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Regulating Reproductive Medicine in a World without Roe
Kimberly Mutcherson, J.D.
doi : 10.1056/NEJMp2203089
January 26, 2023 Vol. 388 No. 4
Sources of Innovation in Gene Therapies — Approaches to Achieving Affordable Prices
Kerstin N. Vokinger, M.D., J.D., Ph.D., L.L.M., Jerry Avorn, M.D., and Aaron S. Kesselheim, M.D., J.D., M.P.H.
doi : 10.1056/NEJMp2211729
Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest
Martje M. Suverein, M.D., Thijs S.R. Delnoij, M.D., Roberto Lorusso, M.D., Ph.D., George J. Brandon Bravo Bruinsma, M.D., Ph.D., Luuk Otterspoor, M.D., Ph.D., Carlos V. Elzo Kraemer, M.D., Alexander P.J. Vlaar, M.D., Ph.D., Joris J. van der Heijden, M.D., Erik Scholten, M.D., Corstiaan den Uil, M.D., Ph.D., Tim Jansen, M.D., Ph.D., Bas van den Bogaard, M.D., Ph.D., Marijn Kuijpers, M.D., Ka Yan Lam, M.D., José M. Montero Cabezas, M.D., Antoine H.G. Driessen, M.D., Ph.D., Saskia Z.H. Rittersma, M.D., Ph.D., Bram G. Heijnen, M.D., Dinis Dos Reis Miranda, M.D., Ph.D., Gabe Bleeker, M.D., Ph.D., Jesse de Metz, M.D., Ph.D., Renicus S. Hermanides, M.D., Ph.D., Jorge Lopez Matta, M.D., Susanne Eberl, M.D., Ph.D., Dirk W. Donker, M.D., Ph.D., Robert J. van Thiel, M.D., Sakir Akin, M.D., Ph.D., Oene van Meer, M.D., José Henriques, M.D., Ph.D., Karen C. Bokhoven, M.D., Loes Mandigers, M.D., Jeroen J.H. Bunge, M.D., Martine E. Bol, M.Sc., Bjorn Winkens, Ph.D., Brigitte Essers, Ph.D., Patrick W. Weerwind, Ph.D., Jos G. Maessen, M.D., Ph.D., and Marcel C.G. van de Poll, M.D., Ph.D.
doi : 10.1056/NEJMoa2204511
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive.
Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A
Annette von Drygalski, M.D., Pharm.D., R.M.S.K., Pratima Chowdary, M.D., Roshni Kulkarni, M.D., Sophie Susen, M.D., Ph.D., Barbara A. Konkle, M.D., Johannes Oldenburg, M.D., Davide Matino, M.D., Robert Klamroth, M.D., Ph.D., Angela C. Weyand, M.D., Victor Jimenez-Yuste, M.D., Ph.D., Keiji Nogami, M.D., Stacey Poloskey, M.D.,
doi : 10.1056/NEJMoa2209226
Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor–imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bleeding episodes in previously treated patients with severe hemophilia A are unclear.
Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia
Jennifer R. Brown, M.D., Ph.D., Barbara Eichhorst, M.D., Peter Hillmen, M.B., Ch.B., Ph.D., Wojciech Jurczak, M.D., Ph.D., Maciej Kaźmierczak, M.D., Ph.D., Nicole Lamanna, M.D., Susan M. O’Brien, M.D., Constantine S. Tam, M.B., B.S., M.D., Lugui Qiu, M.D., Ph.D., Keshu Zhou, M.D., Ph.D., Martin Simkovic, M.D., Ph.D., Jiri Mayer, M.D., Amanda Gillespie-Twardy, M.D., Alessandra Ferrajoli, M.D., Peter S. Ganly, B.M., B.Ch., Ph.D., Robert Weinkove, M.B., B.S., Ph.D., Sebastian Grosicki, M.D., Ph.D., Andrzej Mital, M.D., Ph.D., Tadeusz Robak, M.D., Ph.D., Anders Osterborg, M.D., Ph.D., Habte A. Yimer, M.D., Tommi Salmi, M.D., Megan-Der-Yu Wang, Pharm.D., Lina Fu, M.S., Jessica Li, M.S., Kenneth Wu, Ph.D., Aileen Cohen, M.D., Ph.D., and Mazyar Shadman, M.D., M.P.H.
doi : 10.1056/NEJMoa2211582
In a multinational, phase 3, head-to-head trial, ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, was compared with zanubrutinib, a BTK inhibitor with greater specificity, as treatment for relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex
Hans Pottel, Ph.D., Jonas Björk, Ph.D., Andrew D. Rule, M.D., Natalie Ebert, M.D., M.P.H., Björn O. Eriksen, M.D., Ph.D., Laurence Dubourg, M.D., Ph.D., Emmanuelle Vidal-Petiot, M.D., Ph.D., Anders Grubb, M.D., Ph.D., Magnus Hansson, M.D., Ph.D., Edmund J. Lamb, Ph.D., Karin Littmann, M.D., Ph.D., Christophe Mariat, M.D., Ph.D., Toralf Melsom, M.D., Ph.D., Elke Schaeffner, M.D., Ph.D., Per-Ola Sundin, M.D., Ph.D., Anna Åkesson, B.Sc., Anders Larsson, M.D., Ph.D., Etienne Cavalier, Eu.Sp.L.M., Ph.D., Justine B. Bukabau, M.D., Ph.D., Ernest K. Sumaili, M.D., Ph.D., Eric Yayo, Pharm.D., Ph.D., Dagui Monnet, Pharm.D., Ph.D., Martin Flamant, M.D., Ph.D., Ulf Nyman, M.D., Ph.D., and Pierre Delanaye, M.D., Ph.D.
doi : 10.1056/NEJMoa2203769
The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial.
Antiretroviral Therapy and Adverse Pregnancy Outcomes in People Living with HIV
Ahizechukwu C. Eke, M.D., Ph.D., Mark Mirochnick, M.D., and Shahin Lockman, M.D.
doi : 10.1056/NEJMra2212877
Atopic Eruption of Pregnancy
Masakazu Kakurai, M.D., and Kazumasa Oya, M.D., Ph.D.
doi : 10.1056/NEJMicm2207685
Case 3-2023: A 16-Year-Old Girl with Abdominal Pain and Bloody Diarrhea
Stacy A. Kahn, M.D., Maureen M. Leonard, M.D., Sjirk J. Westra, M.D., Jonathan S. Hausmann, M.D., and Sarah B. Mueller, M.D., Ph.D.
doi : 10.1056/NEJMcpc2211367
Extracorporeal CPR in Out-of-Hospital Cardiac Arrest — Still on Life Support?
John F. Keaney, Jr., M.D., and Thomas Münzel, M.D.
doi : 10.1056/NEJMe2214116
Influenza Vaccine in Pediatric Recipients of Hematopoietic-Cell Transplants
doi : 10.1056/NEJMc2210825
