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Editors and Editorial Board.
doi : 10.1161/STR.0000000000000425
Volume 54(2) pgs. 291-638,e25-e51 February 2023
Investigation on Gender Differences in Leadership of Stroke-Related Clinical Trials.
Rawlley, Bharat MBBS; Marchina, Sarah PhD; Cappucci, Stefanie P. MD; Gogia, Bhanu MD; Wang, Jia-Yi MD; Stillman, Alexandra MD; Kumar, Sandeep MD
doi : 10.1161/STROKEAHA.122.039173
Gender disparities among principal investigators of clinical trials (CT) can have implications regarding the areas of investigation, methods, conduct, trial enrollment, and interpretation of results. An estimation of the gender gap in the leadership of stroke-related CTs from North America has to date not been undertaken.
Women and Leadership in Stroke Clinical Trials: Time for a Call to Action.
Walter, Silke MD; Sacco, Simona MD; Sandset, Else Charlotte MD, PhD
Sex Differences in Onset and Progression of Cerebral Amyloid Angiopathy.
Koemans, Emma A. MD; Castello, Juan Pablo MD; Rasing, Ingeborg MD; Abramson, Jessica R. BA; Voigt, Sabine BSc; Perosa, Valentina MD; van Harten, Thijs W. MSc; van Zwet, Erik W. PhD; Terwindt, Gisela M. MD, PhD; Gurol, M. Edip MD, PhD; Rosand, Jonathan MD; Greenberg, Steven M. MD, PhD; van Walderveen, Marianne A.A. MD, PhD; Biffi, Alessandro MD, PhD; Viswanathan, Anand MD, PhD ,*; Wermer, Marieke J.H. MD, PhD ,*
doi : 10.1161/STROKEAHA.122.040823
Cerebral Amyloid Angiopathy (CAA) disease course is highly variable even in hereditary forms. Sex may be a possible modifying factor. We investigated biological sex differences in clinical disease course and magnetic resonance imaging-markers in sporadic (sCAA) and Dutch-type hereditary CAA (D-CAA).
Sex Differences in Carotid Atherosclerosis: A Systematic Review and Meta-Analysis.
van Dam-Nolen, Dianne H.K. MD; van Egmond, Nina C.M. BSc; Koudstaal, Peter J. MD, PhD; van der Lugt, Aad MD, PhD; Bos, Daniel MD, PhD
doi : 10.1161/STROKEAHA.122.041046
Over the last decades, several individual studies on sex differences in carotid atherosclerosis have been performed covering a wide range of plaque characteristics and including different populations.
Sex-Related Differences in Outcomes of Endovascular Treatment for Anterior Circulation Large Vessel Occlusion.
Sun, Dapeng MD; Raynald, MD; Huo, Xiaochuan MD; Jia, Baixue MD; Tong, Xu MD; Ma, Gaoting MD; Wang, Anxin PhD; Ma, Ning MD; Gao, Feng MD; Mo, Dapeng MD; Nguyen, Thanh N. MD; Miao, Zhongrong MD; on behalf of ANGEL-ACT Study Group; Miao, Zhongrong; Gui, Liqiang; Song, Cunfeng; Peng, Ya; Wu, Jin; Zhao, Shijun; Zhao, Junfeng; Zhou, Zhiming; Li, Yongli; Jing, Ping; Yang, Lei; Liu, Yajie; Zhao, Qingshi; Liu, Yan; Peng, Xiaoxiang; Gao, Qingchun; Guo, Zaiyu; Chen, Wenhuo; Li, Weirong; Cheng, Xiaojiang; Xu, Yun; Zhang, Yongqiang; Zhang, Guilian; Lu, Yijiu; Lu, Xinyu; Wang, Dengxiang; Wang, Yan; Li, Hao; Hua, Yang; Geng, Deqin; Yuan, Haicheng; Wang, Hongwei; Yang, Haihua; Wang, Zengwu; Wei, Liping; Liufu, Xuancong; Shi, Xiangqun; Li, Juntao; Yang, Wenwu; Jing, Wenji; Yong, Xiang; Wang, Leyuan; Li, Chunlei; Cao, Yibin; Zhu, Qingfeng; Zhang, Peng; Luo, Xiang; Chen, Shengli; Peng, WenWu; Wang, Lixin; Wen, Xue; Shi, Shugui; Wang, Wanming; Bo, Wang; Yuan, Pu; Wang, Dong; Guan, Haitao; Liang, Wenbao; Ma, Daliang; Chen, Long; Xiao, Yan; Xie, Xiangdong; Shi, Zhonghua; Zeng, Xiangjun; Su, Fanfan; Chang, MingZe; Yin, Jijun; Sun, Hongxia; Li, Chong; Bi, Yong; Xie, Gang; Zhao, Yuwu; Wang, Chao; Zhang, Peng; Wang, Xianjun; Li, Dongqun; Liang, Hui; Chen, Zhonglun; Wang, Yan; Wang, Yuxin; Yin, Lin; Qiu, HongKai; Wei, Jun; Sun, Yaxuan; Feng, Xiaoya; Wu, Weihua; Gao, Lianbo; Ai, Zhibing; Tan, Lan; Ding, Li; Liang, Qilong; Wang, Zhimin; Yang, Jianwen; Xu, Ping; Dong, Wei; Zheng, Quanle; Zhu, Zhenyun; Zhao, Liyue; Meng, Qingbo; Wei, Yuqing; Chen, Xianglin; Wang, Wei; Sun, Dong; Yan, Yongxing; Yuan, Guangxiong; Yang, Yadong; Zhou, Jianfeng; Yang, Zhi; Zhang, Zhenzhong; Guan, Ning; Wang, Huihong
doi : 10.1161/STROKEAHA.122.041195
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly in an Asian population.
Maternal Health Outcomes After Pregnancy-Associated Stroke: A Population-Based Study With 19 Years of Follow-Up.
Yu, Amy Y.X. MD, MSc; Nerenberg, Kara A. MD, MSc; Diong, Christina MSc; Fang, Jiming PhD; Chu, Anna MSc; Kapral, Moira K. MD, MSc; Edwards, Jodi D. PhD; Dancey, Sonia R.; Austin, Peter C. PhD; Auger, Nathalie MD, MSc
doi : 10.1161/STROKEAHA.122.041471
Pregnancy-associated stroke carries high short-term morbidity and mortality, but data on subsequent maternal outcomes are limited. We evaluated long-term maternal health outcomes after pregnancy-associated stroke.
Poststroke Disability: Association Between Sex and Patient-Reported Outcomes.
Oliveira, Lara C. MD; Ponciano, Ana MD, MSc; Tuozzo, Carissa BS; Viswanathan, Anand MD, PhD; Rost, Natalia S. MD, MPH; Etherton, Mark R. MD, PhD
doi : 10.1161/STROKEAHA.122.041502
Ischemic stroke (IS) is a leading cause of long-term disability with sex-specific differences in outcomes. Identifying the influential factors that contribute to sex-specific disparities in stroke outcomes, therefore, holds potential to develop individualized interventions for reducing long-term disability.
Worsened Stroke Outcome in a Model of Preeclampsia is Associated With Poor Collateral Flow and Oxidative Stress.
Cipolla, Marilyn J. PhD; Tremble, Sarah M. BS; DeLance, Nicole BS; Johnson, Abbie C. PhD
doi : 10.1161/STROKEAHA.122.041637
Preeclampsia increases the incidence of maternal stroke, a devastating condition that is on the rise. We investigated stroke outcome in a model of experimental preeclampsia with and without treatment with clinically relevant doses of magnesium sulfate (experimental preeclampsia+MgSO4) compared to normal late-pregnant and nonpregnant rats.
Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice.
Zhu, Wenbin MD; Davis, Catherine M. PhD; Allen, Elyse M. BA, BS; Feller, Sarah L. BS; Bah, Thierno M. PhD; Shangraw, Robert E. MD, PhD; Wang, Ruikang K. PhD; Alkayed, Nabil J. MD, PhD
doi : 10.1161/STROKEAHA.122.040972
Type 2 diabetes (DM2) exacerbates stroke injury, reduces efficacy of endovascular therapy, and worsens long-term functional outcome. Sex differences exist in stroke incidence, response to therapy, poststroke microvascular dysfunction, and functional recovery.
Health Equity and Actionable Disparities in Stroke: 2022 Update.
Towfighi, Amytis MD; Ovbiagele, Bruce MD, MSc, MAS, MBA, MLS
doi : 10.1161/STROKEAHA.122.041892
AB There are stark inequities in stroke incidence, prevalence, care, and outcomes. This issue of Stroke features manuscripts from the third annual HEADS-UP (Health Equity and Actionable Disparities in Stroke: Understanding and Problem-Solving) symposium, which took place the day before the International Stroke Conference in February 2022.
Kenton Award Lecture-Stroke Disparities Research: Learning From the Past, Planning for the Future.
Kapral, Moira K. MD, MSc
doi : 10.1161/STROKEAHA.122.039562
AB Inequities in stroke care and outcomes have been documented both within and among countries based on factors, such as race, geography, and socioeconomic status. Research can help us to identify, understand, and address inequities, and this article offers considerations for scientists working in this area.
Care Transition Interventions to Improve Stroke Outcomes: Evidence Gaps in Underserved and Minority Populations.
Reeves, Mathew J. PhD; Boden-Albala, Bernadette PhD; Cadilhac, Dominique A. PhD
doi : 10.1161/STROKEAHA.122.039565
AB In many countries hospital length of stay after an acute stroke admission is typically just a few days, therefore, most of a person's recovery from stroke occurs in the community.
Telehealth Trials to Address Health Equity in Stroke Survivors.
Sharrief, Anjail Z. MD, MPH; Guzik, Amy K. MD; Jones, Erica MD, MPH; Okpala, Munachi MSN, NP-C, DNP; Love, Mary F. MSN, RN, PhD; Ranasinghe, Tamra Ishan Jayenda MD; Bushnell, Cheryl MD, MS
doi : 10.1161/STROKEAHA.122.039566
AB Telehealth has seen rapid expansion into chronic care management in the past 3 years because of the COVID-19 pandemic. Telehealth for acute care management has expanded access to equitable stroke care to many patients over the past two decades, but there is limited evidence for its benefit for addressing disparities in the chronic care of patients living with stroke
Polypill Programs to Prevent Stroke and Cut Costs in Low Income Countries: Moving From Clinical Efficacy to Pragmatic Implementation.
Sarfo, Fred Stephen MD, PhD; Nichols, Michelle PhD, RN; Opare-Addo, Priscilla Abrafi MD; Ovbiagele, Bruce MD, MSc, MAS, MBA, MLS
doi : 10.1161/STROKEAHA.122.039567
AB Current projections are that the already overwhelming burden of strokes and atherosclerotic cardiovascular diseases in low- and middle-income countries (LMICs) will continue to rise over the coming decades as the prevalence of traditional vascular risk factors burgeon in these countries.
Golden Hour Treatment With tPA (Tissue-Type Plasminogen Activator) in the BEST-MSU Study.
Mackey, Jason MD; Yamal, Jose-Miguel PhD; Parker, Stephanie A. MHA; Silnes, Kelly MS; Rajan, Suja S. PhD; Jacob, Asha P. MD; Wang, Mengxi PhD; Singh, Noopur MPH; Jones, William J. MD; Spokoyny, Ilana MD; Navi, Babak B. MD; Saver, Jeffrey L. MD; Grotta, James C. MD; for the BEST-MSU Study Group
doi : 10.1161/STROKEAHA.122.039821
Treatment of patients with acute ischemic stroke on mobile stroke units (MSUs) improves outcomes compared with management by standard emergency medical services ambulances and is associated with more patients treated with intravenous tPA (tissue-type plasminogen activator) in the first golden hour after last known normal.
Mobile Stroke Units and Pursuit of Intravenous Tissue-Type Plasminogen Activator Treatment in the Golden Hour.
Tanaka, Kanta MD, PhD; Reeves, Mathew J. PhD
Intracranial Artery Calcifications Profile as a Predictor of Recanalization Failure in Endovascular Stroke Treatment.
Rodrigo-Gisbert, Marc MD; Requena, Manuel MD, PhD; Rubiera, Marta MD, PhD; Khalife, Jane MD; Lozano, Prudencio MD; De Dios Lascuevas, Marta MD; Garcia-Tornel, Alvaro MD, PhD; Olive-Gadea, Marta MD, PhD; Pinana, Carlos MD; Rizzo, Federica MD; Boned, Sandra MD, PhD; Muchada, Marian MD, PhD; Rodriguez-Villatoro, Noelia MD, PhD; Rodriguez-Luna, David MD, PhD; Juega, Jesus MD, PhD; Pagola, Jorge MD, PhD; Hernandez, David MD; Molina, Carlos A. MD, PhD; Tomasello, Alejandro MD; Ribo, Marc MD, PhD
doi : 10.1161/STROKEAHA.122.041257
Acute ischemic stroke with large or medium-vessel occlusion associated with intracranial artery calcification (IAC) is an infrequent phenomenon presumably associated with intracranial atherosclerotic disease. We aimed to characterize IAC and its impact on endovascular treatment outcomes.
Risk Factors and Causes of Ischemic Stroke in 1322 Young Adults.
Ekker, Merel S. MD; Verhoeven, Jamie I. MD; Schellekens, Mijntje M.I. MD; Boot, Esther M. MD; van Alebeek, Mayte E. MD, PhD; Brouwers, Paul J.A.M. MD, PhD; Arntz, Renate M. MD, PhD; van Dijk, Gert W. MD, PhD; Gons, Rob A.R. MD, PhD; van Uden, Inge W.M. MD, PhD; den Heijer, Tom MD, PhD; de Kort, Paul L.M. MD, PhD; de Laat, Karlijn F. MD, PhD; van Norden, Anouk G.W. MD, PhD; Vermeer, Sarah E. MD, PhD; van Zagten, Marian S.G. MD, PhD; van Oostenbrugge, Robert J. MD, PhD; Wermer, Marieke J.H. MD, PhD; Nederkoorn, Paul J. MD, PhD; Zonneveld, Thomas P. MD; Kerkhoff, Henk MD, PhD; Rooyer, Fergus A. MD; van Rooij, Frank G. MD, PhD; van den Wijngaard, Ido R. MD, PhD; Klijn, Catharina J.M. MD, PhD; Tuladhar, Anil M. MD, PhD; de Leeuw, Frank-Erik MD, PhD
doi : 10.1161/STROKEAHA.122.040524
Identification of risk factors and causes of stroke is key to optimize treatment and prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke according to current classification systems (Trial of ORG 10172 in Acute Stroke Treatment [TOAST] and atherosclerosis, small vessel disease, cardiac pathology, other causes, dissection [ASCOD]).
Distal Embolization in Relation to Radiological Thrombus Characteristics, Treatment Details, and Functional Outcome.
Bala, Fouzi MD, MSc; Kappelhof, Manon MD, PhD; Ospel, Johanna M. MD, PhD; Cimflova, Petra MD; Qiu, Wu PhD; Singh, Nishita MD; Zhu, Kairan PhD; Kim, Beom Joon MD, PhD; Wadhwa, Ankur MD; Almekhlafi, Mohammed A. MD, MSc; Menon, Bijoy K. MD, MSc; Arrarte Terreros, Nerea PhD; Marquering, Henk MD, PhD; Majoie, Charles MD, PhD; Hill, Michael D. MD, MSc; Goyal, Mayank MD, PhD; for the ESCAPE-NA1 Investigators
doi : 10.1161/STROKEAHA.122.040542
Distal embolization (DE) is a common complication of endovascular treatment (EVT). We investigated the association of radiological thrombus characteristics and treatment details with DE.
Safety of Carotid Endarterectomy for Symptomatic Stenosis by Age: Meta-Analysis With Individual Patient Data.
Leung, Ya Yuan Rachel MB, ChB; Bera, Kasia DPhil; Urriza Rodriguez, Daniel FRCS; Dardik, Alan MD, PhD; Mas, Jean-Louis MD; Simonte, Gioele MD, PhD; Rerkasem, Kittipan MD, PhD; Howard, Dominic P.J. DPhil
doi : 10.1161/STROKEAHA.122.040819
There is uncertainty whether elderly patients with symptomatic carotid stenosis have higher rates of adverse events following carotid endarterectomy. In trials, recurrent stroke risk on medical therapy alone increased with age, whereas operative stroke risk was not related.
Factors and Behaviors Related to Successful Transition of Care After Hospitalization for Ischemic Stroke.
Dong, Chuanhui PhD; Gardener, Hannah ScD; Rundek, Tatjana MD, PhD; Marulanda, Erika MD, MS; Gutierrez, Carolina M. PhD; Campo-Bustillo, Iszet MD, MPH; Gordon Perue, Gillian MBBS, DM; Johnson, Karlon H. MPH; Sacco, Ralph L. MD, MS; Romano, Jose G. MD; on behalf of the Transitions of Care Stroke Disparities Study (TCSD-S) Investigators
doi : 10.1161/STROKEAHA.122.040891
Our objective is to describe adoption of the posthospitalization behaviors associated with successful transition of care and related baseline characteristics.
Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: External Validation of Prediction Models.
van der Ende, Nadinda A.M. MD; Kremers, Femke C.C. MSc; van der Steen, Wouter MD; Venema, Esmee MD, PhD; Kappelhof, Manon MD, PhD; Majoie, Charles B.L.M. MD, PhD; Postma, Alida A. MD, PhD; Boiten, Jelis MD, PhD; van den Wijngaard, Ido R. MD, PhD; van der Lugt, Aad MD, PhD; Dippel, Diederik W.J. MD, PhD; Roozenbeek, Bob MD, PhD; on behalf of the MR CLEAN Registry Investigators
doi : 10.1161/STROKEAHA.122.040065
Symptomatic intracranial hemorrhage (sICH) is a severe complication of reperfusion therapy for ischemic stroke. Multiple models have been developed to predict sICH or intracranial hemorrhage (ICH) after reperfusion therapy.
Radiomics Analysis of Diffusion-Weighted Imaging and Long-Term Unfavorable Outcomes Risk for Acute Stroke.
Jiang, Liang MD ,*; Miao, Zhengfei MD ,*; Chen, Huiyou MD; Geng, Wen MD; Yong, Wei MD; Chen, Yu-Chen PhD; Zhang, Hong MD; Duan, Shaofeng PhD; Yin, Xindao PhD; Zhang, Zhiqiang PhD
doi : 10.1161/STROKEAHA.122.040418
Diffusion-weighted imaging radiomics could be used as prognostic biomarkers in acute ischemic stroke. We aimed to identify a clinical and diffusion-weighted imaging radiomics model for individual unfavorable outcomes risk assessment in acute ischemic stroke.
Prognostic Role of Hemispherical Functional Connectivity in Stroke: A Study via Graph Theory Versus Coherence of Electroencephalography Rhythms.
Vecchio, Fabrizio PhD; Pappalettera, Chiara MSc; Miraglia, Francesca PhD; Deinite, Gregorio MD; Manenti, Rosa PhD; Judica, Elda MD, PhD; Caliandro, Pietro MD, PhD; Rossini, Paolo Maria MD, PhD
doi : 10.1161/STROKEAHA.122.040747
The objective of the present study is to explore whether acute stroke may result in changes in brain network architecture by electroencephalography functional coupling analysis and graph theory.
Osteoprotegerin and Ischemic Stroke Prognosis: A Prospective Multicenter Study and Mendelian Randomization Analysis.
Zhu, Zhengbao MD, PhD; Guo, Daoxia MD, PhD; Zhang, Kaixin MD; Yang, Pinni MD; Jia, Yiming MD; Shi, Mengyao MD, PhD; Peng, Yanbo MD, PhD; Chen, Jing MD, MS; Wang, Aili MD, PhD; Xu, Tan MD, PhD; Zhang, Yonghong MD, PhD; He, Jiang MD, PhD
doi : 10.1161/STROKEAHA.122.040800
Osteoprotegerin was implicated in vascular injury and inflammatory responses, but its prognostic value in ischemic stroke remained unclear. We aimed to prospectively investigate the association between plasma osteoprotegerin and ischemic stroke prognosis combined with a Mendelian randomization analysis.
Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke.
Chen, Huanwen MD ,,,*; Khunte, Mihir BS ,,*; Colasurdo, Marco MD; Jindal, Gaurav MD; Malhotra, Ajay MD; Gandhi, Dheeraj MD; Chaturvedi, Seemant MD
doi : 10.1161/STROKEAHA.122.041749
Osteoarthritis and other musculoskeletal disorders are the leading causes of disability in the United States. While osteoarthritis is not a direct risk factor for stroke, osteoarthritis may impact patient selection for endovascular thrombectomy (EVT) due to prestroke disability.
Comparative Effectiveness and Safety of Seizure Prophylaxis Among Adults After Acute Ischemic Stroke.
Moura, Lidia M.V.R. MD, PhD, MPH; Donahue, Maria A. MD; Yan, Zhiyu MS; Smith, Louisa H. PhD; Hsu, John MD, MBA, MSCE; Newhouse, Joseph P. PhD; Schwamm, Lee H. MD; Haneuse, Sebastien PhD; Hernandez-Diaz, Sonia MD, DPH; Blacker, Deborah MD, ScD
doi : 10.1161/STROKEAHA.122.039946
Older adults occasionally receive seizure prophylaxis in an acute ischemic stroke (AIS) setting, despite safety concerns. There are no trial data available about the net impact of early seizure prophylaxis on post-AIS survival.
Early Antiplatelet Resumption and the Risks of Major Bleeding After Intracerebral Hemorrhage.
Liu, Chi-Hung MD, MSc ,,*; Wu, Yi-Ling DrPH ,*; Hsu, Chih-Cheng MD, DrPH ,,+; Lee, Tsong-Hai MD, PhD ,+
doi : 10.1161/STROKEAHA.122.040500
The appropriate timing of resuming antithrombotic therapy after intracerebral hemorrhage (ICH) remains unclear. The aim of this study was to compare the risks of major bleeding between early and late antiplatelet resumption in ICH survivors.
Timing of Antiplatelet Resumption After Intracerebral Hemorrhage: A Sophie's Choice.
Balali, Pargol MD; Katsanos, Aristeidis H. MD, PhD; Shoamanesh, Ashkan MD
Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.
Tozer, Daniel J. PhD; Brown, Robin B. MRCP; Walsh, Jessica PhD; Hong, Young T. PhD; Williams, Guy B. PhD; O'Brien, John T. DM; Aigbirhio, Franklin I. DPhil; Fryer, Tim D. PhD; Markus, Hugh S. DM
doi : 10.1161/STROKEAHA.122.039517
Recent studies have demonstrated increased microglial activation using 11C-PK11195 positron emission tomography imaging, indicating central nervous system inflammation, in cerebral small vessel disease. However, whether such areas of neuroinflammation progress to tissue damage is uncertain.
Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke.
Alzahrani, Awad MSc; Zhang, Xinyu MPH; Albukhari, Adel MD; Wardlaw, Joanna M. MD; Mair, Grant MD
doi : 10.1161/STROKEAHA.122.041241
Treatment for ischemic stroke can be offered beyond conventional time limits for patients with favorable computed tomography perfusion (CTP), but this is not universally available.
Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion.
Morotti, Andrea MD; Boulouis, Gregoire MD, PhD; Nawabi, Jawed MD; Li, Qi MD, PhD; Charidimou, Andreas MD, PhD; Pasi, Marco MD, PhD; Schlunk, Frieder MD; Shoamanesh, Ashkan MD; Katsanos, Aristeidis H. MD; Mazzacane, Federico MD; Busto, Giorgio MD; Arba, Francesco MD, PhD; Brancaleoni, Laura MD; Giacomozzi, Sebastiano MD; Simonetti, Luigi MD; Warren, Andrew D. BS; Laudisi, Michele MD; Cavallini, Anna MD; Gurol, Edip M. MD, MSc; Viswanathan, Anand MD, PhD; Zini, Andrea MD; Casetta, Ilaria MD, PhD; Fainardi, Enrico MD, PhD; Greenberg, Steven M. MD, PhD; Padovani, Alessandro MD, PhD; Rosand, Jonathan MD, MSc; Goldstein, Joshua N. MD, PhD
doi : 10.1161/STROKEAHA.122.041302
Noncontrast computed tomography hypodensities are a validated predictor of hematoma expansion (HE) in intracerebral hemorrhage and a possible alternative to the computed tomography angiography (CTA) spot sign but their added value to available prediction models remains unclear.
High Mobility Group Box 1 as an Autocrine Chemoattractant for Oligodendrocyte Lineage Cells in White Matter Stroke.
Choi, Jun Young MD, PhD ,,*; Jin, Xuelian MD ,,,*; Kim, Hanki MD; Koh, Seungyon MD; Cho, Hyo Jin MS; Kim, Byung Gon MD, PhD
doi : 10.1161/STROKEAHA.122.041414
The migration of oligodendrocyte precursor cells (OPC) is a key process of remyelination, which is essential for the treatment of white matter stroke. This study aimed to investigate the role of HMGB1 (high mobility group box 1), a damage-associated molecular pattern released from dying oligodendrocytes, as an autocrine chemoattractant that promotes OPC migration.
A Measure of Neural Function Provides Unique Insights into Behavioral Deficits in Acute Stroke.
Vanderschelden, Benjamin MD; Erani, Fareshte MS; Wu, Jennifer MD, PhD; de Havenon, Adam MD; Srinivasan, Ramesh PhD; Cramer, Steven C. MD
doi : 10.1161/STROKEAHA.122.040841
Clinical and neuroimaging measures incompletely explain behavioral deficits in the acute stroke setting. We hypothesized that electroencephalography (EEG)-based measures of neural function would significantly improve prediction of acute stroke deficits.
Endometriosis Increases the Risk of Stroke: A Mendelian Randomization Study.
Zheng, Ming MD, PhD ,,*; Zheng, Shaoping MMedSci ,*
Pseudohyperdense Middle Cerebral Artery and Brain Cancer: An Unusual Association.
Lekoubou, Alain MD, MS; Srinivasan, Pavitra MD; Kanekar, Sangam G. MD
Border Zone Infarcts in the Setting of Eosinophilia.
Jensen-Kondering, Ulf MD; Johannes Koch, Philipp MD; Hagelstein, Victoria MD
Cashew Nut Sign: A Concave Parenchymal Hemorrhage Caused by Cerebral Venous Thrombosis.
Schlechter, Maia BA; Lucey, Kenia MD; Peng, Teng J. MD; Amin, Hardik MD
Evaluation of Neointimal Coverage After Placement of a Flow Diverter Using Angioscopy.
Fukutome, Kenji MD, PhD; Shiba, Mikio MD, PhD; Matsuoka, Ryuta MD, PhD; Aketa, Shuta MD, PhD; Motoyama, Yasushi MD, PhD
Stroke in Women and Unique Risk Factors.
Bushnell, Cheryl D. MD, MHS; Kapral, Moira K. MD, MSc
doi : 10.1161/STROKEAHA.122.041734
AB There has been a plethora of studies focused on female-specific risk factors and sex differences in stroke published in the past year. This article summarizes several of those novel studies which provide new knowledge about the field of stroke in women.
Acute and Interventional Treatments.
Campbell, Bruce C.V. MBBS, PhD; Hill, Michael D. MD, MSc; Nguyen, Thanh N. MD; Broderick, Joseph P. MD
Sleep Health as a Determinant of Disparities in Stroke Risk and Health Outcome.
Khot, Sandeep P. MD, MPH; Taylor, Breana L. MD; Longstreth, W.T. Jr MD, MPH; Brown, Arleen F. MD, PhD
doi : 10.1161/STROKEAHA.122.039524
AB Sleep is essential to human survival and overall vascular health. Sleep health encompasses the objective and subjective qualities associated with one's daily pattern of sleep and wakefulness and has become a growing clinical and public health concern.
Role of Inflammatory Processes in Hemorrhagic Stroke.
Ohashi, Sarah N. BA ,,*; DeLong, Jonathan H. PhD ,,*; Kozberg, Mariel G. MD, PhD ,,*; Mazur-Hart, David J. MD ,*; van Veluw, Susanne J. PhD ,,+; Alkayed, Nabil J. MD, PhD ,+; Sansing, Lauren H. MD, MS ,,+
doi : 10.1161/STROKEAHA.122.037155
AB Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in older individuals is cerebral amyloid angiopathy.
Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial.
Morais, Andreia PhD; Locascio, Joseph J. PhD; Sansing, Lauren H. MD; Lamb, Jessica BS; Nagarkatti, Karisma MS; Imai, Takahiko PharmD, PhD; van Leyen, Klaus PhD; Aronowski, Jaroslaw MD, PhD; Koenig, James I. PhD; Bosetti, Francesca PhD; Lyden, Patrick MD; Ayata, Cenk MD, PhD; on behalf of the SPAN Investigators; Bosetti, Francesca PhD; Koenig, James I. PhD; Lyden, Patrick D. MD; Lamb, Jessica BS; Nagarkatti, Karisma MS; Hess, David C. MD; Kamat, Pradip K. PhD; Khan, Mohammad Badruzzaman PhD; Dhandapani, Krishnan PhD; Arbab, Ali S. MD, PhD; Siddiqui, Shahneela MS; Smith, Cameron MS; Nisar, Mohammad BS; Leira, Enrique C. MD, MS; Chauhan, Anil K. PhD; Dhanesha, Nirav PhD; Patel, Rakesh B. PhD; Kumskova, Mariia PhD; Thedens, Daniel PhD; Wang, Kai PhD; Ayata, Cenk MD, PhD; Morais, Andreia PhD; Imai, Takahiko PharmD, PhD; Qin, Tao; Jin, Xuyan PhD; Erdogan, Taylan Denis BS; Yu, Lili MD; Mandeville, Joseph B. PhD; Kimberly, William Taylor MD, PhD; Whittier, Jonah Patrick Weigand BS; Lo, Eng PhD; Arai, Ken PhD; Van Leyen, Klaus PhD; Sansing, Lauren H. MD; Hyder, Fahmeed PhD; Mihailovic, Jelena M. PhD; Sanganahalli, Basavaraju G. PhD; Diaz-Perez, Sebastian BS; Velazquez, Sofia E. BS; Beatty, Hannah E. BS; Johnson, Conor BS; Herman, Alison L. BA; Boisserand, Ligia S. B. PhD; Immakavar, Emma BS; Koehler, Raymond C. PhD; Dawson, Ted PhD; Dawson, Valina PhD; Shi, Yanrong MD, MS; Avery, Brooklyn BS; Lannon, Steven BS; Bibic, Adnan PhD; Akhter, Kazi PhD; Karuppagounder, Senthilkumar S. PhD; Aronowski, Jaroslaw MD, PhD; McCullough, Louise D. MD, PhD; Obertas, Lidiya PhD; Goh, Andrew MS; Huang, Shuning PhD; Chauhan, Anjali PhD.
doi : 10.1161/STROKEAHA.122.040638
AB The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization and blinding and large samples, SPAN aimed to introduce heterogeneity to simulate the heterogeneity embodied in clinical trials for robust conclusions.
Recruitment in Acute Stroke Trials: Challenges and Potential Solutions.
Broderick, Joseph P. MD; Aziz, Yasmin N. MD; Adeoye, Opeolu M. MD; Grotta, James C. MD; Naidech, Andrew M. MD, MSPH; Barreto, Andrew D. MD, MS; Derdeyn, Colin P. MD; Sucharew, Heidi J. PhD; Elm, Jordan J. PhD; Khatri, Pooja MD
doi : 10.1161/STROKEAHA.122.040071
AB Randomized clinical trials of acute stroke have led to major advances in acute stroke therapy over the past decade. Despite these successes, recruitment in acute trials is often difficult.
February Literature Synopses.
Bake, Shameena PhD; Sohrabji, Farida PhD
Gender and Sex Equity in Stroke Research, Education, and Care.
Volpe, Salvatore G. MA; Zuniga, Mary C. MD; Caunca, Michelle R. MD, PhD; Rosendale, Nicole MD
Cortical Superficial Siderosis and Transient Focal Neurological Episode Preceding Lobar Hemorrhage in Cerebral Amyloid Angiopathy.
Theodorou, Aikaterini MD; Chondrogianni, Maria MD; Bakola, Eleni MD; Kaloudi, Georgia MD; Foska, Aikaterini MD; Michalakakou, Smaragdi MD; Melanis, Konstantinos MD; Paraskevas, Georgios P. MD; Tsivgoulis, Georgios MD
