Gratitude

Neil Skolnik

doi : 10.1161/CIRCULATIONAHA.120.053279

Circulation. 2021 | Volume 143, Issue 11: 1071–1072

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The Affordability of Guideline-Directed Medical Therapy

Alexander T. Sandhu, Paul A. Heidenreich

doi : 10.1161/CIRCULATIONAHA.120.053291

Circulation. 2021 | Volume 143, Issue 11: 1073–1075

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Bench to Bedside Discovery, Innovation, Global Health Equity, and Security

Victor J. Dzau

doi : 10.1161/CIRCULATIONAHA.121.054151

Circulation. 2021 | Volume 143, Issue 11: 1076–1080

Dr Dzau was born in Shanghai. He received his Bachelor of Science in Biology and his MD degree from McGill University. He was a medical resident, Chief Resident, and the founding Chief of the Division of Vascular Medicine at the Peter Bent Brigham Hospital (now the Brigham and Women’s Hospital). He moved to Stanford in 1990 as the Chief of the Division of Cardiovascular Medicine and later became Chairman of the Department of Medicine. Six years later, he returned to Harvard Medical School as the Hersey Professor of the Theory and Practice of Medicine and as Chairman of the Department of Medicine at Brigham and Women’s Hospital. He then became the Chancellor for Health Affairs, President, and CEO of the Duke University Medical Center. In 2014, he was elected to become the President of the Institute of Medicine (now the National Academy of Medicine). He is a member of the National Academy of Medicine, the American Academy of Arts and Sciences, and the European Academy of Sciences and Arts.

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Durable Polymer Versus Biodegradable Polymer Drug-Eluting Stents After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome

Hyo-Soo Kim, Jeehoon Kang, Doyeon Hwang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Seok Yeon Kim, Keun-Ho Park, Seung-Woon Rha, Won-Yong Shin, Hong-Seok Lim, Kyungil Park, Kyung Woo Park and On behalf of the HOST-REDUCE-POLYTECH-ACS Trial Investigators

doi : 10.1161/CIRCULATIONAHA.120.051700

Circulation. 2021 | Volume 143, Issue 11: 1081–1091

Large-scale randomized comparison of drug-eluting stents (DES) based on durable polymer versus biodegradable polymer technology is currently insufficient in patients with acute coronary syndrome (ACS). The present study aimed to prove the noninferiority of the durable polymer DES (DP-DES) compared with the biodegradable polymer DES (BP-DES) in such patients.

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Durable or Biodegradable Polymer Stent Coatings

Robert A. Byrne, Colm G. Hanratty

doi : 10.1161/CIRCULATIONAHA.121.052485

Circulation. 2021 | Volume 143, Issue 11: 1092–1094

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Temporal Release of High-Sensitivity Cardiac Troponin T and I and Copeptin After Brief Induced Coronary Artery Balloon Occlusion in Humans

?sthildur ?rnad?ttir, Sune Pedersen, Rasmus Bo Hasselbalch, Jens P. Goetze, Lennart J. Friis-Hansen, Anna-Marie Bloch-Münster, Jan Skov Jensen, Henning Bundgaard, Kasper Iversen

doi : 10.1161/CIRCULATIONAHA.120.046574

Circulation. 2021 | Volume 143, Issue 11: 1095–1104

Cardiac troponins (cTns) are the cornerstone of diagnosing acute myocardial infarction. There is limited knowledge on the duration of ischemia necessary to induce a measurable release of cTns or the very-early-release kinetics of cTns after an ischemic event. Copeptin may have a supplementary role in ruling out myocardial infarction early. We investigated the release of cTns and copeptin in the first hours after experimental balloon-induced ischemia in humans.

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Rapid Cardiac Troponin Release After Transient Ischemia

Christopher R. deFilippi, Nicholas L. Mills

doi : 10.1161/CIRCULATIONAHA.120.052649

Circulation. 2021 | Volume 143, Issue 11: 1105–1108

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Clinical Efficacy and Safety of Alirocumab After Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol

Gregory G. Schwartz, Philippe Gabriel Steg, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J. Wouter Jukema, Yong-Un Kim, Qian H. Li, Garen Manvelian, Robert Pordy, Timothée Sourdille, Harvey D. White, Michael Szarek and For the ODYSSEY OUTCOMES Committees and Investigators

doi : 10.1161/CIRCULATIONAHA.120.049447

Circulation. 2021 | Volume 143, Issue 11: 1109–1122

Recent international guidelines have lowered recommended target levels of low-density lipoprotein cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below the conventional targets. Inferences from previous analyses are limited because patients who achieve lower versus higher LDL-C on lipid-lowering therapy differ in other characteristics prognostic for MACE and because few achieved very low LDL-C levels. To overcome these limitations, we performed a propensity score–matching analysis of the ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) which compared alirocumab with placebo in 18?924 patients with recent acute coronary syndrome receiving intensive or maximum-tolerated statin treatment.

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Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans

Andrii Boguslavskyi, Sergiy Tokar, Oleksandra Prysyazhna, Olena Rudyk, David Sanchez-Tatay, Hamish A.L. Lemmey, Kim A. Dora, Christopher J. Garland, Helen R. Warren, Alexander Doney, Colin N.A. Palmer, Mark J. Caulfield, Julia Vlachaki Walker, Jacqueline Howie, William Fuller, Michael J. Shattock

doi : 10.1161/CIRCULATIONAHA.119.040557

Circulation. 2021 | Volume 143, Issue 11: 1123–1138

Although it has long been recognized that smooth muscle Na/K ATPase modulates vascular tone and blood pressure (BP), the role of its accessory protein phospholemman has not been characterized. The aim of this study was to test the hypothesis that phospholemman phosphorylation regulates vascular tone in vitro and that this mechanism plays an important role in modulation of vascular function and BP in experimental models in vivo and in humans.

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Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy

Matthew Hoffman, Dimitra Palioura, Ioannis D. Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P. Christian Schulze, Ira J. Goldberg, Raj Kishore, Vincent W. Yang, Thomas D. Bannister, Agnieszka B. Bialkowska, Craig H. Selzman, Stavros G. Drakos, Konstantinos Drosatos

doi : 10.1161/CIRCULATIONAHA.120.047420

Circulation. 2021 | Volume 143, Issue 11: 1139–1156

We previously showed that cardiomyocyte Kr?ppel-like factor (KLF) 5 regulates cardiac fatty acid oxidation. As heart failure has been associated with altered fatty acid oxidation, we investigated the role of cardiomyocyte KLF5 in lipid metabolism and pathophysiology of ischemic heart failure.

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Cardiovascular Disease in Chronic Kidney Disease

Joachim Jankowski, Jürgen Floege, Danilo Fliser, Michael B?hm, Nikolaus Marx

doi : 10.1161/CIRCULATIONAHA.120.050686

Circulation. 2021 | Volume 143, Issue 11: 1157–1172

Patients with chronic kidney disease (CKD) exhibit an elevated cardiovascular risk manifesting as coronary artery disease, heart failure, arrhythmias, and sudden cardiac death. Although the incidence and prevalence of cardiovascular events is already significantly higher in patients with early CKD stages (CKD stages 1–3) compared with the general population, patients with advanced CKD stages (CKD stages 4–5) exhibit a markedly elevated risk. Cardiovascular rather than end-stage kidney disease (CKD stage 5) is the leading cause of death in this high-risk population. CKD causes a systemic, chronic proinflammatory state contributing to vascular and myocardial remodeling processes resulting in atherosclerotic lesions, vascular calcification, and vascular senescence as well as myocardial fibrosis and calcification of cardiac valves. In this respect, CKD mimics an accelerated aging of the cardiovascular system. This overview article summarizes the current understanding and clinical consequences of cardiovascular disease in CKD.

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Irregular Complex Tachycardia

Ding Peng, Xiaojian Liu, Yangyang Pan

doi : 10.1161/CIRCULATIONAHA.120.052913

Circulation. 2021 | Volume 143, Issue 11: 1173–1176

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Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile

Marios K. Georgakis, Rainer Malik, Xue Li, Dipender Gill, Michael G. Levin, Ha My T. Vy, Renae Judy, Marylyn Ritchie, Shefali S. Verma and Regeneron Genetics Center, Girish N. Nadkarni, Scott M. Damrauer, Evropi Theodoratou, Martin Dichgans

doi : 10.1161/CIRCULATIONAHA.120.052604

Circulation. 2021 | Volume 143, Issue 11: 1177–1180

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Letter by Grace et al Regarding Article, “A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy”

Andrew Grace, Greg Mellor, Lynne Williams

doi : 10.1161/CIRCULATIONAHA.120.051270

Circulation. 2021 | Volume 143, Issue 11: e786–e787

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Response by Mital et al to Letter Regarding Article, “A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy”

Seema Mital, Katey R. Armstrong, Ryan J. Butts, Jennifer Conway, Steve Fan, Letizia Gardin, Paul F. Kantor, Beth Kaufman, Myriam Lafreniere-Roula, Anastasia Miron, Marc E. Richmond, Joseph W. Rossano, Mark W. Russell, Chet Villa, Robert G. Weintraub and PRIMaCY Investigators

doi : 10.1161/CIRCULATIONAHA.120.051632

Circulation. 2021 | Volume 143, Issue 11: e788–e789

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