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Toward Meeting the Challenges of Improving Cardiovascular Health in Egypt
Magdi Yacoub, Dina Labib
doi : 10.1161/CIRCULATIONAHA.119.040939
Circulation. 2021 | Volume 143, Issue 14: 1341–1342
Relationship of LVEF and Myocardial Scar to Long-Term Mortality Risk and Mode of Death in Patients With Nonischemic Cardiomyopathy
Igor Klem, Michael Klein, Mohammad Khan, Eric Y. Yang, Faisal Nabi, Alexander Ivanov, Lubna Bhatti, Brenda Hayes, Edward A. Graviss, Duc T. Nguyen, Robert M. Judd, Raymond J. Kim, John F. Heitner, Dipan J. Shah
doi : 10.1161/CIRCULATIONAHA.120.048477
Circulation. 2021 | Volume 143, Issue 14: 1343–1358
Nonischemic cardiomyopathy is a leading cause of reduced left ventricular ejection fraction (LVEF) and is associated with high mortality risk from progressive heart failure and arrhythmias. Myocardial scar on cardiovascular magnetic resonance imaging is increasingly recognized as a risk marker for adverse outcomes; however, left ventricular dysfunction remains the basis for determining a patient’s eligibility for primary prophylaxis with implantable cardioverter-defibrillator. We investigated the relationship of LVEF and scar with long-term mortality and mode of death in a large cohort of patients with nonischemic cardiomyopathy.
Prognostic Value of Nonischemic Ringlike Left Ventricular Scar in Patients With Apparently Idiopathic Nonsustained Ventricular Arrhythmias
Daniele Muser, Gaetano Nucifora, Daniele Muser, Gaetano Nucifora, Maurizio Pieroni, Simon A. Castro, Ruben Casado Arroyo, Shingo Maeda, Daniel A. Benhayon, Ioan Liuba, Mouhannad Sadek, Silvia Magnani, Andres Enriquez, Jackson J. Liang, Biagio Sassone, Benoit Desjardins, Sanjay Dixit, Rajat Deo, Fermin C. Garcia, David J. Callans, David S. Frankel, Joseph B. Selvanayagam, Francis E. Marchlinski, Pasquale Santangeli
doi : 10.1161/CIRCULATIONAHA.120.047640
Circulation. 2021 | Volume 143, Issue 14: 1359–1373
Left ventricular (LV) scar on late gadolinium enhancement (LGE) cardiac magnetic resonance has been correlated with life-threatening arrhythmic events in patients with apparently idiopathic ventricular arrhythmias (VAs). We investigated the prognostic significance of a specific LV-LGE phenotype characterized by a ringlike pattern of fibrosis.
Cardiac Magnetic Resonance Imaging in Nonischemic Cardiomyopathy
N.A. Mark Estes, Samir Saba
doi : 10.1161/CIRCULATIONAHA.120.052929
Circulation. 2021 | Volume 143, Issue 14: 1374–1376
Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure
Douglas L. Packer, Jonathan P. Piccini, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, Peter A. Noseworthy, Jeanne E. Poole, Tristram D. Bahnson, Kerry L. Lee, Daniel B. Mark and For the CABANA Investigators
doi : 10.1161/CIRCULATIONAHA.120.050991
Circulation. 2021 | Volume 143, Issue 14: 1377–1390
In patients with heart failure and atrial fibrillation (AF), several clinical trials have reported improved outcomes, including freedom from AF recurrence, quality of life, and survival, with catheter ablation. This article describes the treatment-related outcomes of the AF patients with heart failure enrolled in the CABANA trial (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation).
The Cabana Trial and Heart Failure
Lynda E. Rosenfeld, Alan D. Enriquez
doi : 10.1161/CIRCULATIONAHA.120.053160
Circulation. 2021 | Volume 143, Issue 14: 1391–1393
BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State
Lei Wang, Megan Rice, Sandra Swist, Thomas Kubin, Fan Wu, Shengpeng Wang, Simone Kraut, Norbert Weissmann, Thomas B?ttger, Matthew Wheeler, Andre Schneider, Thomas Braun
doi : 10.1161/CIRCULATIONAHA.120.047375
Circulation. 2021 | Volume 143, Issue 14: 1394–1410
Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity, allowing acquisition of contractile or synthetic states, but critical information is missing about the physiologic signals, promoting formation, and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 (bone morphogenetic protein) are known to regulate endothelial quiescence after secretion from the liver and right atrium, whereas a direct role in the regulation of VSMCs was not investigated. We studied the role of BMP9 and BMP10 for controlling formation of contractile VSMCs.
Suppression-Replacement KCNQ1 Gene Therapy for Type 1 Long QT Syndrome
Steven M. Dotzler, C.S. John Kim, William A.C. Gendron, Wei Zhou, Dan Ye, J. Martijn Bos, David J. Tester, Michael A. Barry, Michael J. Ackerman
doi : 10.1161/CIRCULATIONAHA.120.051836
Circulation. 2021 | Volume 143, Issue 14: 1411–1425
Type 1 long QT syndrome (LQT1) is caused by loss-of-function variants in the KCNQ1-encoded Kv7.1 potassium channel ?-subunit that is essential for cardiac repolarization, providing the slow delayed rectifier current. No current therapies target the molecular cause of LQT1.
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
doi : 10.1161/CIRCULATIONAHA.120.049254
Circulation. 2021 | Volume 143, Issue 14: 1426–1449
Exosomes are small membrane-bound vesicles of endocytic origin that are actively secreted. The potential of exosomes as effective communicators of biological signaling in myocardial function has previously been investigated, and a recent explosion in exosome research not only underscores their significance in cardiac physiology and pathology, but also draws attention to methodological limitations of studying these extracellular vesicles. In this review, we discuss recent advances and challenges in exosome research with an emphasis on scientific innovations in isolation, identification, and characterization methodologies, and we provide a comprehensive summary of web-based resources available in the field. Importantly, we focus on the biology and function of exosomes, highlighting their fundamental role in cardiovascular pathophysiology to further support potential applications of exosomes as biomarkers and therapeutics for cardiovascular diseases.
Severe Arrhythmia Caused by a Chinese Herb Liquor
Xiao-Ce Dai, Zhuo-Yu An
doi : 10.1161/CIRCULATIONAHA.121.053765
Circulation. 2021 | Volume 143, Issue 14: 1450–1451
Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background
Alessandro Bolli, Paolo Di Domenico, Roberta Pastorino, George B. Busby, Giordano Bottà
doi : 10.1161/CIRCULATIONAHA.120.051843
Circulation. 2021 | Volume 143, Issue 14: 1452–1454
Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease
Michael Brauer, Barbara Casadei, Robert A. Harrington, Richard Kovacs, Karen Sliwa and the WHF Air Pollution Expert Group
doi : 10.1161/CIRCULATIONAHA.120.052666
Circulation. 2021 | Volume 143, Issue 14: e800–e804
Although the attention of the world and the global health community specifically is deservedly focused on the COVID-19 pandemic, other determinants of health continue to have large impacts and may also interact with COVID-19. Air pollution is one crucial example. Established evidence from other respiratory viruses and emerging evidence for COVID-19 specifically indicates that air pollution alters respiratory defense mechanisms leading to worsened infection severity. Air pollution also contributes to comorbidities that are known to worsen outcomes among those infected with COVID-19, and air pollution may also enhance infection transmission due to its impact on more frequent coughing. Yet despite the massive disruption of the COVID-19 pandemic, there are reasons for optimism: broad societal lockdowns have shown us a glimpse of what a future with strong air pollution measures could yield. Thus, the urgency to combat air pollution is not diminished, but instead heightened in the context of the pandemic.
Letter by Ferraro and Arbab-Zadeh Regarding Article, “Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials”
Richard Ferraro, Armin Arbab-Zadeh
doi : 10.1161/CIRCULATIONAHA.120.050595
Circulation. 2021 | Volume 143, Issue 14: e805–e806
Letter by Shah Regarding Article, “Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials”
Rahman Shah
doi : 10.1161/CIRCULATIONAHA.120.051396
Circulation. 2021 | Volume 143, Issue 14: e807–e808
Response by Bangalore et al to Letter Regarding Article, “Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials”
Sripal Bangalore, David J. Maron, Gregg W. Stone, Judith S. Hochman
doi : 10.1161/CIRCULATIONAHA.120.052370
Circulation. 2021 | Volume 143, Issue 14: e809–e810
