, Masahiro Nagai

doi : 10.1016/j.jns.2023.120549

Volume 445, 15 February 2023, 120549

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