دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
-
http://medilib.ir
- ﻣﺪﺕ ﺯﻣﺎﻥ : 365 ﺭﻭﺯ
قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Enhancement of Gene Editing and Base Editing with Therapeutic Ribonucleoproteins through In Vivo Delivery Based on Absorptive Silica Nanoconstruct (Adv. Healthcare Mater. 4/2023)
Seongchan Kim, You Kyeong Jeong, Chang Sik Cho, SeokHoon Lee, Chang Ho Sohn, Jeong Hun Kim, Youngdo Jeong, Dong Hyun Jo, Sangsu Bae, Hyojin Lee
doi : 10.1002/adhm.202370014
Volume 12, Issue 4
Bioactive Nonthermal Biocompatible Plasma Enhances Migration on Human Gingival Fibroblasts (Adv. Healthcare Mater. 4/2023)
Ihn Han, In-Seok Song, Seung Ah Choi, Taebok Lee, Maksudbek Yusupov, Priyanka Shaw, Annemie Bogaerts, Eun Ha Choi, Jae Jun Ryu
doi : 10.1002/adhm.202370015
3D-Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery (Adv. Healthcare Mater. 4/2023)
Tien-Jen Chang, Rolf Bech Kjeldsen, Juliane Fjelrad Christfort, Eduard Marzo Vila, Tommy Sonne Alstrøm, Kinga Zór, En-Te Hwu, Line Hagner Nielsen, Anja Boisen
doi : 10.1002/adhm.202370019
ZipperCells Exhibit Enhanced Accumulation and Retention at the Site of Myocardial Infarction (Adv. Healthcare Mater. 4/2023)
Natalie E. Jasiewicz, Kuo-Ching Mei, Hannah M. Oh, Parth Chansoria, Dylan A. Hendy, Emily E. Bonacquisti, Eric M. Bachelder, Kristy M. Ainslie, Haifeng Yin, Li Qian, Brian C. Jensen, Juliane Nguyen
doi : 10.1002/adhm.202370020
Recent Progress in Carrier-Free Nanomedicine for Tumor Phototherapy
Ying-Tao Zhong, Yi Cen, Lin Xu, Shi-Ying Li, Hong Cheng
doi : 10.1002/adhm.202202307
Safe and effective strategies are urgently needed to fight against the life-threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy and surgery, exhibit suboptimal efficacy for malignant tumors owing to the serious side effects, drug resistance and even relapse.
Enhancement of Gene Editing and Base Editing with Therapeutic Ribonucleoproteins through In Vivo Delivery Based on Absorptive Silica Nanoconstruct
Seongchan Kim, You Kyeong Jeong, Chang Sik Cho, SeokHoon Lee, Chang Ho Sohn, Jeong Hun Kim, Youngdo Jeong, Dong Hyun Jo, Sangsu Bae, Hyojin Lee
doi : 10.1002/adhm.202201825
Key to the widespread and secure application of genome editing tools is the safe and effective delivery of multiple components of ribonucleoproteins (RNPs) into single cells, which remains a biological barrier to their clinical application.
Bioactive Nonthermal Biocompatible Plasma Enhances Migration on Human Gingival Fibroblasts
Ihn Han, In-Seok Song, Seung Ah Choi, Taebok Lee, Maksudbek Yusupov, Priyanka Shaw, Annemie Bogaerts, Eun Ha Choi, Jae Jun Ryu
doi : 10.1002/adhm.202200527
This study hypothesizes that the application of low-dose nonthermal biocompatible dielectric barrier discharge plasma (DBD-NBP) to human gingival fibroblasts (HGFs) will inhibit colony formation but not cell death and induce matrix metalloproteinase (MMP) expression, extracellular matrix (ECM) degradation, and subsequent cell migration, which can result in enhanced wound healing.
3D-Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery
Tien-Jen Chang, Rolf Bech Kjeldsen, Juliane Fjelrad Christfort, Eduard Marzo Vila, Tommy Sonne Alstrøm, Kinga Zór, En-Te Hwu, Line Hagner Nielsen, Anja Boisen
doi : 10.1002/adhm.202201897
During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs.
ZipperCells Exhibit Enhanced Accumulation and Retention at the Site of Myocardial Infarction
Natalie E. Jasiewicz, Kuo-Ching Mei, Hannah M. Oh, Parth Chansoria, Dylan A. Hendy, Emily E. Bonacquisti, Eric M. Bachelder, Kristy M. Ainslie, Haifeng Yin, Li Qian, Brian C. Jensen, Juliane Nguyen
doi : 10.1002/adhm.202201094
There has been extensive interest in cellular therapies for the treatment of myocardial infarction, but bottlenecks concerning cellular accumulation and retention remain.
Bioactive MXene Promoting Angiogenesis and Skeletal Muscle Regeneration through Regulating M2 Polarization and Oxidation Stress
Ting Li, Junping Ma, Wensi Wang, Bo Lei
doi : 10.1002/adhm.202201862
Complete repair of skeletal muscles caused by severe mechanical damage and muscle-related diseases remains a challenge. 2D Ti3C2Tx (MXene) possesses special photoelectromagnetic properties and has attracted considerable attention in materials science and engineering.
Functional Blood–Brain Barrier Model with Tight Connected Minitissue by Liquid Substrates Culture
Nian Liu, Yuanbo Zhu, Kang Yu, Zeming Gu, Shang Lv, Yuewei Chen, Chaofan He, Jianzhong Fu, Yong He
doi : 10.1002/adhm.202201984
4D Printing of Overall Radiopaque Customized Bionic Occlusion Devices
Cheng Lin, Zhipeng Huang, Qinglong Wang, Zhichen Zou, Wenbo Wang, Liwu Liu, Yanju Liu, Jinsong Leng
doi : 10.1002/adhm.202201999
Percutaneous closure of ventricular septal defect (VSD) can effectively occlude abnormal blood flow between ventricles. However, commonly used Nitinol occlusion devices have non-negligible limitations, such as nondegradability leading to life-threatening embolization; limited device size predisposing to displacement and wear; only a few radiopaque markers resulting in inaccurate positioning.
Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health
Jaeho Shin, Heling Wang, Kyeongha Kwon, Diana Ostojich, Zach Christiansen, Jaime Berkovich, Yoonseok Park, Zhengwei Li, Geumbee Lee, Rania Nasif, Ted S. Chung, Chun-Ju Su, Jaeman Lim, Hitoki Kubota, Akihiko Ikoma, Yi-An Lu, Derrick H. Lin, Shuai Xu, Anthony Banks, Jan-Kai Chang, John A. Rogers
doi : 10.1002/adhm.202202021
Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health.
Regulable Polyelectrolyte-Surfactant Complex for Antibacterial Biomedical Catheter Coating via a Readily Scalable Route
Huan Yu, Lei Wang, Zhenyan Zhang, Xu Zhang, Shifang Luan, Hengchong Shi
doi : 10.1002/adhm.202202096
Constructing multifunctional surfaces is one of the practical approaches to address catheter-related multiple complications but is generally time-consuming and substrate-dependent.
Multi-Targeting Nano-Systems Targeting Heterogeneous Cancer Cells for Therapeutics and Biomarker Detection
Xiao-He Ren, Di Han, Xiao-Yan He, Tao Guo, Xue-Si Chen, Xuan Pang, Si-Xue Cheng
doi : 10.1002/adhm.202202155
Cancer heterogeneity plays a vital part in cancer resistance and metastasis. To provide a reliable approach to exert a therapy action and evaluate its efficiency in heterogeneous cancer cells, a multiple targeting delivery vector composed of histone encapsulating the therapeutic or diagnostic agent, hyaluronic acid targeting CD44 overexpressed in stem tumor cells, SYL3C aptamer targeting epithelial cell adhesion molecule (EpCAM) overexpressed in epithelial cancer cells, and CL4 aptamer targeting epidermal growth factor receptor (EGFR) overexpressed in mesenchymal cancer cells, is developed.
Patterned Duplex Fabric Based on Genetically Modified Spidroin for Smart Wound Management (Adv. Healthcare Mater. 4/2023)
Baoyang Lin, Liquan Yuan, Bingbing Gao, Bingfang He
doi : 10.1002/adhm.202370018
Patterned Duplex Fabric Based on Genetically Modified Spidroin for Smart Wound Management
Baoyang Lin, Liquan Yuan, Bingbing Gao, Bingfang He
doi : 10.1002/adhm.202202213
The treatment of diabetic wounds remains a great challenge for the medical community. Here, a smart patterned DNA double helix (duplex)-like fabric based on genetically modified spider silk protein (PDF-S) which is inspired by soft plant tendrils, is proposed for diabetic wound treatment.
One-Pot Facile Encapsulation of Dimethyloxallyl Glycine by Nanoscale Zeolitic Imidazolate Frameworks-8 for Enhancing Vascularized Bone Regeneration
Xin Zhang, Jun-Yu Chen, Xiang Pei, Ya-Hong Li, Hao Feng, Zi-Han He, Wen-Jia Xie, Xi-Bo Pei, Zhou Zhu, Qian-Bing Wan, Jian Wang
doi : 10.1002/adhm.202202317
In the process of bone tissue regeneration, regulation of osteogenesis–angiogenesis coupling is of great importance. Therefore, dimethyloxallyl glycine (DMOG) is loaded by nanoscale zeolitic imidazolate frameworks-8 (ZIF-8) to obtain a drug-loading system that can promote osteogenesis–angiogenesis coupling.
Nitric Oxide Scavenging and Hydrogen Sulfide Production Synergistically Treat Rheumatoid Arthritis
Wenbo Geng, Xuezhe Liu, Bailong Tao, Ye He, Ke Li, Pengfei Gao, Qian Feng, Peng Zhao, Zhong Luo, Kaiyong Cai
doi : 10.1002/adhm.202202380
To restore the disordered endogenous gas levels is an efficient alternative for the treatment of rheumatoid arthritis (RA). Both insufficient hydrogen sulfide (H2S) and excessive nitric oxide (NO) contribute to synovial inflammation.
One-Step Preparation of an Injectable Hydrogel Scaffold System Capable of Sequential Dual-Growth Factor Release to Maximize Bone Regeneration
Jun Kim, Young-Min Kim, Soo-Chang Song
doi : 10.1002/adhm.202202401
Numerous growth factors are involved in the natural bone healing process, which is precisely controlled in a time- and concentration-dependent manner.
Nonlysosomal Route of mRNA Delivery and Combining with Epigenetic Regulation Optimized Antitumor Immunoprophylactic Efficacy
Yu Liu, Xu Liu, Jiaxin Huang, Yingying Shi, Zhenyu Luo, Junlei Zhang, Xuemeng Guo, Mengshi Jiang, Xiang Li, Hang Yin, Bing Qin, Guannan Guan, Lihua Luo, Yun Zhou, Jian You
doi : 10.1002/adhm.202202460
Currently, mRNA-based tumor therapies are in full flow because in vitro-transcribed (IVT) mRNA has the potential to express tumor antigens to initiate the adaptive immune responses.
