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Clinical remission in paired phase two and three studies in inflammatory bowel disease: a systematic review with meta-analysis.
Tandon, Parul a; Natt, Navneet b; Malhi, Gurpreet c; Wong, Emily CL d; Matthews, Priscilla d; Reinisch, Walter e,*; Narula, Neeraj d,*
doi : 10.1097/MEG.0000000000002490
Volume 35(3) pgs. 231-352 March 2023
AB Discrepancies in phase two and three studies can result in significant patient and financial burden, as well as the nonapproval of potentially efficacious drugs. We aimed to determine whether this discrepancy exists for clinical trials in inflammatory bowel disease (IBD).
Impact of metformin on the incidence of human cholangiocarcinoma in diabetic patients: a systematic review and meta-analysis.
Laffusa, Alice; Ciaccio, Antonio; Elvevi, Alessandra; Gallo, Camilla; Ratti, Laura; Invernizzi, Pietro; Massironi, Sara
doi : 10.1097/MEG.0000000000002503
AB Cholangiocarcinoma (CCA) is the second most common liver cancer. Diabetes is a well-known risk factor; however, treatment with metformin has been reported to be protective for several cancers, but data on CCA are still sparse and heterogeneous.
Development of risk scores for early and late recurrence of colonic diverticular hemorrhage.
Watanabe, Sho a; Miyakawa, Akihiro b; Sato, Ayako c; Uchida, Hitoshi a; Uga, Misugi a; Machida, Tomoyo a; Matsukawa, Naoki a; Kurihara, Masamichi a; Yauchi, Tsunehito a
doi : 10.1097/MEG.0000000000002478
Colonic diverticular hemorrhage (CDH) often recurs. Although several studies have suggested that early rebleeding (ER) and late rebleeding (LR) should be treated independently, and several ER/LR risk factors have been identified, an integrated system for risk evaluation is still lacking.
Infectious mononucleosis is associated with an increased incidence of Crohn's disease: results from a cohort study of 31 862 outpatients in Germany.
Loosen, Sven H. a,*; Kostev, Karel b,*; Scholer, David a; Orth, Hans-Martin a; Freise, Noemi F. a; Jensen, Bjorn-Erik Ole a; May, Petra a; Bode, Johannes G. a; Roderburg, Christoph a,#; Luedde, Tom a,#
doi : 10.1097/MEG.0000000000002505
The pathogenesis of inflammatory bowel disease (IBD) has not been fully uncovered to date. Epstein-Barr-Virus (EBV) infection has recently been associated with the pathogenesis of multiple sclerosis, suggesting a general link between EBV and autoimmune diseases.
Long-term effectiveness and safety of ustekinumab in Crohn's disease: a prospective cohort study.
Thomas, Pepijn W.A. a; van Caem, Mark a; West, Rachel L. b; Russel, Maurice G.V.M c; Jansen, Jeroen M. d; Romkens, Tessa E.H. e; Hoentjen, Frank a,f; on behalf of the IBDREAM registry
doi : 10.1097/MEG.0000000000002506
Real-world data showed that ustekinumab is an effective treatment for Crohn's disease for up to 52 weeks. Yet, long-term effectiveness and safety outcomes beyond 52 weeks are limited. This study aimed to evaluate the corticosteroid-free clinical remission for up to 104 weeks.
Outcomes of immunomodulator and advanced therapies for primary sclerosing cholangitis-associated inflammatory bowel disease.
Sayed, Amr a,b; Assis, David N. b; Silveira, Marina G. b; Deng, Yanhong c; Ciarleglio, Maria c; Gaidos, Jill K.J. b; Proctor, Deborah D. b; Al-Bawardy, Badr b
doi : 10.1097/MEG.0000000000002510
Inflammatory bowel disease (IBD) coexists in up to 80% of patients with primary sclerosing cholangitis (PSC). The aim of this study is to investigate the outcomes of immunomodulator (IMM)/advanced therapies for the treatment of PSC-IBD.
Clinical characteristics and quality of life in patients with inflammatory bowel disease-associated anemia in Southeast China.
Xue, Mengli a,b; Chen, Jintong a,b; Zheng, Weiwei a,b; Liu, Yijuan a,b; Lin, Yijuan a,b; Wang, Chengdang a,b
doi : 10.1097/MEG.0000000000002511
Clinical characteristics of inflammatory bowel disease (IBD) with anemia have not been fully elucidated. This study aimed to investigate the frequency of, risk factors for, and management of anemia in IBD patients and to evaluate the quality of life (QOL) in IBD patients with anemia.
Impact of improved upper endoscopy quality on detection of gastric precancerous lesions.
Manfredi, Guido a; Pedaci, Marianna a; Iiritano, Elena a; Alicante, Saverio a; Romeo, Samanta a; Berte, Roberto a; Londoni, Claudio a; Menozzi, Fernanda a; Brambilla, Gianfranco a; Pezzilli, Raffaele b; Zullo, Angelo c; Buscarini, Elisabetta a
doi : 10.1097/MEG.0000000000002513
Intestinal metaplasia (IM) is the point of no return in gastric carcinogenesis, and patients with extensive (antrum plus corpus) IM are at high risk of developing gastric cancer.
Post-endoscopy colorectal cancer after colectomy in inflammatory bowel disease patients: a population-based register study.
Stjarngrim, Jessica a; Widman, Linnea b,c; Schmidt, Peter T d; Ekbom, Anders a; Forsberg, Anna a
doi : 10.1097/MEG.0000000000002514
Long-standing inflammatory bowel disease (IBD) colitis is an indication for endoscopic surveillance. Postcolonoscopy colorectal cancer (PCCRC), cancer detected after a negative colonoscopy, is a quality indicator for colonoscopy.
Positive hepatitis B core antibody is associated with advanced fibrosis and mortality in nonalcoholic fatty liver disease.
Zhang, Pengyan a,b; Liu, Zhenqiu c,d; Fan, Hong a,b,d; Shi, Tingting a,b; Han, Xinyu a,b; Suo, Chen a,b,d; Chen, Xingdong c,d; Zhang, Tiejun a,b,d
doi : 10.1097/MEG.0000000000002488
Concomitant hepatitis B virus infection and nonalcoholic fatty liver disease (NAFLD) are relatively common, while little is known about the impact of anti-hepatitis B core antibody (anti-HBc) on NAFLD individuals.
External validation of Chronic Liver Failure-Consortium Acute Decompensation score in the risk stratification of cirrhotic patients hospitalized with acute variceal bleeding.
Zhu, Zongyi a,b; Jiang, Huiqing a
doi : 10.1097/MEG.0000000000002487
Acute variceal bleeding (AVB) is a serious life-threatening complication of cirrhosis. This study aimed to validate the predictive value of Chronic Liver Failure-Consortium Acute Decompensation score (CLIF-C ADs) in the risk stratification of cirrhotic patients hospitalized with AVB.
Contrast-enhanced ultrasound pattern of hepatocellular carcinoma in noncirrhotic liver - results from the prospective multicentre DEGUM CEUS HCC study.
Schellhaas, Barbara; Jesper, Daniel; Strobel, Deike; DEGUM CEUS HCC Study Group.
doi : 10.1097/MEG.0000000000002491
Contrast-enhanced ultrasound (CEUS) has a high diagnostic accuracy for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in cirrhosis. However, as HCC in noncirrhosis becomes an emerging clinical concern, our study aimed to assess the diagnostic value of CEUS and the CEUS algorithms CEUS LI-RADS and ESCULAP in noncirrhotic liver in a prospective multicentre real-life setting.
What does quantitative HBsAg level mean in chronic hepatitis D infection?.
Ebik, Berat a; Cangul, M. Sadik b; Yalcin, Kendal c
doi : 10.1097/MEG.0000000000002489
In hepatitis delta virus (HDV) infection, which is an important etiological cause of chronic liver disease, the relationship between serum quantitative HBsAg level and fibrosis and histological activity was investigated.
Targeted liver ultrasound performed by an expert is the pivotal imaging examination for low phospholipid-associated cholelithiasis.
Su, Shu a,*; Trinh, Andrew b,*; Metz, Andrew J. b; Speer, Tony b; Simkin, Paul a; Buchanan, Daniel c,d,e; Boussioutas, Alex b,f; Gibson, Robert a,g
doi : 10.1097/MEG.0000000000002492
Low phospholipid-associatedcholelithiasis (LPAC) is a clinical syndrome that can be associated with variants in the adenosinetriphosphate-binding cassette subfamily B, member 4 (ABCB4) transporter gene, in a proportion of patients.
Development and validation of the Adult cirrhosiS Knowledge Questionnaire.
Leung, Hak Keith a; Mahadeva, Sanjiv a; Rajaram, Ruveena Bahavani a; Lai, Pauline Siew Mei b
doi : 10.1097/MEG.0000000000002493
Assessing a patient's knowledge regarding liver cirrhosis is important to improve patient outcomes. This study aimed to develop and validate the Adult cirrhosiS Knowledge Questionnaire (ASK-Q) to assess patients' knowledge regarding liver cirrhosis from multiple aspects.
Nomogram model for predicting esophsagogastric varices in hepatocellular carcinoma with cirrhosis.
Zhang, Daoming *,; Deng, Junjian *,; Guo, Xufeng *,; Zheng, Yongfa; Xu, Ximing
