Japanese National Plan for Promotion of Measures Against Cerebrovascular and Cardiovascular Disease

Masanari Kuwabara, Megumu Mori, Shigekazu Komoto

doi : 10.1161/CIRCULATIONAHA.120.052737

Circulation. 2021 | Volume 143, Issue 20: 1929–1931

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Mission “UnACCOMPLISHed”: Optimal Antihypertensive Therapy

Robert D. Brook, Phillip D. Levy, Kenneth A. Jamerson

doi : 10.1161/CIRCULATIONAHA.120.053151

Circulation. 2021 | Volume 143, Issue 20: 1932–1934

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High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events

Congzhuo Jia, Josephine L.C. Anderson, Eke G. Gruppen, Yu Lei, Stephan J.L. Bakker, Robin P.F. Dullaart, Uwe J.F. Tietge

doi : 10.1161/CIRCULATIONAHA.120.050808

Circulation. 2021 | Volume 143, Issue 20: 1935–1945

The role of high-density lipoprotein (HDL) function in cardiovascular disease represents an important emerging concept. The present study investigated whether HDL anti-inflammatory capacity is prospectively associated with first cardiovascular events in the general population.

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Stressing the Endothelium to Assess Localized Inflammatory Potential and the Risk for Atherosclerotic Cardiovascular Disease

Anand Rohatgi

doi : 10.1161/CIRCULATIONAHA.121.053989

Circulation. 2021 | Volume 143, Issue 20: 1946–1948

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Cardiovascular Risk Factor Trajectories Since Childhood and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study

Juuso O. Hakala, Katja Pahkala, Markus Juonala, Pia Salo, Mika K?h?nen, Nina Hutri-K?h?nen, Terho Lehtim?ki, Tomi P. Laitinen, Eero Jokinen, Leena Taittonen, P?ivi Tossavainen, Jorma S.A. Viikari, Olli T. Raitakari, Suvi P. Rovio

doi : 10.1161/CIRCULATIONAHA.120.052358

Circulation. 2021 | Volume 143, Issue 20: 1949–1961

Cardiovascular risk factors, such as high blood pressure, adverse serum lipids, and elevated body mass index in midlife, may harm cognitive performance. It is important to note that longitudinal accumulation of cardiovascular risk factors since childhood may be associated with cognitive performance already since childhood, but the previous evidence is scarce. We studied the associations of cardiovascular risk factors from childhood to midlife, their accumulation, and midlife cognitive performance.

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Dapagliflozin and Recurrent Heart Failure Hospitalizations in Heart Failure With Reduced Ejection Fraction: An Analysis of DAPA-HF

Pardeep S. Jhund, Piotr Ponikowski, Kieran F. Docherty, Samvel B. Gasparyan, Michael B?hm, Chern-En Chiang, Akshay S. Desai, Jonathon Howlett, Masafumi Kitakaze, Mark C. Petrie, Subodh Verma, Olof Bengtsson, Anna-Maria Langkilde, Mikaela Sj?strand, Silvio E. Inzucchi, Lars K?ber, Mikhail N. Kosiborod, Felipe A. Martinez, Marc S. Sabatine, Scott D. Solomon, John J.V. McMurray

doi : 10.1161/CIRCULATIONAHA.121.053659

Circulation. 2021 | Volume 143, Issue 20: 1962–1972

Patients with heart failure (HF) and reduced ejection fraction will experience multiple hospitalizations for heart failure during the course of their disease. We assessed the efficacy of dapagliflozin on reducing the rate of total (ie, first and repeat) hospitalizations for heart failure in the DAPA-HF trial (Dapagliflozin and Prevention of Adverse-Outcomes in Heart Failure).

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Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration

Jiyoung Bae, Rebecca J. Salamon, Emma B. Brandt, Wyatt G. Paltzer, Ziheng Zhang, Emily C. Britt, Timothy A. Hacker, Jing Fan, Ahmed I. Mahmoud

doi : 10.1161/CIRCULATIONAHA.120.049952

Circulation. 2021 | Volume 143, Issue 20: 1973–1986

Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to oxidative phosphorylation, which results in a significant increase in reactive oxygen species production that induces DNA damage. These cellular changes contribute to cardiomyocyte cell cycle exit and loss of the capacity for cardiac regeneration. The mechanisms that regulate this metabolic switch and the increase in reactive oxygen species production have been relatively unexplored. Current evidence suggests that elevated reactive oxygen species production in ischemic tissues occurs as a result of accumulation of the mitochondrial metabolite succinate during ischemia via succinate dehydrogenase (SDH), and this succinate is rapidly oxidized at reperfusion. Mutations in SDH in familial cancer syndromes have been demonstrated to promote a metabolic shift into glycolytic metabolism, suggesting a potential role for SDH in regulating cellular metabolism. Whether succinate and SDH regulate cardiomyocyte cell cycle activity and the cardiac metabolic state remains unclear.

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From Fragrances to Heart Regeneration: Malonate Repairs Broken Hearts

James W. McNamara, Enzo R. Porrello

doi : 10.1161/CIRCULATIONAHA.121.054313

Circulation. 2021 | Volume 143, Issue 20: 1987–1990

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Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

Eva Querdel, Marina Reinsch, Liesa Castro, Deniz K?se, Andrea B?hr, Svenja Reich, Birgit Geertz, B?rbel Ulmer, Mirja Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stüdemann, Maria K?hne, Constantin von Bibra, Nadja Hornaschewitz, Simon Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, M. Krane, C. Kupatt, Thomas Eschenhagen, Florian Weinberger

doi : 10.1161/CIRCULATIONAHA.120.047904

Circulation. 2021 | Volume 143, Issue 20: 1991–2006

Human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical application requires upscaling, adaptation to good manufacturing practices, and determination of the effective dose.

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LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis

Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian’an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang

doi : 10.1161/CIRCULATIONAHA.120.050812

Circulation. 2021 | Volume 143, Issue 20: 2007–2022

Heart failure (HF) is among the leading causes of morbidity and mortality, and its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) is a master regulator that governs the DNA damage response and RNAPII (RNA polymerase II) pausing pathway, but its role in HF pathogenesis is incompletely understood.

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From the Literature

Tracy Hampton

doi : 10.1161/CIRCULATIONAHA.121.055221

Circulation. 2021 | Volume 143, Issue 20: 2023–2024

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Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber–Specific Gene Regulation

Alina S. Bilal, Erik A. Blackwood, Donna J. Thuerauf, Christopher C. Glembotski

doi : 10.1161/CIRCULATIONAHA.120.052437

Circulation. 2021 | Volume 143, Issue 20: 2025–2027

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Letter by Morgan et al Regarding Article, “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial”

Holly Morgan, Tim Clayton, Divaka Perera

doi : 10.1161/CIRCULATIONAHA.120.051850

Circulation. 2021 | Volume 143, Issue 20: e959–e960

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Response by Lopes et al to Letter Regarding Article, “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial”

Renato D. Lopes, Karen P. Alexander, Judith S. Hochman, David J. Maron

doi : 10.1161/CIRCULATIONAHA.121.053672

Circulation. 2021 | Volume 143, Issue 20: e961–e962

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Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association

Walter R. Wilson, Michael Gewitz, Peter B. Lockhart, Ann F. Bolger, Daniel C. DeSimone, Dhruv S. Kazi, David J. Couper, Andrea Beaton, Catherine Kilmartin, Jose M. Miro, Craig Sable, Mary Anne Jackson, Larry M. Baddour and On behalf of the American Heart Association Young Hearts Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; and the Council on Quality of Care and Outcomes Research

doi : 10.1161/CIR.0000000000000969

Circulation. 2021 | Volume 143, Issue 20: e963–e978

In 2007, the American Heart Association published updated evidence-based guidelines on the recommended use of antibiotic prophylaxis to prevent viridans group streptococcal (VGS) infective endocarditis (IE) in cardiac patients undergoing invasive procedures. The 2007 guidelines significantly scaled back the underlying conditions for which antibiotic prophylaxis was recommended, leaving only 4 categories thought to confer the highest risk of adverse outcome. The purpose of this update is to examine interval evidence of the acceptance and impact of the 2007 recommendations on VGS IE and, if needed, to make revisions based on this evidence.

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Correction to: Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

doi : 10.1161/CIR.0000000000000987

Circulation. 2021 | Volume 143, Issue 20: e979

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