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Unloading the Stenotic Path to Identifying Medical Therapy for Calcific Aortic Valve Disease
Brian R. Lindman, W. David Merryman
doi : 10.1161/CIRCULATIONAHA.120.052531
Circulation. 2021 | Volume 143, Issue 15: 1455–1457
Association of Metabolic Surgery With Major Adverse Cardiovascular Outcomes in Patients With Previous Myocardial Infarction and Severe Obesity
Erik N?slund, Erik Stenberg, Robin Hofmann, Johan Ottosson, Magnus Sundbom, Richard Marsk, Per Svensson, Karolina Szummer, Tomas Jernberg
doi : 10.1161/CIRCULATIONAHA.120.048585
Circulation. 2021 | Volume 143, Issue 15: 1458–1467
The number of patients with myocardial infarction and severe obesity is increasing and there is a lack of evidence how these patients should be treated. The aim of this study was to investigate the association between metabolic surgery (Roux-en-Y gastric bypass and sleeve gastrectomy) and major adverse cardiovascular events in patients with previous myocardial infarction (MI) and severe obesity.
Bariatric Surgery and Cardiovascular Outcomes in Patients With Obesity and Cardiovascular Disease
Aristithes G. Doumouras, Jorge A. Wong, J. Michael Paterson, Yung Lee, Branavan Sivapathasundaram, Jean-Eric Tarride, Lehana Thabane, Dennis Hong, Salim Yusuf, Mehran Anvari
doi : 10.1161/CIRCULATIONAHA.120.052386
Circulation. 2021 | Volume 143, Issue 15: 1468–1480
Bariatric surgery has been shown to significantly reduce cardiovascular risk factors. However, whether surgery can reduce major adverse cardiovascular events (MACE), especially in patients with established cardiovascular disease, remains poorly understood. The present study aims to determine the association between bariatric surgery and MACE among patients with cardiovascular disease and severe obesity.
After 70 Years, Metabolic Surgery Has Earned a Cardiovascular Outcome Trial
Philip R. Schauer, Steven E. Nissen
doi : 10.1161/CIRCULATIONAHA.120.051752
Circulation. 2021 | Volume 143, Issue 15: 1481–1483
no abstract
Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction
S?ren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfu?, Tim Seidler, Andreas Schuster
doi : 10.1161/CIRCULATIONAHA.120.051542
Circulation. 2021 | Volume 143, Issue 15: 1484–1498
Right heart catheterization using exercise stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiac magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary noninvasive alternative for diagnosing HFpEF.
Real-Time Cardiac Magnetic Resonance Imaging
Barry A. Borlaug, Michael D. Nelson
doi : 10.1161/CIRCULATIONAHA.120.053026
Circulation. 2021 | Volume 143, Issue 15: 1499–1501
Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing
Anke J. Tijsen, Luc?a C?cera Ortega, Yolan J. Reckman, Xiaolei Zhang, Ingeborg van der Made, Simona Aufiero, Jiuru Li, Selina C. Kamps, Anouk van den Bout, Harsha D. Devalla, Karin Y. van Spaendonck-Zwarts, Stefan Engelhardt, Lior Gepstein, James S. Ware, Yigal M. Pinto
doi : 10.1161/CIRCULATIONAHA.120.050455
Circulation. 2021 | Volume 143, Issue 15: 1502–1512
TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the TTN transcript are the most frequent cause of hereditary heart failure. We showed before that TTN produces a class of circular RNAs (circRNAs) that depend on RBM20 to be formed. In this study, we show that the back-splice junction formed by this class of circRNAs creates a unique motif that binds SRSF10 to enable it to regulate splicing. Furthermore, we show that one of these circRNAs (cTTN1) distorts both localization of and splicing by RBM20.
MicroRNA-21–Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload
Deepak Ramanujam, Anna Patricia Sch?n, Christina Beck, Paula Vaccarello, Giulia Felician, Anne Dueck, Dena Esfandyari, Gunter Meister, Thomas Meitinger, Christian Schulz, Stefan Engelhardt
doi : 10.1161/CIRCULATIONAHA.120.050682
Circulation. 2021 | Volume 143, Issue 15: 1513–1525
Cardiac macrophages (cMPs) are increasingly recognized as important regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these cells is largely unknown. Small RNA sequencing of the entire miRNomes of the major cardiac cell fractions revealed microRNA-21 (miR-21) as the single highest expressed microRNA in cMPs, both in health and disease (25% and 43% of all microRNA reads, respectively). MiR-21 has been previously reported as a key microRNA driving tissue fibrosis. Here, we aimed to determine the function of macrophage miR-21 on myocardial homeostasis and disease-associated remodeling.
From the Literature
Tracy Hampton
doi : 10.1161/CIRCULATIONAHA.121.054372
Circulation. 2021 | Volume 143, Issue 15: 1526–1527
A Plumbing and Electrical Problem
John Birchak, Arfaat Khan, Waddah Maskoun
doi : 10.1161/CIRCULATIONAHA.120.052890
Circulation. 2021 | Volume 143, Issue 15: 1528–1532
Cardiac Effects of Repeated Weightlessness During Extreme Duration Swimming Compared With Spaceflight
James P. MacNamara, Katrin A. Dias, Satyam Sarma, Stuart M.C. Lee, David Martin, Maks Romeijn, Vlad G. Zaha, Benjamin D. Levine
doi : 10.1161/CIRCULATIONAHA.120.050418
Circulation. 2021 | Volume 143, Issue 15: 1533–1535
Letter by Chen et al Regarding Article, “gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration”
Hui Chen, Yun Tang, Zhanjun Yang
doi : 10.1161/CIRCULATIONAHA.120.052195
Circulation. 2021 | Volume 143, Issue 15: e811–e812
Response by Li et al to Letter Regarding Article, “gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration”
Yandong Li, Jie Feng, Yu Nie
doi : 10.1161/CIRCULATIONAHA.120.052610
Circulation. 2021 | Volume 143, Issue 15: e813–e814
Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association
Timothy D. Henry, Matthew I. Tomey, Jacqueline E. Tamis-Holland, Holger Thiele, Sunil V. Rao, Venu Menon, Deborah G. Klein, Yoshifumi Naka, Ileana L. Pi?a, Navin K. Kapur, George D. Dangas and On behalf of the American Heart Association Interventional Cardiovascular Care Committee of the Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Cardiovascular and Stroke Nursing
doi : 10.1161/CIR.0000000000000959
Circulation. 2021 | Volume 143, Issue 15: e815–e829
Cardiogenic shock (CS) remains the most common cause of mortality in patients with acute myocardial infarction. The SHOCK trial (Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock) demonstrated a survival benefit with early revascularization in patients with CS complicating acute myocardial infarction (AMICS) 20 years ago. After an initial improvement in mortality related to revascularization, mortality rates have plateaued. A recent Society of Coronary Angiography and Interventions classification scheme was developed to address the wide range of CS presentations. In addition, a recent scientific statement from the American Heart Association recommended the development of CS centers using standardized protocols for diagnosis and management of CS, including mechanical circulatory support devices (MCS). A number of CS programs have implemented various protocols for treating patients with AMICS, including the use of MCS, and have published promising results using such protocols. Despite this, practice patterns in the cardiac catheterization laboratory vary across health systems, and there are inconsistencies in the use or timing of MCS for AMICS. Furthermore, mortality benefit from MCS devices in AMICS has yet to be established in randomized clinical trials. In this article, we outline the best practices for the contemporary interventional management of AMICS, including coronary revascularization, the use of MCS, and special considerations such as the treatment of patients with AMICS with cardiac arrest.
Correction to: An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
doi : 10.1161/CIR.0000000000000978
Circulation. 2021 | Volume 143, Issue 15: e830
Correction to: Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing
doi : 10.1161/CIR.0000000000000980
Circulation. 2021 | Volume 143, Issue 15: e831
