Aqeeb Ur Rehman a, Aleenah Mohsin a, Huzaifa Ahmad Cheema a,*, Afra Zahid a, Muhammad Ebaad Ur Rehman b, Muhammad Zain Ameer a, Muhammad Ayyan a, Muhammad Ehsan a, Abia Shahid a,*, Muhammad Aemaz Ur Rehman c, Jaffer Shah d, Ayaz Khawaja
doi : 10.1016/j.jns.2022.120537
Volume 445, 15 February 2023, 120537
Studies on tenecteplase have been yielding mixed results for several important outcomes at different doses, thus hampering objective guideline recommendations in acute ischemic stroke management. This meta-analysis stratifies doses in order to refine our interpretation of outcomes and quantify the benefits and harms of tenecteplase at different doses.
Shivam Rana a,1, Anjali Pradhan a,g, Joshua Casaos a, Khashayar Mozaffari a, Farinaz Ghodrati a,g, Brianna Sugimoto h, Isaac Yang a,b,c,d,e,f,g,*, Daniel T. Nagasawa
doi : 10.1016/j.jns.2022.120539
Volume 445, 15 February 2023, 120539
Ganglion cysts are benign soft tissue lesions found in joints, most commonly wrists. The incidence for juxtafacet cysts, the condition under which spinal ganglion cysts are categorized, is between 0.06% and 5.8%.
Naomi Louisa Paula Starmans a,*, Anna Elisabeth Leeuwis b, Geert Jan Biessels a, Laurens Jaap Kappelle a, Wiesje Maria van der Flier b,c, Nelleke Tolboom
doi : 10.1016/j.jns.2023.120551
Volume 445, 15 February 2023, 120551
Cardiovascular disease is an important contributor to cognitive impairment. This likely involves prototypical vascular disease mechanisms like ischemia, but cardiovascular disease might also impact the brain by accelerating cerebral amyloid-β accumulation. We aimed to determine whether there is an association between heart disease or carotid occlusive disease (COD) and cerebral amyloid-β burden.
Enrico Belgrado a,1, Yan Tereshko b,*,1, Francesco Tuniz c, Christian Lettieri a, Daniele Bagatto d, Sara Fabbro c, Daniele Piccolo c, Gian Luigi Gigli b, Miran Skrap c, Mariarosaria Valente
doi : 10.1016/j.jns.2022.120536
Volume 445, 15 February 2023, 120536
To evaluate the entity of extrapyramidal signs, characterize them and evaluate the dynamics of change by the mean of MDS-UPDRS-III in iNPH patients after the TT to determine if this tool may help the diagnosis of iNPH and the identification of candidates for Ventriculo-Peritoneal Shunting.
Shigeta Miyake a,1, Koji Takahashi b,1, Yasunobu Nakai a, Yu Amano c, Ryoo Yamamoto c, Kazumitsu Amari a, Hiroya Hara b, Ken Johkura
doi : 10.1016/j.jns.2022.120534
Volume 445, 15 February 2023, 120534
Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for ischemic stroke prevention in patients with carotid artery stenosis. However, the beneficial effects of CEA/CAS for cerebral hypoperfusion due to carotid artery stenosis have yet to be fully established.
Olivia Schaffer a, Frank Xie a, Debby Cheng a, Scott N. Grossman a,c, Steven L. Galetta a,c, Laura J. Balcer
doi : 10.1016/j.jns.2022.120538
Volume 445, 15 February 2023, 120538
The primary objective was to determine the effect of the COVID-19 pandemic on volume, demographics, and mechanisms of injury (MOI) for patients seen at an urban multidisciplinary concussion center. During the first phase of the pandemic in the United States, stay-at-home orders led to decreased group activities and required cancellation of outpatient appointments or initiation of telemedicine visits.
Marie Madlener a,*, Christine Strippel b, Franziska S. Thaler c, Kathrin Doppler d, Klaus P. Wandinger e, Jan Lewerenz f, Marius Ringelstein g,h, Rosa Roessling i, Til Menge h, Jonathan Wickel j, Christoph Kellingshaus k, Sigrid Mues l, Andrea Kraft m, Andreas Linsa n, Simone C. Tauber o, Florian Then Berg p, Stefan T. Gerner q, Asterios Paliantonis r, Alexander Finke s, Josef Priller t, Ingo Schirotzek u,v, Marie Süße w, Kurt W. Sühs x, Christian Urbanek y, Makbule Senel f, Claudia Sommer d, Tania Kuempfel c, Harald Pruess i, Gereon R. Fink a,z, Frank Leypoldt aa, Nico Melzer b,g, Michael P. Malter a, German Network for Research on Autoimmune Encephalitis (GENERATE)1
doi : 10.1016/j.jns.2022.120540
Volume 445, 15 February 2023, 120540
Antibodies against glutamic acid decarboxylase (GAD-abs) at high serum levels are associated with diverse autoimmune neurological syndromes (AINS), including cerebellar ataxia, epilepsy, limbic encephalitis and stiff-person syndrome. The impact of low serum GAD-ab levels in patients with suspected AINS remains controversial.
A.A. Tarnutzer a,b,*, B.K. Ward c, A.G. Shaikh
doi : 10.1016/j.jns.2023.120544
Volume 445, 15 February 2023, 120544
Advances in neurotechnologies are revolutionizing our understanding of complex neural circuits and enabling new treatments for disorders of the human brain. In the vestibular system, electromagnetic stimuli can now modulate vestibular reflexes and sensations of self-motion by artificially stimulating the labyrinth, cerebellum, cerebral cortex, and their connections.
John A. Morren a,*, Carol Rheaume b, Erik P. Pioro
doi : 10.1016/j.jns.2022.120532
Volume 445, 15 February 2023, 120532
This study's primary objective is to identify self-reported factors that contribute to diagnostic delay in ALS among Primary Care Providers (PCPs).
Yu Tian a,b,c,d,e, Yuesong Pan a,b,c,d,e, Mengxing Wang a,b,c,d,e, Xia Meng a,b,c,d,e, Xingquan Zhao a,b,c,d,e, Liping Liu a,b,c,d,e, Yongjun Wang a,b,c,d,e, Yilong Wang
doi : 10.1016/j.jns.2022.120522
Volume 445, 15 February 2023, 120522
The residual recurrent risk of stroke, which cannot be entirely explained by the traditional ABCD2 score, still existed. Heart rate variability (HRV), a method for reflecting the function of automatic nervous system (ANS), was a novel predictor of secondary stroke events.
Elena M. Bonke a,b,c, Amanda Clauwaert d, Stefan M. Hillmann e, Uta Tacke f, Caroline Seer d,g, Eukyung Yhang h, Yorghos Tripodis h,i, Stian B. Sandmo j,k, Tim L.T. Wiegand a,c, David Kaufmann a,l, Elisabeth Kaufmann a,m, Sutton B. Richmond d,n, Malo Gaubert a,o,p, Johanna Seitz-Holland c, Alexander Leemans q, Stephan P. Swinnen d, Roald Bahr j, Ofer Pasternak c,r, Florian Heinen e, Inga K. Koerte a,b,c,s, Michaela V. Bonfert e,*,1, Jolien Gooijers
doi : 10.1016/j.jns.2022.120516
Volume 445, 15 February 2023, 120516
Neurological soft signs (NSS) are minor deviations from the norm in motor performance that are commonly assessed using neurological examinations. NSS may be of clinical relevance for evaluating the developmental status of adolescents. Here we investigate whether quantitative force plate measures may add relevant information to observer-based neurological examinations.
J. Carrasco-Zavala a, J.A. DÃaz-RG a, A. Bernabe-Ortiz b,c, M. Lazo-Porras
doi : 10.1016/j.jns.2023.120543
Volume 445, 15 February 2023, 120543
Previous studies have shown that multimorbidity is a risk factor for cognitive dysfunction (CD).Type 2 diabetes mellitus (T2DM) and hypertension (HT) are very common risk factors.The association between multimorbidity due to both diseases and CD has been understudied in low and middle-income countries, in which the strength of the association might be stronger.
Tetsuya Chiba a, Takeshi Yoshimoto b,*, Shinichi Wada c, Masayuki Shiozawa a, Sohei Yoshimura a, Shunsuke Kimura a, Manabu Inoue a,d, Kazunori Toyoda a, Masafumi Ihara b, Masatoshi Koga
doi : 10.1016/j.jns.2023.120546
Volume 445, 15 February 2023, 120546
We examined outcome of acute ischemic stroke (AIS) with administration of antithrombotics within 24Â h after intravenous low-dose alteplase.
Christos Nikitas a,*, Evangelia Kontogianni b, Sofia Papadopoulou a, Michalis Tsoukatos a, Dimitris Kikidis
doi : 10.1016/j.jns.2023.120547
Volume 445, 15 February 2023, 120547
Peripheral vestibular disorders except from reflexes dysfunction correspond also to cognitive decline. The objectives of this cross-sectional study were to a) identify correlations among variables of functional gait, cognitive function, and perceived dizziness and b) explore variables that could be used as prognostic factors of functional gait in people with peripheral vestibular deficits.
Wataru Sako a,b,*, Shotaro Haji b, Takashi Abe c, Yusuke Osaki b, Yuki Matsumoto c, Masafumi Harada c, Yuishin Izumi
doi : 10.1016/j.jns.2023.120548
Volume 445, 15 February 2023, 120548
To investigate whether primary motor cortex (M1) volume measured with an automated approach in MRI reflects upper motor neuron dysfunction and whether it can serve as a potential diagnostic and/or disease-tracking biomarker for amyotrophic lateral sclerosis (ALS).
Allison Powell, Diane S. Berry, Meagen Salinas, Elan D. Louis
doi : 10.1016/j.jns.2023.120550
Volume 445, 15 February 2023, 120550
Essential tremor (ET) is a highly prevalent movement disorder. As the diagnosis is purely clinical, it is important for clinicians to develop a reliable taxonomy of signs and symptoms of ET. Here, we investigate two common clinical maneuvers for determining the presence and severity of postural tremor in ET cases: the evaluation of tremor observed when arms are held in the outstretched and wing posture positions.
Angela Ting a,*, Tyler Story a, Coralie Lecomte b, Adina Estrin b, Sahar Syed b, Edward Lee
doi : 10.1016/j.jns.2022.120531
Volume 445, 15 February 2023, 120531
Despite current treatments, patients with myasthenia gravis (MG) experience unpredictable and inadequately controlled symptoms, lending to variability in the clinical and economic burden of disease.
Akira Tsujino*, Atsushi Nagaoka, Shunsuke Yoshimura
doi : 10.1016/j.jns.2023.120541
Volume 445, 15 February 2023, 120541
Sarah Hoffmanna,*, Werner Stenzelb, Andreas Meisel
doi : 10.1016/j.jns.2023.120542
Volume 445, 15 February 2023, 120542
Michele Salvagno*, Fabio Silvio Taccone, Elisa Gouvea Bogossian
doi : 10.1016/j.jns.2022.120535
Volume 445, 15 February 2023, 120535
Noriyuki Miyaue*, Yuko H. Ito, Chikako Ochi, Yuki Yamanishi, Satoshi Tada, Rina Ando, Masahiro Nagai
doi : 10.1016/j.jns.2023.120549
Volume 445, 15 February 2023, 120549
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