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Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
Li Qi, Yongsheng Chen
doi : 10.1210/clinem/dgac659
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Bile acids (BAs) are pivotal signaling molecules that regulate energy metabolism and inflammation. Recent epidemiological studies have reported specific alterations in circulating BA profiles in certain disease states, including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and Alzheimer disease (AD).
Current Controversies in Low-Risk Differentiated Thyroid Cancer: Reducing Overtreatment in an Era of Overdiagnosis
Timothy M Ullmann, Maria Papaleontiou, Julie Ann Sosa
doi : 10.1210/clinem/dgac646
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Low-risk differentiated thyroid cancer (DTC) is overdiagnosed, but true incidence has increased as well. Owing to its excellent prognosis with low morbidity and mortality, balancing treatment risks with risks of disease progression can be challenging, leading to several areas of controversy.
Utility of In Vivo Magnetic Resonance Imaging Is Predictive of Gestational Diabetes Mellitus During Early Pregnancy
Brian Lee, Carla Janzen, Holden Wu, Sitaram S Vangala, Sherin U Devaskar, Kyunghyun Sung
doi : 10.1210/clinem/dgac602
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023,
Gestational diabetes (GDM) imposes long-term adverse health effects on the mother and fetus. The role of magnetic resonance imaging (MRI) during early gestation in GDM has not been well-studied.
Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study
Hailuan Zeng, Jieyu Ge, Wenjie Xu, Hui Ma, Lingyan Chen, Mingfeng Xia, Baishen Pan, Huandong Lin, Sijia Wang, Xin Gao
doi : 10.1210/clinem/dgac597
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Previous genome-wide association studies (GWASs) of bone mineral density (BMD) were mainly conducted in Europeans.
Radioactive Iodine-Refractory Pulmonary Metastases of Papillary Thyroid Cancer in Children, Adolescents, and Young Adults
Tian Tian, Shuhui Huang, Hongyuan Dai, Mengfang Qi, Bin Liu, Rui Huang
doi : 10.1210/clinem/dgac600
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Few studies have explored radioactive iodine–refractory (RAIR) disease in children, adolescents, and young adults with papillary thyroid cancer (CAYA-PTC).
Metabolomic Profile of Children Conceived With Medically Assisted Technologies
Alisha T Tolani, Marcelle I Cedars, Lydia B Zablotska, Paolo F Rinaudo
doi : 10.1210/clinem/dgac589
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Assisted reproductive technologies (ART) and non–in vitro fertilization fertility treatments (NIFT) are treatments for infertility. These technologies may have long-term health effects in children such as increased hypertension, glucose intolerance, and hypertriglyceridemia. Few studies have compared children born following ART and NIFT to those conceived spontaneously by subfertile couples.
Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults
Gaëlle Nannette, Céline Bar, Gwenaëlle Diene, Catherine Pienkowski, Isabelle Oliver-Petit, Béatrice Jouret, Audrey Cartault, Valérie Porquet-Bordes, Jean-Pierre Salles, Solange Grunenwald, Thomas Edouard, Catherine Molinas, Maithé Tauber
doi : 10.1210/clinem/dgac583
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the literature.
Changes in Serum Testosterone and Adrenal Androgen Levels in Transgender Women With and Without Gonadectomy
Sarah Collet, Noor C Gieles, Chantal M Wiepjes, Annemieke C Heijboer, Tim Reyns, Tom Fiers, Bruno Lapauw, Martin den Heijer, Guy T'Sjoen
doi : 10.1210/clinem/dgac576
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Initiating feminizing gender-affirming hormone therapy (GAHT) in transgender women causes a steep decline in serum testosterone. It is unknown if testosterone concentrations change further and whether adrenal androgen levels change during feminizing GAHT and after gonadectomy.
Maternal Thyroid Dysfunction and Neuropsychological Development in Children
Yuanzhi Chen, Zhong-Cheng Luo, Ting Zhang, Pianpian Fan, Rui Ma, Jun Zhang, Fengxiu Ouyang
doi : 10.1210/clinem/dgac577
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Thyroid hormones are essential for fetal brain development. The potential effects of maternal gestational thyroid dysfunction on offspring neuropsychological development remain inconclusive.
Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status
Karin C Wu, Sisi Cao, Connie M Weaver, Nicole J King, Sheena Patel, Tiffany Y Kim, Dennis M Black, Hillary Kingman, Martin M Shafer, Stanley J Rogers, Lygia Stewart, Jonathan T Carter, Andrew M Posselt, Anne L Schafer
doi : 10.1210/clinem/dgac579
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Laparoscopic sleeve gastrectomy (LSG), now the most commonly performed bariatric operation, is a highly effective treatment for obesity. While Roux-en-Y gastric bypass is known to impair intestinal fractional calcium absorption (FCA) and negatively affect bone metabolism, LSG's effects on calcium homeostasis and bone health have not been well characterized.
Diabetes Mellitus is Associated With Higher Serum Neurofilament Light Chain Levels in the General US Population
Stefano Ciardullo, Emanuele Muraca, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Francesca Zerbini, Gianluca Perseghin
doi : 10.1210/clinem/dgac580
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023,
Serum neurofilament light chain (sNfL) levels are biomarkers of neuroaxonal injury in multiple neurological diseases.
Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer
Ben Ma, Shishuai Wen, Yi Luo, Tingting Zhang, Yichen Yang, Cenkai Shen, Yan Zhang, Qinghai Ji, Ning Qu, Yu Wang
doi : 10.1210/clinem/dgac548
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Hypoxia is commonly observed in multiple aggressive cancers. Its role remains unclear in the biology and therapy of dedifferentiated thyroid cancer (DDTC).
Statins, Type 2 Diabetes, and Body Mass Index: A Univariable and Multivariable Mendelian Randomization Study
Guoyi Yang, C Mary Schooling
doi : 10.1210/clinem/dgac562
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Statins and possibly other lipid modifiers increase type 2 diabetes risk and body mass index (BMI). However, to what extent BMI mediates the diabetogenic effects of lipid modifiers remains unclear.
Recurrent Disease in Patients With Sporadic Pheochromocytoma and Paraganglioma
Minghao Li, Tamara Prodanov, Leah Meuter, Michiel N Kerstens, Nicole Bechmann, Aleksander Prejbisz, Hanna Remde, Henri J L M Timmers, Svenja Nölting, Sara Talvacchio, Annika M A Berends, Stephanie Fliedner, Mercedes Robledo, Jacques W M Lenders, Karel Pacak, Graeme Eisenhofer, Christina Pamporaki
doi : 10.1210/clinem/dgac563
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Long-term follow-up has been recommended for patients with pheochromocytoma or paraganglioma (PPGL) due to potential for recurrent disease. However, the need to follow patients with sporadic PPGL has recently become controversial.
Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study
Peizhi Deng, Qingwei Yu, Haibo Tang, Yao Lu, Yingdong He
doi : 10.1210/clinem/dgac566
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
The association between visceral adipose tissue (VAT) and pre-eclampsia (PE) shows inconsistent results and the underlying mediator remains unknown.
Just as Tall on Testosterone; a Neutral to Positive Effect on Adult Height of GnRHa and Testosterone in Trans Boys
Lieve Anne Willemsen, Lidewij Sophia Boogers, Chantal Maria Wiepjes, Daniel Tatting Klink, Adrianus Sarinus Paulus van Trotsenburg, Martin den Heijer, Sabine Elisabeth Hannema
doi : 10.1210/clinem/dgac571
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Growth is an important topic for many transgender boys. However, few studies have investigated the impact of puberty suppression (PS) and gender-affirming hormone treatment (GAHT) on growth and adult height.
A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia
Mika Hori, Atsushi Takahashi, Kiminori Hosoda, Masatsune Ogura, Mariko Harada-Shiba
doi : 10.1210/clinem/dgac572
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Heterozygous familial hypercholesterolemia (HeFH) is caused by a rare pathogenic variant in the LDLR, APOB, and PCSK9 genes. However, the causative variants in these genes have not been identified in approximately 40% of HeFH patients.
Novel Causal Plasma Proteins for Hypothyroidism: A Large-scale Plasma Proteome Mendelian Randomization Analysis
Hongqun Yang, Lanlan Chen, Yahui Liu
doi : 10.1210/clinem/dgac575
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Although several risk proteins for hypothyroidism have been reported in recent years, many more plasma proteins have not been tested.
Leukocyte Telomere Length in Children With Congenital Adrenal Hyperplasia
Christina Raftopoulou, Ozair Abawi, Grit Sommer, Maria Binou, George Paltoglou, Christa E Flück, Erica L T van den Akker, E Charmandari
doi : 10.1210/clinem/dgac560
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Exposure to chronic stress and hypercortisolism is associated with decreased leukocyte telomere length (LTL), a marker for biological aging and cardiovascular disease. Children with congenital adrenal hyperplasia (CAH) are treated with glucocorticoids.
Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins
Amalia Christina Vadmand, Anne Anker Nissen, Sidsel Mathiesen, Maria Ebbesen Soerum, Tina Gerbek, Martin Kaj Fridh, Kaspar Sørensen, Bolette Hartmann, Jens Juul Holst, Klaus Müller
doi : 10.1210/clinem/dgac561
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Survivors of pediatric hematopoietic stem cell transplantation (HSCT) have increased risk of developing metabolic syndrome (MetS), but the mechanisms are poorly understood.
Nonalcoholic Fatty Liver Disease and Adverse Pregnancy Outcomes in Women With Normal Prepregnant Weight
Yiling Qian, Yu Zhang, Xiaofang Fan, Hongmei Yan, Xuesong Li, Yujuan Fan, Yuping Song, Shuai Ma, Zheng Hu, Xin Gao, Jialin Yang
doi : /10.1210/clinem/dgac567
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Existing studies focusing on the effects of nonalcoholic fatty liver disease (NAFLD) combined with normal prepregnant weight on pregnancy outcomes are limited.
Approach to the Patient With a Suppressed TSH
Stephanie Smooke Praw, Gregory A Brent
doi : 10.1210/clinem/dgac635
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Subclinical hyperthyroidism (SCH) is a laboratory diagnosis defined by a serum thyrotropin (TSH) concentration below the reference range (< 0.4 mU/L in most assays), and a free thyroxine (FT4) and 3,5,3′-triiodothyronine levels (FT3) in the reference range.
Approach to the Patient With Nonalcoholic Fatty Liver Disease
Renata Belfort-DeAguiar, Romina Lomonaco, Kenneth Cusi
doi : 10.1210/clinem/dgac624
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes (T2D), causing substantial burden from hepatic and extrahepatic complications. However, endocrinologists often follow people who are at the highest risk of its more severe form with nonalcoholic steatohepatitis or NASH (i.e., T2D or obesity with cardiometabolic risk factors). Endocrinologists are in a unique position to prevent cirrhosis in this population with early diagnosis and treatment.
Exclusion Tests in Unilateral Primary Aldosteronism (ExcluPA) Study
Rui Zhu, Tungalagtamir Shagjaa, Giacomo Rossitto, Brasilina Caroccia, Teresa Maria Seccia, Dario Gregori, Gian Paolo Rossi
doi : 10.1210/clinem/dgac654
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Determining the diagnostic accuracy of “exclusion� tests for primary aldosteronism (PA) compared to the aldosterone to renin ratio (ARR) is fundamental to avoid invasive subtyping in false-positive patients at screening.
Is Sleep the Best Medicine?
Caterina Conte
doi : 10.1210/clinem/dgac647
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Body Weight Variability and Cardiovascular Health in Diabetes
Sanjay Kumar Bhadada, Bhanu Malhotra, Anirudh J Shetty
doi : 10.1210/clinem/dgac629
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Islet Inflammation Can Be Linked to the Disruption of Proinsulin Processing in Type 1 Diabetes but not in Type 2 Diabetes
Gordon C Weir
doi : 10.1210/clinem/dgac638
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Delays in Surgery for Differentiated Thyroid Carcinomas: How Long Is Reasonable, and What Questions Remain?
Jordan M Broekhuis, Benjamin C James
doi : 10.1210/clinem/dgac641
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
It's Not Just About the Hot Flashes: Menopausal Hormone Changes and Disrupted Sleep
Fiona C Baker
doi : 10.1210/clinem/dgac628
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Lifestyle Interventions Reduce the Risk of Type 2 Diabetes Through Decreasing Branched-Chain Amino Acids: Newer Insights
Deep Dutta, Deepak Khandelwal
doi : 10.1210/clinem/dgac633
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Correction to “Machine Learning-Based Prediction of Elevated PTH Levels Among the US General Population�
doi : 10.1210/clinem/dgac676
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Correction to “Bone health in adults with Prader-Willi syndrome: clinical recommendations based on a multicenter cohort study�
doi : 10.1210/clinem/dgac680
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
Correction to “Reduced Sensitivity to Thyroid Hormones Is Associated With High Remnant Cholesterol Levels in Chinese Euthyroid Adults�
doi : 10.1210/clinem/dgac626
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 2, February 2023
