دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Supporting International Medical Graduates in Rheumatology: A Call to Action
Ruth Fernandez-Ruiz, Alà Duarte-GarcÃa, Noelle A. Rolle, Sebastian E. Sattui, Didem Saygin, Sharon Dowell, Swetha A. Alexander, Bharat Kumar, Maria I. Danila, Namrata Singh
doi : 10.1002/art.42373
At the Heart of Treating Kawasaki Disease: The Search for New Approaches to Prevent Coronary Artery Aneurysms
Yan Du, Pui Y. Lee
doi : 10.1002/art.42346
Genetic Influences in Cancer-Associated Myositis
Karina Patasova, Ingrid E. Lundberg, Marie Holmqvist
doi : 10.1002/art.42345
Idiopathic inflammatory myopathies (IIMs) comprise a heterogeneous group of rare immune-mediated disorders that primarily affect muscles but also lead to dysfunction in other organs.
Combination of Two Monoclonal Anti–Citrullinated Protein Antibodies Induced Tenosynovitis, Pain, and Bone Loss in Mice in a Peptidyl Arginine Deiminase-4–Dependent Manner
Akilan Krishnamurthy, Alexandra Circiumaru, Jitong Sun, Yogan Kisten, Peter Damberg, Koji Sakuraba, Katalin Sandor, Patrik Jarvoll, Tunhe Zhou, Vivianne Malmström, Camilla I. Svensson, Aase Hensvold, Anca I. Catrina, Lars Klareskog, Bence Réthi
doi : 10.1002/art.42320
The appearance of anti–citrullinated protein antibodies (ACPAs) in the circulation represents a major risk factor for developing rheumatoid arthritis (RA). Patient-derived ACPAs have been shown to induce pain and bone erosion in mice, suggesting an active role in the pathogenicity of RA. We undertook this study to investigate whether ACPAs can induce tenosynovitis, an early sign of RA, in addition to pain and bone loss and whether these symptoms are dependent on peptidyl arginine deiminase 4 (PAD4).
A Multicenter, Prospective, Randomized, Parallel-Group Trial on the Effects of Temporary Methotrexate Discontinuation for One Week Versus Two Weeks on Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis
Jin Kyun Park, Yun Jong Lee, Kichul Shin, Eun Ha Kang, You-Jung Ha, Jun Won Park, Min Jung Kim, Mi Hyeon Kim, Se Rim Choi, Youjin Jung, Ju Ho Lee, Ji In Jung, Ju Yeon Kim, Kevin L. Winthrop, Eun Bong Lee
doi : 10.1002/art.42318
This clinical trial was conducted to investigate whether discontinuing methotrexate (MTX) for 1 week after seasonal influenza vaccination is noninferior to discontinuing for 2 weeks after vaccination in patients with rheumatoid arthritis (RA).
The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross-Sectional Study
Marc P. Maurits, Fenne Wouters, Ellis Niemantsverdriet, Thomas W. J. Huizinga, Erik B. van den Akker, Saskia Le Cessie, Annette H. M. van der Helm-van Mil, Rachel Knevel
doi : 10.1002/art.42323
To investigate whether established genetic predictors for rheumatoid arthritis (RA) differentiate healthy controls, patients with clinically suspect arthralgia (CSA), and RA patients.
Assessing the Immune Cell Subset and Genetic Mutations in Patients With Palindromic Rheumatism Seronegative for Rheumatoid Factor and Anti–Cyclic Citrullinated Peptide
Chin-An Yang, Ju-Pi Li, Yi-Hua Lai, Ya-Ling Huang, Chien-Yu Lin, Joung-Liang Lan
doi : 10.1002/art.42297
The etiology underlying cases of palindromic rheumatism (PR) not associated with other rheumatic diseases in patients who are seronegative for rheumatoid factor and anti–cyclic citrullinated peptide (seronegative PR) is unclear. We aimed to investigate the immune cells and genes involved.
Genicular Nerve Block for Pain Management in Patients With Knee Osteoarthritis: A Randomized Placebo-Controlled Trial
Ernst M. Shanahan, Lucinda Robinson, Suellen Lyne, Richard Woodman, Fin Cai, Kokum Dissanayake, Kate Paddick, Giovanna Cheung, Frank Voyvodic
doi : 10.1002/art.42384
This study was undertaken to determine the efficacy of ultrasound-guided genicular nerve block (GNB) for the management of knee pain in patients with knee osteoarthritis.
Keep an Eye on the Back: Spondyloarthritis in Patients With Acute Anterior Uveitis
Judith Rademacher, Hanna Müllner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy
doi : 10.1002/art.42315
This study was undertaken to analyze the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), to identify parameters associated with the presence of SpA, and to evaluate the performance of referral algorithms for identifying patients with a high probability of having SpA.
Paradoxical Effects of Endoplasmic Reticulum Aminopeptidase 1 Deficiency on HLA–B27 and Its Role as an Epistatic Modifier in Experimental Spondyloarthritis
Tri M. Tran, Tejpal Gill, Joshua Bennett, Sohee Hong, Vance Holt, Anders J. Lindstedt, Sufia Bakshi, Keith Sikora, Joel D. Taurog, Maxime Breban, Fatemeh Navid, Robert A. Colbert
doi : 10.1002/art.42327
We undertook this study to examine the functional basis for epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA–B27 in experimental spondyloarthritis (SpA).
Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry
Rouhin Sen, Emmeline Kim, Ruth J. Napier, Elizabeth Cheng, Andrea Fernandez, Evan S. Manning, Eric R. Anderson, Kyle D. Maier, Mena Hashim, Gail S. Kerr, Meika A. Fang, Jason K. Hou, Elizabeth Chang, Jessica A. Walsh, Siba P. Raychadhuri, Andreas Reimold, Liron Caplan
doi : 10.1002/art.42333
This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers.
Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial
Eric Morand, Marilyn Pike, Joan T. Merrill, Ronald van Vollenhoven, Victoria P. Werth, Coburn Hobar, Nikolay Delev, Vaishali Shah, Brian Sharkey, Thomas Wegman, Ian Catlett, Subhashis Banerjee, Shalabh Singhal
doi : 10.1002/art.42391
To assess the efficacy and safety of deucravacitinib, an oral, selective, allosteric inhibitor of TYK2, in a phase II trial in adult patients with active systemic lupus erythematosus (SLE).
A Randomized, Placebo-Controlled Phase III Extension Trial of the Long-Term Safety and Tolerability of Anifrolumab in Active Systemic Lupus Erythematosus
Kenneth C. Kalunian, Richard Furie, Eric F. Morand, Ian N. Bruce, Susan Manzi, Yoshiya Tanaka, Kevin Winthrop, Ihor Hupka, Lijin (Jinny) Zhang, Shanti Werther, Gabriel Abreu
doi : 10.1002/art.42392
To explore long-term safety and tolerability of anifrolumab 300 mg compared with placebo in patients with systemic lupus erythematosus (SLE) who completed a Treatment of Uncontrolled Lupus via the Interferon Pathway (TULIP) trial and enrolled in the placebo-controlled 3-year long-term extension (LTE) study (ClinicalTrials.gov identifier: NCT02794285).
Alterations of Gut Microbiome, Metabolome, and Lipidome in Takayasu Arteritis
Luyun Fan, Junru Chen, Lili Pan, Xiaohong Xin, Bin Geng, Lirui Yang, Qian Wang, Wenjun Ma, Ying Lou, Jin Bian, Xiao Cui, Jing Li, Lu Wang, Zhenzhen Chen, Wenjie Wang, Changting Cui, Shuangyue Li, Qiannan Gao, Qirui Song, Yue Deng, Jiali Fan, Jiachen Yu, Huimin Zhang, Yafeng Li, Jun Cai
doi : 10.1002/art.42331
Mounting evidence has linked microbiome and metabolome to systemic autoimmunity and cardiovascular diseases (CVDs). Takayasu arteritis (TAK) is a rare disease that shares features of immune-related inflammatory diseases and CVDs, about which there is relatively limited information.
Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis
Nila H. Servaas, Sanne Hiddingh, Eleni Chouri, Catharina G. K. Wichers, Alsya J. Affandi, Andrea Ottria, Cornelis P. J. Bekker, Marta Cossu, Sandra C. Silva-Cardoso, Maarten van der Kroef, Anneline C. Hinrichs, Tiago Carvalheiro, Nadia Vazirpanah, Lorenzo Beretta, Marzia Rossato, Femke Bonte-Mineur, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Marianne Boes, Aridaman Pandit
doi : 10.1002/art.42319
This study was undertaken to identify key disease pathways driving conventional dendritic cell (cDC) alterations in systemic sclerosis (SSc).
A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings
John K. Botson, Kenneth Saag, Jeff Peterson, Naval Parikh, Stephen Ong, Dan La, Karon LoCicero, Katie Obermeyer, Yan Xin, Jason Chamberlain, Brian LaMoreaux, Supra Verma, Stephen Sainati, Suneet Grewal, Amar Majjhoo, John R. P. Tesser, Michael E. Weinblatt
doi : 10.1002/art.42335
To assess efficacy, safety, pharmacokinetics, and immunogenicity of pegloticase plus methotrexate (MTX) versus pegloticase plus placebo cotreatment for uncontrolled gout in a randomized, placebo-controlled, double-blind trial.
Mechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease
Angus T. Stock, Sarah Parsons, Damian B. D'Silva, Jacinta A. Hansen, Varun J. Sharma, Fiona James, Graham Starkey, Rohit D'Costa, Claire L. Gordon, Ian P. Wicks
doi : 10.1002/art.42340
Remodeling of the coronary arteries is a common feature in severe cases of Kawasaki disease (KD). This pathology is driven by the dysregulated proliferation of vascular fibroblasts, which can lead to coronary artery aneurysms, stenosis, and myocardial ischemia. We undertook this study to investigate whether inhibiting fibroblast proliferation might be an effective therapeutic strategy to prevent coronary artery remodeling in KD.
Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis
Joeri W. van Straalen, Lianne Kearsley-Fleet, Jens Klotsche, Sytze de Roock, Kirsten Minden, Arnd Heiligenhaus, Kimme L. Hyrich, Joke H. de Boer, Lovro Lamot, Alma N. Olivieri, Romina Gallizzi, Elzbieta Smolewska, Enrique Faugier, Serena Pastore, Philip J. Hashkes, Cristina N. Herrera, Wolfgang Emminger, Rita Consolini, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart, on behalf of the Paediatric Rheumatology International Trials Organisation (PRINTO), UK CAPS study, and German ICON study
doi : 10.1002/art.42329
To develop and externally validate a prediction model for new-onset chronic uveitis in children with juvenile idiopathic arthritis (JIA) for clinical application.
More than half of patients with a rheumatic disease or immunologic condition undergoing methotrexate treatment reside in states in which the overturning of Roe v. Wade can jeopardize access to medications with abortifacient potential
Kathryn Starzyk, Veena Hoffman, Zhaohui Su, Roger Meng, Mudit Bhartia, Gary Curhan, Kazuki Yoshida, Jessica K. Paulus
doi : 10.1002/art.42398
High increase in levels of lipoprotein(a) in plasma of patients with rheumatoid arthritis after COVID-19
David Stahl, Ruth L. Esser, Carolin Brück, Jan Thiele, Veronica Di Cristanziano, Carola tho Pesch, David M. Kofler
doi : 10.1002/art.42374
