دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Enhanced Topical Co-delivery of Acyclovir and Lidocaine Gel Formulation Across Dermatomed Human Skin
Manjusha Annaji, Nur Mita, Shivani Rangari, Mohammed F. Aldawsari, Ahmed Alsaqr, Ishwor Poudel, Oladiran Fasina & R. Jayachandra Babu
doi : 10.1208/s12249-022-02458-8
Volume 23, issue 8, November 2022
Acyclovir a widely used drug in the treatment of herpes simplex virus (HSV) infections and lidocaine a local anesthetic were combined in a topical gel formulation.
Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
Sadia Rehman, Asadullah Madni, Qazi Adnan Jameel, Faisal Usman, M. Rafi Raza, Faiz Ahmad, Hina Shoukat, Hamdan Aali & Afifa Shafiq
doi : 10.1208/s12249-022-02456-w
The current study sought to create graphene oxide-based superstructures for gastrointestinal drug delivery. Graphene oxide has a large surface area that can be used to load anti-cancer drugs via non-covalent methods such as surface adsorption and hydrogen bonding.
Recent Advances on the Biological Study of Pharmaceutical Cocrystals
Zhipeng Wang, Yifei Xie, Mingchao Yu, Shiying Yang, Yang Lu & Guanhua Du
doi : 10.1208/s12249-022-02451-1
As a low-risk, low-cost, but high-reward route, cocrystallization of drugs with appropriate coformers is applied to improve the physiochemical and biopharmaceutical properties of drugs. Currently, most researchers concentrate their efforts on the preparation, characterization, and improvement of physicochemical properties of pharmaceutical cocrystals.
Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide
Adejumoke Lara Ajiboye, Amélie Jacopin, Claudia Mattern, Uttom Nandi, Andrew Hurt & Vivek Trivedi
doi : 10.1208/s12249-022-02453-z
Progesterone (PRG) and testosterone (TST) were impregnated on mesoporous silica (ExP) particles via supercritical carbon dioxide (scCO2) processing at various pressures (10–18 MPa), temperatures (308.2–328.2 K), and time (30–360 min).
Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid Formulations Containing Baclofen for Hospital Use
Elisa de Saldanha Simon, Nathalie Ribeiro Wingert, Caren Gobetti, Gabriele Bordignon Primieri, Márcio VinÃcius Ayres, Silvia Helena Oliveira de Almeida, Nadia Maria Volpato & Martin Steppe
doi : 10.1208/s12249-022-02447-x
The absence of oral liquid pharmaceutical forms appropriate for use in pediatric and adult patients with difficulty swallowing is a public health problem, especially in the hospital context.
Insights into the Role of Compendial/Biorelevant Media on the Supersaturation Behaviour of Drug Combination (Drug-Drug Interaction) and Precipitation Inhibition by Polymers
Prachi Joshi & Abhay T. Sangamwar
doi : 10.1208/s12249-022-02448-w
Combination drug therapy (CDT) plays an immense role in the treatment of various diseases such as malaria, hypertension, cancer, HIV-AIDS, helminthiasis, and many more. However, in vitro drug-drug interaction (DDI) is not well reported for better efficacy of CDT.
Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs
Leela Sai Lokesh Janardhanam, Ashwini Suresh Deokar, Srivarsha Reddy Bollareddy & Venkata Vamsi Krishna Venuganti
doi : 10.1208/s12249-022-02450-2
The aim of the study was to investigate the pharmacokinetic parameters of 5-fluorouracil (5FU) and moxifloxacin HCl (MF) after oral administration using layer-by-layer assembled film in enteric-coated capsule.
A Preliminary Pharmacodynamic Study for the Management of Alzheimer’s Disease Using Memantine-Loaded PLGA Nanoparticles
Atinderpal Kaur, Kuldeep Nigam, Amit Tyagi & Shweta Dang
doi : 10.1208/s12249-022-02449-9
Alzheimer’s disease is becoming a common disorder of the elderly population due to shrinkage of the brain size with age and many other neurological complications.
Detrimental Effects of Elevated Temperatures on the Structure and Activity of Phenylalanine Ammonia Lyase-Bovine Serum Albumin Mixtures and the Stabilizing Potential of Surfactant and Sugars
Amerh Alahmadi & Anil Dmello
doi : 10.1208/s12249-022-02446-y
We propose encapsulating phenylalanine ammonia lyase (PAL)-bovine serum albumin (BSA) mixtures as potential oral therapy for the management of phenylketonuria. PAL will metabolize phenylalanine in the gastrointestinal tract while BSA will minimize product inhibition and allow PAL to work at its Vmax.
Self-Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability—a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal Delivery of a Hydrophilic Model Drug
Tomohiko Sano, Akie Okada, Kazunori Kawasaki, Takuji Kume, Minoru Fukui, Hiroaki Todo & Kenji Sugibayashi
doi : 10.1208/s12249-022-02452-0
Self-assembled surfactant structures, such as liquid crystals, have the potential to enhance transdermal drug delivery.
In Vitro Study to Evaluate the Efficacy of Ultrasonicated Ethanolic Extract of Rosmarinus officinalis and its Chitosan-Based Nanoparticles Against Eimeria tenella Oocysts of Chickens
Shaimaa M. Kasem, Nabila M. Mira, Magdy E. Mahfouz & Ibrahim B. Helal
doi : 10.1208/s12249-022-02445-z
In this study, chitosan nanoparticles (CsNPs) were used as nanocarrier for ultrasonicated ethanolic extract of Rosmarinus officinalis (UEERO) as a new nanoformulation against Eimeria tenella.
Progesterone Phospholipid Gel for Intramuscular Administration Prepared by In Situ-Phase Separation
Ning Dong, Lihua Tang, Meihui Zhao, Yingchao Zhang, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Yue Yuan & Xing Tang
doi : 10.1208/s12249-022-02442-2
Long-term daily injection of progesterone for the treatment of threatened abortion can be a source of considerable pain to patients.
Proliposome-Based Nanostrategies: Challenges and Development as Drug Delivery Systems
Mangilal Choudhary, Nishtha Chaurawal, Md. Abul Barkat & Kaisar Raza
doi : 10.1208/s12249-022-02443-1
Many attempts have been made to the refinement of liposomal stability. In 1986, Payne et al. developed the approach of proliposomes to derelict the physicochemical instability confronted in some liposome suspensions, i.e., fusion, aggregation, hydrolysis, and oxidation.
Exploiting Recent Trends in the Treatment of Androgenic Alopecia through Topical Nanocarriers of Minoxidil
Khushbakht Saleem, Bazla Siddiqui, Asim .ur.Rehman, Malik Mumtaz Taqi & Naveed Ahmed
doi : 10.1208/s12249-022-02444-0
Androgenic alopecia, a polygenetic disorder, is characterized by well-defined hair loss that progresses gradually.
Vacuum Foam Drying Method Improved the Thermal Stability and Long-Term Shelf Life of a Live Attenuated Newcastle Disease Virus Vaccine
Fang Lyu, Yan-hong Zhao, Yu Lu, Xiao-xin Zuo, Bi-hua Deng, Min-qian Zeng, Jun-ning Wang, Ademola Olaniran, Jibo Hou & Thandeka Khoza
doi : 10.1208/s12249-022-02440-4
Vaccines used for managing Newcastle disease virus (NDV) rely heavily on cold chain, and this results in major constraints in their successful application, shipping, and storage.
Simultaneous Evaluation of Dissolution and Absorption Study of Compound Danshen Tablets and Capsules Based on Cellular Electrical Sensing Model
Lixia Ma, Yue Zhou, Jia Zhang, Xi Yuan, Yimeng Zhao, Wei Gu, Jinhuo Pan, Zhaogang Yang, Tulin Lu & Guojun Yan
doi : 10.1208/s12249-022-02441-3
This study explores the dissolution mechanism and absorption process of compound Danshen tablets (CDTs) and compound Danshen capsules (CDCs) in vitro.
Magnetic Targeting of 5-Fluorouracil-Loaded Liposome-Nanogels for In Vivo Breast Cancer Therapy and the Cytotoxic Effects on Liver and Kidney
Damla Ulker, Rumeysa Ozyurt, Nilufer Erkasap & Vural Butun
doi : 10.1208/s12249-022-02438-y
In our previous paper, we demonstrated the ex vivo studies of non-toxic liposome-nanogel systems by which the long-term drug release could be provided from hybrid systems for the 5-fluorouracil (5-FU) drug molecule.
Thermoreversible Carbamazepine In Situ Gel for Intranasal Delivery: Development and In Vitro, Ex Vivo Evaluation
K. Mohananaidu, Bappaditya Chatterjee, Farahidah Mohamed, Syed Mahmood & Samah Hamed Almurisi
doi : 10.1208/s12249-022-02439-x
Over the past decade, intranasal (IN) delivery has been gaining attention as an alternative approach to conventional drug delivery routes targeting the brain. Carbamazepine (CBZ) is available as an orally ingestible formulation.
Construction and Evaluation of Hyaluronic Acid–Coated Flurbiprofen-Layered Double Hydroxide Ocular Drug Delivery System
Donghao Gu, Hao Pan, Shuo Xu, Wenyue Chen, Renfang Zhu, Wenjing Jiang & Weisan Pan
doi : 10.1208/s12249-022-02418-2
In this study, flurbiprofen (FB) was selected as the model drug, and hyaluronic acid–coated flurbiprofen-layered double hydroxide ophthalmic drug delivery system (HA-FB-LDH) was designed and prepared.
Particle Property Characterization and Data Curation for Effective Powder Property Modeling in the Pharmaceutical Industry
Robert C. Wadams, Ilgaz Akseli, Jacob Albrecht, Ana P. Ferreira, John F. Gamble, Michael Leane, Stephen Thomas, Yue Schuman, Lauren Taylor & Mike Tobyn
doi : 10.1208/s12249-022-02434-2
Computational modeling, machine learning, and statistical data analysis are increasingly utilized to mitigate chemistry, manufacturing, and control failures related to particle properties in solid dosage form manufacture.
An Application of Tumor-Associated Macrophages as Immunotherapy Targets: Sialic Acid–Modified EPI-Loaded Liposomes Inhibit Breast Cancer Metastasis
Xianmin Meng, Mingqi Wang, Kaituo Zhang, Dezhi Sui, Meng Chen, Zihan Xu, Tiantian Guo, Xinrong Liu, Yihui Deng & Yanzhi Song
doi : 10.1208/s12249-022-02432-4
Breast cancer metastasis is an important cause of death in patients with breast cancer and is closely related to circulating tumor cells (CTCs) and the metastatic microenvironment.
Drug-Carrier Miscibility in Solid Dispersions of Glibenclamide and a Novel Approach to Enhance Its Solubility Using an Effervescent Agent
Muralidhar Pisay, K. Vijaya Bhaskar, Chetan Hasmukh Mehta, Usha Yogendra Nayak, Kunnatur Balasundara Koteshwara & Srinivas Mutalik
doi : 10.1208/s12249-022-02437-z
The present research aims to investigate the miscibility, physical stability, solubility, and dissolution rate of a poorly water-soluble glibenclamide (GLB) in solid dispersions (SDs) with hydrophilic carriers like PEG-1500 and PEG-50 hydrogenated palm glycerides (Acconon).
Antitumor Immunotherapy of Sialic Acid and/or GM1 Modified Coenzyme Q10 Submicron Emulsion
Xianmin Meng, Na Yan, Tiantian Guo, Meng Chen, Dezhi Sui, Mingqi Wang, Kaituo Zhang, Xinrong Liu, Yihui Deng & Yanzhi Song
doi : 10.1208/s12249-022-02426-2
Immunotherapy is a novel therapeutic approach for controlling and killing tumor cells by stimulating or reconstituting the immune system, among which T cells serve as immune targets.
Surface Characterization as a Tool for Identifying the Factors Affecting the Dissolution Rate of Amorphous Solid Dispersion Tablets
Dongyue Yu 1 · Frederick Fiddler2 · Ahmed Ibrahim1 · Raymond Sanedrin2 · Heidi Tremblay 2 · Stephen W. Hoag
doi : 10.1208/s12249-022-02413-7
An amorphous solid dispersion (ASD) is a commonly used approach to enhancing the dissolution of poorly aqueous soluble drugs. Selecting the desired polymer and drug loading can be time-consuming.
