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The changing landscape of scientific communication at EASD
Chantal Mathieu, Eleanor Kennedy, Patrick Schrauwen & Hindrik Mulder
Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies
Stephen R. Karpen, Jessica L. Dunne, Brigitte I. Frohnert, Marjana Marinac, Claudia Richard, Sarah E. David & Inish M. O’Doherty on behalf of the Type 1 Diabetes Consortium
doi : 10.1007/s00125-022-05751-0
The development of medical products that can delay or prevent progression to stage 3 type 1 diabetes faces many challenges. Of note, optimising patient selection for type 1 diabetes prevention clinical trials is hindered by significant patient heterogeneity and a lack of characterisation of the time-varying probability of progression to stage 3 type 1 diabetes in individuals positive for two or more islet autoantibodies.
Cardiovascular outcomes in type 1 and type 2 diabetes
Annika Rosengren & Pigi Dikaiou
doi : 10.1007/s00125-022-05857-5
Diabetes is one of the most prevalent cardiometabolic disorders on the planet. Type 1 diabetes accounts for only a minority of all cases (recently estimated to be ~2% globally); however, since this is a disorder with an early onset, many people live with type 1 diabetes for a long time.
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register
Minna Harsunen, Jarno L. T. Kettunen, Taina Härkönen, Om Dwivedi, Mikko Lehtovirta, Paula Vähäsalo, Riitta Veijola, Jorma Ilonen, Päivi J. Miettinen, Mikael Knip & Tiinamaija Tuomi
doi : 10.1007/s00125-022-05834-y
Monogenic forms of diabetes (MODY, neonatal diabetes mellitus and syndromic forms) are rare, and affected individuals may be misclassified and treated suboptimally.
Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes
Alexandra Coomans de Brachène, Corentin Scoubeau, Anyïshai E. Musuaya, Jose Maria Costa-Junior, Angela Castela, Julie Carpentier, Vitalie Faoro, Malgorzata Klass, Miriam Cnop & Decio L. Eizirik
doi : 10.1007/s00125-022-05837-9
Diabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process; preventing beta cell loss remains a major unmet need.
Timing of physical activity in relation to liver fat content and insulin resistance
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal & Renée de Mutsert
doi : 10.1007/s00125-022-05813-3
We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined cross-sectional associations of breaks in sedentary time and timing of physical activity with liver fat content and insulin resistance in a Dutch cohort.
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
Banafsheh Arshi, Jinluan Chen, M. Arfan Ikram, M. Carola Zillikens & Maryam Kavousi
doi : 10.1007/s00125-022-05821-3
The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study.
Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort
Elisa Dal Canto, Petra J. M. Elders, Amber A. van der Heijden, Adriana J. van Ballegooijen, Birgit I. Lissenberg-Witte, Femke Rutters & Joline W. J. Beulens
doi : 10.1007/s00125-022-05826-y
Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m2) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults with diabetes.
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Hyunkyung Kim, Kenneth E. Westerman, Kirk Smith, Joshua Chiou, Joanne B. Cole, Timothy Majarian, Marcin von Grotthuss, Soo Heon Kwak, Jaegil Kim, Josep M. Mercader, Jose C. Florez, Kyle Gaulton, Alisa K. Manning & Miriam S. Udler
doi : 10.1007/s00125-022-05848-6
Type 2 diabetes is highly polygenic and influenced by multiple biological pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to identify such pathways.
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes
Ele Ferrannini, Andrea Mari, Gabriela S. F. Monaco, Jay S. Skyler & Carmella Evans-Molina
doi : 10.1007/s00125-022-05836-w
The risk of progressing from autoantibody positivity to type 1 diabetes is inversely related to age. Separately, whether age influences patterns of C-peptide loss or changes in insulin sensitivity in autoantibody-positive individuals who progress to stage 3 type 1 diabetes is unclear.
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Sejal Mistry, Ramkiran Gouripeddi, Vandana Raman & Julio C. Facelli
doi : 10.1007/s00125-022-05843-x
Islet autoantibodies can be detected prior to the onset of type 1 diabetes and are important tools for aetiologic studies, prevention trials and disease screening. Current risk stratification models rely on the positivity status of islet autoantibodies alone, but additional autoantibody characteristics may be important for understanding disease onset.
Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes
Xiaona Cui, Jin Feng, Tianjiao Wei, Linxi Zhang, Shan Lang, Kun Yang, Jin Yang, Junling Liu, Michael Sterr, Heiko Lickert, Rui Wei & Tianpei Hong
doi : 10.1007/s00125-022-05822-2
Glucagon receptor (GCGR) antagonism ameliorates hyperglycaemia and promotes beta cell regeneration in mouse models of type 2 diabetes. However, the underlying mechanisms remain unclear. The present study aimed to investigate the mechanism of beta cell regeneration induced by GCGR antagonism in mice.
Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes
Joanne Boldison, Jessica R. Hopkinson, Joanne Davies, James A. Pearson, Pia Leete, Sarah Richardson, Noel G. Morgan & F. Susan Wong
doi : 10.1007/s00125-022-05839-7
B cells play an important role in driving the development of type 1 diabetes; however, it remains unclear how they contribute to local beta cell destruction during disease progression.
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice
Rafael C. Gaspar, Kun Lyu, Brandon T. Hubbard, Brooks P. Leitner, Panu K. Luukkonen, Sandro M. Hirabara, Ikki Sakuma, Ali Nasiri, Dongyan Zhang, Mario Kahn, Gary W. Cline, José Rodrigo Pauli, Rachel J. Perry, Kitt F. Petersen & Gerald I. Shulman
doi : 10.1007/s00125-022-05838-8
Athletes exhibit increased muscle insulin sensitivity, despite increased intramuscular triacylglycerol content. This phenomenon has been coined the ‘athlete’s paradox’ and is poorly understood.
Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy
Haifa Maalmi, Alexander Strom, Agnese Petrera, Stefanie M. Hauck, Klaus Strassburger, Oliver Kuss, Oana-Patricia Zaharia, Gidon J. Bönhof, Wolfgang Rathmann, Sandra Trenkamp, Volker Burkart, Julia Szendroedi, Dan Ziegler, Michael Roden, Christian Herder & the GDS Group
doi : 10.1007/s00125-022-05846-8
No established blood-based biomarker exists to monitor diabetic sensorimotor polyneuropathy (DSPN) and evaluate treatment response. The neurofilament light chain (NFL), a blood biomarker of neuroaxonal damage in several neurodegenerative diseases, represents a potential biomarker for DSPN.
CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice
Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman & Timothy S. Kern
doi : 10.1007/s00125-022-05860-w
Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy.
Utility of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies: a viewpoint from the FDA
Justin Penzenstadler, Justin C. Earp, Lauren K. Wood Heickman & Kristen Pluchino
GLP1RAs vs SGLT2is were associated with lower risk of major adverse limb events and similar risks of heart failure hospitalisation and stroke?
Lixin Du, Pan Wang, Hongwei Chen, Yu Zhang & Jianlan Ma
