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Renal artery stenting in the correct patients with atherosclerotic renovascular disease: time for a proper renal and cardiovascular outcome study?
Marieta P Theodorakopoulou, Artemios G Karagiannidis, Charles J Ferro, Alberto Ortiz, Pantelis A Sarafidis
doi : 10.1093/ckj/sfac140
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 201–204
Atherosclerotic renovascular disease (ARVD) represents the most common type of renal artery stenosis.
Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification
Armando Luis Negri
doi : 10.1093/ckj/sfac224
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 205–209
Morbidity and mortality of chronic kidney disease (CKD) patients are largely associated with vascular calcification, an actively regulated process in which vascular smooth muscle cells (VSMCs) change into cells similar to osteocytes/chondrocytes, known as trans-differentiation.
Peritoneal dialysis for acute kidney injury: back on the front-line
Brett Cullis
doi : 10.1093/ckj/sfac201
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 210–217
Peritoneal dialysis (PD) for acute kidney injury (AKI) has been available for nearly 80 years and has been through periods of use and disuse largely determined by availability of other modalities of kidney replacement therapy and the relative enthusiasm of clinicians
PoCUS in nephrology: a new tool to improve our diagnostic skills
Gregorio Romero-González, Joaquin Manrique, MarÃa F Slon-Roblero, Faeq Husain-Syed, Rafael De la Espriella, Fiorenza Ferrari, Jordi Bover, Alberto Ortiz, Claudio Ronco
doi : 10.1093/ckj/sfac203
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 218–229
Point-of-Care Ultrasonography (PoCUS) aims to include a fifth pillar (insonation) in the classical physical examination in order to obtain images to answer specific questions by the clinician at the patient's bedside, allowing rapid identification of structural or functional abnormalities, enabling more accurate volume assessment and supporting diagnosis, as well as guiding procedures.
Novel strategies in nephrology: what to expect from the future?
Sidar Copur, Cem Tanriover, Furkan Yavuz, Maria J Soler, Alberto Ortiz, Adrian Covic, Mehmet Kanbay
doi : 10.1093/ckj/sfac212
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 230–244
Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically.
Age and the eGFR-dependent risk for adverse clinical outcomes
Ping Liu, Pietro Ravani
doi : 10.1093/ckj/sfac213
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 245–253
Although the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller.
Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival
Mehmet Kanbay, Sidar Copur, Duygu Ucku, Carmine Zoccali
doi : 10.1093/ckj/sfac216
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 254–261
The effect of donor obesity on kidney transplantation success has long been an overlooked clinical research area. Even though there is no strict guideline in most countries prohibiting donation from obese individuals, most candidates with a body mass index >35–40 kg/m2 are rejected due to concerns regarding long-term renal functional deterioration in the donor.
Hypoxia during maintenance hemodialysis—the critical role of pH
Scott McGuire, Nithya Krishnan, Abdul R Malik, Alex Waddell, Sophie L Russell, Francesca Denton, Stuart Ennis, Elizabeth Horton, Djordje Jakovljevic, Gordon McGregor
doi : 10.1093/ckj/sfac191
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 262–271
The impact and management of subclinical hypoxia during hemodialysis is a significant medical challenge. As key determinants of O2 availability and delivery, proposed mechanisms contributing to hypoxia include ischemia, alkalemia and pulmonary leukocyte sequestration
Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury
Ander Vergara, Kaiming Wang, Daniele Colombo, Mahmoud Gheblawi, Jaslyn Rasmuson, Rupasri Mandal, Franca Del Nonno, Brian Chiu, James W Scholey, MarÃa José Soler, David S Wishart, Gavin Y Oudit
doi : 10.1093/ckj/sfac215
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 272–284
Angiotensin-converting enzyme 2 (ACE2), the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed in the kidneys.
A prospective study on serum citrate levels and clinical correlations in patients receiving regional citrate anticoagulation
Harmony H M To, Arthur M C Kwan, Natalie Y Y Leung, W M Chan, C W Ngai, Alfred S K Wong, Polly N W Tsai, Tammy S K Ma, Irene Yam, Pauline Yeung Ng, Desmond Y H Yap
doi : 10.1093/ckj/sfac223
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 285–292
Current ways to diagnose citrate accumulation (CA) in patients receiving regional citrate anticoagulation (RCA) continuous renal replacement therapy (CRRT) are confounded by various clinical factors.
A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease
Rajiv Agarwal, Bertram Pitt, Biff F Palmer, Csaba P Kovesdy, Ellen Burgess, Gerasimos Filippatos, Jolanta Małyszko, Luis M Ruilope, Patrick Rossignol, Peter Rossing, Roberto Pecoits-Filho, Stefan D Anker, Amer Joseph, Robert Lawatscheck, Daniel Wilson, Martin Gebel, George L Bakris
doi : 10.1093/ckj/sfac234
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 293–302
Mineralocorticoid receptor antagonists (MRAs) reduce systolic blood pressure (SBP) and increase serum potassium concentration ([K+]). This indirect comparison investigated any differences in SBP-lowering and hyperkalemia risk between finerenone, a nonsteroidal MRA, and the steroidal MRA spironolactone ± a potassium binder.
Prevalence of anaemia in adults with chronic kidney disease in a representative sample of the United States population: analysis of the 1999–2018 National Health and Nutrition Examination Survey
Csaba P Kovesdy, Jill R Davis, Ian Duling, Dustin J Little
doi : 10.1093/ckj/sfac240
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 303–311
Population-based estimates of anaemia prevalence in patients with chronic kidney disease (CKD) vary, and data on the prevalence of severe anaemia of CKD are limited. This study examined the prevalence of anaemia and anaemia eligible for erythropoiesis-stimulating agent (ESA) treatment in patients with CKD in the USA.
Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019
Yang Li, Yichun Ning, Bo Shen, Yiqin Shi, Nana Song, Yi Fang, Xiaoqiang Ding
doi : 10.1093/ckj/sfac218
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 312–321
This study aimed to characterize the temporal trends of chronic kidney disease (CKD) burden in China during 1990–2019, evaluate their age, period and cohort effects, and predict the disease burden for the next 10 years.
2009 CKD-EPI glomerular filtration rate estimation in Black individuals outside the United States: a systematic review and meta-analysis
Carolina Pires Zingano, Gustavo Monteiro Escott, Bruna Martins Rocha, Indianara Franciele Porgere, Candice Cristine Moro, Pierre Delanaye, Sandra Pinho Silveiro
doi : 10.1093/ckj/sfac238
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 322–330
The 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is the most used equation to estimate glomerular filtration rate (GFR), with race being a factor thereof, increasing GFR by 16% in self-identified Black persons compared with non-Black persons.
Collaboration between local nephrologists and the transplant centre ensures good outcomes in post-transplant care
Yves L Kaufmann, Seraina von Moos, Tahm Spitznagel, Laurenz S Matter, Thomas F Mueller, Thomas Schachtner
doi : 10.1093/ckj/sfac232
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 331–341
Despite substantial improvements in short-term kidney allograft survival, median long-term survival remains at a standstill. It is unclear whether and to what extent a transplant centre’s post-transplant care influences long-term outcomes.
Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization
Benjamin M Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J Ferro, Thomas A Jackson, Adnan Sharif
doi : 10.1093/ckj/sfac241
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 342–354
Frailty and depression are highly prevalent in haemodialysis recipients, exhibit a reciprocal relationship, and are associated with increased mortality and hospitalization, and lower quality of life.
The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait
Hamad Ali, Medhat Naim, Sarah R Senum, Ali AlSahow, Yousif Bahbahani, Mohamed Abu-Farha, Jehad Abubaker, Anwar Mohammad, Adel Al-Hunayan, Akram M Asbeutah, Mohamed Zayed, Sriraman Devarajan, Naser Hussain, Sumi Elsa John, Arshad Channanath, Thangavel Alphonse Thanaraj, Mohammad Al-Ali, Mustafa AlMousawi, Fahd Al-Mulla, Peter C Harris
doi : 10.1093/ckj/sfac236
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 355–366
Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disease, characterized by bilateral accumulation of renal fluid-filled cysts leading to progressive renal volume enlargement and gradual impairment of kidney function, often resulting in end-stage renal disease.
Renal arcuate vein thrombosis–induced acute kidney injury: a rare multiple-Hit–mediated disease
Clara Pardinhas, Rui Filipe, Paul Vergnaud, Mathilde Grapin, Elsa Ferrière, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Pérot, Olivia Boyer, Marion Rabant, Jean-Paul Duong Van Huyen, Pierre Isnard
doi : 10.1093/ckj/sfac244
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 367–373
Renal arcuate vein thrombosis (RAVT) is a rare and recently recognized cause of acute kidney injury (AKI) in young adults. However, the precise incidence and underlying pathophysiologic mechanisms leading to AKI in these patients remain elusive.
Acute and chronic kidney disease and risk of hospital mortality during COVID-19 pandemic waves in the pre-vaccination era
José Portolés, Paula López-Sánchez, Leyre Martin-RodrÃguez, MarÃa Luisa Serrano-Salazar, Maria Valdenebro-Recio, Antonio Ramos, Rosa MarÃa Malo, Felipe Zalamea, Juan Manuel Martin-Giner, MarÃa Marques, Alberto Ortiz
doi : 10.1093/ckj/sfac239
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 374–383
Chronic kidney disease (CKD) is a risk factor for death from coronavirus disease 2019 (COVID-19), and COVID-19 may cause acute kidney injury (AKI) which also influences outcomes.
Microvascular perfusion, perfused boundary region and glycocalyx shedding in patients with autosomal dominant polycystic kidney disease: results from the GlycoScore III study
Alexander Fuchs, Jennifer Dederichs, Sita Arjune, Polina Todorova, Fabian Wöstmann, Philipp Antczak, Anja Illerhaus, Birgit Gathof, Franziska Grundmann, Roman-Ulrich Müller, Thorsten Annecke
doi : 10.1093/ckj/sfac229
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 384–393
Vascular abnormalities and endothelial dysfunction are part of the spectrum of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms behind these manifestations, including potential effects on the endothelial surface layer (ESL) and glycocalyx integrity, remain unknown.
Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections
Chau Wei Ling, Kamal Sud, Rahul P Patel, Gregory M Peterson, Ronald L Castelino
doi : 10.1093/ckj/sfac131
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 394–395
Reply to ‘Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections’
David W Johnson, Simon Wai Yin So, Philip Kam-Tao Li
doi : 10.1093/ckj/sfac132
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Page 396
Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C?
Viola D'Ambrosio, Pietro Manuel Ferraro, Valeria Guglielmino, Marco Luigetti
doi : 10.1093/ckj/sfac156
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 397–398
Reply to ‘Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C?’
Justine Solignac, Noémie Jourde-Chiche
doi : 10.1093/ckj/sfac157
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Page 399
No difference in mortality after three different kidney replacement therapy initiation strategies in acute kidney injury
Jia-Jin Chen, George Kuo, Tao Han Lee, Chih-Hsiang Chang
doi : 10.1093/ckj/sfac231
Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 400–402
