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The American Journal of Gastroenterology: Reflections on 2022 and the Road Ahead.
Long, Millie D. MD, MPH, FACG 1; Bajaj, Jasmohan MD, MS, FACG 2
doi : 10.14309/ajg.0000000000002166
Volume 118(2) pgs. 183-380 February 2023
Let's Have Some Clarity on Academic Parity.
Shawcross, Debbie L. MBBS, MD 1; Wong, Florence MBBS, MD 2
Women in Medicine: Honoring the Past and Bringing Women Further Into the Scope of Gastroenterology.
Oxentenko, Amy S. MD, FACP, FACG, AGAF
Healthcare Disparities in Gastroesophageal Reflux Disease for Hispanic and Latino Americans: A Solution-Oriented Approach for Improvement.
Kamal, Afrin N. MD, MS 1; Wang, C. Jason MD, PhD 2; Triadafilopoulos, George MD 1; Clarke, John O. MD 1
Endometriosis of the Appendix, Cecum, and Ileum Masquerading as Suspected Crohn's Disease.
Cho, Jonathan J. MD, PhD 1; Pak, Kevin MD 2; Austin, Ryan P. MD 3; Padilla, Leybelis MD 2; Wilkerson, Rashad C. DO 2; Edson, Theodore D. MD 4
Pancreatic Acinar Cell Carcinoma Projected From the Ampulla of Vater With Extensive Intraductal Tumor Growth.
Sakai, Ai MD 1; Takada, Satoshi MD, PhD 1; Katano, Kaoru MD 1; Minami, Hironori MD, PhD 1; Gabata, Ryosuke MD, PhD 1; Okazaki, Mitsuyoshi MD, PhD 1; Ohbatake, Yoshinao MD, PhD 1; Nakanuma, Shinichi MD, PhD 1; Makino, Isamu MD, PhD 1; Yagi, Shintaro MD, PhD 1
A Rare Portopulmonary Arteriovenous Fistula in a Cirrhotic Patient With Portal Hypertension and Inversion of Blood Flow After Liver Transplantation.
Caruso, Settimo MD 1; Miraglia, Roberto MD 1; Alonzo, Laura MD 1; Farinella, Marta MD 1; Carollo, Vincenzo MD 1
Sarcoidosis of the Esophagus.
Cho, Jonathan J. MD, PhD 1; Pak, Kevin MD 2; Penfield, Joshua D. MD 3; Baffi, Cynthia W. MD 4; Speziale, Alissa MD 3
Pemigatinib-Related Calcification in the Liver.
Yang, Xu MD 1,*; Yang, Xiaobo MD 1,*; Zhao, Haitao MD 1
Avoid Iatrogenic Injuries.
Li, Jian-Jun BA 1,*; Zhang, Hong PhD 2,3,*; Peng, Xue BA 1; Yang, Shi-Ming PhD 1; Bai, Jian-Ying PhD 1; Fan, Chao-Qiang MD 1
Continuing Medical Education Questions: February 2023.
Fawley, Ryan K. MD
doi : 10.14309/ajg.0000000000002161
Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline (C) The American College of Gastroenterology 2023. All Rights Reserved
Continuing Medical Education Questions: February 2023.
Gandhi, Seema R. MD, FACG
doi : 10.14309/ajg.0000000000002162
Application of the Latest Advances in Evidence-Based Medicine in Primary Biliary Cholangitis (C) The American College of Gastroenterology 2023. All Rights Reserved.
Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline.
Sengupta, Neil MD 1; Feuerstein, Joseph D. MD 2; Jairath, Vipul MD, PhD 3; Shergill, Amandeep K. MD 4; Strate, Lisa L. MD, MPH 5,6; Wong, Robert J. MD, MS (GRADE Methodologist) 7,8; Wan, David MD 9
doi : 10.14309/ajg.0000000000002130
AB Acute lower gastrointestinal bleeding (LGIB) is a common reason for hospitalization in the United States and is associated with significant utilization of hospital resources, as well as considerable morbidity and mortality.
Application of the Latest Advances in Evidence-Based Medicine in Primary Biliary Cholangitis.
Kowdley, Kris V. MD 1; Bowlus, Christopher L. MD 2; Levy, Cynthia MD 3; Mayo, Marlyn J. MD 4; Pratt, Daniel S. MD 5; Vuppalanchi, Raj MD 6; Younossi, Zobair M. MD, MPH 7
doi : 10.14309/ajg.0000000000002070
AB Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune liver disease that can progress to end-stage liver disease and its complications. A previous expert review panel collaborated on a consensus document for gastroenterologists and other healthcare professionals regarding the care of patients with PBC.
Comparative Performance of Endoscopic Ultrasound-Based Techniques in Patients With Pancreatic Cystic Lesions: A Network Meta-Analysis.
Li, Shi-yu MD 1,*; Wang, Zhi-jie MD 1,*; Pan, Cheng-ye MD 1,*; Wu, Cheng PhD 2; Li, Zhao-shen PhD, MD 1; Jin, Zhen-dong MD 1; Wang, Kai-xuan MD 1
doi : 10.14309/ajg.0000000000002088
Evidence on the comparative diagnostic performance of endoscopic ultrasound (EUS)-based techniques for pancreatic cystic lesions (PCLs) is limited. This network meta-analysis comprehensively compared EUS-based techniques for PCL diagnosis.
Working to Answer the Effectiveness of Nutrition in IBD: Still a Ways to Go.
Otley, Anthony MD, MSc, FRCPC 1; Grover, Zubin MBBS, MD, FRACP, PhD 2; Moayyedi, Paul MB ChB, PhD, MPH, FACG 3
doi : 10.14309/ajg.0000000000002040
AB The Specific Carbohydrate diet (SCD) is an exclusion diet widely popular among patients with IBD, which restricts carbohydrates and processed foods. Two recently concluded controlled studies PRODUCE (Personalized Research on Diet in Ulcerative Colitis (UC) and Crohn's Disease) and DINE-CD (The Diet to Induce Remission in Crohn's disease) confirm efficacy of SCD on symptom control but fail to demonstrate a sustained anti-inflammatory response.
Screening for Lynch Syndrome: Optimal Strategies and Performance Remain a Moving Target.
Rustgi, Sheila D. MD 1,2; Kastrinos, Fay MD, MPH 1,2
Low Risk of Lymphoma in Children With IBD Is Reassuring to Clinicians and Families.
Murthy, Sanjay K. MD, PhD, FRCPC 1,2,3,4; Benchimol, Eric I. MD, PhD, FRCPC 4,5,6,7
Eosinophilic Gastritis and Enteritis Are Increased in Families With Eosinophilic Esophagitis.
Allen-Brady, Kristina PhD 1,*; Colletier, Keegan J. MD 2,*; Woller, Scott MD 3; Eliason, Kyle MD 5; Uchida, Amiko M. MD 2; Ro, Gabrielle BA 2; Newman, Mike PhD 6; Peterson, Kathryn A. MD, MSci 2
doi : 10.14309/ajg.0000000000002021
There are limited data on the familial risk of distal eosinophilic gastrointestinal diseases (EGIDs) in patients with eosinophilic esophagitis (EoE). We analyzed the risk of eosinophilic gastritis/gastroenteritis (EG/EGE) and eosinophilic colitis (EC) as forms of distal EGIDs using International Disease Classification-9/10 codes in subjects with EoE and their relatives.
Rates of Antimicrobial Resistance in Helicobacter pylori Isolates From Clinical Trial Patients Across the US and Europe.
Megraud, Francis MD 1; Graham, David Y. MD 2; Howden, Colin W. MD 3; Trevino, Ernest BSMT 4; Weissfeld, Alice PhD 4; Hunt, Barbara MS 5; Smith, Neila MD 5; Leifke, Eckhard MD 5; Chey, William D. MD 6
doi : 10.14309/ajg.0000000000002045
Guidelines recommend that proton pump inhibitor-based triple regimens with clarithromycin not be used for Helicobacter pylori infection in areas where clarithromycin resistance is >=15%, or in patients with prior macrolide use. Up-to-date information on local resistance patterns is limited, especially in the US. Here, we report resistance rates to antibiotics commonly used to treat H.
Efficacy and Safety of a Novel Hemostatic Peptide Solution During Endoscopic Submucosal Dissection: A Multicenter Randomized Controlled Trial.
Uraoka, Toshio MD, PhD 1; Uedo, Noriya MD, PhD 2; Oyama, Tsuneo MD, PhD 3; Saito, Yutaka MD, PhD 4; Yahagi, Naohisa MD, PhD 5; Fujimoto, Ai MD, PhD 6; Kawahara, Yoshiro MD, PhD 7; Mabe, Katsuhiro MD, PhD 8; Hikichi, Takuto MD, PhD 9; Yamamoto, Yorimasa MD, PhD 10; Tajiri, Hisao MD, PhD 11
doi : 10.14309/ajg.0000000000002060
To compare the effectiveness of the novel hemostatic peptide, TDM-621, with that of conventional hemostatic methods in treating intraoperative blood oozing during endoscopic submucosal dissection (ESD).
Systematic Review and Meta-Analysis on the Effects of Lactulose and Rifaximin on Patient-Reported Outcomes in Hepatic Encephalopathy.
Moon, Andrew M. MD, MPH 1; Kim, Hannah P. MD, MSCR 2; Jiang, Yue PhD 3; Lupu, Gabriel MD 4; Bissram, Jennifer S. MSIS, MBA 5; Barritt, A. Sidney IV MD, MSCR 1; Tapper, Elliot B. MD 6,7
doi : 10.14309/ajg.0000000000002008
Patients with hepatic encephalopathy (HE) suffer from significant symptoms and impaired quality of life. Improved understanding on the potential benefits of first-line HE therapies may aid patient-provider discussions regarding expected benefits of HE treatments.
Patterns of Care Utilization and Hepatocellular Carcinoma Surveillance: Tracking Care Across the Pandemic.
Serper, Marina MD, MS 1,2,3; Tapper, Elliot B. MD 4,5; Kaplan, David E. MD, MSc 1,3; Taddei, Tamar H. MD 6,7; Mahmud, Nadim MD, MSHP, MSCE 1,2,3,8
doi : 10.14309/ajg.0000000000002011
We studied longitudinal trends in mortality, outpatient, and inpatient care for cirrhosis in a national cohort in the first 2 years of the coronavirus disease-2019 pandemic.
Characteristics and Effect of Anxiety and Depression Trajectories in Inflammatory Bowel Disease.
Fairbrass, Keeley M. MBChB 1,2; Guthrie, Elspeth A. MD 3; Black, Christopher J. PhD 1,2; Selinger, Christian P. MD 1,2; Gracie, David J. PhD 1,2,*; Ford, Alexander C. MD 1,2,*
doi : 10.14309/ajg.0000000000002063
Symptoms of common mental disorders, such as anxiety or depression, are associated with adverse clinical outcomes in inflammatory bowel disease (IBD). We report trajectories of these symptoms in IBD, patient characteristics associated with different trajectories, and effects on healthcare utilization and prognosis.
The Real-World Effectiveness and Safety of Ustekinumab in the Treatment of Crohn's Disease: Results From the SUCCESS Consortium.
Johnson, Amanda M. MD 1; Barsky, Maria MD 2; Ahmed, Waseem MD 3; Zullow, Samantha MD 4; Galati, Jonathan MD 5; Jairath, Vipul MD 6; Narula, Neeraj MD 7; Peerani, Farhad MD 8; Click, Benjamin H. MD 9; Coburn, Elliot S. MD 10; Dang, ThucNhi Tran MD 8; Gold, Stephanie MD 11; Agrawal, Manasi MD, MS 11; Garg, Rajat MD, FACC, FSCAI 9; Aggarwal, Manik MD 9; Mohammad, Danah MD 7; Halloran, Brendan MD 8; Kochhar, Gursimran S. MD 12; Todorowski, Hannah DO 12; Ud Din, Nabeeha Mohy MD 12; Izanec, James MD 13; Teeple, Amanda MPH 13; Gasink, Chris MD 13; Muser, Erik PharmD, MPH 13; Ding, Zhijie PhD, MS 13; Swaminath, Arun MD 14; Lakhani, Komal MD 14; Hogan, Dan DO 14; Datta, Samit MD 14; Ungaro, Ryan C. MD 11; Boland, Brigid S. MD 2; Bohm, Matthew MD 3; Fischer, Monika MD 3; Sagi, Sashidhar MD 3; Afzali, Anita MD 15; Ullman, Thomas MD 16; Lawlor, Garrett MD 17; Baumgart, Daniel C. PhD, MD, MBA 8; Chang, Shannon MD 4; Hudesman, David MD 4; Lukin, Dana MD 5; Scherl, Ellen J. MD 5; Colombel, Jean-Frederic MD 11; Sands, Bruce E. MD 11; Siegel, Corey A. MD, MS 10; Regueiro, Miguel MD 9; Sandborn, William J. MD 2; Bruining, David MD 1; Kane, Sunanda MD 1; Loftus, Edward V. Jr MD 1; Dulai, Parambir S. MD 2,18
doi : 10.14309/ajg.0000000000002047
We evaluated the real-world effectiveness and safety of ustekinumab (UST) in patients with Crohn's disease (CD). METHODS: This study used a retrospective, multicenter, multinational consortium of UST-treated CD patients.
Meditation and Yoga for Irritable Bowel Syndrome: A Randomized Clinical Trial.
D'Silva, Adrijana PhD 1; Marshall, Deborah A. PhD 1,2; Vallance, Jeff K. PhD 3; Nasser, Yasmin MD, PhD 4,5; Rajagopalan, Vidya MHA 4; Szostakiwskyj, Jessie H. MSc 6; Raman, Maitreyi MD, MSc 1,4,5
doi : 10.14309/ajg.0000000000002052
Delivered in person, yoga is effective in managing irritable bowel syndrome (IBS) symptoms. The evidence for efficacy, feasibility, and safety of virtually delivered yoga for patients with IBS is unknown.
Time Trends in Colorectal Cancer Incidence From 1992 to 2016 and Colorectal Cancer Mortality From 1980 to 2018 by Age Group and Geography in Canada.
Decker, Kathleen M. PhD 1,2,3; Lambert, Pascal MSc 2,3; Bravo, Jen MSc 3; Demers, Alain PhD 4; Singh, Harminder MD, MPH 1,2,5
doi : 10.14309/ajg.0000000000002058
Several reports have highlighted increasing colorectal cancer (CRC) incidence among younger individuals. However, little is known about variations in CRC incidence or mortality across age subgroups in different geographical locations.
A Canadian Provincial Screening Program for Lynch Syndrome.
Stone, James K. MD 1; Winter, Remington MD 1; Khan, Deirdre PhD 2; Rothenmund, Heidi MSc 3,4; Klein, Julianne MD 5; Chodirker, Bernard MD 3,4; Wightman, Robert MD 5; Kim, Christina A. MD 1,2; Nugent, Zoann PhD 1; Singh, Harminder MD, MPH 1,2,4,5
doi : 10.14309/ajg.0000000000002059
Manitoba implemented the first Canadian provincial program of reflex screening through mismatch repair immunohistochemistry (MMR-IHC) for all colorectal cancers diagnosed at age 70 years or younger in December 2017.
Low Risk of Lymphoma in Pediatric Patients Treated for Inflammatory Bowel Disease.
Egberg, Matthew D. MD, MPH, MMSc 1,2; Zhang, Xian PhD 1; Smitherman, Andrew B. MD, MSc 3,4; Kappelman, Michael D. MD, MPH 1,2
doi : 10.14309/ajg.0000000000002053
Despite the effectiveness of immune-suppressing therapies in treating pediatric inflammatory bowel diseases (IBDs), concerns of lymphoma may limit their use. We used a large administrative claims database to evaluate the risk of lymphoma in pediatric IBD and conducted a case series analysis of medication exposure in children diagnosed with lymphoma.
Tailored Treatment Based on Helicobacter pylori Genetic Markers of Resistance Is Associated With Higher Eradication Success.
Cummings, Linda C. MD, MS 1,2,*; Hojat, Leila S. MD, MS 2,3,*; Nguyen, David C. MD 2,4; Stempak, Lisa M. MD 5,6; Rhoads, Daniel D. MD 7; Sadri, Navid MD, PhD 5,6
doi : 10.14309/ajg.0000000000002085
Increasing antimicrobial resistance with Helicobacter pylori infection has focused efforts to tailor eradication therapy based on identifying genetic markers of resistance to predict antimicrobial susceptibility.
Chylous Ascites: Reassessment of Diagnostic Criteria in Patients With Portal Hypertension.
Matchett, Caroline L. MD *,1; Rattan, Puru MD *,2; McConnell, Joseph P. PhD, DABCC, FAACC 3; Donato, Leslie J. PhD 4; Simonetto, Douglas A. MD 2; Kamath, Patrick S. MD 2
doi : 10.14309/ajg.0000000000002072
The triglyceride (TG) threshold for diagnosis of chylous ascites in patients with portal hypertension remains uncertain. METHODS: Retrospective analysis of lipoprotein electrophoresis was conducted in 286 consecutive ascites samples.
Fecal Calprotectin and Quality of Life Questionnaires Are Responsive to Change in Pouch Disease Activity After Antibiotic Therapy: Results From a Prospective Clinical Trial.
Ollech, Jacob E. MD 1,2; Yanai, Henit MD 1,2; Avni-Biron, Irit MD 1,2; Snir, Yifat MD 1,2; Banai, Hagar MD 1,2; Barkan, Revital RN 1,2; Godny, Lihi PhD 1,2; Wasserberg, Nir MD 2,3; White, Ian MD 2; Dotan, Iris MD 1,2
doi : 10.14309/ajg.0000000000002038
Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity in patients with a J-pouch is unknown. METHODS: Patients with acute pouchitis were prospectively treated with a 2-week course of antibiotics. The full Pouchitis Disease Activity Index, FC, and QoL questionnaires were measured at baseline and after antibiotic therapy.
Pitfalls of Advanced Endoscopy Technologies in Gastrointestinal Cancer Screening.
Ishii, Naoki MD, PhD, MPH 1; Yano, Takahiko MD 1; Shiratori, Yasutoshi MD, PhD, MPH 2; Omata, Fumio MD, PhD, MPH 1
Evaluation of Post-POEM GERD: Underestimate or Overestimate?.
Lei, Wei-Yi MD, PhD 1; Chen, Chien-Lin MD, PhD 1,2
