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The Role of Diet in Multiple Sclerosis: Food for Thought.
Spain, Rebecca I. MD, MSPH *; Piccio, Laura MD, PhD *; Langer-Gould, Annette M. MD, PhD *
doi : 10.1212/WNL.0000000000201565
Volume 100(4) pgs. 167-220,e357-e453 January 24, 2023
Low Glucocerebrosidase Activity Predicts Dementia in Parkinson Disease: Less Is Not More!
Aldridge, Chad M. DPT, MS-CR
Dravet Syndrome: Don't Hesitate, Just Vaccinate!
Nickels, Katherine C. MD; Wirrell, Elaine C. MD
Efficacy of Diet on Fatigue and Quality of Life in Multiple Sclerosis: A Systematic Review and Network Meta-analysis of Randomized Trials.
Snetselaar, Linda G. PhD, RD; Cheek, Joshua J. BS; Fox, Sara Shuger PhD; Healy, Heather S. MA, MLS; Schweizer, Marin L. PhD; Bao, Wei MD, PhD; Kamholz, John MD, PhD; Titcomb, Tyler J. PhD, RD
doi : 10.1212/WNL.0000000000201371
Emerging evidence suggests a role for diet in multiple sclerosis (MS) care; however, owing to methodological issues and heterogeneity of dietary interventions in preliminary trials, the current state of evidence does not support dietary recommendations for MS.
Levodopa Response in Patients With Early Parkinson Disease: Further Observations of the LEAP Study.
Frequin, Henrieke L. MD; Schouten, Jason MD; Verschuur, Constant V.M. MD; Suwijn, Sven R. MD, PhD; Boel, Judith A. PhD; Post, Bart MD, PhD; Bloem, Bastiaan R. MD, PHD; van Hilten, Johannes J. MD, PhD; van Laar, Teus MD, PhD; Tissingh, Gerrit MD, PhD; Munts, Alexander G. MD; Dijk, Joke M. MD, PhD; Deuschl, Gunther MD, PhD; Lang, Anthony MD; Dijkgraaf, Marcel G.W. PhD; de Haan, Rob J. PhD; de Bie, Rob M.A. MD, PhD; on behalf of the LEAP Study Group
doi : 10.1212/WNL.0000000000201448
The Levodopa in EArly Parkinson's Disease (LEAP) study enabled us to conduct post hoc analyses concerning the effects of levodopa in patients with early Parkinson disease.
Effects of Exercise on Depressive Symptoms in Patients With Parkinson Disease: A Meta-analysis.
Kim, Ryul MD; Lee, Tae Lee BS; Lee, Hanall MS; Ko, Do Kyung BS; Jeon, Beomseok MD, PhD; Kang, Nyeonju PhD
doi : 10.1212/WNL.0000000000201453
The purpose of this study was to provide clear evidence in support of the use of exercise to improve depressive symptoms in patients with Parkinson disease (PD) and to investigate whether this effect differs by exercise type and intensity.
Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease.
Oftedal, Linn PhD; Maple-Grodem, Jodi PhD; Dalen, Ingvild PhD; Tysnes, Ole-Bjorn PhD, MD; Pedersen, Kenn Freddy PhD, MD; Alves, Guido PhD, MD; Lange, Johannes PhD
doi : 10.1212/WNL.0000000000201418
Variations in the glucocerebrosidase gene (GBA) are common risk factors for Parkinson disease (PD) and dementia in PD (PDD) and cause a reduction in the activity of the lysosomal enzyme glucocerebrosidase (GCase).
Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.
Saracino, Dario MD, PhD *; Sellami, Leila MD, MSc *; Boniface, Hugo MSc *; Houot, Marion MSc; Pelegrini-Issac, Melanie PhD; Funkiewiez, Aurelie PhD; Rinaldi, Daisy PhD; Locatelli, Maxime PhD; Azuar, Carole MD; Causse-Lemercier, Valerie MD; Jaillard, Alice MD, PhD; Pasquier, Florence MD, PhD; Chastan, Mathieu MD; Wallon, David MD, PhD; Hitzel, Anne MD; Pariente, Jeremie MD, PhD; Pallardy, Amandine MD, PhD; Boutoleau-Bretonniere, Claire MD, PhD; Guedj, Eric MD, PhD; Didic, Mira MD, PhD; Migliaccio, Raffaella MD, PhD; Kas, Aurelie MD, PhD; Habert, Marie-Odile MD, PhD +; Le Ber, Isabelle MD, PhD +; on behalf of Predict-PGRN
doi : 10.1212/WNL.0000000000201439
GRN variants are a frequent cause of familial frontotemporal dementia (FTD). Monitoring disease progression in asymptomatic carriers of genetic variants is a major challenge in delivering preventative therapies before clinical onset.
Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
Nguyen, Thanh N. MD, FRCPC; Qureshi, Muhammad M. MBBS, MPH; Klein, Piers MA; Yamagami, Hiroshi MD, PhD; Mikulik, Robert MD, PhD; Czlonkowska, Anna MD, PhD; Abdalkader, Mohamad MD; Sedova, Petra MD, PhD; Sathya, Anvitha; Lo, Hannah C. BS; Mansour, Ossama Yassin MD, PhD; Vanguru, Husitha Reddy MD; Lesaine, Emilie MD; Tsivgoulis, Georgios MD, PhD; Loochtan, Aaron I. DO; Demeestere,
doi : 10.1212/WNL.0000000000201426
Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic.
Global Burden of Ischemic Stroke in Young Adults in 204 Countries and Territories.
Zhang, Ruijie MD; Liu, Huina MD; Pu, Liyuan MD; Zhao, Tian MD; Zhang, Shun MD; Han, Kun PhD; Han, Liyuan PhD
doi : 10.1212/WNL.0000000000201467
To estimate the rates of incidence, death, and disability-adjusted life years (DALYs) of ischemic stroke in young adults aged 15-49 years and the relevant risk factors by sex, age group, and sociodemographic index (SDI) in 204 countries and territories
Complications of Influenza A or B Virus Infection in Individuals With SCN1A-Positive Dravet Syndrome.
Howell, Katherine B. PhD; Butcher, Sophie MPHTM; Schneider, Amy L. MGenCouns; Russ-Hall, Sophie BSc (Hons); Muzariri, Pearl R. DSc; Kerr, Rachel BSpPath; Overmars, Isabella MPH; Hayman, Michael MBBS; Kornberg, Andrew J. MD; Danchin, Margie PhD; Crawford, Nigel W. PhD; Scheffer, Ingrid E. PhD
doi : 10.1212/WNL.0000000000201438
To determine the frequency and spectrum of complications of influenza infection in individuals with SCN1A-positive Dravet syndrome (SCN1A-DS).
Infratentorial Brain Injury Among Patients Suspected of Death by Neurologic Criteria: A Systematic Review and Meta-analysis.
Neves Briard, Joel MD, MSc; Plourde, Guillaume MD, PhD; Nitulescu, Roy MA; Boyd, J. Gordon MD, PhD; Carrier, Francois Martin MD, MSc; Couillard, Philippe MD; Keezer, Mark R. MD, PhD; Kramer, Andreas H. MD; Shemie, Sam D. MD; Stapf, Christian MD; Chasse, Michael MD, PhD
doi : 10.1212/WNL.0000000000201449
There is a paucity of data on the frequency and prognosis of infratentorial brain injury among patients suspected of death by neurologic criteria (DNC), which likely contributes to scientific uncertainty regarding the role of isolated brainstem death in DNC determination.
Pediatric Stroke-Are We Asking the Right Questions?: The 2022 Sidney Carter Award Lecture.
Amlie-Lefond, Catherine MD
doi : 10.1212/WNL.0000000000201487
AB Over the past few decades, robust clinical and research collaborations among pediatric stroke researchers have informed and improved the care of children with stroke. Risk factors and presentation of childhood stroke have been described, and the acute and chronic burden of childhood stroke has been better delineated.
Clinical Reasoning: A Young Man With Subacute Onset of Spastic Paraparesis.
Rossi, Salvatore MD; Concolino, Paola PhD; Di Natale, Daniele MD; Pasquetti, Domizia MD; Di Lella, Giuseppe Maria MD, PhD; Chiurazzi, Pietro MD, PhD; Silvestri, Gabriella MD, PhD
doi : 10.1212/WNL.0000000000201516
AB Leukodystrophies are a group of rare neurodegenerative disorders, usually presenting in infancy with a variable combination of cognitive, motor, and coordination impairment. Adult-onset cases are even more rare, often representing a diagnostic challenge even for experienced neurologists.
Clinical Reasoning: A Young Adult Man With Cognitive Changes, Gait Difficulty, and Renal Insufficiency.
Stamm, Brian MD; DiBiase, Rebecca MD, MPH; Harris, Glenn Ryan MD; Kaprielian, Hagop MD; Brahmbhatt, Nupur MD; Wu, Allan D. MD; Baker, Joshua DO *; Liotta, Eric M. MD, MS *
doi : 10.1212/WNL.0000000000201500
AB A 22-year-old right-handed man with recently diagnosed gout and renal insufficiency presented with 3 months of progressive gait instability and cognitive changes. He initially presented to an outside institution and underwent a broad workup, but an etiology for his symptoms was not found.
Teaching NeuroImage: Ultrafast Dynamic CT Myelography for the Identification of Leakage Level in Multiple Meningeal Diverticula.
Correa de Almeida Teixeira, Bernardo MD, PhD; Henrique de Aragao, Afonso MD; Ferreira, Camila Carneiro MD; Hussein, Mohammed Ali MD; Ramina, Kristofer Fingerle MD
Teaching Video NeuroImage: Tadpole Pupil.
Lamri, Amel Thaninna MD; Van Den Eeckhaute, Laura MD; Buelens, Tom MD
Editors' Note: Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow).
Siegler, James E. MD; Galetta, Steven MD, FAAN
Reader Response: Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow).
ter Schiphorst, Adrien; Oppenheim, Catherine; Baron, Jean-Claude
Author Response: Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow).
Ng, Felix C.
Editors' Note: Clinical Reasoning: A 65-Year-Old Woman With Cancer History and Wrist Drop.
Siegler, James E. MD; Galetta, Steven MD, FAAN
Reader Response: Clinical Reasoning: A 65-Year-Old Woman With Cancer History and Wrist Drop.
Zhai, Qiongqiong
Author Response: Clinical Reasoning: A 65-Year-Old Woman With Cancer History and Wrist Drop.
Merrill, Rebecca L.; Strowd, Roy E.
