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Cholangioscopy-Guided Surgical Clip Extraction During Giant Stone Lithotripsy
Pedro López-Muñoz, MarÃa GarcÃa-Campos, Vicente Lorenzo-Zúñiga, Noelia Alonso-Lázaro, Lidia Argüello, Marco Bustamante-Balén & Vicente Pons-Beltrán
doi : 10.1007/s10620-022-07701-7
Volume 68, issue 2, February 2023
Narrowing the Quality Chasm in Achalasia
Jennifer X. Cai, Eric E. Low & Rena Yadlapati
Polyp Fact or Polyp Fiction: Endoscopic Identification of Polyps Using Established Criteria to Improve the Quality of Endoscopic Evaluation and Cost Effectiveness
Ihsan Al Bayati, Sarah Al Obaidi & Mohammed Bashashati
Secondary Treatment of Primary Biliary Cholangitis: Early Prediction of Inadequate Response to Ursodeoxycholic Acid in Patients with PBC
Benjamin D. Liu & Kamran Qureshi
Viral Vector Vaccines Are Victorious Against COVID-19 in Patients with Cirrhosis
Raphaella D. Ferreira & Binu V. John
Entrust Me: Embedding Entrustable Professional Activities in a Gastroenterology Residency Program
Andrew Ming-Liang Ong & Clasandra Hum
doi : 10.1007/s10620-022-07815-y
Entrustable Professional Activities (EPAs) are defined as a process of gradually entrusting key tasks to specialty fellows during their training.
Ironing It All Out: A Comprehensive Review of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients
Laura A. Maas, Mahesh Krishna & Alyssa M. Parian
doi : 10.1007/s10620-022-07599-1
Iron deficiency anemia affects approximately 45% of patients with inflammatory bowel disease (IBD), negatively impacts the quality of life in this patient population, and significantly burdens our healthcare system.
Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer
Linsen Shi, Yumei Xu & Min Feng
doi : 10.1007/s10620-022-07689-0
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC.
Opportunistic Knocks: A Gardener with Ulcerative Colitis and New Pulmonary Nodules
Andrew Canakis, Sindhura Kolachana, Van K. Holden & Raymond K. Cross
doi : 10.1007/s10620-022-07785-1
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease that is usually classified either ulcerative colitis (UC) or Crohn’s disease (CD).
Upadacitinib Is Safe and Effective for Crohn’s Disease: Real-World Data from a Tertiary Center
Cindy Traboulsi, Fares Ayoub, Alexa Silfen, Tina G. Rodriguez & David T. Rubin
doi : 10.1007/s10620-022-07582-w
Upadacitinib is a selective JAK-1 inhibitor approved for the treatment of rheumatoid arthritis and more recently, ulcerative colitis. Phase II trials demonstrated that upadacitinib induces endoscopic remission in patients with moderate-to-severe Crohn’s disease.
Achalasia Quality Indicator Adherence
Emily Romanoff, Justin Zhuo, Annsa C. Huang, Deron Amador, Fouad Otaki, Afrin N. Kamal, Priya Kathpalia & David A. Leiman
doi : 10.1007/s10620-022-07658-7
Quality indicators (QIs) are formal ways to track health care performance and outcomes, guide quality improvement, and identify gaps in care delivery. We developed twelve quality indicators for achalasia management which cover the domains of patient education, diagnosis, and treatment of achalasia.
Worsened Fibrostenotic Outcomes in Eosinophilic Esophagitis Patients Due to COVID-19-Related Endoscopy Cancellations
Adolfo A. Ocampo & Evan S. Dellon
doi : 10.1007/s10620-022-07610-9
Indirect consequences of COVID-19 in eosinophilic esophagitis (EoE) are not known.
Azathioprine Withdrawal Is Cost-Effective in Patients with Crohn’s Disease in Remission on Infliximab and Azathioprine
Gaurav Syal, Gil Y. Melmed, Christopher V. Almario & Brennan M. R. Spiegel
doi : 10.1007/s10620-022-07789-x
In Crohn’s disease, combination therapy with infliximab and azathioprine is more effective than either drug alone but is associated with a higher risk of therapy-related complications. Though therapy de-escalation can reduce risks and save costs, it is associated with a risk of Crohn’s disease relapse.
Trends in Biochemical Parameters, Healthcare Resource and Medication Use in the 5 Years Preceding IBD Diagnosis: A Health Maintenance Organization Cohort Study
Nathaniel A. Cohen, Efrat Kliper, Noa Zamstein, Tomer Ziv-Baran, Matti Waterman, Gabriel Hodik, Amir Ben Tov & Revital Kariv
doi : 10.1007/s10620-022-07714-2
Few data describing pre-diagnosis changes in patients with inflammatory bowel disease (IBD) exist. We aimed to determine if there is a pattern of change in use of health resources, medications and laboratory results in the years preceding diagnosis.
Incidence, Burden, and Predictors of Readmission for Acute Alcoholic Pancreatitis: A National Analysis over 11Â Months
Luis M. Nieto, Miguel Salazar, Jami Kinnucan, Frank J. Lukens & Pedro Palacios Argueta
doi : 10.1007/s10620-022-07798-w
Data regarding incidence, health-care burden, and predictors for readmission in patients with acute alcoholic pancreatitis (AAP) is scarce. We aim to identify incidence, health-care burden, and predictors of readmission over an 11-month period.
Primary Care Providers and Nonalcoholic Fatty Liver Disease: A Needs Assessment Survey
Kendall B. Islam, Danielle Brandman, Janet N. Chu, Max L. Goldman & Rena K. Fox
doi : 10.1007/s10620-022-07706-2
Primary care providers (PCPs) face increasing numbers of patients at risk for NAFLD and are responsible for the detection of NAFLD and the decision on referral to specialists. We conducted a PCP needs assessment to ascertain the barriers and desired supports for NAFLD in primary care.
Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi & Yoshihiro Ogawa
doi : 10.1007/s10620-022-07637-y
The specific role of the M3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds.
CD8+ Lymphocyte Infiltration Is a Specific Feature of Colitis Induced by Immune Checkpoint Inhibitors
Yoshiyuki Takahashi, Tadanobu Nagaya, Yugo Iwaya, Takuma Okamura, Atsuhiro Hirayama, Mai Iwaya, Takeshi Uehara & Takeji Umemura
doi : 10.1007/s10620-022-07598-2
Immune checkpoint inhibitors (ICPIs) have revolutionized cancer therapy, although immune-related adverse events (irAEs) remain a serious issue. The clinical characteristics of colitis induced by ICPIs are very similar to inflammatory bowel disease.
Serum and Mucosal CD30 in Pediatric Inflammatory Bowel Diseases: Useful Biomarker for Diagnosis and Disease Activity Monitoring?
Ondrej Fabian, Adam Klocperk, Tereza Lerchova, Pavla Jencova, Lucie Stolova, Marie Belhajova, Dagmar Voriskova, Denis Kazeka, Ales Vicha, Ondrej Hradsky & Jiri Bronsky
doi : 10.1007/s10620-022-07677-4
Inflammatory bowel diseases (IBD) frequently manifest in pediatric age, but may have atypical clinical, histological and laboratory features. Their underlying immune pathophysiology is incompletely understood, rendering quick diagnosis followed by tailored therapy difficult.
Isolation and Characterization of Stem Cells from the Anal Canal Transition Zone in Pigs
Alexandre Balaphas, Jeremy Meyer, Nicolas C. Buchs, Ali Modarressi, Leo H. Bühler, Christian Toso, Carmen Gonelle-Gispert & Frédéric Ris
doi : 10.1007/s10620-022-07690-7
Utilization of autologous stem cells has been proposed for the treatment of anal incontinence despite a lack of understanding of their mechanism of action and of the physiological healing process of anal sphincters after injury.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin
Jie Yang, Fei Han, Guanghai Wu, Ya Dong, Hang Su, Jing Xu & Jun Li
doi : 10.1007/s10620-022-07606-5
Patients with hypertriglyceridemia (HTG) are prone to develop more severe acute pancreatitis (AP). However, the specific molecular mechanism still has not been elaborated clearly, and effective drugs for treating HTG-AP are not yet readily available. Baicalin is an ingredient isolated from a natural product that with potential to attenuate inflammation and pain in AP.
Downregulation of miR-20b-5p Contributes to the Progression of Liver Fibrosis via the STAT3 Signaling Pathway In Vivo and In Vitro
Ling Lv, Dong Wang, Jikai Yin, Tao Yang, Bo Huang, Yanlong Cao & Jianguo Lu
doi : 10.1007/s10620-022-07660-z
Activated hepatic stellate cells (HSCs) are primarily involved in liver fibrosis and portal hypertension (PHT). We aimed to investigate the effect of miR-20b-5p on HSCs, liver fibrosis, and PHT.
Association of Heparin-Like Effect, Factor VII/XIII Deficiency and Fibrinolysis with Rebleeding Risk in Cirrhosis with Acute Variceal Bleeding
Madhumita Premkumar, Rohit Mehtani, Anand V. Kulkarni, Ajay Kumar Duseja, Arka De, Sunil Taneja, Virendra Singh, Nipun Verma, Jasmina Ahluwalia, Kamal Kajal, Smita Divyaveer, Akash Roy, Akash Gandotra, Narender Kalson, Kushal Kekan, Harmanpreet Kaur & Harpreet Kaur
doi : 10.1007/s10620-022-07656-9
Hyperfibrinolysis and coagulation dysfunction may occur in cirrhotic patients with acute variceal bleed (AVB) despite successful endotherapy.
Response to Ursodeoxycholic Acid May Be Assessed Earlier to Allow Second-Line Therapy in Patients with Unresponsive Primary Biliary Cholangitis
Guilherme Grossi Lopes Cançado, Cláudia Alves Couto, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Cristiane Alves Villela-Nogueira, Maria Lucia Gomes Ferraz, Michelle Harriz Braga, Mateus Jorge Nardelli, Luciana Costa Faria, Nathalia Mota de Faria Gomes, Elze Maria Gomes Oliveira, Vivian Rotman, Maria Beatriz Oliveira, Simone Muniz Carvalho Fernandes da Cunha, Marlone Cunha-Silva, Liliana Sampaio Costa Mendes, Claudia Alexandra Pontes Ivantes, Liana Codes, Valéria Ferreira de Almeida e Borges, Fabio Heleno de Lima Pace, Mario Guimarães Pessoa, Laura Vilar Guedes, Izabelle Venturini Signorelli, Gabriela Perdomo Coral, Cynthia Levy, Paulo Lisboa Bittencourt & Members of the Brazilian Cholestasis Study Group Consortium
doi : 10.1007/s10620-022-07654-x
Response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) has been traditionally assessed 1 to 2Â years after treatment initiation. With the development of new drugs, some patients may benefit from an earlier introduction of second-line therapies.
Clinical Efficacy of Tandospirone on Functional Dyspepsia Patients with Anxiety: A Randomized, Placebo-Controlled Study
Lulu Liu, Wenguang Yang, Ya Lu, Jue Wang, Yan Zheng & Sai Gu
doi : 10.1007/s10620-022-07717-z
Functional dyspepsia (FD) is characterized with multiple symptoms of indigestion and often accompanied with anxiety. However, there is currently an absence of effective treatment. Tandospirone is commonly used to treat generalized anxiety disorders. Whether tandospirone can improve the clinical symptoms of FD remain unknown.
Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease
Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia & Sunita Malhotra
doi : 10.1007/s10620-022-07762-8
A strict lifelong gluten-free diet (GFD) remains the only treatment of celiac disease (CD). Adherence to gluten-free diet is best reflected by mucosal healing. Noninvasive tools capable of predicting mucosal recovery in CD patients need to be identified.
Standard Adult Gastric Emptying Scintigraphy Criteria Is Applicable for Partial Meal Ingestion
Hina Shah, Reethy Sundar, David E. Arboleda Prado, Jian W. Dong, David Z. Chow, Braden Kuo, Stephan D. Voss, Heather A. Jacene, Matthew S. Robertson & Thomas S. C. Ng
doi : 10.1007/s10620-022-07667-6
Gastric emptying scintigraphy is commonly performed to assess for dysmotility. A standardized meal with associated threshold criteria was established in 2000 to enable robust interpretation. However, no guidance is available to interpret results when patients do not ingest the entire meal. The purpose of this study is to determine the continued appropriateness of the threshold criteria in contemporary clinical practice and its relevance for partially ingested meals.
Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease
Arsheya Patel, Somashekar G. Krishna, Kishan Patel, Darrell M. Gray II, Khalid Mumtaz, Peter P. Stanich, Alice Hinton & Hisham Hussan
doi : 10.1007/s10620-022-07589-3
Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Non-malignant colorectal conditions are understudied in this population. We hypothesize that developing severe obesity in young adulthood also corresponds with increased hospitalization rates for non-malignant colorectal conditions.
Side Effects of COVID-19 Vaccines in Patients with Inflammatory Bowel Disease in Japan
Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi & Yuzo Kodama
doi : 10.1007/s10620-022-07703-5
Patients with inflammatory bowel disease (IBD) are recommended to receive the coronavirus disease 2019 (COVID-19) vaccine. However, a recent survey showed that patients with IBD are more hesitant to receive the vaccine than the general population. Detailed information on the side effects of the COVID-19 vaccine is necessary to encourage vaccination among patients with IBD.
Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis
Michaela S. Tracy, Prasanna K. Challa, Lauren Canha, Kristin Burke, Ashwin N. Ananthakrishnan, Emily W. Lopes, James M. Richter, Andrew T. Chan & Hamed Khalili
doi : 10.1007/s10620-022-07678-3
Microscopic colitis is a chronic inflammatory disease that most commonly affects post-menopausal women. Exogenous hormone use has recently been linked with increased risk of microscopic colitis.
Evaluation of Nutritional Characteristics Reveals Similar Prevalence of Malnutrition in Patients with Ulcerative Colitis and Crohn’s Disease
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall & Ajit Sood
doi : 10.1007/s10620-022-07652-z
Inflammatory bowel disease (IBD) is associated with an increased risk of malnutrition and sarcopenia.
A Method Using Longitudinal Laboratory Data to Predict Future Intestinal Complication in Patients with Crohn’s Disease
James Irwin, Anton Lord, Emma Ferguson, Lisa A. Simms, Katherine Hanigan, Carlos A. Montoya & Graham Radford-Smith
doi : 10.1007/s10620-022-07639-w
Stenosis, fistulization, and perforation of the bowel are severe outcomes which can occur in patients with Crohn’s disease. Accurate prediction of these events may enable clinicians to alter treatment strategies and avoid these outcomes.
Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease
Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease
doi : 10.1007/s10620-022-07630-5
The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown.
Accuracy and Inter-observer Agreement Among Endoscopists for Visual Identification of Colorectal Polyps Using Endoscopy Images
Thi Khuc, Amol Agarwal, Feng Li, Sergey Kantsevoy, Bryan Curtin, Matilda Hagan, Mary Harris, Anurag Maheshwari, Amit Raina, Elinor Zhou & Paul Thuluvath
doi : 10.1007/s10620-022-07643-0
It is essential to accurately distinguish small benign hyperplastic colon polyps (HP) from sessile serrated lesions (SSL) or adenomatous polyps (TA) based on endoscopic appearances. Our objective was to determine the accuracy and inter-observer agreements for the endoscopic diagnosis of small polyps.
Comparison of Opioid-Based Patient-Controlled Analgesia with Physician-Directed Analgesia in Acute Pancreatitis: A Retrospective Cohort Study
Supisara Tintara, Ishani Shah, William Yakah, John J. Kowalczyk, Cristina Sorrento, Cinthana Kandasamy, Awais Ahmed, Steven D. Freedman, Darshan J. Kothari & Sunil G. Sheth
doi : 10.1007/s10620-022-07573-x
Patient-controlled analgesia (PCA) is commonly used for acute postoperative pain management. Clinicians may also use PCA in the management of acute pancreatitis (AP); however, there is limited data on its impact on patient outcomes.
Infections in Acute Pancreatitis: Organisms, Resistance-Patterns and Effect on Mortality
Fang Li, Feng Zhang, Xueqin Wan, Kesong Wu, Qing Liu, Chuiyan Qiu, Haiyan Yin & Jun Lyu
doi : 10.1007/s10620-022-07793-1
Acute pancreatitis (AP) is a common gastrointestinal disease in which infection is a serious complication. Understanding its bacterial spectrum and antibiotic resistance is of great significance for treatment.
Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children
Soofia Khan, Heidi J. Kalkwarf, Lindsey Hornung, Robert Siegel, Ana Catalina Arce-Clachar, Rachel Sheridan, Holly M. Ippisch & Stavra A. Xanthakos
doi : 10.1007/s10620-022-07563-z
Lower whole body bone mineral density (BMD) has been reported in children with nonalcoholic fatty liver disease (NAFLD), but potential mediators remain uncertain.
Positive Association Between the Chinese Visceral Adiposity Index and Nonalcoholic Fatty Liver Disease in Lean Adults
Shuxia Shen, Hangkai Huang, Jinghua Wang, Zexi Tang, Chao Shen & Chengfu Xu
doi : 10.1007/s10620-022-07787-z
Chinese visceral adiposity index (CVAI) is a novel indicator that precisely evaluates visceral obesity and has been shown to be significantly associated with nonalcoholic fatty liver disease (NAFLD) in the general population. However, the relationship between CVAI and NAFLD in lean adults remains unclear.
Retreatment Efficacy and Renal Safety of Tenofovir Alafenamide, Entecavir, and Tenofovir Disoproxil Fumarate After Entecavir or Tenofovir Cessation
Shao-Ming Chiu, Kuo-Chin Chang, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu & Chien-Hung Chen
doi : 10.1007/s10620-022-07657-8
We aimed to compare the one-year retreatment efficacy and renal safety of entecavir, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF) after HBV relapse in patients who discontinued entecavir or TDF.
Antibody Response and Safety of ChAdOx1-nCOV (Covishield) in Patients with Cirrhosis: A Cross-Sectional, Observational Study
Amandeep Singh, Arka De, Mini P. Singh, Sahaj Rathi, Nipun Verma, Madhumita Premkumar, Sunil Taneja, Ajay Duseja & Virendra Singh
doi : 10.1007/s10620-022-07641-2
Patients with cirrhosis have a higher risk of severe COVID-19 and mortality and are high-priority patients for vaccination. However, cirrhotics were excluded from the phase 2/3 vaccine trials. Hence, we aimed to assess the antibody response and safety of Covishield (ChAdOx1nCoV-19) among patients with cirrhosis.
Impact of Interferon-Free Direct-Acting Antivirals on the Incidence of Extrahepatic Malignancies in Patients with Chronic Hepatitis C
Yuichi Honma, Michihiko Shibata, Kahori Morino, Yudai Koya, Tsuguru Hayashi, Noriyoshi Ogino, Masashi Kusanaga, Shinji Oe, Koichiro Miyagawa, Shintaro Abe, Akinari Tabaru & Masaru Harada
doi : 10.1007/s10620-022-07686-3
The incidence of extrahepatic malignancies (EHMs) after hepatitis C virus (HCV) eradication by interferon (IFN)-based and IFN-free direct-acting antivirals (DAAs) treatment remains unclear.
Methodological Issues to Be Considered in Evaluating Advanced Endoscopic Resection Techniques in Cirrhosis
Zi-Jing Wang, Xiu-He Lv & Jin-Lin Yang
Adverse Outcomes of E-cigarette in Inflammatory Bowel Disease
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Liatsos, Maria Tzitiridou-Chatzopoulou, Dimitrios Chatzopoulos, Elisabeth Vardaka, Dimitra Gialamprinou, Georgios Kotronis, Tharshika Thavayogarajah & Michael Doulberis
Neutrophil-to-Lymphocyte Ratio for the Diagnosis and Monitoring of Inflammatory Bowel Disease
Cong Dai, Min Jiang & Yu-hong Huang
Correction: Comparing Predictability of Non‑invasive Tools for Hepatocellular Carcinoma in Treated Chronic Hepatitis C Patients
Yen-Chun Liu, Ya-Ting Cheng, Yi-Cheng Chen, Yi-Chung Hsieh, Wen-Juei Jeng, Chun-Yen Lin, Rong-Nan Chien, Dar-In Tai & I.-Shyan Sheen
Cholangioscopy-Guided Surgical Clip Extraction During Giant Stone Lithotripsy
Pedro López-Muñoz, MarÃa GarcÃa-Campos, Vicente Lorenzo-Zúñiga, Noelia Alonso-Lázaro, Lidia Argüello, Marco Bustamante-Balén & Vicente Pons-Beltrán
doi : 10.1007/s10620-022-07701-7
Volume 68, issue 2, February 2023
Narrowing the Quality Chasm in Achalasia
Jennifer X. Cai, Eric E. Low & Rena Yadlapati
Polyp Fact or Polyp Fiction: Endoscopic Identification of Polyps Using Established Criteria to Improve the Quality of Endoscopic Evaluation and Cost Effectiveness
Ihsan Al Bayati, Sarah Al Obaidi & Mohammed Bashashati
Secondary Treatment of Primary Biliary Cholangitis: Early Prediction of Inadequate Response to Ursodeoxycholic Acid in Patients with PBC
Benjamin D. Liu & Kamran Qureshi
Viral Vector Vaccines Are Victorious Against COVID-19 in Patients with Cirrhosis
Raphaella D. Ferreira & Binu V. John
Entrust Me: Embedding Entrustable Professional Activities in a Gastroenterology Residency Program
Andrew Ming-Liang Ong & Clasandra Hum
doi : 10.1007/s10620-022-07815-y
Entrustable Professional Activities (EPAs) are defined as a process of gradually entrusting key tasks to specialty fellows during their training.
Ironing It All Out: A Comprehensive Review of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients
Laura A. Maas, Mahesh Krishna & Alyssa M. Parian
doi : 10.1007/s10620-022-07599-1
Iron deficiency anemia affects approximately 45% of patients with inflammatory bowel disease (IBD), negatively impacts the quality of life in this patient population, and significantly burdens our healthcare system.
Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer
Linsen Shi, Yumei Xu & Min Feng
doi : 10.1007/s10620-022-07689-0
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC.
Opportunistic Knocks: A Gardener with Ulcerative Colitis and New Pulmonary Nodules
Andrew Canakis, Sindhura Kolachana, Van K. Holden & Raymond K. Cross
doi : 10.1007/s10620-022-07785-1
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease that is usually classified either ulcerative colitis (UC) or Crohn’s disease (CD).
Upadacitinib Is Safe and Effective for Crohn’s Disease: Real-World Data from a Tertiary Center
Cindy Traboulsi, Fares Ayoub, Alexa Silfen, Tina G. Rodriguez & David T. Rubin
doi : 10.1007/s10620-022-07582-w
Upadacitinib is a selective JAK-1 inhibitor approved for the treatment of rheumatoid arthritis and more recently, ulcerative colitis. Phase II trials demonstrated that upadacitinib induces endoscopic remission in patients with moderate-to-severe Crohn’s disease.
Achalasia Quality Indicator Adherence
Emily Romanoff, Justin Zhuo, Annsa C. Huang, Deron Amador, Fouad Otaki, Afrin N. Kamal, Priya Kathpalia & David A. Leiman
doi : 10.1007/s10620-022-07658-7
Quality indicators (QIs) are formal ways to track health care performance and outcomes, guide quality improvement, and identify gaps in care delivery. We developed twelve quality indicators for achalasia management which cover the domains of patient education, diagnosis, and treatment of achalasia.
Worsened Fibrostenotic Outcomes in Eosinophilic Esophagitis Patients Due to COVID-19-Related Endoscopy Cancellations
Adolfo A. Ocampo & Evan S. Dellon
doi : 10.1007/s10620-022-07610-9
Indirect consequences of COVID-19 in eosinophilic esophagitis (EoE) are not known.
Azathioprine Withdrawal Is Cost-Effective in Patients with Crohn’s Disease in Remission on Infliximab and Azathioprine
Gaurav Syal, Gil Y. Melmed, Christopher V. Almario & Brennan M. R. Spiegel
doi : 10.1007/s10620-022-07789-x
In Crohn’s disease, combination therapy with infliximab and azathioprine is more effective than either drug alone but is associated with a higher risk of therapy-related complications. Though therapy de-escalation can reduce risks and save costs, it is associated with a risk of Crohn’s disease relapse.
Trends in Biochemical Parameters, Healthcare Resource and Medication Use in the 5 Years Preceding IBD Diagnosis: A Health Maintenance Organization Cohort Study
Nathaniel A. Cohen, Efrat Kliper, Noa Zamstein, Tomer Ziv-Baran, Matti Waterman, Gabriel Hodik, Amir Ben Tov & Revital Kariv
doi : 10.1007/s10620-022-07714-2
Few data describing pre-diagnosis changes in patients with inflammatory bowel disease (IBD) exist. We aimed to determine if there is a pattern of change in use of health resources, medications and laboratory results in the years preceding diagnosis.
Incidence, Burden, and Predictors of Readmission for Acute Alcoholic Pancreatitis: A National Analysis over 11Â Months
Luis M. Nieto, Miguel Salazar, Jami Kinnucan, Frank J. Lukens & Pedro Palacios Argueta
doi : 10.1007/s10620-022-07798-w
Data regarding incidence, health-care burden, and predictors for readmission in patients with acute alcoholic pancreatitis (AAP) is scarce. We aim to identify incidence, health-care burden, and predictors of readmission over an 11-month period.
Primary Care Providers and Nonalcoholic Fatty Liver Disease: A Needs Assessment Survey
Kendall B. Islam, Danielle Brandman, Janet N. Chu, Max L. Goldman & Rena K. Fox
doi : 10.1007/s10620-022-07706-2
Primary care providers (PCPs) face increasing numbers of patients at risk for NAFLD and are responsible for the detection of NAFLD and the decision on referral to specialists. We conducted a PCP needs assessment to ascertain the barriers and desired supports for NAFLD in primary care.
Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi & Yoshihiro Ogawa
doi : 10.1007/s10620-022-07637-y
The specific role of the M3 muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds.
CD8+ Lymphocyte Infiltration Is a Specific Feature of Colitis Induced by Immune Checkpoint Inhibitors
Yoshiyuki Takahashi, Tadanobu Nagaya, Yugo Iwaya, Takuma Okamura, Atsuhiro Hirayama, Mai Iwaya, Takeshi Uehara & Takeji Umemura
doi : 10.1007/s10620-022-07598-2
Immune checkpoint inhibitors (ICPIs) have revolutionized cancer therapy, although immune-related adverse events (irAEs) remain a serious issue. The clinical characteristics of colitis induced by ICPIs are very similar to inflammatory bowel disease.
Serum and Mucosal CD30 in Pediatric Inflammatory Bowel Diseases: Useful Biomarker for Diagnosis and Disease Activity Monitoring?
Ondrej Fabian, Adam Klocperk, Tereza Lerchova, Pavla Jencova, Lucie Stolova, Marie Belhajova, Dagmar Voriskova, Denis Kazeka, Ales Vicha, Ondrej Hradsky & Jiri Bronsky
doi : 10.1007/s10620-022-07677-4
Inflammatory bowel diseases (IBD) frequently manifest in pediatric age, but may have atypical clinical, histological and laboratory features. Their underlying immune pathophysiology is incompletely understood, rendering quick diagnosis followed by tailored therapy difficult.
Isolation and Characterization of Stem Cells from the Anal Canal Transition Zone in Pigs
Alexandre Balaphas, Jeremy Meyer, Nicolas C. Buchs, Ali Modarressi, Leo H. Bühler, Christian Toso, Carmen Gonelle-Gispert & Frédéric Ris
doi : 10.1007/s10620-022-07690-7
Utilization of autologous stem cells has been proposed for the treatment of anal incontinence despite a lack of understanding of their mechanism of action and of the physiological healing process of anal sphincters after injury.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin
Jie Yang, Fei Han, Guanghai Wu, Ya Dong, Hang Su, Jing Xu & Jun Li
doi : 10.1007/s10620-022-07606-5
Patients with hypertriglyceridemia (HTG) are prone to develop more severe acute pancreatitis (AP). However, the specific molecular mechanism still has not been elaborated clearly, and effective drugs for treating HTG-AP are not yet readily available. Baicalin is an ingredient isolated from a natural product that with potential to attenuate inflammation and pain in AP.
Downregulation of miR-20b-5p Contributes to the Progression of Liver Fibrosis via the STAT3 Signaling Pathway In Vivo and In Vitro
Ling Lv, Dong Wang, Jikai Yin, Tao Yang, Bo Huang, Yanlong Cao & Jianguo Lu
doi : 10.1007/s10620-022-07660-z
Activated hepatic stellate cells (HSCs) are primarily involved in liver fibrosis and portal hypertension (PHT). We aimed to investigate the effect of miR-20b-5p on HSCs, liver fibrosis, and PHT.
Association of Heparin-Like Effect, Factor VII/XIII Deficiency and Fibrinolysis with Rebleeding Risk in Cirrhosis with Acute Variceal Bleeding
Madhumita Premkumar, Rohit Mehtani, Anand V. Kulkarni, Ajay Kumar Duseja, Arka De, Sunil Taneja, Virendra Singh, Nipun Verma, Jasmina Ahluwalia, Kamal Kajal, Smita Divyaveer, Akash Roy, Akash Gandotra, Narender Kalson, Kushal Kekan, Harmanpreet Kaur & Harpreet Kaur
doi : 10.1007/s10620-022-07656-9
Hyperfibrinolysis and coagulation dysfunction may occur in cirrhotic patients with acute variceal bleed (AVB) despite successful endotherapy.
Response to Ursodeoxycholic Acid May Be Assessed Earlier to Allow Second-Line Therapy in Patients with Unresponsive Primary Biliary Cholangitis
Guilherme Grossi Lopes Cançado, Cláudia Alves Couto, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado, Cristiane Alves Villela-Nogueira, Maria Lucia Gomes Ferraz, Michelle Harriz Braga, Mateus Jorge Nardelli, Luciana Costa Faria, Nathalia Mota de Faria Gomes, Elze Maria Gomes Oliveira, Vivian Rotman, Maria Beatriz Oliveira, Simone Muniz Carvalho Fernandes da Cunha, Marlone Cunha-Silva, Liliana Sampaio Costa Mendes, Claudia Alexandra Pontes Ivantes, Liana Codes, Valéria Ferreira de Almeida e Borges, Fabio Heleno de Lima Pace, Mario Guimarães Pessoa, Laura Vilar Guedes, Izabelle Venturini Signorelli, Gabriela Perdomo Coral, Cynthia Levy, Paulo Lisboa Bittencourt & Members of the Brazilian Cholestasis Study Group Consortium
doi : 10.1007/s10620-022-07654-x
Response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) has been traditionally assessed 1 to 2Â years after treatment initiation. With the development of new drugs, some patients may benefit from an earlier introduction of second-line therapies.
Clinical Efficacy of Tandospirone on Functional Dyspepsia Patients with Anxiety: A Randomized, Placebo-Controlled Study
Lulu Liu, Wenguang Yang, Ya Lu, Jue Wang, Yan Zheng & Sai Gu
doi : 10.1007/s10620-022-07717-z
Functional dyspepsia (FD) is characterized with multiple symptoms of indigestion and often accompanied with anxiety. However, there is currently an absence of effective treatment. Tandospirone is commonly used to treat generalized anxiety disorders. Whether tandospirone can improve the clinical symptoms of FD remain unknown.
Role of Serology, Dietary Assessment, and Fecal Gluten Immunogenic Peptides for Predicting Histologic Recovery in Children with Celiac Disease
Keerthivasan Seetharaman, Sadhna Bhasin Lal, Kaushal Kishor Prasad, Yashwant Kumar, Alka Bhatia & Sunita Malhotra
doi : 10.1007/s10620-022-07762-8
A strict lifelong gluten-free diet (GFD) remains the only treatment of celiac disease (CD). Adherence to gluten-free diet is best reflected by mucosal healing. Noninvasive tools capable of predicting mucosal recovery in CD patients need to be identified.
Standard Adult Gastric Emptying Scintigraphy Criteria Is Applicable for Partial Meal Ingestion
Hina Shah, Reethy Sundar, David E. Arboleda Prado, Jian W. Dong, David Z. Chow, Braden Kuo, Stephan D. Voss, Heather A. Jacene, Matthew S. Robertson & Thomas S. C. Ng
doi : 10.1007/s10620-022-07667-6
Gastric emptying scintigraphy is commonly performed to assess for dysmotility. A standardized meal with associated threshold criteria was established in 2000 to enable robust interpretation. However, no guidance is available to interpret results when patients do not ingest the entire meal. The purpose of this study is to determine the continued appropriateness of the threshold criteria in contemporary clinical practice and its relevance for partially ingested meals.
Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease
Arsheya Patel, Somashekar G. Krishna, Kishan Patel, Darrell M. Gray II, Khalid Mumtaz, Peter P. Stanich, Alice Hinton & Hisham Hussan
doi : 10.1007/s10620-022-07589-3
Colorectal cancer incidence is rising in adults < 50 years old, possibly due to obesity. Non-malignant colorectal conditions are understudied in this population. We hypothesize that developing severe obesity in young adulthood also corresponds with increased hospitalization rates for non-malignant colorectal conditions.
Side Effects of COVID-19 Vaccines in Patients with Inflammatory Bowel Disease in Japan
Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi & Yuzo Kodama
doi : 10.1007/s10620-022-07703-5
Patients with inflammatory bowel disease (IBD) are recommended to receive the coronavirus disease 2019 (COVID-19) vaccine. However, a recent survey showed that patients with IBD are more hesitant to receive the vaccine than the general population. Detailed information on the side effects of the COVID-19 vaccine is necessary to encourage vaccination among patients with IBD.
Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis
Michaela S. Tracy, Prasanna K. Challa, Lauren Canha, Kristin Burke, Ashwin N. Ananthakrishnan, Emily W. Lopes, James M. Richter, Andrew T. Chan & Hamed Khalili
doi : 10.1007/s10620-022-07678-3
Microscopic colitis is a chronic inflammatory disease that most commonly affects post-menopausal women. Exogenous hormone use has recently been linked with increased risk of microscopic colitis.
Evaluation of Nutritional Characteristics Reveals Similar Prevalence of Malnutrition in Patients with Ulcerative Colitis and Crohn’s Disease
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall & Ajit Sood
doi : 10.1007/s10620-022-07652-z
Inflammatory bowel disease (IBD) is associated with an increased risk of malnutrition and sarcopenia.
A Method Using Longitudinal Laboratory Data to Predict Future Intestinal Complication in Patients with Crohn’s Disease
James Irwin, Anton Lord, Emma Ferguson, Lisa A. Simms, Katherine Hanigan, Carlos A. Montoya & Graham Radford-Smith
doi : 10.1007/s10620-022-07639-w
Stenosis, fistulization, and perforation of the bowel are severe outcomes which can occur in patients with Crohn’s disease. Accurate prediction of these events may enable clinicians to alter treatment strategies and avoid these outcomes.
Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease
Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease
doi : 10.1007/s10620-022-07630-5
The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown.
Accuracy and Inter-observer Agreement Among Endoscopists for Visual Identification of Colorectal Polyps Using Endoscopy Images
Thi Khuc, Amol Agarwal, Feng Li, Sergey Kantsevoy, Bryan Curtin, Matilda Hagan, Mary Harris, Anurag Maheshwari, Amit Raina, Elinor Zhou & Paul Thuluvath
doi : 10.1007/s10620-022-07643-0
It is essential to accurately distinguish small benign hyperplastic colon polyps (HP) from sessile serrated lesions (SSL) or adenomatous polyps (TA) based on endoscopic appearances. Our objective was to determine the accuracy and inter-observer agreements for the endoscopic diagnosis of small polyps.
Comparison of Opioid-Based Patient-Controlled Analgesia with Physician-Directed Analgesia in Acute Pancreatitis: A Retrospective Cohort Study
Supisara Tintara, Ishani Shah, William Yakah, John J. Kowalczyk, Cristina Sorrento, Cinthana Kandasamy, Awais Ahmed, Steven D. Freedman, Darshan J. Kothari & Sunil G. Sheth
doi : 10.1007/s10620-022-07573-x
Patient-controlled analgesia (PCA) is commonly used for acute postoperative pain management. Clinicians may also use PCA in the management of acute pancreatitis (AP); however, there is limited data on its impact on patient outcomes.
Infections in Acute Pancreatitis: Organisms, Resistance-Patterns and Effect on Mortality
Fang Li, Feng Zhang, Xueqin Wan, Kesong Wu, Qing Liu, Chuiyan Qiu, Haiyan Yin & Jun Lyu
doi : 10.1007/s10620-022-07793-1
Acute pancreatitis (AP) is a common gastrointestinal disease in which infection is a serious complication. Understanding its bacterial spectrum and antibiotic resistance is of great significance for treatment.
Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children
Soofia Khan, Heidi J. Kalkwarf, Lindsey Hornung, Robert Siegel, Ana Catalina Arce-Clachar, Rachel Sheridan, Holly M. Ippisch & Stavra A. Xanthakos
doi : 10.1007/s10620-022-07563-z
Lower whole body bone mineral density (BMD) has been reported in children with nonalcoholic fatty liver disease (NAFLD), but potential mediators remain uncertain.
Positive Association Between the Chinese Visceral Adiposity Index and Nonalcoholic Fatty Liver Disease in Lean Adults
Shuxia Shen, Hangkai Huang, Jinghua Wang, Zexi Tang, Chao Shen & Chengfu Xu
doi : 10.1007/s10620-022-07787-z
Chinese visceral adiposity index (CVAI) is a novel indicator that precisely evaluates visceral obesity and has been shown to be significantly associated with nonalcoholic fatty liver disease (NAFLD) in the general population. However, the relationship between CVAI and NAFLD in lean adults remains unclear.
Retreatment Efficacy and Renal Safety of Tenofovir Alafenamide, Entecavir, and Tenofovir Disoproxil Fumarate After Entecavir or Tenofovir Cessation
Shao-Ming Chiu, Kuo-Chin Chang, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu & Chien-Hung Chen
doi : 10.1007/s10620-022-07657-8
We aimed to compare the one-year retreatment efficacy and renal safety of entecavir, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF) after HBV relapse in patients who discontinued entecavir or TDF.
Antibody Response and Safety of ChAdOx1-nCOV (Covishield) in Patients with Cirrhosis: A Cross-Sectional, Observational Study
Amandeep Singh, Arka De, Mini P. Singh, Sahaj Rathi, Nipun Verma, Madhumita Premkumar, Sunil Taneja, Ajay Duseja & Virendra Singh
doi : 10.1007/s10620-022-07641-2
Patients with cirrhosis have a higher risk of severe COVID-19 and mortality and are high-priority patients for vaccination. However, cirrhotics were excluded from the phase 2/3 vaccine trials. Hence, we aimed to assess the antibody response and safety of Covishield (ChAdOx1nCoV-19) among patients with cirrhosis.
Impact of Interferon-Free Direct-Acting Antivirals on the Incidence of Extrahepatic Malignancies in Patients with Chronic Hepatitis C
Yuichi Honma, Michihiko Shibata, Kahori Morino, Yudai Koya, Tsuguru Hayashi, Noriyoshi Ogino, Masashi Kusanaga, Shinji Oe, Koichiro Miyagawa, Shintaro Abe, Akinari Tabaru & Masaru Harada
doi : 10.1007/s10620-022-07686-3
The incidence of extrahepatic malignancies (EHMs) after hepatitis C virus (HCV) eradication by interferon (IFN)-based and IFN-free direct-acting antivirals (DAAs) treatment remains unclear.
Methodological Issues to Be Considered in Evaluating Advanced Endoscopic Resection Techniques in Cirrhosis
Zi-Jing Wang, Xiu-He Lv & Jin-Lin Yang
Adverse Outcomes of E-cigarette in Inflammatory Bowel Disease
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Christos Liatsos, Maria Tzitiridou-Chatzopoulou, Dimitrios Chatzopoulos, Elisabeth Vardaka, Dimitra Gialamprinou, Georgios Kotronis, Tharshika Thavayogarajah & Michael Doulberis
Neutrophil-to-Lymphocyte Ratio for the Diagnosis and Monitoring of Inflammatory Bowel Disease
Cong Dai, Min Jiang & Yu-hong Huang
Correction: Comparing Predictability of Non‑invasive Tools for Hepatocellular Carcinoma in Treated Chronic Hepatitis C Patients
Yen-Chun Liu, Ya-Ting Cheng, Yi-Cheng Chen, Yi-Chung Hsieh, Wen-Juei Jeng, Chun-Yen Lin, Rong-Nan Chien, Dar-In Tai & I.-Shyan Sheen
